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The map label for this gene is cobT [H]

Identifier: 50841924

GI number: 50841924

Start: 485439

End: 487106

Strand: Direct

Name: cobT [H]

Synonym: PPA0441

Alternate gene names: 50841924

Gene position: 485439-487106 (Clockwise)

Preceding gene: 50841922

Following gene: 50841925

Centisome position: 18.96

GC content: 62.77

Gene sequence:

>1668_bases
ATGGCCCGCCTGCCCGAATCCCTATCCGCCGAAAGCTTGCTTGCACGCACGGTGCGAGGCATCCGAGGAGCTGATGCGAA
AGCCTTGGAGGCGGCCCGAGCCCGTCAGCAGTTACTTACCAAACCCGAGGGGTCGCTAGGGCTGTTGGAGGATCTGTCGA
TTCGATTGGCCGGAATGTACGGGCAGGTGCCAGTGACGGTGCCGAGCCATCCGGTTGTCGGGCTGTTTGCCGGTGATCAC
GGGGTATGGGCGCAAGGTGTTTCCCCTGATCCTCAGGAGATCACCACCCAGCAGATGATCAATATGGCGGCTGGTGGGGC
GGCGATCAGCGTGTTGTCGCGCCAGATGGGTGCACAGCTGTGGATCACTGACGTCGGAGCCCGCCACGAGGTCGACGCCC
CGATTCGGCAGCGGTGTGTGCGTCGTGGCACTGACGACATCTCCCAAGGCCCGGCGATGAGCCTTGACGAGGCTGTCGAG
GCCCTTGAGGTCGGTATTGAGACTGGGGTGGCGGCCGTCGAGCAGGGGGCTGACATCCTTATCACCGGAGAGATGGGAAT
CGCTAACACCACCCCGGCGTCGGCCCTCATCAGCGTCTTCACCGGGTTGCCGCCCGCTGAGGTGACCGGGAGGGGAGCTG
GGTCGGATGATCGTCGTCACCAGCACAAGATCGGAGTCGTCGCTCGCGCATTGCAGGTTAATCGACCCGAGGCCAAACAT
CCGATTGAGGCCTTGGCGAAGGTGGGAGGTTTTGAGCACGCCGCCATGGCCGGTTTTATTCTGGCTGCAGCGTCGTCACG
GATCCCCGTGCTCATTGACGGTGTTATCGCTTGTTCTGCCGCCCTGACGGCCACCGCGATCTGTCCTGAAGCGCGAGATT
TCATCATCACGAGTCACGCCGGTGCCGAGCCAGGAATCACGGCGTCGACCTCTGCCCTGGGCCTGCCCGCTCTGTTGGAC
CTTGGTATGAGGCTAGGAGAGGGGTCCGGGGCTATCCTGACTCTACCGATCGTGCAGGCAAGCGCTCACATCCTTAACGA
GATGGCCACCTTTGAGGACGCTGAGGTCATCGACATCAAAGTGAGCGGGGAAACCGAGATTCCCGATACCGTCCAGACGA
GTGTTCCTCCTTGTCGGATGCTTGTCATTGGGGGTGCCCGCTCGGGAAAATCGACCTTTGCCGAGTCGAGGCTGCCTCGC
GATTCCCGTGTCACCTATGTTGCGACCTCCCAGCGCAACCCTGGCGACGCGGAGTGGGAGGAGCGAATCCGCCTGCACCA
AGCTCGGCGCCCGGCCACGTGGCAGACTGTCGAGACCACCGACATCGCTTCAGTGCTGCTGGCCGACGACGACTCCCCGG
TGCTGGTGGATTGCCTTGGGGTGTGGATCACTCGGATTCTTGACGAGGTTGGCGCCTGGGCTGCCGCTCCTGGTGACGAA
GCCTGGCAGAACGATCTAAGACGCCACGTTAATGACTTGGCCAGCGCCATCCGTGGTACCCGACGTGACGTCATTTTTGT
CTCTAACGAGGTGGGGATGGGGGTCGTGCCCGACACCCCGGCTGGACGGCTCTTCCGCGACGAGTTGGGGCGACTCAACG
CCGCCGTCGGGGAAGCATGCGACGAGGTGTGGATGTGTGTGGCCGGAATCCCCAAGAGGTGGGCATGA

