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The map label for this gene is groEL [H]

Identifier: 51598904

GI number: 51598904

Start: 690400

End: 692037

Strand: Direct

Name: groEL [H]

Synonym: BG0672

Alternate gene names: 51598904

Gene position: 690400-692037 (Clockwise)

Preceding gene: 51598900

Following gene: 51598905

Centisome position: 76.35

GC content: 36.63

Gene sequence:

>1638_bases
ATGGCTAAAGACATATATTTTAATGAAGATGCTAGAAAAAGCTTACTTAGTGGCGTTGAAAAATTATCCAATGCTGTAAA
AGTAACTCTTGGGCCAAAAGGGAGAAATGTTCTTATTGATAAAAAGTTCGGTTCTCCAACGGTTACAAAAGATGGGGTTA
GCGTTGCTCGCGAGATTGAGCTTGAAAATCCGTTTGAAAATATGGGAGCGCAGCTTTTAAAGGAAGTTGCTATTAAAACA
AATGATGTTGCCGGCGATGGAACAACAACTGCTACTGTTCTTGCTTATGCTATTGCAAGAGAAGGCCTTAAGAATGTGTC
TTCAGGAATTAATCCTATTGGAATAAAAAAGGGAATAGATCATGCTGTAAATTTAGCTGCTGAGAAAATTCGTCAGTCTG
CAAAGAAAATCACAACAAAAGAAGAGATTGCACAAGTAGCTTCAATTTCTGCTAATAATGACAGTTATATAGGTGAAAAA
ATTGCTGAGGCAATGGATAAAGTTGGAAAAGATGGGGTTATAACAGTTGAAGAGTCAAAAACTTTTGATACTACGATTTC
TTATGTTGAGGGTATGCAATTTGACAGAGGATATCTTTCTCCTTATTTTTCCACCAATAAAGAGAATATGAGCGTTAGCT
TTGATGATGCTTTTATATTAATATATGAGAAGAAAATTAGTTCTATTAAAGAGCTTTTACCAGTTCTTGAGAAAGTTTTA
GGAACAAATAAACCTTTATTAATTATTGCTGAGGACATTGAAGGGGATGCTCTTGCCGCTCTTGTTTTAAATAGCGTTAG
AGGAGCCTTGAAAGTTTGTGCAATTAAATCGCCTGGTTTTGGTGATAGACGAAAAGCAATGCTTGAGGATATTGCAGTGC
TTACCGGTGGTGTTTTAATCAGTGAGGAGCTAGGTATTACTCTTGAGACAGTTGAAATTGAGCAACTTGGACAGGCTAAA
ACTATTAAGGTTGATAAGGACAATACTACTATTATTAATACCGGCAATAAAGAGCAAATAAAAGAGCGTTCAGAGCTTAT
TAAAAAACAAATTGAAGATTCAACATCTGAATATGATAAAGAAAAACTTCAAGAACGTCTTGCAAAGCTTGTTGGCGGAG
TTGCGGTTATTAATGTTGGAGCTGTTACTGAAGTAGAGCTTAAGGAAAAAAAACATAGAGTTGAAGATGCTCTTTCTGCA
ACTCGCGCTGCTGTTGAAGAGGGTGTTGTGCCTGGTGGCGGATCAACTCTTATTGAAGTTGCCATGTATTTGGATACAAT
AGATACAAGCAAATTAAGCTATGAGGAAAAGCAAGGTTTTGAGATTGTAAAAAGAAGTCTTGAAGAGCCAATGAGACAGA
TTATTTCAAATGCTGGTTTTGAAGGATCTATTTATATCCATCAAATTAAAACTGAGAAAAAGGGGCTTGGGTTTGATGCT
TCCAGCTTCAAGTGGGTAAATATGATTGAGAGTGGAATAATTGATCCTGCTAAGGTTACAAGAAGCGCGCTTCAAAATGC
TGCTTCAATTGCTGGGCTTTTATTAACAACAGAATGCGCAATCACCGATATTAAAGAAGAGAAAAATACTTCTGGTGGCG
GTGGTTATCCTATGGACCCGGGAATGGGAATGATGTAA

Upstream 100 bases:

>100_bases
ATATACAGAAGTAATACTCTATAGCGAATGTATTAAGTTTATGTTAATCTTATATTGTTAAATATAAATTATTTTATGTA
TAAAAAGGGGTAAAATTTTT

Downstream 100 bases:

>100_bases
ATTAAAGTTTCACCGGTGAACTTTTGTTTTTGCCGGTGAAATATTTTATTATTCAAAGGAATTTGTTTTGAGTGAGGATG
AATTTGTTTTTTGTATAGGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAKDIYFNEDARKSLLSGVEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENPFENMGAQLLKEVAIKT
NDVAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDHAVNLAAEKIRQSAKKITTKEEIAQVASISANNDSYIGEK
IAEAMDKVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAFILIYEKKISSIKELLPVLEKVL
GTNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKSPGFGDRRKAMLEDIAVLTGGVLISEELGITLETVEIEQLGQAK
TIKVDKDNTTIINTGNKEQIKERSELIKKQIEDSTSEYDKEKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSA
TRAAVEEGVVPGGGSTLIEVAMYLDTIDTSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFEGSIYIHQIKTEKKGLGFDA
SSFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITDIKEEKNTSGGGGYPMDPGMGMM

Sequences:

>Translated_545_residues
MAKDIYFNEDARKSLLSGVEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENPFENMGAQLLKEVAIKT
NDVAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDHAVNLAAEKIRQSAKKITTKEEIAQVASISANNDSYIGEK
IAEAMDKVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAFILIYEKKISSIKELLPVLEKVL
GTNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKSPGFGDRRKAMLEDIAVLTGGVLISEELGITLETVEIEQLGQAK
TIKVDKDNTTIINTGNKEQIKERSELIKKQIEDSTSEYDKEKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSA
TRAAVEEGVVPGGGSTLIEVAMYLDTIDTSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFEGSIYIHQIKTEKKGLGFDA
SSFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITDIKEEKNTSGGGGYPMDPGMGMM
>Mature_544_residues
AKDIYFNEDARKSLLSGVEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENPFENMGAQLLKEVAIKTN
DVAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDHAVNLAAEKIRQSAKKITTKEEIAQVASISANNDSYIGEKI
AEAMDKVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAFILIYEKKISSIKELLPVLEKVLG
TNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKSPGFGDRRKAMLEDIAVLTGGVLISEELGITLETVEIEQLGQAKT
IKVDKDNTTIINTGNKEQIKERSELIKKQIEDSTSEYDKEKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSAT
RAAVEEGVVPGGGSTLIEVAMYLDTIDTSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFEGSIYIHQIKTEKKGLGFDAS
SFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITDIKEEKNTSGGGGYPMDPGMGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=49.9058380414313, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=49.9058380414313, Blast_Score=507, Evalue=1e-143,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=59.1603053435115, Blast_Score=609, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=47.4576271186441, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=48.1132075471698, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.6615969581749, Blast_Score=531, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322524, Length=129, Percent_Identity=32.5581395348837, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=48.6742424242424, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=48.6742424242424, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=46.3137996219282, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=46.3137996219282, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=46.3137996219282, Blast_Score=485, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17864606, Length=554, Percent_Identity=41.5162454873646, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=36.3809523809524, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=36.3809523809524, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24583944, Length=169, Percent_Identity=24.8520710059172, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58925; Mature: 58794

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIYFNEDARKSLLSGVEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIE
CCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHCC
LENPFENMGAQLLKEVAIKTNDVAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGID
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HAVNLAAEKIRQSAKKITTKEEIAQVASISANNDSYIGEKIAEAMDKVGKDGVITVEESK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
TFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAFILIYEKKISSIKELLPVLEKVL
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHH
GTNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKSPGFGDRRKAMLEDIAVLTGGVLI
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHCCEEE
SEELGITLETVEIEQLGQAKTIKVDKDNTTIINTGNKEQIKERSELIKKQIEDSTSEYDK
ECCCCCEEEEEEHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSATRAAVEEGVVPGGGSTLIEV
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AMYLDTIDTSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFEGSIYIHQIKTEKKGLGFDA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
SSFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITDIKEEKNTSGGGGYPMDP
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GMGMM
CCCCC
>Mature Secondary Structure 
AKDIYFNEDARKSLLSGVEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIE
CCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHHHCC
LENPFENMGAQLLKEVAIKTNDVAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGID
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HAVNLAAEKIRQSAKKITTKEEIAQVASISANNDSYIGEKIAEAMDKVGKDGVITVEESK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCC
TFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAFILIYEKKISSIKELLPVLEKVL
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHH
GTNKPLLIIAEDIEGDALAALVLNSVRGALKVCAIKSPGFGDRRKAMLEDIAVLTGGVLI
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHCCEEE
SEELGITLETVEIEQLGQAKTIKVDKDNTTIINTGNKEQIKERSELIKKQIEDSTSEYDK
ECCCCCEEEEEEHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSATRAAVEEGVVPGGGSTLIEV
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AMYLDTIDTSKLSYEEKQGFEIVKRSLEEPMRQIISNAGFEGSIYIHQIKTEKKGLGFDA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
SSFKWVNMIESGIIDPAKVTRSALQNAASIAGLLLTTECAITDIKEEKNTSGGGGYPMDP
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GMGMM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA