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The map label for this gene is creC

Identifier: 51597481

GI number: 51597481

Start: 3728163

End: 3729581

Strand: Reverse

Name: creC

Synonym: YPTB3170

Alternate gene names: 51597481

Gene position: 3729581-3728163 (Counterclockwise)

Preceding gene: 51597482

Following gene: 51597480

Centisome position: 78.61

GC content: 50.88

Gene sequence:

>1419_bases
ATGAAGATTGGTGTACGGTTGCTACTTGGCTATTTCCTGATTGTGGCTATCGCTGGCTACTTTGTTATTCGTATTTTTTT
GCAGGAAGTCAAACCCGGAGTGCGGCGCGCGACTGAAGGCACCTTAGTGGATACGGCGACCTTACTGGCGCAATTCGCCC
GGCAGGATATATTGCAGAACAAAGTGGCCGACGGGCAATTGGCGCAAGCATTTTCTTCCCTTAATCTGCGGCCTATTGGT
GCCAATATTGAAGGTATCCGTAAGGATCGCAATGAATATAGGGTCTATCTGACCGATACTGATGGGCAGGTGATTTTTGA
TTCATCAGGCCGAGCATTAGGGCAAGACTATTCACGTTGGAATGATGTCTGGTTGACGCTACGTGGTGAGTATGGCGCCC
GCAGTAGCCGCACTGACCCCGACGATGCAGAAAGTTCGGTAATGTATGTGGCGGCACCGGTCATCGTCGAAAATCGTATT
GTTGGTGTACTGAGTATAGGTAAGCCGAATCTCTCCATGGTGCCGGTGATCAAACGCAGTGAACGCAAGATCCTGTTTGC
AGGTGGGCTGCTGTTAGGCATTGCATTGCTGATTGGGTTGGGGTTTGTGTGGTGGATTAACCGGGCGATCGGCAAGTTGG
TGGACTACGCAGAACGGGTTGCCGAGGGGCAGGCGGTGGCTCTGCCAGCGATGGGGAGCAGTGAATTGAATGATTTGGCA
CTGGCGCTGGAAAGCATGCGTCTCAAATTGGATGGCAAAGCCTATATCGAACAATATGTTCACACGCTGACTCATGAATT
GAAAAGCCCGCTGGCCGCTATCTCCGGGGCGGCTGAGTTACTGCGAGAGTCTCCACCGCCAGAGACCGCACAACGTTTTC
TGATCAATATTGAGCAGCAAAGTGCACGAATCCAGCAACTGGTAGATAAAATGCTGGTGCAAGCACGGCTGGAGAGCCGG
GTAGATCTACAACTCTCCCCCTTGGAAATCAGCCATATACTCAAGCAGAGCTTTAGCGCCAAAGAAGCTCAGGCGGTTAG
CCGAGGGGTCACTCTGCGGCTAAAATCTGTAGATAACGCGATGTTGATCGGCGATGGGCTGTTGCTCAGCCAGGCCTTAA
ACAATCTGATTGATAATGCTCTGGATTTTACGCCCGCGGGAGGAGAAATTAGCGTGAGTGGCGAACGGCAAGATGATACC
TATCTGATCACGGTTGAAGACAGTGGCAGTGGTATTCCTGGTTATGCCCAAGAGAAGATTTTTGACCGCTTTTATTCGTT
ACCACGGGCTAATAGCGTCAAAAGTACAGGGTTAGGGCTAAATTTTGTACGTGAAGTTGCTGCTATTCACCAAGGAAGTA
TTTGTTTGGAGAACCGCCTGCCGCAAGGGGTTAGCGCGCGTTTGACATTACCGCTGTAG

Upstream 100 bases:

>100_bases
CTACGATCAAAATTACGCACGGTTTACGCTGAAGACTCACCCATTCGCACACATCGTGGATTGGGCTATAGCCTGGGTTA
TCAGCCATGAGCCGCTATAA

Downstream 100 bases:

>100_bases
AGGGTTTATCGCCAACTTCACGTTCACTTCACATAGCCTCATTCACCTTTCACTTCATGGTCGTAAACTGCTCTCCTGAT
GTTAAAAGGAGTGCAATTCA

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQNKVADGQLAQAFSSLNLRPIG
ANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRWNDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRI
VGVLSIGKPNLSMVPVIKRSERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQSARIQQLVDKMLVQARLESR
VDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNAMLIGDGLLLSQALNNLIDNALDFTPAGGEISVSGERQDDT
YLITVEDSGSGIPGYAQEKIFDRFYSLPRANSVKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPL

Sequences:

>Translated_472_residues
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQNKVADGQLAQAFSSLNLRPIG
ANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRWNDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRI
VGVLSIGKPNLSMVPVIKRSERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQSARIQQLVDKMLVQARLESR
VDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNAMLIGDGLLLSQALNNLIDNALDFTPAGGEISVSGERQDDT
YLITVEDSGSGIPGYAQEKIFDRFYSLPRANSVKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPL
>Mature_472_residues
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQNKVADGQLAQAFSSLNLRPIG
ANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRWNDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRI
VGVLSIGKPNLSMVPVIKRSERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQSARIQQLVDKMLVQARLESR
VDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNAMLIGDGLLLSQALNNLIDNALDFTPAGGEISVSGERQDDT
YLITVEDSGSGIPGYAQEKIFDRFYSLPRANSVKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPL

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=470, Percent_Identity=58.5106382978723, Blast_Score=553, Evalue=1e-159,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=26.5682656826568, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=26.1467889908257, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=28.0487804878049, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=28.7735849056604, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082128, Length=290, Percent_Identity=25.8620689655172, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=27.3092369477912, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=273, Percent_Identity=26.7399267399267, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI48994928, Length=218, Percent_Identity=27.5229357798165, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787374, Length=351, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=26.8115942028986, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=213, Percent_Identity=26.2910798122066, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=212, Percent_Identity=27.3584905660377, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788279, Length=265, Percent_Identity=24.1509433962264, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=208, Percent_Identity=30.2884615384615, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=29.2237442922374, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789149, Length=193, Percent_Identity=26.4248704663212, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51657; Mature: 51657

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KVADGQLAQAFSSLNLRPIGANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRW
HCCCCHHHHHHHHCCCEEECCCHHHHHCCCCCEEEEEECCCCEEEECCCCCCHHCHHHCC
NDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRIVGVLSIGKPNLSMVPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEECCCCCCEECCEECC
ERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQ
HHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SARIQQLVDKMLVQARLESRVDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNA
HHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCE
MLIGDGLLLSQALNNLIDNALDFTPAGGEISVSGERQDDTYLITVEDSGSGIPGYAQEKI
EEEECHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHH
FDRFYSLPRANSVKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEECCC
>Mature Secondary Structure
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KVADGQLAQAFSSLNLRPIGANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRW
HCCCCHHHHHHHHCCCEEECCCHHHHHCCCCCEEEEEECCCCEEEECCCCCCHHCHHHCC
NDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRIVGVLSIGKPNLSMVPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEECCCCCCEECCEECC
ERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQ
HHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SARIQQLVDKMLVQARLESRVDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNA
HHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCE
MLIGDGLLLSQALNNLIDNALDFTPAGGEISVSGERQDDTYLITVEDSGSGIPGYAQEKI
EEEECHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHH
FDRFYSLPRANSVKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]