Click here to switch to the map view.

The map label for this gene is lptB [H]

Identifier: 51598824

GI number: 51598824

Start: 588153

End: 588959

Strand: Direct

Name: lptB [H]

Synonym: BG0584

Alternate gene names: 51598824

Gene position: 588153-588959 (Clockwise)

Preceding gene: 51598823

Following gene: 51598825

Centisome position: 65.04

GC content: 27.51

Gene sequence:

>807_bases
ATGGCTATTGAAGTTTCTAATGTGAAATTTTCTTATAAGGGAAAAGAAGTTTACTCAGATTTGAATTTAAATATTGAGAC
TCCTCAAGCTTATTTGCTTCTTGGTAAAAATGGGGTTGGAAAAACAACTTTGCTTAAACTTGTAAGTGGACTTTTAGAGC
CATTAAAGGGGAAGGTTTTATTCAACTCTTTGGCAGCTTTCCCAAGAAATCCCTTAAATTTAATGAATTTATTTTTTGTT
CCTGAAGAATTTTCACTTCCCAGATTGTCTTTGGTCGAATACAGTAAAGCTTTATCTAGATTTTATCCAAATTTTAATAA
GGCAGATTTTGAAAAATATTTATTAGATTTTAATCTAGATATTTCCCTTGATCTATCTTCCGCTTCTTTTGGACAAAAGA
AAAAAAGTATTATTGCATTTTCTCTAGCTACAAATGTTTCTTGCTTATTGTTTGACGAGCCAACAAATAGTCTTGATATT
GTTTCAAAAAATGTTTTTAGAAATCTACTTTCTAATTTAAATGATAGAGTAATTTTTATTACAGGTCACAATGTGAGGGA
TTTGATAGGAGTTATAGATTATTTAATTATTGTTGGGGAGAAGTCAATTTTTTTTTCCAATTCAATATCTTATATTAATA
AAAATTATAAGATTAAAATTATCAGTGAACTTAATGGAAATGAATTGTATTATGAAAAAAATAAAGATGGGTTTAAGGCA
CTTTATTTTGAGAGTAGCAATGGAGCTGAAGTTGTTGATATTGAATTTTTCTTTTTATATGTTACTGAAAATAAAAAGGA
GAGGTAA

Upstream 100 bases:

>100_bases
TTTCTATATTTATTTATAAGTTGTTTATAAAGAATTGAATTTATATTTTTGGAATAATTAATTTTTTTTATATTTTGACC
TTTAATATTAAGGAGTATTT

Downstream 100 bases:

>100_bases
TAAAGGATGTTTAGCTTAAAAAGATTTTTAAATTTATTTTATTTTGATTTTTTTTATAATAAAAAATTCTATATTTTATT
AATAATTAAAATTTTAGGAA

Product: ABC transporter, ATP-binding protein

Products: ADP; phosphate; S2O32- [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MAIEVSNVKFSYKGKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKVLFNSLAAFPRNPLNLMNLFFV
PEEFSLPRLSLVEYSKALSRFYPNFNKADFEKYLLDFNLDISLDLSSASFGQKKKSIIAFSLATNVSCLLFDEPTNSLDI
VSKNVFRNLLSNLNDRVIFITGHNVRDLIGVIDYLIIVGEKSIFFSNSISYINKNYKIKIISELNGNELYYEKNKDGFKA
LYFESSNGAEVVDIEFFFLYVTENKKER

Sequences:

>Translated_268_residues
MAIEVSNVKFSYKGKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKVLFNSLAAFPRNPLNLMNLFFV
PEEFSLPRLSLVEYSKALSRFYPNFNKADFEKYLLDFNLDISLDLSSASFGQKKKSIIAFSLATNVSCLLFDEPTNSLDI
VSKNVFRNLLSNLNDRVIFITGHNVRDLIGVIDYLIIVGEKSIFFSNSISYINKNYKIKIISELNGNELYYEKNKDGFKA
LYFESSNGAEVVDIEFFFLYVTENKKER
>Mature_267_residues
AIEVSNVKFSYKGKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKVLFNSLAAFPRNPLNLMNLFFVP
EEFSLPRLSLVEYSKALSRFYPNFNKADFEKYLLDFNLDISLDLSSASFGQKKKSIIAFSLATNVSCLLFDEPTNSLDIV
SKNVFRNLLSNLNDRVIFITGHNVRDLIGVIDYLIIVGEKSIFFSNSISYINKNYKIKIISELNGNELYYEKNKDGFKAL
YFESSNGAEVVDIEFFFLYVTENKKER

Specific function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1788761, Length=241, Percent_Identity=27.8008298755187, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789593, Length=224, Percent_Identity=25.4464285714286, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081709, Length=251, Percent_Identity=24.7011952191235, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788210, Length=200, Percent_Identity=27.5, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789586, Length=248, Percent_Identity=22.5806451612903, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786319, Length=211, Percent_Identity=27.4881516587678, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788165, Length=201, Percent_Identity=23.3830845771144, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321121, Length=211, Percent_Identity=28.9099526066351, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320874, Length=216, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: 3.6.3.25 [C]

Molecular weight: Translated: 30484; Mature: 30353

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEVSNVKFSYKGKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKVL
CEEEEECEEEEECCHHHHHCCCEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHH
FNSLAAFPRNPLNLMNLFFVPEEFSLPRLSLVEYSKALSRFYPNFNKADFEKYLLDFNLD
HHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHEEEEECCE
ISLDLSSASFGQKKKSIIAFSLATNVSCLLFDEPTNSLDIVSKNVFRNLLSNLNDRVIFI
EEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEE
TGHNVRDLIGVIDYLIIVGEKSIFFSNSISYINKNYKIKIISELNGNELYYEKNKDGFKA
ECCCHHHHHHHHHHHHEECCCCEEEECCHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
LYFESSNGAEVVDIEFFFLYVTENKKER
EEEECCCCCEEEEEEEEEEEEECCCCCC
>Mature Secondary Structure 
AIEVSNVKFSYKGKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKVL
EEEEECEEEEECCHHHHHCCCEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHH
FNSLAAFPRNPLNLMNLFFVPEEFSLPRLSLVEYSKALSRFYPNFNKADFEKYLLDFNLD
HHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHEEEEECCE
ISLDLSSASFGQKKKSIIAFSLATNVSCLLFDEPTNSLDIVSKNVFRNLLSNLNDRVIFI
EEEEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEE
TGHNVRDLIGVIDYLIIVGEKSIFFSNSISYINKNYKIKIISELNGNELYYEKNKDGFKA
ECCCHHHHHHHHHHHHEECCCCEEEECCHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
LYFESSNGAEVVDIEFFFLYVTENKKER
EEEECCCCCEEEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S2O32- [Periplasm]; H2O; SO42- [Periplasm]; ATP [C]

Specific reaction: ATP + S2O32- [Periplasm] + H2O = ADP + phosphate + S2O32- [Cytoplasm] SO42- [Periplasm] + H2O + ATP = SO42- [Cytoplasm] + phosphate + ADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]