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The map label for this gene is yxnA [H]

Identifier: 50085224

GI number: 50085224

Start: 2094267

End: 2095049

Strand: Reverse

Name: yxnA [H]

Synonym: ACIAD2104

Alternate gene names: 50085224

Gene position: 2095049-2094267 (Counterclockwise)

Preceding gene: 50085225

Following gene: 50085222

Centisome position: 58.22

GC content: 41.12

Gene sequence:

>783_bases
ATGCAATTATCTAATGCAAATGTTTTACTCACGGGTGCGAGTGGCGGGATAGGATTGGCACTGTGTGAAGCGCTGTGTCG
TGAAGGCGCAAAAGTACTGGCAGTGGCCCGTAATATTCAATCTTTAGAAGGTTTGCAGCAGAAATATATCGGACAAATCA
AAATTATCCGTGCTGATCTGCTCGATTTTCAGGATTTGAATAAAGTCATTCAGGTCGCTTCACAAGTTGAGGGATTGAAT
TTATTGATTAATGCAGCAGGTGTGAATTGTTTTGCAACGCTTGATCATCAGTCACCTGAACAGATTCATCAACTGGTACA
ACTGAATGTCACGGCACCAATGAGTTTGACTGCGGGTTTAATTGCAAAATTAAATGCTGTATCTGAAGCGAAAATTGTCA
ATGTGGGTTCGATTTATGGATCACTTGGTTTTGCTGGCTACACTACATATTGTGCAACCAAATTCGCATTACGAGGTTTT
TCGGAAGCCCTGCGACGTGAATTGGCCGATAGCAATATTCAAGTGTTGTATGTTGCACCTAGAGCAACGCAAACAACAAT
GAATAGTCAGGCTGCACAAGATTTGATGCAAGCAATGGGAAGTAAAGCAGATAGTCCAGAACTTGTAGCCAAGATTATTA
TACAGTCGATTAAACAAGGTAAACAGAATACTTATATTGGTTGGCCCGAGCGCGGATTTGTCATGATGAATTCGATTATG
CCGCATTTAGTCGATCAAGGTGTAAGAAAGCATTTAAGCTTAATTCATCAGTTGGGCCACTAA

Upstream 100 bases:

>100_bases
CATTGTTCTAAGGTTGTATTTAAGCTTTATACACAAATGTATGAGCAGGTACCTGATATTCATTTGAAGTTTGCAGCGTA
ATCTAAAGGGAATAGAGTCT

Downstream 100 bases:

>100_bases
TCATTGATGTCTAAGAAAACGACAAGGTTTATTTTAAATCAGGGCTTTGAAATATATTCAAAGCCCGATTATTTTTGCTC
TAGATTGTTAATAAATATTC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MQLSNANVLLTGASGGIGLALCEALCREGAKVLAVARNIQSLEGLQQKYIGQIKIIRADLLDFQDLNKVIQVASQVEGLN
LLINAAGVNCFATLDHQSPEQIHQLVQLNVTAPMSLTAGLIAKLNAVSEAKIVNVGSIYGSLGFAGYTTYCATKFALRGF
SEALRRELADSNIQVLYVAPRATQTTMNSQAAQDLMQAMGSKADSPELVAKIIIQSIKQGKQNTYIGWPERGFVMMNSIM
PHLVDQGVRKHLSLIHQLGH

Sequences:

>Translated_260_residues
MQLSNANVLLTGASGGIGLALCEALCREGAKVLAVARNIQSLEGLQQKYIGQIKIIRADLLDFQDLNKVIQVASQVEGLN
LLINAAGVNCFATLDHQSPEQIHQLVQLNVTAPMSLTAGLIAKLNAVSEAKIVNVGSIYGSLGFAGYTTYCATKFALRGF
SEALRRELADSNIQVLYVAPRATQTTMNSQAAQDLMQAMGSKADSPELVAKIIIQSIKQGKQNTYIGWPERGFVMMNSIM
PHLVDQGVRKHLSLIHQLGH
>Mature_260_residues
MQLSNANVLLTGASGGIGLALCEALCREGAKVLAVARNIQSLEGLQQKYIGQIKIIRADLLDFQDLNKVIQVASQVEGLN
LLINAAGVNCFATLDHQSPEQIHQLVQLNVTAPMSLTAGLIAKLNAVSEAKIVNVGSIYGSLGFAGYTTYCATKFALRGF
SEALRRELADSNIQVLYVAPRATQTTMNSQAAQDLMQAMGSKADSPELVAKIIIQSIKQGKQNTYIGWPERGFVMMNSIM
PHLVDQGVRKHLSLIHQLGH

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=241, Percent_Identity=28.2157676348548, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI40254992, Length=187, Percent_Identity=28.8770053475936, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI7706318, Length=214, Percent_Identity=28.5046728971963, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI109715829, Length=225, Percent_Identity=31.1111111111111, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI50726952, Length=207, Percent_Identity=29.4685990338164, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI20149619, Length=237, Percent_Identity=23.2067510548523, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI157739938, Length=276, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI38348362, Length=183, Percent_Identity=32.2404371584699, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7705925, Length=200, Percent_Identity=30, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI38424085, Length=184, Percent_Identity=32.0652173913043, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI31542939, Length=195, Percent_Identity=29.7435897435897, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI32483357, Length=197, Percent_Identity=25.3807106598985, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=187, Percent_Identity=27.807486631016, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786701, Length=192, Percent_Identity=29.6875, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786812, Length=191, Percent_Identity=29.3193717277487, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787820, Length=175, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082100, Length=213, Percent_Identity=25.8215962441315, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI2367365, Length=237, Percent_Identity=25.3164556962025, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=201, Percent_Identity=30.3482587064677, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=267, Percent_Identity=23.5955056179775, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=261, Percent_Identity=23.7547892720307, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71997402, Length=231, Percent_Identity=25.1082251082251, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=200, Percent_Identity=30.5, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560176, Length=196, Percent_Identity=26.0204081632653, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25152911, Length=197, Percent_Identity=27.9187817258883, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=185, Percent_Identity=27.5675675675676, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=193, Percent_Identity=25.9067357512953, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=268, Percent_Identity=28.3582089552239, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320089, Length=191, Percent_Identity=26.7015706806283, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=187, Percent_Identity=33.1550802139037, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI23397609, Length=182, Percent_Identity=31.8681318681319, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21356301, Length=239, Percent_Identity=26.7782426778243, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21358495, Length=234, Percent_Identity=26.4957264957265, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364892, Length=224, Percent_Identity=25.4464285714286, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=26, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161076933, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24584748, Length=190, Percent_Identity=28.4210526315789, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28571526, Length=243, Percent_Identity=25.5144032921811, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28027; Mature: 28027

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSNANVLLTGASGGIGLALCEALCREGAKVLAVARNIQSLEGLQQKYIGQIKIIRADL
CCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHH
LDFQDLNKVIQVASQVEGLNLLINAAGVNCFATLDHQSPEQIHQLVQLNVTAPMSLTAGL
HCHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHH
IAKLNAVSEAKIVNVGSIYGSLGFAGYTTYCATKFALRGFSEALRRELADSNIQVLYVAP
HHHHHHHHHHHEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
RATQTTMNSQAAQDLMQAMGSKADSPELVAKIIIQSIKQGKQNTYIGWPERGFVMMNSIM
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
PHLVDQGVRKHLSLIHQLGH
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLSNANVLLTGASGGIGLALCEALCREGAKVLAVARNIQSLEGLQQKYIGQIKIIRADL
CCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHH
LDFQDLNKVIQVASQVEGLNLLINAAGVNCFATLDHQSPEQIHQLVQLNVTAPMSLTAGL
HCHHHHHHHHHHHHHHCCHHEEEEECCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHH
IAKLNAVSEAKIVNVGSIYGSLGFAGYTTYCATKFALRGFSEALRRELADSNIQVLYVAP
HHHHHHHHHHHEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
RATQTTMNSQAAQDLMQAMGSKADSPELVAKIIIQSIKQGKQNTYIGWPERGFVMMNSIM
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
PHLVDQGVRKHLSLIHQLGH
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]