Upstream 100 bases:

>100_bases
CCCGACCGGGGTGGGACCACTGCGGCGCACGCGCGCGGCGCCCAGGCCTGCGAGGACACAGGCCCGGGGGATGCGGCGGC
GTTCCCGACGATGGAGCATG

Downstream 100 bases:

>100_bases
CGGACGAGCAGCATCCGGATCTTGGGAGACTCGGGCCACTGCGTGGAGTTGCTGAGGCTTTGTCTCTCTTTACGATCTTG
CCCGGGCCATATCTGAACGA

Product: phosphoribosyltransferase, cobalamin biosynthesis enzyme, fusion CobTU

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase [H]

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MARLPESLSAESLLARTVRGIRGADAKALEAARARQQLLTKPEGSLGLLEDLSIRLAGMYGQVPVTVPSHPVVGLFAGDH
GVWAQGVSPDPQEITTQQMINMAAGGAAISVLSRQMGAQLWITDVGARHEVDAPIRQRCVRRGTDDISQGPAMSLDEAVE
ALEVGIETGVAAVEQGADILITGEMGIANTTPASALISVFTGLPPAEVTGRGAGSDDRRHQHKIGVVARALQVNRPEAKH
PIEALAKVGGFEHAAMAGFILAAASSRIPVLIDGVIACSAALTATAICPEARDFIITSHAGAEPGITASTSALGLPALLD
LGMRLGEGSGAILTLPIVQASAHILNEMATFEDAEVIDIKVSGETEIPDTVQTSVPPCRMLVIGGARSGKSTFAESRLPR
DSRVTYVATSQRNPGDAEWEERIRLHQARRPATWQTVETTDIASVLLADDDSPVLVDCLGVWITRILDEVGAWAAAPGDE
AWQNDLRRHVNDLASAIRGTRRDVIFVSNEVGMGVVPDTPAGRLFRDELGRLNAAVGEACDEVWMCVAGIPKRWA

Sequences:

>Translated_555_residues
MARLPESLSAESLLARTVRGIRGADAKALEAARARQQLLTKPEGSLGLLEDLSIRLAGMYGQVPVTVPSHPVVGLFAGDH
GVWAQGVSPDPQEITTQQMINMAAGGAAISVLSRQMGAQLWITDVGARHEVDAPIRQRCVRRGTDDISQGPAMSLDEAVE
ALEVGIETGVAAVEQGADILITGEMGIANTTPASALISVFTGLPPAEVTGRGAGSDDRRHQHKIGVVARALQVNRPEAKH
PIEALAKVGGFEHAAMAGFILAAASSRIPVLIDGVIACSAALTATAICPEARDFIITSHAGAEPGITASTSALGLPALLD
LGMRLGEGSGAILTLPIVQASAHILNEMATFEDAEVIDIKVSGETEIPDTVQTSVPPCRMLVIGGARSGKSTFAESRLPR
DSRVTYVATSQRNPGDAEWEERIRLHQARRPATWQTVETTDIASVLLADDDSPVLVDCLGVWITRILDEVGAWAAAPGDE
AWQNDLRRHVNDLASAIRGTRRDVIFVSNEVGMGVVPDTPAGRLFRDELGRLNAAVGEACDEVWMCVAGIPKRWA
>Mature_554_residues
ARLPESLSAESLLARTVRGIRGADAKALEAARARQQLLTKPEGSLGLLEDLSIRLAGMYGQVPVTVPSHPVVGLFAGDHG
VWAQGVSPDPQEITTQQMINMAAGGAAISVLSRQMGAQLWITDVGARHEVDAPIRQRCVRRGTDDISQGPAMSLDEAVEA
LEVGIETGVAAVEQGADILITGEMGIANTTPASALISVFTGLPPAEVTGRGAGSDDRRHQHKIGVVARALQVNRPEAKHP
IEALAKVGGFEHAAMAGFILAAASSRIPVLIDGVIACSAALTATAICPEARDFIITSHAGAEPGITASTSALGLPALLDL
GMRLGEGSGAILTLPIVQASAHILNEMATFEDAEVIDIKVSGETEIPDTVQTSVPPCRMLVIGGARSGKSTFAESRLPRD
SRVTYVATSQRNPGDAEWEERIRLHQARRPATWQTVETTDIASVLLADDDSPVLVDCLGVWITRILDEVGAWAAAPGDEA
WQNDLRRHVNDLASAIRGTRRDVIFVSNEVGMGVVPDTPAGRLFRDELGRLNAAVGEACDEVWMCVAGIPKRWA

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) [H]

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family [H]

Homologues:

Organism=Escherichia coli, GI1788300, Length=347, Percent_Identity=39.4812680115274, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788302, Length=177, Percent_Identity=37.8531073446328, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846 [H]

Pfam domain/function: PF02277 DBI_PRT [H]

EC number: =2.4.2.21 [H]

Molecular weight: Translated: 58545; Mature: 58414

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLPESLSAESLLARTVRGIRGADAKALEAARARQQLLTKPEGSLGLLEDLSIRLAGMY
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEEEEEC
GQVPVTVPSHPVVGLFAGDHGVWAQGVSPDPQEITTQQMINMAAGGAAISVLSRQMGAQL
CCCEEECCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
WITDVGARHEVDAPIRQRCVRRGTDDISQGPAMSLDEAVEALEVGIETGVAAVEQGADIL
EEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
ITGEMGIANTTPASALISVFTGLPPAEVTGRGAGSDDRRHQHKIGVVARALQVNRPEAKH
EECCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
PIEALAKVGGFEHAAMAGFILAAASSRIPVLIDGVIACSAALTATAICPEARDFIITSHA
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEECC
GAEPGITASTSALGLPALLDLGMRLGEGSGAILTLPIVQASAHILNEMATFEDAEVIDIK
CCCCCCCCCCHHCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEE
VSGETEIPDTVQTSVPPCRMLVIGGARSGKSTFAESRLPRDSRVTYVATSQRNPGDAEWE
ECCCCCCCCHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCCHH
ERIRLHQARRPATWQTVETTDIASVLLADDDSPVLVDCLGVWITRILDEVGAWAAAPGDE
HHHHHHHHCCCCCCCEEEHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
AWQNDLRRHVNDLASAIRGTRRDVIFVSNEVGMGVVPDTPAGRLFRDELGRLNAAVGEAC
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEVWMCVAGIPKRWA
HHHHHHHHCCCCCCC
>Mature Secondary Structure 
ARLPESLSAESLLARTVRGIRGADAKALEAARARQQLLTKPEGSLGLLEDLSIRLAGMY
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEEEEEC
GQVPVTVPSHPVVGLFAGDHGVWAQGVSPDPQEITTQQMINMAAGGAAISVLSRQMGAQL
CCCEEECCCCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCEE
WITDVGARHEVDAPIRQRCVRRGTDDISQGPAMSLDEAVEALEVGIETGVAAVEQGADIL
EEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
ITGEMGIANTTPASALISVFTGLPPAEVTGRGAGSDDRRHQHKIGVVARALQVNRPEAKH
EECCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
PIEALAKVGGFEHAAMAGFILAAASSRIPVLIDGVIACSAALTATAICPEARDFIITSHA
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCEEEEECC
GAEPGITASTSALGLPALLDLGMRLGEGSGAILTLPIVQASAHILNEMATFEDAEVIDIK
CCCCCCCCCCHHCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEE
VSGETEIPDTVQTSVPPCRMLVIGGARSGKSTFAESRLPRDSRVTYVATSQRNPGDAEWE
ECCCCCCCCHHHCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCCHH
ERIRLHQARRPATWQTVETTDIASVLLADDDSPVLVDCLGVWITRILDEVGAWAAAPGDE
HHHHHHHHCCCCCCCEEEHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCH
AWQNDLRRHVNDLASAIRGTRRDVIFVSNEVGMGVVPDTPAGRLFRDELGRLNAAVGEAC
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEVWMCVAGIPKRWA
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA