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The map label for this gene is dmsA [H]

Identifier: 50842001

GI number: 50842001

Start: 568015

End: 570576

Strand: Reverse

Name: dmsA [H]

Synonym: PPA0517

Alternate gene names: 50842001

Gene position: 570576-568015 (Counterclockwise)

Preceding gene: 50842002

Following gene: 50842000

Centisome position: 22.29

GC content: 56.75

Gene sequence:

>2562_bases
GTGGAATCCTATTCGACGAATATACCTGGGCTAAAGACCAAGGCAAGTCGCCGTGAATTCATGAAATGGTCCGCCGTGGT
CGGCGGGACTGCCGCCCTCGCCCCAGTATTACACGAGACGAAAGATGCACTAGCCAACAAGCCAACCAACGACGCTTCGA
CCTTCGTGTGGTCTGCTTGCACCGTCAATTGCGGCTCACGCTGTCCGCTGCGCCTGGAAGTCAAGGACGGCACCATCGTA
CGCGTGCTACCCGACGATACCGCAAACAACAAAGTGGGCTCCCAACAAGTACGTGCCTGCGTGCGAGGACGTTCGATTCG
CCACCGCATTTACAATCCCGACCGATTAAAGAAGCCAATGAAACGCAAGCCCGGCACCAAGCGGGGAGATGAACAATGGG
TAACGATCAGTTGGGATCAAGCCCTCGACGAGATCGCCGAAAAAATGAAAAAGATCAAAGCCAGGTACGGCAACGAAGCC
TTTTACATTAACTACGGCACTGGCACTTTAGGCTCAGTGATGGCCAAGTCATGGCCGCCGGATCAGAGCGCCTTCGCCCG
GCTCATGAACACGTGGGGAGGTTACCTCGACCATTACAGTGACTACTCGACCACCGAGATAACTCAGGCCTACCCGTATT
TCTACGGATCATGGGTCGGAAGCAACTCATTTGATGACGTGAAAAACTCCAAACTTCAGGTCATGTTTGGCAACAACCCT
GCGGAAACACGCATGTCAGGCGGCGGCCAAGTGTTCGTTTCCCAGCAGACACGCAAGGCCTCGGGTGTACGCACGATAGT
CATCGACCCGCGCTACTCTGAAACGGCCATTACTATGGCTGACGAATGGATTCCGATTCGGCCCGGCACCGATGCCGCCT
TGGTCGCAGGTCTCATCCATACCATGATCACCGAGGACCTGCACAACCAAGCTTTCCTTGATCGCTACTGCGTCGGTTTC
GATGACAAACATCTACCCGAAGGAACATCAGCCGGTTCATCTTACCGAGCCTATCTGGAGGGGAAGGGACCCGACCATAC
