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The map label for this gene is pepD [H]

Identifier: 50085328

GI number: 50085328

Start: 2191174

End: 2192637

Strand: Reverse

Name: pepD [H]

Synonym: ACIAD2220

Alternate gene names: 50085328

Gene position: 2192637-2191174 (Counterclockwise)

Preceding gene: 50085329

Following gene: 50085326

Centisome position: 60.93

GC content: 41.39

Gene sequence:

>1464_bases
ATGCAACAATTTGACTTTTCTCTACTCTCGCCTCAAATCGTTTGGAAGCATTTTTCTACACTCTGTCGTATCCCTAGACT
ATCCAAACAAGAACATAAGTTACGTGATTATCTAAATGATTGGGCGAAAAGTCGTGGTTTAGAAACCTATATTGATCATA
TTGGCAATCTGATTATTCGTAAGCCTGCAGTTTCTGGAAAGGAAAATGTTAAAGGTGTGATTTTGCAGGGGCATCTGGAT
ATGGTGACTCAAGCGAATACAGGAACACAGCACGATTTTAACAAAGATCCCATTCGACCAGTTCTAGAAGATGATTGGTT
AATTGCTCCTGATACCACCTTGGGCGCTGATAATGGTATTGGGGTCGCTTTGGCTCTGGCAGTGCTTGAATCTAGTGATA
TTTCACATGGTCCAATTGAAGTACTTCTTACCGTGGATGAAGAAGCGGGTATGAGTGGGGCACGCTTACTTGAGTCTAAT
ATACTCAATGGACACTGGTTATTTAACATTGATACAGAGGAATGGGGTGAGCTTTATCTGGGCTGTGCGGGCAGTCAGGA
TGTGGAAATTCATCAACAACTTAAATATGTAGCAACACCTCAACTTGATCTTGAAGCAATAGAGATACGCATTTCAGGTT
TGAGAGGTGGCCATTCAGGTGTTGATATTCATCTTGGACGTGGCAATGCCAATGTTATTTTATCCAGATTTTTGCATCAA
CACTTACAGGAACTGGATGGTTATCTGGTCGAGCTTCATGGTGGTACAGCACGCAATGCTTTACCTCGTGAAGCATATGC
TAAAATCATTTTACCTAAAATCAATATTGATTTGCTTGAGCAGCGTCTTGATGAATATGAAGCACGGTGGAACCAGTCAC
TTAAAGGCATAGATGATCAGCTTAAAATTGAAGTTCAAATCAATCGAGCTTTAGGAAATGAAATTATCCATCCAGAACAG
CAAGCAGCTTGGCTAGAAGCATTGGCAACTTGTCCATATGGTGTAGCGCAAATGAGTTCAGCTTTGCCAGATGTAGTGGA
AACTTCAAATAATATTGGTGTGGTTCATTTAGATCGAGATGGTGCTCAAGCTGTGATCATGGTGAGATCAATGGTAAATA
CTGAAGCTCAGGCATTTTCACAAAAAATTGCAACGCACTTTATGAAATTTGGTATTACATCTGAACTTGCACCGCTGGTT
TCAGGTTGGAAACCAAATCCTGACTCCGCTGCTCTAAAGTGCTTACAGCAAGCCTATCAAAAGGCTTTTAATATTGAGCC
GAATCTTAAAGTGATCCATGCAGGCTTGGAGTGTGGGATTATTGCCGAACATTATCCAAATTTACAGATGGTTTCATTTG
GACCGGATATTCAGGGGGCACATGCACCAGGCGAACGAGTCAAAGTAGATACCGTAGAGAAATGCTGGAAGTTGTTGGTG
ACGGCTTTGGAAAGTGTGGAGTAA

Upstream 100 bases:

>100_bases
CACATTTTGAATGGACAAAGTAAAAGAAATAGTTCTGCATACTGTCACTATGTTGTGTATATTCTAAGAATGTTCTCGTC
TATAAATCGAGTAAATCTGA

Downstream 100 bases:

>100_bases
GTTGATTGAGACGATAATGACAGTGATCGAGTCAAAAAGTATTTGAATCGATTTGGCTTAACGTGGGAAATCATTCATTC
CGCACGTTAAACACTTCAAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MQQFDFSLLSPQIVWKHFSTLCRIPRLSKQEHKLRDYLNDWAKSRGLETYIDHIGNLIIRKPAVSGKENVKGVILQGHLD
MVTQANTGTQHDFNKDPIRPVLEDDWLIAPDTTLGADNGIGVALALAVLESSDISHGPIEVLLTVDEEAGMSGARLLESN
ILNGHWLFNIDTEEWGELYLGCAGSQDVEIHQQLKYVATPQLDLEAIEIRISGLRGGHSGVDIHLGRGNANVILSRFLHQ
HLQELDGYLVELHGGTARNALPREAYAKIILPKINIDLLEQRLDEYEARWNQSLKGIDDQLKIEVQINRALGNEIIHPEQ
QAAWLEALATCPYGVAQMSSALPDVVETSNNIGVVHLDRDGAQAVIMVRSMVNTEAQAFSQKIATHFMKFGITSELAPLV
SGWKPNPDSAALKCLQQAYQKAFNIEPNLKVIHAGLECGIIAEHYPNLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLV
TALESVE

Sequences:

>Translated_487_residues
MQQFDFSLLSPQIVWKHFSTLCRIPRLSKQEHKLRDYLNDWAKSRGLETYIDHIGNLIIRKPAVSGKENVKGVILQGHLD
MVTQANTGTQHDFNKDPIRPVLEDDWLIAPDTTLGADNGIGVALALAVLESSDISHGPIEVLLTVDEEAGMSGARLLESN
ILNGHWLFNIDTEEWGELYLGCAGSQDVEIHQQLKYVATPQLDLEAIEIRISGLRGGHSGVDIHLGRGNANVILSRFLHQ
HLQELDGYLVELHGGTARNALPREAYAKIILPKINIDLLEQRLDEYEARWNQSLKGIDDQLKIEVQINRALGNEIIHPEQ
QAAWLEALATCPYGVAQMSSALPDVVETSNNIGVVHLDRDGAQAVIMVRSMVNTEAQAFSQKIATHFMKFGITSELAPLV
SGWKPNPDSAALKCLQQAYQKAFNIEPNLKVIHAGLECGIIAEHYPNLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLV
TALESVE
>Mature_487_residues
MQQFDFSLLSPQIVWKHFSTLCRIPRLSKQEHKLRDYLNDWAKSRGLETYIDHIGNLIIRKPAVSGKENVKGVILQGHLD
MVTQANTGTQHDFNKDPIRPVLEDDWLIAPDTTLGADNGIGVALALAVLESSDISHGPIEVLLTVDEEAGMSGARLLESN
ILNGHWLFNIDTEEWGELYLGCAGSQDVEIHQQLKYVATPQLDLEAIEIRISGLRGGHSGVDIHLGRGNANVILSRFLHQ
HLQELDGYLVELHGGTARNALPREAYAKIILPKINIDLLEQRLDEYEARWNQSLKGIDDQLKIEVQINRALGNEIIHPEQ
QAAWLEALATCPYGVAQMSSALPDVVETSNNIGVVHLDRDGAQAVIMVRSMVNTEAQAFSQKIATHFMKFGITSELAPLV
SGWKPNPDSAALKCLQQAYQKAFNIEPNLKVIHAGLECGIIAEHYPNLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLV
TALESVE

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=482, Percent_Identity=40.8713692946058, Blast_Score=380, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53934; Mature: 53934

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQFDFSLLSPQIVWKHFSTLCRIPRLSKQEHKLRDYLNDWAKSRGLETYIDHIGNLIIR
CCCCCCHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEE
KPAVSGKENVKGVILQGHLDMVTQANTGTQHDFNKDPIRPVLEDDWLIAPDTTLGADNGI
CCCCCCCCCCCEEEEECCCHHEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCH
GVALALAVLESSDISHGPIEVLLTVDEEAGMSGARLLESNILNGHWLFNIDTEEWGELYL
HHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECHHHHCCEEE
GCAGSQDVEIHQQLKYVATPQLDLEAIEIRISGLRGGHSGVDIHLGRGNANVILSRFLHQ
ECCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHH
HLQELDGYLVELHGGTARNALPREAYAKIILPKINIDLLEQRLDEYEARWNQSLKGIDDQ
HHHHHCCEEEEECCCCCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCE
LKIEVQINRALGNEIIHPEQQAAWLEALATCPYGVAQMSSALPDVVETSNNIGVVHLDRD
EEEEEEEEHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHCCCCEEEEEECCC
GAQAVIMVRSMVNTEAQAFSQKIATHFMKFGITSELAPLVSGWKPNPDSAALKCLQQAYQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KAFNIEPNLKVIHAGLECGIIAEHYPNLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLV
HHCCCCCCCEEEEECCCCCEEHHCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHH
TALESVE
HHHHHCC
>Mature Secondary Structure
MQQFDFSLLSPQIVWKHFSTLCRIPRLSKQEHKLRDYLNDWAKSRGLETYIDHIGNLIIR
CCCCCCHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEE
KPAVSGKENVKGVILQGHLDMVTQANTGTQHDFNKDPIRPVLEDDWLIAPDTTLGADNGI
CCCCCCCCCCCEEEEECCCHHEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCH
GVALALAVLESSDISHGPIEVLLTVDEEAGMSGARLLESNILNGHWLFNIDTEEWGELYL
HHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECHHHHCCEEE
GCAGSQDVEIHQQLKYVATPQLDLEAIEIRISGLRGGHSGVDIHLGRGNANVILSRFLHQ
ECCCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHH
HLQELDGYLVELHGGTARNALPREAYAKIILPKINIDLLEQRLDEYEARWNQSLKGIDDQ
HHHHHCCEEEEECCCCCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCE
LKIEVQINRALGNEIIHPEQQAAWLEALATCPYGVAQMSSALPDVVETSNNIGVVHLDRD
EEEEEEEEHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHCCCCEEEEEECCC
GAQAVIMVRSMVNTEAQAFSQKIATHFMKFGITSELAPLVSGWKPNPDSAALKCLQQAYQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
KAFNIEPNLKVIHAGLECGIIAEHYPNLQMVSFGPDIQGAHAPGERVKVDTVEKCWKLLV
HHCCCCCCCEEEEECCCCCEEHHCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHH
TALESVE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]