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The map label for this gene is ycnB [H]

Identifier: 50085241

GI number: 50085241

Start: 2110549

End: 2112003

Strand: Reverse

Name: ycnB [H]

Synonym: ACIAD2122

Alternate gene names: 50085241

Gene position: 2112003-2110549 (Counterclockwise)

Preceding gene: 50085242

Following gene: 50085240

Centisome position: 58.69

GC content: 42.82

Gene sequence:

>1455_bases
ATGACTGATATATCCAGAGTACACGCTACTCAACATTCATGTGATGAAAAATCAATGATATCTCGGTGGGTGATGCTATG
CGTGATGTTGGGAACTGGGACAGTAAGTCTTAACAATAGTAGTTTTAATCCTGCACTTGTACAACTGATGCATGATTTTA
ATATTGGTGAAGCGGCTGTGAGCTGGTTCATGGTCAGTTTTTTACTGGCCATGAGTTTAAGTCTGCTGCTTACTGGTTTC
TTGAGTCAGCGATTTGGTAAACGTGAAGTTTATCTTGGCGCACTTGCATTATTTGTATTGGCATCAGCGATTGGCGGTTG
TGCAAAACATTATGAAACGGTACTGGCCGTGCGGGCAGTGCAAGGTTTTGCAAGTGGACTCATGATCCCACTATCACTGG
GTATTATTTTTTCAGTCACCTCACAACAAAAACGCGGAGCAGCAACTGGATTATGGGGAGCCATGATCATGTTGACGCTG
GCCTGCGGTCCTATGTTGGGTGCAGTGCTTTTAATCTGGTGGGATTGGCCTGCTTTGTTTCTAGTGAATATTCCCTTTGG
TGTGCTTGCTTTGGTGCTGGGCTGGATACATTTGCCAAAGCAGACTAAAAATCGCTCTGAGAGGTTCGACTGGTTTGCTT
ATTCACTATTGTCTGCATCGATCATCAGTTTGCTACTGGCGCTGAGTCAGGTCAAAACCTTGTCTGATCTGGAAAGCTTC
AAGTTCTTTCTCCTAATACTCATAAGCATACTTTCAGGTCTATGGTTTTGGATAATAACCCGTAAACAGCAGTCTTCTCT
GATCAAGTGGCAAATATTTAACAGTCAAGGCTTTAATTATAGTTTGTTCATTTCGGTCATGCATACAACTGGATTATTTA
TTAGCTTATTGGTCATTCCGTTATTTATACAAAACACCTTGAAACTCAGTCCTATCTGGACGGGTATTTTACTGATGACA
AGTGCCCTTACCACCAGTTTATGTAGTAAGTGGGCGGGAGAGTTTCTCGACCAACATGGTGCAAAATTTCTGATTTCATT
TGGCATCATTCTTACTGCTTTGGCATTTATAGGACTGGCTTTGGGTGGTCATTTACCTCTGACCTATCTGATCGTATGTA
TGGCTCTACATGGTTTGGGTTTTGGTCTGTCGTATATGCCTGCAACTACAGCAGGGCTTAATAGCTTATCCGATCAGGAA
TTGGTGACACAGGGTGCAGCCATCAACAATCTGCTTAGACGCACTTGTTCTGCTGTCGCGGTTGTAATCGCAGCACTTTA
CTTACAAATCCGGACACATTCACTTTTAGCATCCTACGATTTGGATAGAGCACAACTGACCTCAATTCGCGAATTATTTT
TGATATGTGCAGCGCTACTCCTGCTGGCATTGCCTTACGCGTGGAAATTTCCGTATTCCAAACCATTGGATGCTCATCGT
TCATCAAAGATTTAA

Upstream 100 bases:

>100_bases
TCATACAAAAAGCTCTCAGTCTGAGGACATGTTCTTGCACTTTTCTGGGAAACAGTCTTTAGCTGCTTCTAAATGCACGA
CCAGTCGTGAAGGATAAATC

Downstream 100 bases:

>100_bases
AAAATTAAGGAAAAGATATGGGAAACTTACAAACTTTATTAGGCAAAGATGATTTTACACTTTCTCCATACGTTGCATGG
CAACAACCCGATGCCAAAAC

Product: MFS superfamily multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTDISRVHATQHSCDEKSMISRWVMLCVMLGTGTVSLNNSSFNPALVQLMHDFNIGEAAVSWFMVSFLLAMSLSLLLTGF
LSQRFGKREVYLGALALFVLASAIGGCAKHYETVLAVRAVQGFASGLMIPLSLGIIFSVTSQQKRGAATGLWGAMIMLTL
ACGPMLGAVLLIWWDWPALFLVNIPFGVLALVLGWIHLPKQTKNRSERFDWFAYSLLSASIISLLLALSQVKTLSDLESF
KFFLLILISILSGLWFWIITRKQQSSLIKWQIFNSQGFNYSLFISVMHTTGLFISLLVIPLFIQNTLKLSPIWTGILLMT
SALTTSLCSKWAGEFLDQHGAKFLISFGIILTALAFIGLALGGHLPLTYLIVCMALHGLGFGLSYMPATTAGLNSLSDQE
LVTQGAAINNLLRRTCSAVAVVIAALYLQIRTHSLLASYDLDRAQLTSIRELFLICAALLLLALPYAWKFPYSKPLDAHR
SSKI

Sequences:

>Translated_484_residues
MTDISRVHATQHSCDEKSMISRWVMLCVMLGTGTVSLNNSSFNPALVQLMHDFNIGEAAVSWFMVSFLLAMSLSLLLTGF
LSQRFGKREVYLGALALFVLASAIGGCAKHYETVLAVRAVQGFASGLMIPLSLGIIFSVTSQQKRGAATGLWGAMIMLTL
ACGPMLGAVLLIWWDWPALFLVNIPFGVLALVLGWIHLPKQTKNRSERFDWFAYSLLSASIISLLLALSQVKTLSDLESF
KFFLLILISILSGLWFWIITRKQQSSLIKWQIFNSQGFNYSLFISVMHTTGLFISLLVIPLFIQNTLKLSPIWTGILLMT
SALTTSLCSKWAGEFLDQHGAKFLISFGIILTALAFIGLALGGHLPLTYLIVCMALHGLGFGLSYMPATTAGLNSLSDQE
LVTQGAAINNLLRRTCSAVAVVIAALYLQIRTHSLLASYDLDRAQLTSIRELFLICAALLLLALPYAWKFPYSKPLDAHR
SSKI
>Mature_483_residues
TDISRVHATQHSCDEKSMISRWVMLCVMLGTGTVSLNNSSFNPALVQLMHDFNIGEAAVSWFMVSFLLAMSLSLLLTGFL
SQRFGKREVYLGALALFVLASAIGGCAKHYETVLAVRAVQGFASGLMIPLSLGIIFSVTSQQKRGAATGLWGAMIMLTLA
CGPMLGAVLLIWWDWPALFLVNIPFGVLALVLGWIHLPKQTKNRSERFDWFAYSLLSASIISLLLALSQVKTLSDLESFK
FFLLILISILSGLWFWIITRKQQSSLIKWQIFNSQGFNYSLFISVMHTTGLFISLLVIPLFIQNTLKLSPIWTGILLMTS
ALTTSLCSKWAGEFLDQHGAKFLISFGIILTALAFIGLALGGHLPLTYLIVCMALHGLGFGLSYMPATTAGLNSLSDQEL
VTQGAAINNLLRRTCSAVAVVIAALYLQIRTHSLLASYDLDRAQLTSIRELFLICAALLLLALPYAWKFPYSKPLDAHRS
SKI

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=365, Percent_Identity=22.7397260273973, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081983, Length=379, Percent_Identity=25.8575197889182, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789042, Length=366, Percent_Identity=22.6775956284153, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790195, Length=315, Percent_Identity=24.1269841269841, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788392, Length=416, Percent_Identity=22.8365384615385, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324264, Length=160, Percent_Identity=31.25, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322071, Length=141, Percent_Identity=29.0780141843972, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53201; Mature: 53070

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDISRVHATQHSCDEKSMISRWVMLCVMLGTGTVSLNNSSFNPALVQLMHDFNIGEAAV
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHHH
SWFMVSFLLAMSLSLLLTGFLSQRFGKREVYLGALALFVLASAIGGCAKHYETVLAVRAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGFASGLMIPLSLGIIFSVTSQQKRGAATGLWGAMIMLTLACGPMLGAVLLIWWDWPALF
HHHHCCCHHHHHHHHHHEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LVNIPFGVLALVLGWIHLPKQTKNRSERFDWFAYSLLSASIISLLLALSQVKTLSDLESF
HHHCCHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFFLLILISILSGLWFWIITRKQQSSLIKWQIFNSQGFNYSLFISVMHTTGLFISLLVIP
HHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHH
LFIQNTLKLSPIWTGILLMTSALTTSLCSKWAGEFLDQHGAKFLISFGIILTALAFIGLA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LGGHLPLTYLIVCMALHGLGFGLSYMPATTAGLNSLSDQELVTQGAAINNLLRRTCSAVA
HCCCCHHHHHHHHHHHHHHCCCCHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVIAALYLQIRTHSLLASYDLDRAQLTSIRELFLICAALLLLALPYAWKFPYSKPLDAHR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
SSKI
CCCC
>Mature Secondary Structure 
TDISRVHATQHSCDEKSMISRWVMLCVMLGTGTVSLNNSSFNPALVQLMHDFNIGEAAV
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHHH
SWFMVSFLLAMSLSLLLTGFLSQRFGKREVYLGALALFVLASAIGGCAKHYETVLAVRAV
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGFASGLMIPLSLGIIFSVTSQQKRGAATGLWGAMIMLTLACGPMLGAVLLIWWDWPALF
HHHHCCCHHHHHHHHHHEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LVNIPFGVLALVLGWIHLPKQTKNRSERFDWFAYSLLSASIISLLLALSQVKTLSDLESF
HHHCCHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFFLLILISILSGLWFWIITRKQQSSLIKWQIFNSQGFNYSLFISVMHTTGLFISLLVIP
HHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHH
LFIQNTLKLSPIWTGILLMTSALTTSLCSKWAGEFLDQHGAKFLISFGIILTALAFIGLA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LGGHLPLTYLIVCMALHGLGFGLSYMPATTAGLNSLSDQELVTQGAAINNLLRRTCSAVA
HCCCCHHHHHHHHHHHHHHCCCCHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VVIAALYLQIRTHSLLASYDLDRAQLTSIRELFLICAALLLLALPYAWKFPYSKPLDAHR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCC
SSKI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]