Click here to switch to the map view.

The map label for this gene is pdp [H]

Identifier: 50364934

GI number: 50364934

Start: 142941

End: 144245

Strand: Reverse

Name: pdp [H]

Synonym: Mfl119

Alternate gene names: 50364934

Gene position: 144245-142941 (Counterclockwise)

Preceding gene: 50364973

Following gene: 50364919

Centisome position: 18.18

GC content: 30.57

Gene sequence:

>1305_bases
ATGAACTACAGTTTTAGTGAAATTATAGAAAAAAAGAAACATTCAATAGAATTATCAGCTGAAGAAATTAAATGATTGAT
AAACAGTTACGTTAAAAATAATGTAACAGATTATCAAATGGCTGCTTTTGCTATGGCGGTTTATTTTAATGGAATGACCA
AAGCAGAAACTTTAGCATTAACCCAATCTTATGTTGAATCAGGATATGTTTATGATGTCAGTGAGGTTACAGGTTTAAAA
GCTGATAAGCATTCAACTGGCGGAGTTGGAGACAAAACAAGTTTAGTATATAGTCCGTTAGTTGCAAGTTATGGAGTAAA
GGTTTGTAAACTTTCTGGTAGAGGACTTGGAGTAACTGGTGGTACTATTGATAAATTAGAGTCATGTAAAGGTTGAACAA
GTGAATTATCTAAAGAAAAATTCATTAAAACAATTAATGAAGTTGGAATGAGCATCACAGGTCAGTCAGATGATATTGTT
CCTGCTGATAAAAAAATGTATGCACTAAGAGATGTTACTGGAACTGTTGATTCTATTCCTTTAATCGCTGCTTCTATTAT
GAGCAAAAAATTAGTAATCGATAGTGACAGTTTAATTCTAGATGTTAAAGTTGGAGCTGGTGCATTTATGAAAAATGTAG
ACATTGCTGAAAAACTAGCAAACGAAATGATTACTATTGGGCACGGGTATAATAGAAAAGTTTCAATTCTTCTTACTGAC
ATGCAAAAACCTTTAGGAAAAGCTATAGGAAATGCAATTGAAGTTAAGGAAGCTTGAGATACTTTAAATAACAATGGTCC
AGAAGATTTAAAAGAAGTTGTTTGTACAGCTGCTGGATTAACTTTAACTGACTTAGGTATTTTTGATAAATTAGAAGATG
CTATAACTGATTGTTATAAAAAACTAGAAACTGGTGAATGTGCACATTACTTGGAAGAATTCGTTGAAGCTCAGGGCGGA
AATTTTGAGTTAATCAAAAACTATGATCAAAATTTTACAACTAAGAATAAAATTGAAGTATTCGCTGAAAAAGATGGTTA
CATCATTTCACAAGACGCTGAAACTATAGGTTTACTTTCAATGGATCTTGGAGCCGGTAGAAAAACAAAAGAGGATTTAA
TAGATTTCTCTGCTGGAATATATTTAAATAAAAAAACTGGTGATGTTGTAAAAACTGGTGATGTTGTTTTAACTTTCTAC
ACAAACTTTGATATTAACAATGATTGAATAGAGAGAGCTAAAAAAAGTTTTATTATTTCAACTGAAAATGAAAAACAACA
AAATATTATAAAGATTATTAGATAA

Upstream 100 bases:

>100_bases
AACCATTTGTACTCCTTATGTTTTTTATATGTCTATTCTATTATAATATAGTAGAAAGAGTAATGGTGTAAATATTGTGC
ACTCTTACAAAAGGAGACTT

Downstream 100 bases:

>100_bases
AAAAAATGAGTTCTTTCAATAGGCGCAAACCTATGAAAAAACTCATTTTTAATAACTTAATTATAATTTGATAATTTTAT
TGAACTTATTTAACTCTTCT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNYSFSEIIEKKKHSIELSAEEIKWLINSYVKNNVTDYQMAAFAMAVYFNGMTKAETLALTQSYVESGYVYDVSEVTGLK
ADKHSTGGVGDKTSLVYSPLVASYGVKVCKLSGRGLGVTGGTIDKLESCKGWTSELSKEKFIKTINEVGMSITGQSDDIV
PADKKMYALRDVTGTVDSIPLIAASIMSKKLVIDSDSLILDVKVGAGAFMKNVDIAEKLANEMITIGHGYNRKVSILLTD
MQKPLGKAIGNAIEVKEAWDTLNNNGPEDLKEVVCTAAGLTLTDLGIFDKLEDAITDCYKKLETGECAHYLEEFVEAQGG
NFELIKNYDQNFTTKNKIEVFAEKDGYIISQDAETIGLLSMDLGAGRKTKEDLIDFSAGIYLNKKTGDVVKTGDVVLTFY
TNFDINNDWIERAKKSFIISTENEKQQNIIKIIR

Sequences:

