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The map label for this gene is moaA

Identifier: 50841986

GI number: 50841986

Start: 550932

End: 551972

Strand: Reverse

Name: moaA

Synonym: PPA0502

Alternate gene names: 50841986

Gene position: 551972-550932 (Counterclockwise)

Preceding gene: 50841990

Following gene: 50841985

Centisome position: 21.56

GC content: 63.21

Gene sequence:

>1041_bases
ATGAGCGCCGCGACGGGCCAGAGTGCCGCCCACCATGGTCTGCCGGACCGTTTCGGACGGCTAGCTACCGACCTGCGGGT
CTCGGTAACCGACCATTGCAACCTGAGGTGCACCTATTGTATGCCCGCCGAAGGCATGGACTGGTTGGCCAACCGTGACC
TGCTCACCGACGACGAGATCATCCGTGTCATTGGCATCGGGATCGAGCGACTCGGCATCACCAAGGTGAGATTCACCGGC
GGGGAGCCCCTGTTGCGCCCTAGTCTGGAAAACCTGGTGGCCGCAACGTCGACGCTGCGCCGCACGAACGGTACCCCACC
GATCACCGCGCTAACGACCAACGGGATCGGCCTGGACCGGCGTGTCGACGGTCTCGTCGAGGCCGGCCTAGATCGGGTCA
ACATCTCCCTGGACACCGTGGACCGCGAACGGTTTGCCACCATCTCCCGACGAGACCGGCTCGCAGACGTCGTGACAGGG
ATCGACGCAGCCCTCGCCGCACGACTATTAGTCAAGATCAATGCCGTCCCCCAGATCGACTCCTACCGCCGTGACATTCC
CGAGTTGCTCGTTTTCTGCCTGGACCGCGGTCTAGAACTACGATTCATCGAGTTCATGCCGATCGGGGCGAATGGCTGGA
AACGGGAGGCAACCGTCAGTGCCGACGACATCCTCACCGTGGTCCGAGATGCAGGTTTCAGCATCACCGCTGACCAGGCT
GCGCGCGGCTCCTCACCCGCGCAACGCTGGTCGGTGAGCTCGCGGCACACACGCCCCGGATGGCTGGGGATCATCGCCTC
AGTGACTCGACCGTTCTGCGCAAACTGCTCGCGCACCCGGCTCACCGCCGACGGCCAGATCCGCAACTGCTTGTTCGCTG
ACCAAGAGGCCGATCTGCGTTCCCTGCTACGCTCAGGAGCCAGCGATGACGAGATCATCGCCGTATGGCAAGGTGAAATG
TGGTGCAAAAGCGCCCACCACGGGGTTGACAACGGGAGTTTTGCCAACTCCCGGCGTCGCATGTCTGCCATTGGAGGGTG
A

Upstream 100 bases:

>100_bases
ATCTGTACAGTGCCGACGTATATCCTCGAGTCGACAGAAGTTCGGCCACGTTAGCGATGACATGACCACACCACAGGCAG
ACCGGGAGGACGGTGAGGTC

Downstream 100 bases:

>100_bases
ATATGCAAGTGCACTACTACGGCGGCACAGCTGAGGCTGCCGGAACCAGTGAGGAGACGGTGGAGACGCCAACCGGCCTG
TCCGTCAATCAGTTACTCGA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSAATGQSAAHHGLPDRFGRLATDLRVSVTDHCNLRCTYCMPAEGMDWLANRDLLTDDEIIRVIGIGIERLGITKVRFTG
GEPLLRPSLENLVAATSTLRRTNGTPPITALTTNGIGLDRRVDGLVEAGLDRVNISLDTVDRERFATISRRDRLADVVTG
IDAALAARLLVKINAVPQIDSYRRDIPELLVFCLDRGLELRFIEFMPIGANGWKREATVSADDILTVVRDAGFSITADQA
ARGSSPAQRWSVSSRHTRPGWLGIIASVTRPFCANCSRTRLTADGQIRNCLFADQEADLRSLLRSGASDDEIIAVWQGEM
WCKSAHHGVDNGSFANSRRRMSAIGG

Sequences:

>Translated_346_residues
MSAATGQSAAHHGLPDRFGRLATDLRVSVTDHCNLRCTYCMPAEGMDWLANRDLLTDDEIIRVIGIGIERLGITKVRFTG
GEPLLRPSLENLVAATSTLRRTNGTPPITALTTNGIGLDRRVDGLVEAGLDRVNISLDTVDRERFATISRRDRLADVVTG
IDAALAARLLVKINAVPQIDSYRRDIPELLVFCLDRGLELRFIEFMPIGANGWKREATVSADDILTVVRDAGFSITADQA
ARGSSPAQRWSVSSRHTRPGWLGIIASVTRPFCANCSRTRLTADGQIRNCLFADQEADLRSLLRSGASDDEIIAVWQGEM
WCKSAHHGVDNGSFANSRRRMSAIGG
>Mature_345_residues
SAATGQSAAHHGLPDRFGRLATDLRVSVTDHCNLRCTYCMPAEGMDWLANRDLLTDDEIIRVIGIGIERLGITKVRFTGG
EPLLRPSLENLVAATSTLRRTNGTPPITALTTNGIGLDRRVDGLVEAGLDRVNISLDTVDRERFATISRRDRLADVVTGI
DAALAARLLVKINAVPQIDSYRRDIPELLVFCLDRGLELRFIEFMPIGANGWKREATVSADDILTVVRDAGFSITADQAA
RGSSPAQRWSVSSRHTRPGWLGIIASVTRPFCANCSRTRLTADGQIRNCLFADQEADLRSLLRSGASDDEIIAVWQGEMW
CKSAHHGVDNGSFANSRRRMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=343, Percent_Identity=38.4839650145773, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI22027536, Length=343, Percent_Identity=38.4839650145773, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1786999, Length=336, Percent_Identity=33.9285714285714, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32566331, Length=326, Percent_Identity=35.8895705521472, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=334, Percent_Identity=35.3293413173653, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=334, Percent_Identity=35.6287425149701, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574488, Length=335, Percent_Identity=37.910447761194, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI28574490, Length=316, Percent_Identity=37.6582278481013, Blast_Score=197, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37809; Mature: 37678

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAATGQSAAHHGLPDRFGRLATDLRVSVTDHCNLRCTYCMPAEGMDWLANRDLLTDDEI
CCCCCCCCHHHCCCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCHHHHCCCCCCHHHH
IRVIGIGIERLGITKVRFTGGEPLLRPSLENLVAATSTLRRTNGTPPITALTTNGIGLDR
HHHHHCCHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHH
RVDGLVEAGLDRVNISLDTVDRERFATISRRDRLADVVTGIDAALAARLLVKINAVPQID
HHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
SYRRDIPELLVFCLDRGLELRFIEFMPIGANGWKREATVSADDILTVVRDAGFSITADQA
HHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHH
ARGSSPAQRWSVSSRHTRPGWLGIIASVTRPFCANCSRTRLTADGQIRNCLFADQEADLR
HCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHEECCCHHHHH
SLLRSGASDDEIIAVWQGEMWCKSAHHGVDNGSFANSRRRMSAIGG
HHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SAATGQSAAHHGLPDRFGRLATDLRVSVTDHCNLRCTYCMPAEGMDWLANRDLLTDDEI
CCCCCCCHHHCCCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCHHHHCCCCCCHHHH
IRVIGIGIERLGITKVRFTGGEPLLRPSLENLVAATSTLRRTNGTPPITALTTNGIGLDR
HHHHHCCHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHH
RVDGLVEAGLDRVNISLDTVDRERFATISRRDRLADVVTGIDAALAARLLVKINAVPQID
HHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
SYRRDIPELLVFCLDRGLELRFIEFMPIGANGWKREATVSADDILTVVRDAGFSITADQA
HHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHH
ARGSSPAQRWSVSSRHTRPGWLGIIASVTRPFCANCSRTRLTADGQIRNCLFADQEADLR
HCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHEECCCHHHHH
SLLRSGASDDEIIAVWQGEMWCKSAHHGVDNGSFANSRRRMSAIGG
HHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA