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The map label for this gene is glpD

Identifier: 51598072

GI number: 51598072

Start: 4490501

End: 4492015

Strand: Direct

Name: glpD

Synonym: YPTB3782

Alternate gene names: 51598072

Gene position: 4490501-4492015 (Clockwise)

Preceding gene: 51598069

Following gene: 51598078

Centisome position: 94.64

GC content: 53.27

Gene sequence:

>1515_bases
ATGGAAACCAAAGACTTGATCGTGATCGGTGGCGGTATTAACGGTGCCGGTATCGCTGCGGACGCTGCTGGGCGTGGCCT
GTCGGTACTGCTGCTGGAAGCGCAAGACTTGGCCTGTGCTACGTCTTCCGCCAGTTCCAAACTTATCCATGGTGGCTTAC
GCTATCTGGAACATTATGAATTCCGCTTGGTAAGTGAAGCCTTGGCCGAGCGTGAAGTGTTACTGAAACTGGCACCGCAT
ATCGCATTCCCTATGCGCTTCCGCCTACCCCACCAGCCTCATCTGCGCCCGGCATGGATGATCCGCACCGGCTTGTTCTT
GTATGACCATTTGGGCAAACGTACCAGCCTGCCAGCCAGTAAAGGGCTGCGTTTTGGGCCGGAATCTGTGTTAAAACCCG
AGTTGGTGCGCGGTTTCGAATATTCTGACTGTTGGGTGGATGATGCCCGCCTGGTGGTGCTGAATGCGCAGGAAGTGGTT
AAACACGGCGGTGAAGTCCGAACCCGTACCAAAGTGACCCGTGCCTGGCGTGAACAAGGCCTATGGATGGTTGAAGCCCT
TGATGTCAATACTGGCAAAACCTTCACCTGGCGGGCTAAAGGCTTAGTGAATGCCACTGGCCCTTGGGTTAAACAGTTCT
TCGACGATGGCCTAAAGCTCAAATCACCTTATGGCATCCGCCTAATTAAAGGCAGCCACATTGTGGTGCCCCGGGTTCAT
AACCAACCGCAGGCGTATATTCTGCAAAATGAAGATCACCGTATCGTTTTCGTTATCCCTTGGTTAGATGACTATTCCAT
CATCGGTACTACCGACGTGGAATACCACGGCGATCCAAAAGAGGTGAAAATTGACGATCAGGAAATGACTTATCTGCTGA
AAGTCTATAACGACCACTTTAAAAAACAGTTGGGTCGTGACGATATCGTCTGGACCTACTCTGGTGTGCGCCCGCTATGC
GACGATGAATCAGATTCACCGCAAGCCGTTACCCGCGATTACACGCTAGATGTGGCCGATGAAGCGGGTCAGGCACCACT
CCTGTCGGTCTTCGGCGGTAAACTCACCACCTACCGTAAATTGGCAGAACATGCGCTGGAAAAACTGTCAGCGTACTACC
CGAATGTCGGCCCAGCGTGGACTAAAACCGGTGCCTTGCCCGGTGGGGATATTGGCGGTAGCCGTGATAGCTATACCGTG
CAATTGCGCCACCGCTATAACTGGTTGCCGGAAGGATTGGCCCGCCGCTATACCCGTACCTATGGTAGCCACAGCGAGCT
AATTTTAGCCAATGCGACCCGTCTTGAAAGCCTGGGTGAGCACTTTGGTCACGGCTTGTATGAGGCTGAATTGCGCTATT
TGGTTGAGAACGAGTGGGTCGTTGAGCTGGATGATGCTATCTGGCGCCGTACCAAATTAGGCATGGCCCTCAGCGATGAA
GAGAAACAGCGGGTAGCCCAGTGGCTGGCTGATGCGCACACTGAAAAACAACAGGCGCTGCCGCTGGTTTCTTAA

Upstream 100 bases:

>100_bases
TTTCTTCGGTTAAATCTTGGCTTATTTGTTGGTTTTTGATTACAATCGTGAGCGAAAACGAACATTAAAGCGCTGTTTCG
AACATTCAGAGGAAGGTAAC

Downstream 100 bases:

>100_bases
TAGCAAAGTTTAACATTGTTTAACTTTCGTTAATTTTTGCCTTTCTGGGCTGCATAGCGTTGTTCAAGCATCTCAAGAAA
TTTAAAAACCCTCTTCATCG

Product: glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
METKDLIVIGGGINGAGIAADAAGRGLSVLLLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPH
IAFPMRFRLPHQPHLRPAWMIRTGLFLYDHLGKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNAQEVV
KHGGEVRTRTKVTRAWREQGLWMVEALDVNTGKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVH
NQPQAYILQNEDHRIVFVIPWLDDYSIIGTTDVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLC
DDESDSPQAVTRDYTLDVADEAGQAPLLSVFGGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTV
QLRHRYNWLPEGLARRYTRTYGSHSELILANATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDE
EKQRVAQWLADAHTEKQQALPLVS

Sequences:

>Translated_504_residues
METKDLIVIGGGINGAGIAADAAGRGLSVLLLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPH
IAFPMRFRLPHQPHLRPAWMIRTGLFLYDHLGKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNAQEVV
KHGGEVRTRTKVTRAWREQGLWMVEALDVNTGKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVH
NQPQAYILQNEDHRIVFVIPWLDDYSIIGTTDVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLC
DDESDSPQAVTRDYTLDVADEAGQAPLLSVFGGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTV
QLRHRYNWLPEGLARRYTRTYGSHSELILANATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDE
EKQRVAQWLADAHTEKQQALPLVS
>Mature_504_residues
METKDLIVIGGGINGAGIAADAAGRGLSVLLLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPH
IAFPMRFRLPHQPHLRPAWMIRTGLFLYDHLGKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNAQEVV
KHGGEVRTRTKVTRAWREQGLWMVEALDVNTGKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVH
NQPQAYILQNEDHRIVFVIPWLDDYSIIGTTDVEYHGDPKEVKIDDQEMTYLLKVYNDHFKKQLGRDDIVWTYSGVRPLC
DDESDSPQAVTRDYTLDVADEAGQAPLLSVFGGKLTTYRKLAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTV
QLRHRYNWLPEGLARRYTRTYGSHSELILANATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDE
EKQRVAQWLADAHTEKQQALPLVS

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=515, Percent_Identity=29.9029126213592, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI285002231, Length=515, Percent_Identity=29.9029126213592, Blast_Score=172, Evalue=5e-43,
Organism=Escherichia coli, GI2367226, Length=504, Percent_Identity=77.3809523809524, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI1788574, Length=474, Percent_Identity=27.8481012658228, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17509253, Length=515, Percent_Identity=29.3203883495146, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI115534726, Length=531, Percent_Identity=29.1902071563089, Blast_Score=141, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322036, Length=534, Percent_Identity=27.1535580524345, Blast_Score=142, Evalue=8e-35,
Organism=Drosophila melanogaster, GI161077125, Length=513, Percent_Identity=30.0194931773879, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24653942, Length=513, Percent_Identity=30.0194931773879, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24653944, Length=513, Percent_Identity=30.0194931773879, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI20130025, Length=513, Percent_Identity=30.0194931773879, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24586295, Length=519, Percent_Identity=26.9749518304432, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19921278, Length=496, Percent_Identity=25, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 56837; Mature: 56837

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKDLIVIGGGINGAGIAADAAGRGLSVLLLEAQDLACATSSASSKLIHGGLRYLEHYE
CCCCCEEEECCCCCCCCEECCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHH
FRLVSEALAEREVLLKLAPHIAFPMRFRLPHQPHLRPAWMIRTGLFLYDHLGKRTSLPAS
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
KGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNAQEVVKHGGEVRTRTKVTRAWREQG
CCCCCCCHHHCCHHHHCCCCCCCCEECCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHCC
LWMVEALDVNTGKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVH
CEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHCCCCEECCCCCEEEEECCEEEEECCC
NQPQAYILQNEDHRIVFVIPWLDDYSIIGTTDVEYHGDPKEVKIDDQEMTYLLKVYNDHF
CCCCEEEEECCCCEEEEEEECCCCCEEEECCCCEECCCCCEEEECHHHHHHHHHHHHHHH
KKQLGRDDIVWTYSGVRPLCDDESDSPQAVTRDYTLDVADEAGQAPLLSVFGGKLTTYRK
HHHCCCCCEEEEECCCCCCCCCCCCCCCEEECCEEEEECCCCCCCCCHHHHCCCHHHHHH
LAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTVQLRHRYNWLPEGLARRYTRT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHH
YGSHSELILANATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDE
CCCCCCEEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECHHHHHHHHCCCEECCH
EKQRVAQWLADAHTEKQQALPLVS
HHHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure
METKDLIVIGGGINGAGIAADAAGRGLSVLLLEAQDLACATSSASSKLIHGGLRYLEHYE
CCCCCEEEECCCCCCCCEECCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHH
FRLVSEALAEREVLLKLAPHIAFPMRFRLPHQPHLRPAWMIRTGLFLYDHLGKRTSLPAS
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
KGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNAQEVVKHGGEVRTRTKVTRAWREQG
CCCCCCCHHHCCHHHHCCCCCCCCEECCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHCC
LWMVEALDVNTGKTFTWRAKGLVNATGPWVKQFFDDGLKLKSPYGIRLIKGSHIVVPRVH
CEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHCCCCEECCCCCEEEEECCEEEEECCC
NQPQAYILQNEDHRIVFVIPWLDDYSIIGTTDVEYHGDPKEVKIDDQEMTYLLKVYNDHF
CCCCEEEEECCCCEEEEEEECCCCCEEEECCCCEECCCCCEEEECHHHHHHHHHHHHHHH
KKQLGRDDIVWTYSGVRPLCDDESDSPQAVTRDYTLDVADEAGQAPLLSVFGGKLTTYRK
HHHCCCCCEEEEECCCCCCCCCCCCCCCEEECCEEEEECCCCCCCCCHHHHCCCHHHHHH
LAEHALEKLSAYYPNVGPAWTKTGALPGGDIGGSRDSYTVQLRHRYNWLPEGLARRYTRT
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHH
YGSHSELILANATRLESLGEHFGHGLYEAELRYLVENEWVVELDDAIWRRTKLGMALSDE
CCCCCCEEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECHHHHHHHHCCCEECCH
EKQRVAQWLADAHTEKQQALPLVS
HHHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1987111; 9278503; 3045087; 3045764 [H]