CATCAAGAACGCCCAATGGGCCTCCCACATCACCGGAGTCCCGGCAGAGCGGATCCGCCGCTTAGCACGTGAGATCGCAG
CAGCCAATCCCTGCGCCATCACCCAAGGCTGGGGGCCCCAGCGTCATGCCAACGGAGAAAATAGTGCTCGGGCGATCTTC
CTGCTCGCAGCCGTCACCGGCAACATTGGCATCCCCGGCGGCGGAACCGGTGCTCGCGAAGGCGCCCAAGCCTTCCAGTT
CACCTTGCCCTTCAACACTGAGATCACCAATACCAAATCCAACAAGATCATCCCAGTGTTCTCTTGGCTGGACGCCATCG
ACCATGGTGAGCAGATGGACACCTTCAACTCTGGGGTGTGTGAAAAGCCAGCCCCCGGAGTACGTGCCAACAAGGTTCCC
ATCGACGAGCACGGCAAGCCGACGAATGTCAAGCTCAGCGCCCCCATCAAGATGGTGTGGCAGTACGCGGGCAACTCGCT
AGTGGGACAGACCGGCAACAACAACCGCTCAGTGGAGATCCTGCGTGACGATTCCAAATGCGAGCTCATCGTCGTTTGTG
ACATCCAGTACACGACCTCGGCCCGCTACGCCGACTACGTCCTGCCTGGCACCTCCACCGCCGAGGAAGAAGACATCCAT
CCAGGCGAGAACGGGGGGCCGATGGCCTATGGAATCGTTTCATCTCAGGCAATCAAGCCTTTGTACGAGTGCCGCAACAT
CTTCGACATCTGCGCCGGACCAGCCAAGCGCCTAGGCACCGAGAAGGAATTTACCGGCGGATTGACCCGTAGCCAATGGC
TGGAACGCACGATCGAAGAGACTCGAAAGAAAGACCCCGGCCTGCCCACCTACCGCGAGTGGAAGAAAATAGGTATCTTC
CGCAAAGACATGGGCCCCTATGTAGAACTTGATGAATTCCGTAAAGACCCGGTTGCCAATCCACTAGAGACCCCCTCAGG
CAAGATCGAGATTTATTCTGAGCGGCTAGCTGCGATGTCCGAAGCGTGGACGTTCGGCACCTTCCGCAAGAAGCTGGCTG
GTGACAAACTCACTGCACTGCCGGAATACGTCGTCACCTGGGAAGGCCCCGAGGAGGCCAAAGCCTCCAAGAAATATCCG
TTCCAGGTGATAGGACACCATTTCAAAGGACGAACCCACTCCAGCTATGGCAATGTTGACTGGCTACTGGACGCTCATCC
CCAGACTGTCTGGATCAACACTCGAGATGCCCGAGCTAAAGGTATCACCAATGGCGATCAAGTCTTTGTTTACAACGACC
GCGGTACCATCCGGCTACCGGCCCGTGTCACCGATCGTATTGCACCCGGCGTTCTCTCAGTGCCGCAGGGCGCTTGGTAC
CGCCCCTTGAGCAACACAAAGGTCGCCCCGCCAAGCAAGGCCAATCCCAAGCAACCGGTCGACATCAATGGAGCCATGAA
TACTCTCACCTCGCTGCACCCCTCGCCGCTAGCGAAGGGTAATGCGGTGCACACAACGATCGCCAATGTGGAGAAAGCAT
GA

Upstream 100 bases:

>100_bases
TGTCCCGTAAGCTGCAATAAGCATAGGCTGAAAATCGCTACGACTTTTCACACGATACGGTAAGTTGTGAATGACGTATC
GTATGTCGGGAGGTCTCAAC

Downstream 100 bases:

>100_bases
ATACCCCGCCCCCACGGGAAACCAGTCAACCGCGCATAAACGCGCCAACATTGAGGCAGAAGAATACATCAGCATATGAC
GAACTAGCATCGGCAACCAT

Product: anaerobic dimethyl sulfoxide reductase chain A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 853; Mature: 853

Protein sequence:

>853_residues
MESYSTNIPGLKTKASRREFMKWSAVVGGTAALAPVLHETKDALANKPTNDASTFVWSACTVNCGSRCPLRLEVKDGTIV
RVLPDDTANNKVGSQQVRACVRGRSIRHRIYNPDRLKKPMKRKPGTKRGDEQWVTISWDQALDEIAEKMKKIKARYGNEA
FYINYGTGTLGSVMAKSWPPDQSAFARLMNTWGGYLDHYSDYSTTEITQAYPYFYGSWVGSNSFDDVKNSKLQVMFGNNP
AETRMSGGGQVFVSQQTRKASGVRTIVIDPRYSETAITMADEWIPIRPGTDAALVAGLIHTMITEDLHNQAFLDRYCVGF
DDKHLPEGTSAGSSYRAYLEGKGPDHTIKNAQWASHITGVPAERIRRLAREIAAANPCAITQGWGPQRHANGENSARAIF
LLAAVTGNIGIPGGGTGAREGAQAFQFTLPFNTEITNTKSNKIIPVFSWLDAIDHGEQMDTFNSGVCEKPAPGVRANKVP
IDEHGKPTNVKLSAPIKMVWQYAGNSLVGQTGNNNRSVEILRDDSKCELIVVCDIQYTTSARYADYVLPGTSTAEEEDIH
PGENGGPMAYGIVSSQAIKPLYECRNIFDICAGPAKRLGTEKEFTGGLTRSQWLERTIEETRKKDPGLPTYREWKKIGIF
RKDMGPYVELDEFRKDPVANPLETPSGKIEIYSERLAAMSEAWTFGTFRKKLAGDKLTALPEYVVTWEGPEEAKASKKYP
FQVIGHHFKGRTHSSYGNVDWLLDAHPQTVWINTRDARAKGITNGDQVFVYNDRGTIRLPARVTDRIAPGVLSVPQGAWY
RPLSNTKVAPPSKANPKQPVDINGAMNTLTSLHPSPLAKGNAVHTTIANVEKA

Sequences:

>Translated_853_residues
MESYSTNIPGLKTKASRREFMKWSAVVGGTAALAPVLHETKDALANKPTNDASTFVWSACTVNCGSRCPLRLEVKDGTIV
RVLPDDTANNKVGSQQVRACVRGRSIRHRIYNPDRLKKPMKRKPGTKRGDEQWVTISWDQALDEIAEKMKKIKARYGNEA
FYINYGTGTLGSVMAKSWPPDQSAFARLMNTWGGYLDHYSDYSTTEITQAYPYFYGSWVGSNSFDDVKNSKLQVMFGNNP
AETRMSGGGQVFVSQQTRKASGVRTIVIDPRYSETAITMADEWIPIRPGTDAALVAGLIHTMITEDLHNQAFLDRYCVGF
DDKHLPEGTSAGSSYRAYLEGKGPDHTIKNAQWASHITGVPAERIRRLAREIAAANPCAITQGWGPQRHANGENSARAIF
LLAAVTGNIGIPGGGTGAREGAQAFQFTLPFNTEITNTKSNKIIPVFSWLDAIDHGEQMDTFNSGVCEKPAPGVRANKVP
IDEHGKPTNVKLSAPIKMVWQYAGNSLVGQTGNNNRSVEILRDDSKCELIVVCDIQYTTSARYADYVLPGTSTAEEEDIH
PGENGGPMAYGIVSSQAIKPLYECRNIFDICAGPAKRLGTEKEFTGGLTRSQWLERTIEETRKKDPGLPTYREWKKIGIF
RKDMGPYVELDEFRKDPVANPLETPSGKIEIYSERLAAMSEAWTFGTFRKKLAGDKLTALPEYVVTWEGPEEAKASKKYP
FQVIGHHFKGRTHSSYGNVDWLLDAHPQTVWINTRDARAKGITNGDQVFVYNDRGTIRLPARVTDRIAPGVLSVPQGAWY
RPLSNTKVAPPSKANPKQPVDINGAMNTLTSLHPSPLAKGNAVHTTIANVEKA
>Mature_853_residues
MESYSTNIPGLKTKASRREFMKWSAVVGGTAALAPVLHETKDALANKPTNDASTFVWSACTVNCGSRCPLRLEVKDGTIV
RVLPDDTANNKVGSQQVRACVRGRSIRHRIYNPDRLKKPMKRKPGTKRGDEQWVTISWDQALDEIAEKMKKIKARYGNEA
FYINYGTGTLGSVMAKSWPPDQSAFARLMNTWGGYLDHYSDYSTTEITQAYPYFYGSWVGSNSFDDVKNSKLQVMFGNNP
AETRMSGGGQVFVSQQTRKASGVRTIVIDPRYSETAITMADEWIPIRPGTDAALVAGLIHTMITEDLHNQAFLDRYCVGF
DDKHLPEGTSAGSSYRAYLEGKGPDHTIKNAQWASHITGVPAERIRRLAREIAAANPCAITQGWGPQRHANGENSARAIF
LLAAVTGNIGIPGGGTGAREGAQAFQFTLPFNTEITNTKSNKIIPVFSWLDAIDHGEQMDTFNSGVCEKPAPGVRANKVP
IDEHGKPTNVKLSAPIKMVWQYAGNSLVGQTGNNNRSVEILRDDSKCELIVVCDIQYTTSARYADYVLPGTSTAEEEDIH
PGENGGPMAYGIVSSQAIKPLYECRNIFDICAGPAKRLGTEKEFTGGLTRSQWLERTIEETRKKDPGLPTYREWKKIGIF
RKDMGPYVELDEFRKDPVANPLETPSGKIEIYSERLAAMSEAWTFGTFRKKLAGDKLTALPEYVVTWEGPEEAKASKKYP
FQVIGHHFKGRTHSSYGNVDWLLDAHPQTVWINTRDARAKGITNGDQVFVYNDRGTIRLPARVTDRIAPGVLSVPQGAWY
RPLSNTKVAPPSKANPKQPVDINGAMNTLTSLHPSPLAKGNAVHTTIANVEKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=864, Percent_Identity=47.8009259259259, Blast_Score=763, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=850, Percent_Identity=48.4705882352941, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=855, Percent_Identity=45.2631578947368, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=884, Percent_Identity=30.7692307692308, Blast_Score=276, Evalue=4e-75,
Organism=Escherichia coli, GI1787231, Length=836, Percent_Identity=30.2631578947368, Blast_Score=267, Evalue=2e-72,
Organism=Escherichia coli, GI145693196, Length=803, Percent_Identity=29.3897882938979, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI3868721, Length=756, Percent_Identity=25.6613756613757, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI3868720, Length=474, Percent_Identity=25.5274261603376, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI1788534, Length=858, Percent_Identity=21.3286713286713, Blast_Score=80, Evalue=8e-16,
Organism=Escherichia coli, GI3868719, Length=472, Percent_Identity=23.3050847457627, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787477, Length=298, Percent_Identity=25.8389261744966, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 94068; Mature: 94068

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESYSTNIPGLKTKASRREFMKWSAVVGGTAALAPVLHETKDALANKPTNDASTFVWSAC
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TVNCGSRCPLRLEVKDGTIVRVLPDDTANNKVGSQQVRACVRGRSIRHRIYNPDRLKKPM
EECCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHCCCCHHHHCHH
KRKPGTKRGDEQWVTISWDQALDEIAEKMKKIKARYGNEAFYINYGTGTLGSVMAKSWPP
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCC
DQSAFARLMNTWGGYLDHYSDYSTTEITQAYPYFYGSWVGSNSFDDVKNSKLQVMFGNNP
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEECCCC
AETRMSGGGQVFVSQQTRKASGVRTIVIDPRYSETAITMADEWIPIRPGTDAALVAGLIH
HHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEECCEEECCCCCHHHHHHHHHH
TMITEDLHNQAFLDRYCVGFDDKHLPEGTSAGSSYRAYLEGKGPDHTIKNAQWASHITGV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCC
PAERIRRLAREIAAANPCAITQGWGPQRHANGENSARAIFLLAAVTGNIGIPGGGTGARE
CHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCC
GAQAFQFTLPFNTEITNTKSNKIIPVFSWLDAIDHGEQMDTFNSGVCEKPAPGVRANKVP
CCCEEEEEECCCCEECCCCCCCEEEHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCC
IDEHGKPTNVKLSAPIKMVWQYAGNSLVGQTGNNNRSVEILRDDSKCELIVVCDIQYTTS
CCCCCCCCCEEEECCHHHHHHHHCCCEEECCCCCCCEEEEEECCCCEEEEEEEEEEECCC
ARYADYVLPGTSTAEEEDIHPGENGGPMAYGIVSSQAIKPLYECRNIFDICAGPAKRLGT
CCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCC
EKEFTGGLTRSQWLERTIEETRKKDPGLPTYREWKKIGIFRKDMGPYVELDEFRKDPVAN
CHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHCCCCCEEHHHHCCCCCCC
PLETPSGKIEIYSERLAAMSEAWTFGTFRKKLAGDKLTALPEYVVTWEGPEEAKASKKYP
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCHHHHHHCCCCC
FQVIGHHFKGRTHSSYGNVDWLLDAHPQTVWINTRDARAKGITNGDQVFVYNDRGTIRLP
HHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEECCCCHHCCCCCCCEEEEECCCCCEEEC
ARVTDRIAPGVLSVPQGAWYRPLSNTKVAPPSKANPKQPVDINGAMNTLTSLHPSPLAKG
HHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHCCCCCCCCC
NAVHTTIANVEKA
CEEEEEHHCCCCC
>Mature Secondary Structure
MESYSTNIPGLKTKASRREFMKWSAVVGGTAALAPVLHETKDALANKPTNDASTFVWSAC
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
TVNCGSRCPLRLEVKDGTIVRVLPDDTANNKVGSQQVRACVRGRSIRHRIYNPDRLKKPM
EECCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHCCHHHHHCCCCHHHHCHH
KRKPGTKRGDEQWVTISWDQALDEIAEKMKKIKARYGNEAFYINYGTGTLGSVMAKSWPP
HHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCC
DQSAFARLMNTWGGYLDHYSDYSTTEITQAYPYFYGSWVGSNSFDDVKNSKLQVMFGNNP
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEECCCC
AETRMSGGGQVFVSQQTRKASGVRTIVIDPRYSETAITMADEWIPIRPGTDAALVAGLIH
HHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCEEEEEECCEEECCCCCHHHHHHHHHH
TMITEDLHNQAFLDRYCVGFDDKHLPEGTSAGSSYRAYLEGKGPDHTIKNAQWASHITGV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCC
PAERIRRLAREIAAANPCAITQGWGPQRHANGENSARAIFLLAAVTGNIGIPGGGTGARE
CHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCC
GAQAFQFTLPFNTEITNTKSNKIIPVFSWLDAIDHGEQMDTFNSGVCEKPAPGVRANKVP
CCCEEEEEECCCCEECCCCCCCEEEHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCC
IDEHGKPTNVKLSAPIKMVWQYAGNSLVGQTGNNNRSVEILRDDSKCELIVVCDIQYTTS
CCCCCCCCCEEEECCHHHHHHHHCCCEEECCCCCCCEEEEEECCCCEEEEEEEEEEECCC
ARYADYVLPGTSTAEEEDIHPGENGGPMAYGIVSSQAIKPLYECRNIFDICAGPAKRLGT
CCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCC
EKEFTGGLTRSQWLERTIEETRKKDPGLPTYREWKKIGIFRKDMGPYVELDEFRKDPVAN
CHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHCCCCCEEHHHHCCCCCCC
PLETPSGKIEIYSERLAAMSEAWTFGTFRKKLAGDKLTALPEYVVTWEGPEEAKASKKYP
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCHHHHHHCCCCC
FQVIGHHFKGRTHSSYGNVDWLLDAHPQTVWINTRDARAKGITNGDQVFVYNDRGTIRLP
HHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEECCCCHHCCCCCCCEEEEECCCCCEEEC
ARVTDRIAPGVLSVPQGAWYRPLSNTKVAPPSKANPKQPVDINGAMNTLTSLHPSPLAKG
HHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHCCCCCCCCC
NAVHTTIANVEKA
CEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]