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The map label for this gene is mtlA

Identifier: 51598203

GI number: 51598203

Start: 4677416

End: 4679347

Strand: Direct

Name: mtlA

Synonym: YPTB3918

Alternate gene names: 51598203

Gene position: 4677416-4679347 (Clockwise)

Preceding gene: 51598202

Following gene: 51598204

Centisome position: 98.58

GC content: 51.24

Gene sequence:

>1932_bases
ATGTTTTCACCAGACGCAAAGGTCAGGGTCCAAAACTTTGGCCGATTCCTAAGCAATATGGTCATGCCCAATATCGGCGC
ATTTATCGCTTGGGGCATTATCACCGCACTGTTTATTCCAACCGGCTGGCTGCCCAATGAAACCTTAGCCAAACTGGTTG
GCCCGATGATTACCTATCTGTTGCCACTGTTGATCGGTTTTACCGGTGGCCGTTTGGTAGGCGGAGATCGCGGTGGCGTA
GTCGGTGCCATCACCACCATGGGGGTGATCGTTGGTGCGGATATGCCAATGTTCCTCGGTGCGATGATTGTCGGCCCGCT
GGGTGGCTGGGCAATTAAACATTTTGACCGCTGGGTTGAAGGTAAAATCAAAAGCGGCTTTGAGATGTTGGTTAACAACT
TCTCATCCGGCATCATTGGTATGTTGCTGGCTCTCCTTGCCTTTATGGCGATTGGTCCGTTGGTTGAAGTCCTGTCTAAA
GGGCTGGCTTACGGTGTGGATGTCATGGTGCAGAATAATCTGTTGCCACTCGCATCGATCTTCGTTGAACCGGCAAAAAT
TCTCTTCCTGAATAACGCTATCAACCACGGTATCTTCTCACCACTGGGTGTCCAGCAAGCCGCTGAAACCGGTAAGTCTA
TCTTCTTCTTGATCGAAGCAAACCCAGGACCGGGGTTGGGTGTGTTGATGGCGTATATGTTCTTCGGCAAAGGTAATGCT
AAGCAGTCAGCTGGCGGTGCCGCTATCATCCATTTCTTCGGTGGTATCCACGAAATTTATTTCCCTTATGTGCTGATGAA
CCCTCGCTTACTGTTGGCGGTGATTCTGGGCGGTATGACAGGTGTGTTCACCCTGACCCTGCTGAACGGCGGGCTGGTCT
CTGCCGCTTCACCGGGTTCTATTCTGGCAATATTGGCCATGACGCCTAAAGGGGCTTACTTTGCCAACATTGCTGCGGTT
GCCACCGCCTTTGCCGTGTCCTTCGTGGTCTCTGCCATCTTGCTGAAAAGCTCTAAGGCTAAAGACGATGAAGAGGGCCT
TGAAGGCGCAACTCGCCGTATGCAAGATATGAAAGCGCAGTCTAAAGGTGTTCAGGCGGCCAATGCCGCTGCCGCTGCTG
GCGATTTAAGCACAGTGCGTAAAATTATCGTTGCCTGTGATGCCGGTATGGGGTCCAGTGCGATGGGGGCCGGTGTTCTG
CGTAAAAAAGTACAAGATGCCGGGCTGAAACATATTGCGGTGACCAACTGTGCAATCAACAACTTACCGGAAGATGTGGA
TCTGGTGATCACGCACCGTGATTTGACTGAGCGGGCGATGCGCCATGCACCGCAGGCACAGCATATCTCGCTGACTAATT
TCCTCGACAGCCAACTGTACAACAGCCTGACGGCGGAGCTGCTGCAAGCCAGTCAATTGGTTGATAATACTAAAGTACAG
AAAGTGATCGAAAAACTGGACGATAGCTTCGAAGCATTTGAAGATAATTTGTTCAAGTTGGGGGCGGAGAATATCTTCCT
CAATCAGCATGCGACAGCCAAAGAGCAGGCTATCCGCTTCGCCGGTGAACAGTTGGTCAAAGGTGGCTATGTCGAACCTG
AATATGTCGAGGCGATGCTGGATCGTGAAAAACTGAGCTCAACGTATCTGGGTGAGTCTATCGCGGTGCCACATGGCACG
ATTGAAGCAAAAGATCGTGTGCTGAAGACCGGGGTGGTGTTCTGTCAATACCCGGAAGGTGTGCGCTTTGGCGATGAAGA
AGATGATATCGCCCGTCTGGTGATTGGTATTGCTGCTCGTAACAACGAGCATATTCAAGTCATTACCAGCCTGACTAACG
CACTGGATGACGACTCGGTGATTGCGCGTTTAAGTAAGACGACCAGCGTGCAGGAAGTATTGGACTTACTGGGCGGTAAA
ACGTCTGCTTGA

Upstream 100 bases:

>100_bases
TGTTTGCATAAGGTAACACTGGCGGGTTTTGCAAAACTGCCTCCAATTAAAATAATTATATCGCGCTCTTATTGTTAGCG
CGTACCAATAGGGGTGTTTT

Downstream 100 bases:

>100_bases
TATACCCGTCATACTTCACGCTGCATGAACGTTGGCTGCTTTGCCTACCTGCAACGCGAATTATTTAGCGTATAAACAAG
TCATAACTGCTAGGGCTGTT

Product: PTS system, mannitol-specific IIABC component

Products: NA

Alternate protein names: EIICBA-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific EIIA component [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MFSPDAKVRVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGFTGGRLVGGDRGGV
VGAITTMGVIVGADMPMFLGAMIVGPLGGWAIKHFDRWVEGKIKSGFEMLVNNFSSGIIGMLLALLAFMAIGPLVEVLSK
GLAYGVDVMVQNNLLPLASIFVEPAKILFLNNAINHGIFSPLGVQQAAETGKSIFFLIEANPGPGLGVLMAYMFFGKGNA
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTLLNGGLVSAASPGSILAILAMTPKGAYFANIAAV
ATAFAVSFVVSAILLKSSKAKDDEEGLEGATRRMQDMKAQSKGVQAANAAAAAGDLSTVRKIIVACDAGMGSSAMGAGVL
RKKVQDAGLKHIAVTNCAINNLPEDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSQLYNSLTAELLQASQLVDNTKVQ
KVIEKLDDSFEAFEDNLFKLGAENIFLNQHATAKEQAIRFAGEQLVKGGYVEPEYVEAMLDREKLSSTYLGESIAVPHGT
IEAKDRVLKTGVVFCQYPEGVRFGDEEDDIARLVIGIAARNNEHIQVITSLTNALDDDSVIARLSKTTSVQEVLDLLGGK
TSA

Sequences:

>Translated_643_residues
MFSPDAKVRVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGFTGGRLVGGDRGGV
VGAITTMGVIVGADMPMFLGAMIVGPLGGWAIKHFDRWVEGKIKSGFEMLVNNFSSGIIGMLLALLAFMAIGPLVEVLSK
GLAYGVDVMVQNNLLPLASIFVEPAKILFLNNAINHGIFSPLGVQQAAETGKSIFFLIEANPGPGLGVLMAYMFFGKGNA
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTLLNGGLVSAASPGSILAILAMTPKGAYFANIAAV
ATAFAVSFVVSAILLKSSKAKDDEEGLEGATRRMQDMKAQSKGVQAANAAAAAGDLSTVRKIIVACDAGMGSSAMGAGVL
RKKVQDAGLKHIAVTNCAINNLPEDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSQLYNSLTAELLQASQLVDNTKVQ
KVIEKLDDSFEAFEDNLFKLGAENIFLNQHATAKEQAIRFAGEQLVKGGYVEPEYVEAMLDREKLSSTYLGESIAVPHGT
IEAKDRVLKTGVVFCQYPEGVRFGDEEDDIARLVIGIAARNNEHIQVITSLTNALDDDSVIARLSKTTSVQEVLDLLGGK
TSA
>Mature_643_residues
MFSPDAKVRVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYLLPLLIGFTGGRLVGGDRGGV
VGAITTMGVIVGADMPMFLGAMIVGPLGGWAIKHFDRWVEGKIKSGFEMLVNNFSSGIIGMLLALLAFMAIGPLVEVLSK
GLAYGVDVMVQNNLLPLASIFVEPAKILFLNNAINHGIFSPLGVQQAAETGKSIFFLIEANPGPGLGVLMAYMFFGKGNA
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTLLNGGLVSAASPGSILAILAMTPKGAYFANIAAV
ATAFAVSFVVSAILLKSSKAKDDEEGLEGATRRMQDMKAQSKGVQAANAAAAAGDLSTVRKIIVACDAGMGSSAMGAGVL
RKKVQDAGLKHIAVTNCAINNLPEDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSQLYNSLTAELLQASQLVDNTKVQ
KVIEKLDDSFEAFEDNLFKLGAENIFLNQHATAKEQAIRFAGEQLVKGGYVEPEYVEAMLDREKLSSTYLGESIAVPHGT
IEAKDRVLKTGVVFCQYPEGVRFGDEEDDIARLVIGIAARNNEHIQVITSLTNALDDDSVIARLSKTTSVQEVLDLLGGK
TSA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=638, Percent_Identity=81.8181818181818, Blast_Score=1040, Evalue=0.0,
Organism=Escherichia coli, GI1789301, Length=470, Percent_Identity=53.8297872340426, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI1788494, Length=147, Percent_Identity=43.5374149659864, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1786951, Length=143, Percent_Identity=31.4685314685315, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 68447; Mature: 68447

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSPDAKVRVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYL
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LPLLIGFTGGRLVGGDRGGVVGAITTMGVIVGADMPMFLGAMIVGPLGGWAIKHFDRWVE
HHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
GKIKSGFEMLVNNFSSGIIGMLLALLAFMAIGPLVEVLSKGLAYGVDVMVQNNLLPLASI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHH
FVEPAKILFLNNAINHGIFSPLGVQQAAETGKSIFFLIEANPGPGLGVLMAYMFFGKGNA
HHCCHHEEEECCHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTLLNGGLVSAASPGS
CCCCCCHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
ILAILAMTPKGAYFANIAAVATAFAVSFVVSAILLKSSKAKDDEEGLEGATRRMQDMKAQ
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SKGVQAANAAAAAGDLSTVRKIIVACDAGMGSSAMGAGVLRKKVQDAGLKHIAVTNCAIN
HCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHC
NLPEDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSQLYNSLTAELLQASQLVDNTKVQ
CCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVIEKLDDSFEAFEDNLFKLGAENIFLNQHATAKEQAIRFAGEQLVKGGYVEPEYVEAML
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DREKLSSTYLGESIAVPHGTIEAKDRVLKTGVVFCQYPEGVRFGDEEDDIARLVIGIAAR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
NNEHIQVITSLTNALDDDSVIARLSKTTSVQEVLDLLGGKTSA
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSPDAKVRVQNFGRFLSNMVMPNIGAFIAWGIITALFIPTGWLPNETLAKLVGPMITYL
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LPLLIGFTGGRLVGGDRGGVVGAITTMGVIVGADMPMFLGAMIVGPLGGWAIKHFDRWVE
HHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
GKIKSGFEMLVNNFSSGIIGMLLALLAFMAIGPLVEVLSKGLAYGVDVMVQNNLLPLASI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHH
FVEPAKILFLNNAINHGIFSPLGVQQAAETGKSIFFLIEANPGPGLGVLMAYMFFGKGNA
HHCCHHEEEECCHHHCCCCCCCCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCCC
KQSAGGAAIIHFFGGIHEIYFPYVLMNPRLLLAVILGGMTGVFTLTLLNGGLVSAASPGS
CCCCCCHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
ILAILAMTPKGAYFANIAAVATAFAVSFVVSAILLKSSKAKDDEEGLEGATRRMQDMKAQ
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SKGVQAANAAAAAGDLSTVRKIIVACDAGMGSSAMGAGVLRKKVQDAGLKHIAVTNCAIN
HCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHC
NLPEDVDLVITHRDLTERAMRHAPQAQHISLTNFLDSQLYNSLTAELLQASQLVDNTKVQ
CCCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVIEKLDDSFEAFEDNLFKLGAENIFLNQHATAKEQAIRFAGEQLVKGGYVEPEYVEAML
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DREKLSSTYLGESIAVPHGTIEAKDRVLKTGVVFCQYPEGVRFGDEEDDIARLVIGIAAR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHCC
NNEHIQVITSLTNALDDDSVIARLSKTTSVQEVLDLLGGKTSA
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6309813; 8041620; 9278503; 3135464; 3142516; 1946374; 9551558 [H]