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The map label for this gene is fruA [H]

Identifier: 50841631

GI number: 50841631

Start: 169597

End: 171609

Strand: Reverse

Name: fruA [H]

Synonym: PPA0142

Alternate gene names: 50841631

Gene position: 171609-169597 (Counterclockwise)

Preceding gene: 50841632

Following gene: 50841630

Centisome position: 6.7

GC content: 63.93

Gene sequence:

>2013_bases
ATGAGCACTCCTCTCATTACCCCGGAATTAGTATCTCTTGACGCCAACCTCGGCTCGACCAAAACCGAGGTCATCACCTC
AGTCGCCGGACTCATTGCTGCCGCTGGACGCGCCGATGCTGACGGCCTCGCCCACGACGCTCTGGACCGCGAGTCCAAAA
GCCCGACCGGTATGCCCGGCGGATTCGCCATCCCCCACTGCCGCTCAGCCGCGGTATCTCAGGTATCCCTGGGGTTCGCC
CGGCTATCGCCCGCTGTCGACTTCAATGGACCTGACGGCCCGGCCGACCTCATCTTTATGATCGCGGCCTCCGAAGACGG
CGGCGCGGACCATATGAAACTTCTGACCAAGCTGGCTCGCGCCCTCGTCAATCCTGAGTTCGTCGAGCAGTTGCGTCAGG
CCCCCGACGCGCAAACCGTCGTCGACCTCATCGGTGGGGTCGTCGAGCCGAAGGAAGAAGCCTCGACCTCATCTGCAACG
GCCCTCCCCGCTCCTGGGCACGCCGCGGTGACCAATGCCGCCTCCGATACGCCCCGCATCGTCGCCATTACGGCCTGTCC
CACCGGCATCGCCCACACTTACATGGCAGCCGACTATTTGAGGGCTGCTGGGAAGAAGCTGGGTGTTGACGTCAAGGTCG
AGCCCCAAGGGTCCACCGCCACCGAGCCTCTCAGCACCGACGACATCGAGGGTGCTGACGCTGTCATTTTCGCCACCGAC
GTTGGTGTCAAGGGCCGGGAGCGCTTCGCCGGAAAGCCAGTCATTGAGTCCGGGGTGAAGCGGGCCGTCGACGAGCCTGA
GAAGATGATTTCGGAGGCCGTCGCCGCCTCCAAAGACCCACACGCCCATCGGGTCCCCGCTGGCCATGGTGAACAGCAGG
AGCCCGAGCAGGCTGGATCTCACATTGGCTGGGGCAAGCGCATCCAGCAGGCCCTCATGACGGGCGTGTCCTACATGATT
CCGTTCGTCGCCGCAGGTGGTCTGCTCATCGCCCTGGGATTCCTCTTCGGCGGGTATGAGATTGCCAAGGACGGCATGGA
TATTGCCTTGCACAACACCTTCAGCAACCTGCCGACGCCAACCGCCCATGCTCTAGGCGGATCAGCCACCATGACCTACA
TCGGCGCGGTCCTTTTCGCGGTCGGACAAGCGGCTTTCGGCTTCTTGCTACCTGCCCTCGCTGGGTATATCGGCTTCGGC
CTGGCAGACCGCCCCGGCATCGCCCCCGGTTTCGTAGCGGGTGCCGTCGCTGGGGTGACCGGGGCGGGATTCATCGGTGC
CATCATCGGTGGTCTGCTCGGCGGTTTCGTCGCCTACTGGTTCACCCGTCTCAACCCGCCGCGCTGGCTGCGTGGCCTCA
TGCCGGTCGTCATCATCCCGCTCGTCGGGTCCCTGGTCGCCGGTGGGTTGATGTACGTCGTACTGGGACGTCCGCTGGCA
GCCTTGACGAACGCTCTCAACAACTGGCTAGGCGGCATGAGCGGCGCCTCGGCCGTCATCCTCGGAATCGTCCTGGGACT
CATGATGTGCTCTGACCTGGGCGGCCCCATCAACAAGGCGGCTTACCTCTTCGCGACAACGAACCTCGCGGTCACCAACG
TCGGATCCCTCAAAGTGATGGCCGCCGTCATGGCTGCCGGGATGGTTCCCCCGCTGGCCATGGCGCTATCGACGACCCTG
CGTCCGAAGCTCTACCAGCCTGCCGAGCGTGAAAACGGCACTGCTGCCTGGCTGCTGGGAGCCTCCTTCATCTCCGAGGG
CGCTATCCCGTTCGCAGCTGCGGATCCGCTACGAGTGATTCCCTCAATGATGGTCGGAGGCGCAATCACCGGTGCCCTGT
CAATGGCTCTGGGGGCCGCTTCTAAAGCTCCCCATGGCGGAATCTTCGTCTTCTTTGCCATTGATCGGGTCTGGGCCTTC
ATCCTGGCCATTGTCGTCGGCACCCTCGTGGCAGCCTTGCTCGTAACCGCTCTCAAAGCCTCAGCTCGGCGCAAGGCCGC
GGCTGCCGCGTAA

Upstream 100 bases:

>100_bases
GTGGGGCACAGCAGCCGCCGCTCTACCGGGGTCAACCATGCCGACCCCGTCACAGGCCGACGCCATTCACGTCAGCCTCA
CCCACCTGTAAGGAGAACCG

Downstream 100 bases:

>100_bases
AATTTCCACACCACAACCCCGAAAGGAACACCATCATGGCCAGCAAAACCGTTAAGGTCGGATCCTCTGTCGGACTCCAC
GCCCGCCCCGCCGCCGTCAT

Product: phosphotransferase system

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MSTPLITPELVSLDANLGSTKTEVITSVAGLIAAAGRADADGLAHDALDRESKSPTGMPGGFAIPHCRSAAVSQVSLGFA
RLSPAVDFNGPDGPADLIFMIAASEDGGADHMKLLTKLARALVNPEFVEQLRQAPDAQTVVDLIGGVVEPKEEASTSSAT
ALPAPGHAAVTNAASDTPRIVAITACPTGIAHTYMAADYLRAAGKKLGVDVKVEPQGSTATEPLSTDDIEGADAVIFATD
VGVKGRERFAGKPVIESGVKRAVDEPEKMISEAVAASKDPHAHRVPAGHGEQQEPEQAGSHIGWGKRIQQALMTGVSYMI
PFVAAGGLLIALGFLFGGYEIAKDGMDIALHNTFSNLPTPTAHALGGSATMTYIGAVLFAVGQAAFGFLLPALAGYIGFG
LADRPGIAPGFVAGAVAGVTGAGFIGAIIGGLLGGFVAYWFTRLNPPRWLRGLMPVVIIPLVGSLVAGGLMYVVLGRPLA
ALTNALNNWLGGMSGASAVILGIVLGLMMCSDLGGPINKAAYLFATTNLAVTNVGSLKVMAAVMAAGMVPPLAMALSTTL
RPKLYQPAERENGTAAWLLGASFISEGAIPFAAADPLRVIPSMMVGGAITGALSMALGAASKAPHGGIFVFFAIDRVWAF
ILAIVVGTLVAALLVTALKASARRKAAAAA

Sequences:

>Translated_670_residues
MSTPLITPELVSLDANLGSTKTEVITSVAGLIAAAGRADADGLAHDALDRESKSPTGMPGGFAIPHCRSAAVSQVSLGFA
RLSPAVDFNGPDGPADLIFMIAASEDGGADHMKLLTKLARALVNPEFVEQLRQAPDAQTVVDLIGGVVEPKEEASTSSAT
ALPAPGHAAVTNAASDTPRIVAITACPTGIAHTYMAADYLRAAGKKLGVDVKVEPQGSTATEPLSTDDIEGADAVIFATD
VGVKGRERFAGKPVIESGVKRAVDEPEKMISEAVAASKDPHAHRVPAGHGEQQEPEQAGSHIGWGKRIQQALMTGVSYMI
PFVAAGGLLIALGFLFGGYEIAKDGMDIALHNTFSNLPTPTAHALGGSATMTYIGAVLFAVGQAAFGFLLPALAGYIGFG
LADRPGIAPGFVAGAVAGVTGAGFIGAIIGGLLGGFVAYWFTRLNPPRWLRGLMPVVIIPLVGSLVAGGLMYVVLGRPLA
ALTNALNNWLGGMSGASAVILGIVLGLMMCSDLGGPINKAAYLFATTNLAVTNVGSLKVMAAVMAAGMVPPLAMALSTTL
RPKLYQPAERENGTAAWLLGASFISEGAIPFAAADPLRVIPSMMVGGAITGALSMALGAASKAPHGGIFVFFAIDRVWAF
ILAIVVGTLVAALLVTALKASARRKAAAAA
>Mature_669_residues
STPLITPELVSLDANLGSTKTEVITSVAGLIAAAGRADADGLAHDALDRESKSPTGMPGGFAIPHCRSAAVSQVSLGFAR
LSPAVDFNGPDGPADLIFMIAASEDGGADHMKLLTKLARALVNPEFVEQLRQAPDAQTVVDLIGGVVEPKEEASTSSATA
LPAPGHAAVTNAASDTPRIVAITACPTGIAHTYMAADYLRAAGKKLGVDVKVEPQGSTATEPLSTDDIEGADAVIFATDV
GVKGRERFAGKPVIESGVKRAVDEPEKMISEAVAASKDPHAHRVPAGHGEQQEPEQAGSHIGWGKRIQQALMTGVSYMIP
FVAAGGLLIALGFLFGGYEIAKDGMDIALHNTFSNLPTPTAHALGGSATMTYIGAVLFAVGQAAFGFLLPALAGYIGFGL
ADRPGIAPGFVAGAVAGVTGAGFIGAIIGGLLGGFVAYWFTRLNPPRWLRGLMPVVIIPLVGSLVAGGLMYVVLGRPLAA
LTNALNNWLGGMSGASAVILGIVLGLMMCSDLGGPINKAAYLFATTNLAVTNVGSLKVMAAVMAAGMVPPLAMALSTTLR
PKLYQPAERENGTAAWLLGASFISEGAIPFAAADPLRVIPSMMVGGAITGALSMALGAASKAPHGGIFVFFAIDRVWAFI
LAIVVGTLVAALLVTALKASARRKAAAAA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=494, Percent_Identity=44.331983805668, Blast_Score=354, Evalue=1e-98,
Organism=Escherichia coli, GI1786951, Length=636, Percent_Identity=34.2767295597484, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI87082348, Length=504, Percent_Identity=33.9285714285714, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1790386, Length=366, Percent_Identity=39.6174863387978, Blast_Score=221, Evalue=2e-58,
Organism=Escherichia coli, GI1790387, Length=96, Percent_Identity=45.8333333333333, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788729, Length=418, Percent_Identity=24.8803827751196, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788726, Length=142, Percent_Identity=31.6901408450704, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI48994992, Length=148, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790390, Length=106, Percent_Identity=33.9622641509434, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 68201; Mature: 68070

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPLITPELVSLDANLGSTKTEVITSVAGLIAAAGRADADGLAHDALDRESKSPTGMPG
CCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
GFAIPHCRSAAVSQVSLGFARLSPAVDFNGPDGPADLIFMIAASEDGGADHMKLLTKLAR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
ALVNPEFVEQLRQAPDAQTVVDLIGGVVEPKEEASTSSATALPAPGHAAVTNAASDTPRI
HHCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHCCCCCCCCCE
VAITACPTGIAHTYMAADYLRAAGKKLGVDVKVEPQGSTATEPLSTDDIEGADAVIFATD
EEEEECCCHHHHHHHHHHHHHHCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEC
VGVKGRERFAGKPVIESGVKRAVDEPEKMISEAVAASKDPHAHRVPAGHGEQQEPEQAGS
CCCCCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCC
HIGWGKRIQQALMTGVSYMIPFVAAGGLLIALGFLFGGYEIAKDGMDIALHNTFSNLPTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEECHHHCCCCC
TAHALGGSATMTYIGAVLFAVGQAAFGFLLPALAGYIGFGLADRPGIAPGFVAGAVAGVT
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
GAGFIGAIIGGLLGGFVAYWFTRLNPPRWLRGLMPVVIIPLVGSLVAGGLMYVVLGRPLA
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ALTNALNNWLGGMSGASAVILGIVLGLMMCSDLGGPINKAAYLFATTNLAVTNVGSLKVM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCEEEEEECCEEEECCCHHHHH
AAVMAAGMVPPLAMALSTTLRPKLYQPAERENGTAAWLLGASFISEGAIPFAAADPLRVI
HHHHHHCCCHHHHHHHHHHHCCHHCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCHHHHH
PSMMVGGAITGALSMALGAASKAPHGGIFVFFAIDRVWAFILAIVVGTLVAALLVTALKA
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SARRKAAAAA
HHHHHHHCCC
>Mature Secondary Structure 
STPLITPELVSLDANLGSTKTEVITSVAGLIAAAGRADADGLAHDALDRESKSPTGMPG
CCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCC
GFAIPHCRSAAVSQVSLGFARLSPAVDFNGPDGPADLIFMIAASEDGGADHMKLLTKLAR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
ALVNPEFVEQLRQAPDAQTVVDLIGGVVEPKEEASTSSATALPAPGHAAVTNAASDTPRI
HHCCHHHHHHHHHCCCHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHCCCCCCCCCE
VAITACPTGIAHTYMAADYLRAAGKKLGVDVKVEPQGSTATEPLSTDDIEGADAVIFATD
EEEEECCCHHHHHHHHHHHHHHCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEEC
VGVKGRERFAGKPVIESGVKRAVDEPEKMISEAVAASKDPHAHRVPAGHGEQQEPEQAGS
CCCCCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCC
HIGWGKRIQQALMTGVSYMIPFVAAGGLLIALGFLFGGYEIAKDGMDIALHNTFSNLPTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEECHHHCCCCC
TAHALGGSATMTYIGAVLFAVGQAAFGFLLPALAGYIGFGLADRPGIAPGFVAGAVAGVT
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
GAGFIGAIIGGLLGGFVAYWFTRLNPPRWLRGLMPVVIIPLVGSLVAGGLMYVVLGRPLA
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
ALTNALNNWLGGMSGASAVILGIVLGLMMCSDLGGPINKAAYLFATTNLAVTNVGSLKVM
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCEEEEEECCEEEECCCHHHHH
AAVMAAGMVPPLAMALSTTLRPKLYQPAERENGTAAWLLGASFISEGAIPFAAADPLRVI
HHHHHHCCCHHHHHHHHHHHCCHHCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCHHHHH
PSMMVGGAITGALSMALGAASKAPHGGIFVFFAIDRVWAFILAIVVGTLVAALLVTALKA
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SARRKAAAAA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]