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The map label for this gene is groEL

Identifier: 50841936

GI number: 50841936

Start: 498152

End: 499786

Strand: Direct

Name: groEL

Synonym: PPA0453

Alternate gene names: 50841936

Gene position: 498152-499786 (Clockwise)

Preceding gene: 50841932

Following gene: 50841939

Centisome position: 19.46

GC content: 61.96

Gene sequence:

>1635_bases
ATGGCAAAGCTCATCGAATTCAACATCGAGGCCCGCCGCGGGCTCGAGGCGGGCATGAATACCCTCGCCGACGCGGTCAA
GGTCACCCTCGGCCCCAAGGGCCGCAACGTCGTTCTCGAAAAGTCGTGGGGCGCTCCCACCATTACCAACGACGGTGTCT
CCATCGCCAAGGAGATCGAGCTCGACGATCCCTACGAGAAAATCGGCGCCGAGCTCGTCAAGGAGGTCGCCAAGAAGACT
GACGACGTCGCTGGCGACGGCACCACTACCGCCACCGTTCTGGCGCAGGCCATGGTTCGTGAAGGCCTGCGCAATGTCAC
CGCTGGCGCTAACCCGATGGGCCTGAAGAAGGGCATCGAGGCCGCCGTCCAGGCTGTTAGCGCTCGTCTGTCCGACATGG
CCATCGACATCGAGACCAAAGACCAGATCGCCTCTACCGCCTCCATCTCGGCCGCCGACCCCACCGTCGGCGAGATTATC
GCCGAGGCCATGGACAAGGTTGGTAAGGAAGGCGTCATCACCGTCGAGGAGTCCAACACCTTCGGCCTGGAGCTTGAGCT
CACCGAGGGCATGCGTTTCGACAAGGGCTACATCTCGCCCTACTTCGTGACTGACACCGAGCGCATGGAGGCTGTCCTCG
AGGATCCCTACATCCTTATCGTCAACTCCAAGATTTCATCGCTGAAGGATCTCCTGCCGGTCCTTGAGAAGGTTATGCAG
TCGGGCAAGCCGCTGTTTGTCATTGCCGAGGACGTCGAGGGTGAGGCCTTGGCTGGCCTCATTGTCAACAAGATCCGCGG
AACCTTCAAGTCTGTCGCCGTGAAGGCTCCAGGTTTTGGCGATCGTCGCAAGGCTATGCTCAATGACATCGCCATCCTGA
CTGGTGGCCAGGTTATCTCCGAAGAAGTTGGCCTGTCCCTCGACGCGGTGACCCTGGACTTGCTGGGTCGCGCTCGTCAG
GTTGTCGTCACCAAGGACGAGGCCACCATTGTCGACGGTGCCGGGGATTCCGAGCAGATCGCCGGCCGTGTCTCCCAGAT
CCGTAAGGAGATCGAGAACTCCGACTCCGACTACGACCGCGAGAAGCTGCAGGAGCGCCTCGCCAAGCTCGCTGGCGGCG
TTGCTGTCATCAAGGTGGGCGCTGCTACCGAGGTTGAACTCAAGGAGCGCAAGCACCGCATTGAGGACGCCGTGCGTAAC
GCTAAGGCCGCCGTTGAGGAAGGCATCATCCCTGGTGGTGGTGTCGCCCTGCTGCAGGCCTCCAAGGCCGCTGAAATCGA
GGGCCTGGAGGGCGACGAGCTCACCGGTGCACAGATCGTTCTGGCCGCGTGCACTGCCCCGCTCAAGCAAATCGCTATCA
ACGCTGGTCTTGAGGGCGGCGTCGTGGCTGAGAAGGTCGCTGGTCTGCCCGCAGGACAGGGCCTCAACGCGGCCAATGAC
GAGTATGTCGACATGGTAGAGGCCGGCATCATTGACCCGGCCAAGGTGACCCGTTCGGCTCTGCAGAACGCCGCGTCCAT
CGCGGCCCTGTTCCTCACCACTGAAGCCGTCATCGCTGACAAGCCCGAGCCTGTTAAGGCTCCCGCTGGCGGCGGTGATA
TGGACGGTATGGGTGGCATGGGCGGCATGATGTGA

Upstream 100 bases:

>100_bases
TCGCGGGCATCACGGGGAATCACAATGCGGGGTCGCTCCCGCCACATCATCTGACGTCCACGGGCTACCAGGCCCACCGG
AGCGGAGGAATCCCCTAAAC

Downstream 100 bases:

>100_bases
TCGTGCATTGCCTTCGCTGATTTGAGGTGGGGCGGTCCTAGTGGCCGCCCCACCTCGCTGTCTTGTTACAAACGTGGTAG
TTGTTCGTGCGGTGCGCATG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Heat shock protein 60 1; Protein Cpn60 1

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAKEIELDDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQAMVREGLRNVTAGANPMGLKKGIEAAVQAVSARLSDMAIDIETKDQIASTASISAADPTVGEII
AEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQ
SGKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVISEEVGLSLDAVTLDLLGRARQ
VVVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRN
AKAAVEEGIIPGGGVALLQASKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAAND
EYVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGMGGMM

Sequences:

>Translated_544_residues
MAKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAKEIELDDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQAMVREGLRNVTAGANPMGLKKGIEAAVQAVSARLSDMAIDIETKDQIASTASISAADPTVGEII
AEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQ
SGKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVISEEVGLSLDAVTLDLLGRARQ
VVVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRN
AKAAVEEGIIPGGGVALLQASKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAAND
EYVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGMGGMM
>Mature_543_residues
AKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAKEIELDDPYEKIGAELVKEVAKKTD
DVAGDGTTTATVLAQAMVREGLRNVTAGANPMGLKKGIEAAVQAVSARLSDMAIDIETKDQIASTASISAADPTVGEIIA
EAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQS
GKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVISEEVGLSLDAVTLDLLGRARQV
VVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNA
KAAVEEGIIPGGGVALLQASKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAANDE
YVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=46.4150943396226, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=46.4150943396226, Blast_Score=464, Evalue=1e-130,
Organism=Homo sapiens, GI5453607, Length=553, Percent_Identity=21.6998191681736, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI58331173, Length=230, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI38455427, Length=121, Percent_Identity=30.5785123966942, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=59.3511450381679, Blast_Score=599, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17555558, Length=527, Percent_Identity=46.2998102466793, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI193210679, Length=237, Percent_Identity=43.8818565400844, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17564182, Length=547, Percent_Identity=22.4862888482633, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=50.5725190839695, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322524, Length=187, Percent_Identity=28.3422459893048, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641193, Length=530, Percent_Identity=46.4150943396226, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24641191, Length=530, Percent_Identity=46.4150943396226, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=44.6564885496183, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=44.6564885496183, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=44.6564885496183, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17864606, Length=551, Percent_Identity=39.3829401088929, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=34.3339587242026, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=34.3339587242026, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24645179, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_PROAC (Q9K2U4)

Other databases:

- EMBL:   AB036414
- EMBL:   AF222061
- EMBL:   AE017283
- RefSeq:   YP_055163.1
- ProteinModelPortal:   Q9K2U4
- SMR:   Q9K2U4
- GeneID:   2932129
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0453
- NMPDR:   fig|267747.1.peg.440
- HOGENOM:   HBG625289
- OMA:   DKPAAGM
- ProtClustDB:   PRK00013
- BioCyc:   PACN267747:PPA0453-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56841; Mature: 56709

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAKEIE
CCCEEEECCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHEECC
LDDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQAMVREGLRNVTAGANPMGLKKGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AAVQAVSARLSDMAIDIETKDQIASTASISAADPTVGEIIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
FGLELELTEGMRFDKGYISPYFVTDTERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQ
EEEEEEECCCCEECCCCCCCEEECCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHEEECCHHHH
EEVGLSLDAVTLDLLGRARQVVVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDR
HHHCCCHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHH
EKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIIPGGGVALLQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
SKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAAND
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCH
EYVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC
>Mature Secondary Structure 
AKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAKEIE
CCEEEECCHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCHHEECC
LDDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQAMVREGLRNVTAGANPMGLKKGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AAVQAVSARLSDMAIDIETKDQIASTASISAADPTVGEIIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
FGLELELTEGMRFDKGYISPYFVTDTERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQ
EEEEEEECCCCEECCCCCCCEEECCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
SGKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVIS
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHEEECCHHHH
EEVGLSLDAVTLDLLGRARQVVVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDR
HHHCCCHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHH
EKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIIPGGGVALLQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
SKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAAND
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCH
EYVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGM
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGMM
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA