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The map label for this gene is 50365203

Identifier: 50365203

GI number: 50365203

Start: 444044

End: 444517

Strand: Reverse

Name: 50365203

Synonym: Mfl385

Alternate gene names: NA

Gene position: 444517-444044 (Counterclockwise)

Preceding gene: 50365204

Following gene: 50365202

Centisome position: 56.04

GC content: 29.54

Gene sequence:

>474_bases
ATGAAAAGAGAGAATTTTTTAAACTGAGAACAATTCTTTATGACTGTTGCTAAAGTTTGTGCAATGAGAAGTAAAGACCC
ATCAACTCAGGTTGGAGCTATTCTTGTTAACAATTTAAATCAAATTATATCAACAGGTTATAATGGATTTCCTAGAGGTG
TTAATGATGATGAATTTCCTTGAACAAGAGAAGGAGAATGAATTGATACTAAATACCCTTATGTAGCTCATGCTGAATTA
AACGCTATTGTAAGCGCAAGAACAAACTTAACTGACTCAGATGTTTATGTTACTTTGTTCCCATGCAACGAGTGTACAAA
AATTATCATTCAAGCAGGAATTAAAAAAGTATATTACCTTGAAGATAAATATAAAGATTCAAACGAAGTTAAAGCTTCTA
AGAGAATGTTAGATGCAGCTAAGATTGAATATAAGCAAATTAATGATTTTAATGTAAAAATATCAATAGATTAA

Upstream 100 bases:

>100_bases
GAAATGAAAATCTATATCCAAAACCTCCAACTGTAGCAACAATTAATTTAGCTTCAACTGCTGATGTTATTACAAACATT
AAATTAGGAATCAAACTATA

Downstream 100 bases:

>100_bases
CAAAAAACCTCACAAGATTAGACTGTGAGGTTTTCTTATAGGCTATTAATTGATAAAATTAAATAAAATAAAAGGATGCA
TTATGATTGAAAATATTGGA

Product: deoxycytidylate deaminase

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKRENFLNWEQFFMTVAKVCAMRSKDPSTQVGAILVNNLNQIISTGYNGFPRGVNDDEFPWTREGEWIDTKYPYVAHAEL
NAIVSARTNLTDSDVYVTLFPCNECTKIIIQAGIKKVYYLEDKYKDSNEVKASKRMLDAAKIEYKQINDFNVKISID

Sequences:

>Translated_157_residues
MKRENFLN*EQFFMTVAKVCAMRSKDPSTQVGAILVNNLNQIISTGYNGFPRGVNDDEFP*TREGE*IDTKYPYVAHAEL
NAIVSARTNLTDSDVYVTLFPCNECTKIIIQAGIKKVYYLEDKYKDSNEVKASKRMLDAAKIEYKQINDFNVKISID
>Mature_157_residues
MKRENFLN*EQFFMTVAKVCAMRSKDPSTQVGAILVNNLNQIISTGYNGFPRGVNDDEFP*TREGE*IDTKYPYVAHAEL
NAIVSARTNLTDSDVYVTLFPCNECTKIIIQAGIKKVYYLEDKYKDSNEVKASKRMLDAAKIEYKQINDFNVKISID

Specific function: Unknown

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=158, Percent_Identity=48.7341772151899, Blast_Score=155, Evalue=9e-39,
Organism=Homo sapiens, GI61742821, Length=158, Percent_Identity=48.7341772151899, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17557019, Length=138, Percent_Identity=52.8985507246377, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24667298, Length=163, Percent_Identity=46.6257668711656, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24667302, Length=163, Percent_Identity=46.6257668711656, Blast_Score=146, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 17466; Mature: 17466

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRENFLNEQFFMTVAKVCAMRSKDPSTQVGAILVNNLNQIISTGYNGFPRGVNDDEFPT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
REGEIDTKYPYVAHAELNAIVSARTNLTDSDVYVTLFPCNECTKIIIQAGIKKVYYLEDK
CCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEEEECCC
YKDSNEVKASKRMLDAAKIEYKQINDFNVKISID
CCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEEC
>Mature Secondary Structure
MKRENFLNEQFFMTVAKVCAMRSKDPSTQVGAILVNNLNQIISTGYNGFPRGVNDDEFPT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
REGEIDTKYPYVAHAELNAIVSARTNLTDSDVYVTLFPCNECTKIIIQAGIKKVYYLEDK
CCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHCCCEEEEECCC
YKDSNEVKASKRMLDAAKIEYKQINDFNVKISID
CCCCHHHHHHHHHHHHHHHHEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8329441 [H]