>Translated_434_residues
MNYSFSEIIEKKKHSIELSAEEIK*LINSYVKNNVTDYQMAAFAMAVYFNGMTKAETLALTQSYVESGYVYDVSEVTGLK
ADKHSTGGVGDKTSLVYSPLVASYGVKVCKLSGRGLGVTGGTIDKLESCKG*TSELSKEKFIKTINEVGMSITGQSDDIV
PADKKMYALRDVTGTVDSIPLIAASIMSKKLVIDSDSLILDVKVGAGAFMKNVDIAEKLANEMITIGHGYNRKVSILLTD
MQKPLGKAIGNAIEVKEA*DTLNNNGPEDLKEVVCTAAGLTLTDLGIFDKLEDAITDCYKKLETGECAHYLEEFVEAQGG
NFELIKNYDQNFTTKNKIEVFAEKDGYIISQDAETIGLLSMDLGAGRKTKEDLIDFSAGIYLNKKTGDVVKTGDVVLTFY
TNFDINND*IERAKKSFIISTENEKQQNIIKIIR
>Mature_434_residues
MNYSFSEIIEKKKHSIELSAEEIK*LINSYVKNNVTDYQMAAFAMAVYFNGMTKAETLALTQSYVESGYVYDVSEVTGLK
ADKHSTGGVGDKTSLVYSPLVASYGVKVCKLSGRGLGVTGGTIDKLESCKG*TSELSKEKFIKTINEVGMSITGQSDDIV
PADKKMYALRDVTGTVDSIPLIAASIMSKKLVIDSDSLILDVKVGAGAFMKNVDIAEKLANEMITIGHGYNRKVSILLTD
MQKPLGKAIGNAIEVKEA*DTLNNNGPEDLKEVVCTAAGLTLTDLGIFDKLEDAITDCYKKLETGECAHYLEEFVEAQGG
NFELIKNYDQNFTTKNKIEVFAEKDGYIISQDAETIGLLSMDLGAGRKTKEDLIDFSAGIYLNKKTGDVVKTGDVVLTFY
TNFDINND*IERAKKSFIISTENEKQQNIIKIIR

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=408, Percent_Identity=35.5392156862745, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI4503445, Length=408, Percent_Identity=35.5392156862745, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI166158922, Length=408, Percent_Identity=35.5392156862745, Blast_Score=228, Evalue=6e-60,
Organism=Escherichia coli, GI1790842, Length=395, Percent_Identity=38.7341772151899, Blast_Score=257, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46950; Mature: 46950

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYSFSEIIEKKKHSIELSAEEIKLINSYVKNNVTDYQMAAFAMAVYFNGMTKAETLALT
CCCCHHHHHHHHHHCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
QSYVESGYVYDVSEVTGLKADKHSTGGVGDKTSLVYSPLVASYGVKVCKLSGRGLGVTGG
HHHHHCCCEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCC
TIDKLESCKGTSELSKEKFIKTINEVGMSITGQSDDIVPADKKMYALRDVTGTVDSIPLI
CHHHHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHEEHHHHCCCHHHHHHH
AASIMSKKLVIDSDSLILDVKVGAGAFMKNVDIAEKLANEMITIGHGYNRKVSILLTDMQ
HHHHHHCEEEEECCCEEEEEEECCCHHHHCCHHHHHHHHCEEEECCCCCCEEEEEEEHHH
KPLGKAIGNAIEVKEADTLNNNGPEDLKEVVCTAAGLTLTDLGIFDKLEDAITDCYKKLE
HHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
TGECAHYLEEFVEAQGGNFELIKNYDQNFTTKNKIEVFAEKDGYIISQDAETIGLLSMDL
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCEEEECCCCEEEEEEECC
GAGRKTKEDLIDFSAGIYLNKKTGDVVKTGDVVLTFYTNFDINNDIERAKKSFIISTENE
CCCCCCHHHHHHHHCCEEEECCCCCEEECCCEEEEEEECCCCCCHHHHHHHCEEEECCCC
KQQNIIKIIR
HHHHHHHHCC
>Mature Secondary Structure
MNYSFSEIIEKKKHSIELSAEEIKLINSYVKNNVTDYQMAAFAMAVYFNGMTKAETLALT
CCCCHHHHHHHHHHCEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
QSYVESGYVYDVSEVTGLKADKHSTGGVGDKTSLVYSPLVASYGVKVCKLSGRGLGVTGG
HHHHHCCCEEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCC
TIDKLESCKGTSELSKEKFIKTINEVGMSITGQSDDIVPADKKMYALRDVTGTVDSIPLI
CHHHHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHEEHHHHCCCHHHHHHH
AASIMSKKLVIDSDSLILDVKVGAGAFMKNVDIAEKLANEMITIGHGYNRKVSILLTDMQ
HHHHHHCEEEEECCCEEEEEEECCCHHHHCCHHHHHHHHCEEEECCCCCCEEEEEEEHHH
KPLGKAIGNAIEVKEADTLNNNGPEDLKEVVCTAAGLTLTDLGIFDKLEDAITDCYKKLE
HHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
TGECAHYLEEFVEAQGGNFELIKNYDQNFTTKNKIEVFAEKDGYIISQDAETIGLLSMDL
CCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCCEEEECCCCEEEEEEECC
GAGRKTKEDLIDFSAGIYLNKKTGDVVKTGDVVLTFYTNFDINNDIERAKKSFIISTENE
CCCCCCHHHHHHHHCCEEEECCCCCEEECCCEEEEEEECCCCCCHHHHHHHCEEEECCCC
KQQNIIKIIR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA