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The map label for this gene is mazG

Identifier: 51595103

GI number: 51595103

Start: 907660

End: 908502

Strand: Direct

Name: mazG

Synonym: YPTB0753

Alternate gene names: 51595103

Gene position: 907660-908502 (Clockwise)

Preceding gene: 51595102

Following gene: 51595104

Centisome position: 19.13

GC content: 50.06

Gene sequence:

>843_bases
ATGACTCAACCTGTTACTTCCCCTGATTCTACAGCAGTCGCCCTGCAACGTTTATTGGATATTATGCGCGCTCTGCGTGA
CCCAGAGCAGGGGTGCCCATGGGATCGCAAACAGACCTTTGACACCATCGCCCCTTATACGTTGGAAGAGACTTACGAGG
TGCTTGATGCGATTGCGCGCAAGGACTTTGATGACCTTCGAGACGAACTGGGTGATTTGCTGTTCCAGGTGGTGTTTTAT
GCCCAAATGGGGCAGGAGCAAGGGCTGTTTACCTTTGATGACGTTTGCCATGCGATTAGCGATAAGCTTGAGCGTCGCCA
TCCCCATGTCTTCTCTAATACGTCTCTAAACGTCACTCAGGCGGCGGTTAACAGTGAGGCCGCTCTGGCGGGCTGGGAAT
CACGAAAAGCCGAAGAACGAGCAGAAAAAGCATTGTATTCGGCATTGGACGATATTCCTGATGCATTGCCCGCCTTGATG
AAGGCCCATAAAATTCAGAAGCGTTGTGCGTCAGTCGGTTTTGATTGGAACACGCTAGGGCCGGTACTCGATAAGGTCTA
CGAAGAGATTGACGAGGTCATGTTTGAAGCGCGTCAGGCAGTCGTCGATGAGGACAAATTGGGAGAGGAAATTGGCGATT
TACTCTTTGCCACGGTTAATCTATCGCGCCATCTGGGCCATAAAGCTGAGAATGCGCTACAAGCGGCTAATCGTAAGTTT
GAACGGCGTTTTCGTCAGGTAGAACAAATAGTTACGGCATCAGGTCAAACCATGGAGAGTGCGACGCTTGATGAAATGGA
AGCCGCCTGGCAGCAAGTTAAAAAGCAAGAAACTGAAATGTAA

Upstream 100 bases:

>100_bases
AAGATCGGGTATACATTTCGGGGGCGTGGCGGGCCGCAATCAATCTGCCTGTGCTTTCGACGCTTTGAATTTAAAAAACA
AAAAAAGTGAATAAATTGAA

Downstream 100 bases:

>100_bases
GGTGTTTTAATTCATTTCACTGATAGTTGTGGAATTTTAATTACGTTAATATATTGAATTATAACGGATAGCAAGACGGT
GTTCTGTGCGGTTTTAGTCG

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTQPVTSPDSTAVALQRLLDIMRALRDPEQGCPWDRKQTFDTIAPYTLEETYEVLDAIARKDFDDLRDELGDLLFQVVFY
AQMGQEQGLFTFDDVCHAISDKLERRHPHVFSNTSLNVTQAAVNSEAALAGWESRKAEERAEKALYSALDDIPDALPALM
KAHKIQKRCASVGFDWNTLGPVLDKVYEEIDEVMFEARQAVVDEDKLGEEIGDLLFATVNLSRHLGHKAENALQAANRKF
ERRFRQVEQIVTASGQTMESATLDEMEAAWQQVKKQETEM

Sequences:

>Translated_280_residues
MTQPVTSPDSTAVALQRLLDIMRALRDPEQGCPWDRKQTFDTIAPYTLEETYEVLDAIARKDFDDLRDELGDLLFQVVFY
AQMGQEQGLFTFDDVCHAISDKLERRHPHVFSNTSLNVTQAAVNSEAALAGWESRKAEERAEKALYSALDDIPDALPALM
KAHKIQKRCASVGFDWNTLGPVLDKVYEEIDEVMFEARQAVVDEDKLGEEIGDLLFATVNLSRHLGHKAENALQAANRKF
ERRFRQVEQIVTASGQTMESATLDEMEAAWQQVKKQETEM
>Mature_279_residues
TQPVTSPDSTAVALQRLLDIMRALRDPEQGCPWDRKQTFDTIAPYTLEETYEVLDAIARKDFDDLRDELGDLLFQVVFYA
QMGQEQGLFTFDDVCHAISDKLERRHPHVFSNTSLNVTQAAVNSEAALAGWESRKAEERAEKALYSALDDIPDALPALMK
AHKIQKRCASVGFDWNTLGPVLDKVYEEIDEVMFEARQAVVDEDKLGEEIGDLLFATVNLSRHLGHKAENALQAANRKFE
RRFRQVEQIVTASGQTMESATLDEMEAAWQQVKKQETEM

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=266, Percent_Identity=72.5563909774436, Blast_Score=395, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31726; Mature: 31595

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPVTSPDSTAVALQRLLDIMRALRDPEQGCPWDRKQTFDTIAPYTLEETYEVLDAIAR
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
KDFDDLRDELGDLLFQVVFYAQMGQEQGLFTFDDVCHAISDKLERRHPHVFSNTSLNVTQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AAVNSEAALAGWESRKAEERAEKALYSALDDIPDALPALMKAHKIQKRCASVGFDWNTLG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
PVLDKVYEEIDEVMFEARQAVVDEDKLGEEIGDLLFATVNLSRHLGHKAENALQAANRKF
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
ERRFRQVEQIVTASGQTMESATLDEMEAAWQQVKKQETEM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQPVTSPDSTAVALQRLLDIMRALRDPEQGCPWDRKQTFDTIAPYTLEETYEVLDAIAR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHH
KDFDDLRDELGDLLFQVVFYAQMGQEQGLFTFDDVCHAISDKLERRHPHVFSNTSLNVTQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
AAVNSEAALAGWESRKAEERAEKALYSALDDIPDALPALMKAHKIQKRCASVGFDWNTLG
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
PVLDKVYEEIDEVMFEARQAVVDEDKLGEEIGDLLFATVNLSRHLGHKAENALQAANRKF
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
ERRFRQVEQIVTASGQTMESATLDEMEAAWQQVKKQETEM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]