Click here to switch to the map view.

The map label for this gene is glpG

Identifier: 51598068

GI number: 51598068

Start: 4486419

End: 4487255

Strand: Direct

Name: glpG

Synonym: YPTB3778

Alternate gene names: 51598068

Gene position: 4486419-4487255 (Clockwise)

Preceding gene: 51598067

Following gene: 51598069

Centisome position: 94.56

GC content: 50.3

Gene sequence:

>837_bases
ATGACTCGAGTGATAGTAATCTCTAACCTACGTCTGGCGCAGGCCTTTGTGGATTATATGGCCACCCACCATGTGGCATT
AGAAATCCGGCCAGACGCTCAAGGCGTTGAAATCTGGTTGGCCGATGATGAGCAACTTTCTGCCGTCCAACATGAGTTGG
AGCAATTTCTACTGGATCCACTTAATCCACGCTATCAGGCCGCCAGTTGGCAAGCTGGGAATGTGAATTCAAATCTGCCC
TATCAGCGTTTTTCTTACCTCCAAACATTACGCAGCCAGGCTGGGCCGTTAACGCTAAGCGTGATGGTGTTGTGTATTGC
CATCTATATTCTGATGCTCATTACGGGGGATATGGCGGTAATGTCCTGGCTGGCATGGCCCTATAACAGCAGCCAGTATC
TACAAATCTGGCGTTGGGTCAGCCATGCCTTCTTGCACTTTTCACTGCTGCACATCCTGTTTAACCTGATGTGGTGGTGG
TATCTGGGCGGGCAGATGGAAAAACGGCTTGGCACCAGCAAATTGCTGGTATTAACTATCGTCTCAGCCGTCTTCAGTGG
CTGGGGGCAATCACTCTTCAGCGGTGCCAACTTTGGTGGTCTATCAGGTGTGGTTTACGCCTTAATGGGCTATGTCTGGC
TGACCGGTGAACGCGCACCCGAGCATGGTATCTCACTGCCCCGTGGCTTGATGGCTTTTTCTGTGCTCTGGCTGATAGCC
GGGTATTTCGATATTTTAGGCTTGTCGATTGCCAATGCAGCTCATGTTTCTGGTTTGATTATTGGGCTACTAATGGCATT
TTGGGATACGCGCAACAGCGCGAGAACCGTACAATAA

Upstream 100 bases:

>100_bases
TTGATGTGGTTTACAGTATTGATGGCGGTTTTGAAGCCTGGGCCAGAAGCTATCCGCAAGACATAACCAGTGAATCTCGT
TAGACGGTAAATAAAATAAT

Downstream 100 bases:

>100_bases
CTGCCTGGCCAACCAGGCGCATTAGGGGATTATCGTGAAGCAAACGCAGCGGCATGATGCGATTATTGAGCTGGTACGCC
TACAAGGTTATGTCAGCACT

Product: intramembrane serine protease GlpG

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDPLNPRYQAASWQAGNVNSNLP
YQRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAVMSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWW
YLGGQMEKRLGTSKLLVLTIVSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPEHGISLPRGLMAFSVLWLIA
GYFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ

Sequences:

>Translated_278_residues
MTRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDPLNPRYQAASWQAGNVNSNLP
YQRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAVMSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWW
YLGGQMEKRLGTSKLLVLTIVSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPEHGISLPRGLMAFSVLWLIA
GYFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ
>Mature_277_residues
TRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDPLNPRYQAASWQAGNVNSNLPY
QRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAVMSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWWY
LGGQMEKRLGTSKLLVLTIVSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPEHGISLPRGLMAFSVLWLIAG
YFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

Organism=Escherichia coli, GI48994938, Length=275, Percent_Identity=53.8181818181818, Blast_Score=315, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 31287; Mature: 31156

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDP
CCEEEEECCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCC
LNPRYQAASWQAGNVNSNLPYQRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHH
MSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWWYLGGQMEKRLGTSKLLVLTI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHH
VSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPEHGISLPRGLMAFSVLWLIA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GYFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TRVIVISNLRLAQAFVDYMATHHVALEIRPDAQGVEIWLADDEQLSAVQHELEQFLLDP
CEEEEECCHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCC
LNPRYQAASWQAGNVNSNLPYQRFSYLQTLRSQAGPLTLSVMVLCIAIYILMLITGDMAV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHH
MSWLAWPYNSSQYLQIWRWVSHAFLHFSLLHILFNLMWWWYLGGQMEKRLGTSKLLVLTI
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHH
VSAVFSGWGQSLFSGANFGGLSGVVYALMGYVWLTGERAPEHGISLPRGLMAFSVLWLIA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GYFDILGLSIANAAHVSGLIIGLLMAFWDTRNSARTVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA