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The map label for this gene is lytS

Identifier: 49188280

GI number: 49188280

Start: 5180591

End: 5182360

Strand: Reverse

Name: lytS

Synonym: BAS5296

Alternate gene names: 49188280

Gene position: 5182360-5180591 (Counterclockwise)

Preceding gene: 49188282

Following gene: 49188279

Centisome position: 99.11

GC content: 36.55

Gene sequence:

>1770_bases
ATGCTAAATTTAGTACTTATGATGATTGAACGCGTCGGACTTATTGTTATTCTAGGATTTTTACTTTCGCATATTAAAAC
ATTCAGGCGCCTTCTTCATAAGCAAGATGGTTATGTAGATAAGCTTAAGCTTATTTGTATTTTTTCGGTGTTTACAATTG
TAAGCAATTACACCGGGATTGAAATAGCAGGGAATACGATTATGAATGAAAATTGGCTACAGGGTGTTTCATCATCGAGT
ACCATTGCAAATACACGTATTATGGGTGTTGGAATTAGTGGATTGCTTGGCGGTCCTATCGTCGGAATTGGAGTAGGATC
GATTGCTGGTATTCACCGTTATATGCTTGGCGGGACGACAGCGCTAAGTTGCGCGATCTCTTCAATTTTAGCAGGCGTTA
TAACTGGGTATATTGGATACATTTTTAAAAAGTATAATCGTACAATTACGCCTAAATTTTCAGCAGTTTTAAGTGTGTTT
ATCGTTTCTTTAGAAATGATTATGATTCTATTAATTGTAGAGGATGGCATTAGCATTGTGAAAACAATTGCGATACCAAT
GATCCTTGTAAATAGCTTTGGAAGTTTTATTTTACTTTCTATGATACAAGCTATTTTGCGCCAGGAAGAGAACGCAAAGG
CACTTCAGACTCATAAGGTATTACGTATTGCAGATAAAACGTTACCGTATTTTCGCCAAGGCTTAACAGAAGAATCTTGT
AAGCATGTGGCACAAATTATTCACCGCTTTACAGGAACAGATGCGGTATCCTTAACAGATACAGAGAAAATATTAGCTCA
TGTTGGATTAGCGTCAGATCACCATATTCCTTCACATAGTTTAATAACCGGTTTGTCGAAAGAAGTGTTACATACAGGGA
AAATAATGAAAGCGAAATCACGTGAGGTCATTAATTGTCAACATGAAGGCTGTCCTTTGCAAGCGGCGATTGTTATTCCG
CTAACTTCACATGGAAATACGATAGGGACATTAAAACTATATTTCAAAAATCCTAACCAGTTAAGTCGTGTGGAAGAGGA
ATTAGCAGAAGGGTTAGCAAAAATATTCTCTACACAACTTGAATTAGGTGAAGCTGAGTTGCAAAGTAAACTATTGCAAG
ATGCGGAGATAAAGGCATTACAAGCACAAATTAACCCACACTTTTTATTTAATGCAATTAATACAGTATCAGCTTTATGC
CGAACAGATGTAGAAAAGGCAAGAAAGTTATTATTACAGCTTAGCGTGTATTTCCGTTGTAATTTGCAAGGGGCACGTCA
GTTATTGATTCCACTAGAACAAGAATTAAACCATGTACAGGCATACTTATCACTAGAACAAGCAAGGTTCCCAAATAAGT
ATGAAGTAAAGATGTATATTGAGGATGAGCTCAAGACAACTTTAGTACCACCGTTTGTTCTTCAACTATTGGTTGAAAAT
GCATTGCGACACGCTTTTCCAAAGAAGCAACCCGTATGTGAAGTGGAAGTGCATGTTTTTGAAAAAGAGGGTATGGTTCA
TTTTGAAGTAAAGGATAATGGACAAGGGATTGAGGAAGAACGTTTAGAACAATTAGGAAAGATGGTAGTTTCGTCAAAAA
AAGGGACTGGAACAGCTTTATATAATATTAATGAACGTCTTATTGGGTTATTTGGGAAGGAAACGATGCTTCATATCGAA
AGTGAAGTAAATGAGGGGACAGAGATTACTTTTGTTATTCCAAAAAAAGTAGGGGAGGAAGAGCAGATTGTTAAAAGTAT
TAGTAGTTGA

Upstream 100 bases:

>100_bases
TATGTGTAAAATATTGCAAAAGGTATTTCATTCTTCTTGACGCCCACTTCACTATTTTCCGATAATAAAACTAACTACTA
TAAAAAGGAATGAATCACAG

Downstream 100 bases:

>100_bases
TGATGAAATGTTAGCACGTGATGAACTAAAGTATTTATTAGAGAGAACGAAGGAAGTTGAGATAATTGGTGAGGCTGATT
GTGTAGAGGACGCATTAGAA

Product: sensor histidine kinase LytS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGIEIAGNTIMNENWLQGVSSSS
TIANTRIMGVGISGLLGGPIVGIGVGSIAGIHRYMLGGTTALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVF
IVSLEMIMILLIVEDGISIVKTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKSREVINCQHEGCPLQAAIVIP
LTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQLELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALC
RTDVEKARKLLLQLSVYFRCNLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTALYNINERLIGLFGKETMLHIE
SEVNEGTEITFVIPKKVGEEEQIVKSISS

Sequences:

>Translated_589_residues
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGIEIAGNTIMNENWLQGVSSSS
TIANTRIMGVGISGLLGGPIVGIGVGSIAGIHRYMLGGTTALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVF
IVSLEMIMILLIVEDGISIVKTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKSREVINCQHEGCPLQAAIVIP
LTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQLELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALC
RTDVEKARKLLLQLSVYFRCNLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTALYNINERLIGLFGKETMLHIE
SEVNEGTEITFVIPKKVGEEEQIVKSISS
>Mature_589_residues
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGIEIAGNTIMNENWLQGVSSSS
TIANTRIMGVGISGLLGGPIVGIGVGSIAGIHRYMLGGTTALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVF
IVSLEMIMILLIVEDGISIVKTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKSREVINCQHEGCPLQAAIVIP
LTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQLELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALC
RTDVEKARKLLLQLSVYFRCNLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTALYNINERLIGLFGKETMLHIE
SEVNEGTEITFVIPKKVGEEEQIVKSISS

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788723, Length=582, Percent_Identity=34.7079037800687, Blast_Score=313, Evalue=3e-86,
Organism=Escherichia coli, GI1788446, Length=584, Percent_Identity=32.0205479452055, Blast_Score=273, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYTS_BACAN (Q81JL2)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_847838.1
- RefSeq:   YP_022375.1
- RefSeq:   YP_031533.1
- ProteinModelPortal:   Q81JL2
- SMR:   Q81JL2
- EnsemblBacteria:   EBBACT00000013275
- EnsemblBacteria:   EBBACT00000017099
- EnsemblBacteria:   EBBACT00000019683
- GeneID:   1085432
- GeneID:   2818681
- GeneID:   2853103
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_5692
- KEGG:   bar:GBAA_5692
- KEGG:   bat:BAS5296
- TIGR:   BA_5692
- TIGR:   GBAA_5692
- GeneTree:   EBGT00070000032226
- HOGENOM:   HBG724694
- OMA:   IGIGDDH
- ProtClustDB:   CLSK887701
- BioCyc:   BANT260799:BAS5296-MONOMER
- BioCyc:   BANT261594:GBAA5692-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00065
- SMART:   SM00387

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 65278; Mature: 65278

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x183b9c44)-; HASH(0x18a07c68)-; HASH(0x18755ca4)-; HASH(0x176332c8)-; HASH(0x1789ce80)-; HASH(0x17ddc338)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
EIAGNTIMNENWLQGVSSSSTIANTRIMGVGISGLLGGPIVGIGVGSIAGIHRYMLGGTT
EEECCCCCCCHHHCCCCCCCCHHHCEEEEECHHHHCCCCEEEECHHHHHHHHHHHHCCHH
ALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVFIVSLEMIMILLIVEDGISIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKS
HHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCC
REVINCQHEGCPLQAAIVIPLTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQL
CCCEECCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALCRTDVEKARKLLLQLSVYFRC
HCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
NLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHCCCHHHHHHHHHH
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTAL
HHHHCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
YNINERLIGLFGKETMLHIESEVNEGTEITFVIPKKVGEEEQIVKSISS
EECCHHHHHHHCCHHHEEEHHHCCCCCEEEEEECCCCCCHHHHHHHHCH
>Mature Secondary Structure
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
EIAGNTIMNENWLQGVSSSSTIANTRIMGVGISGLLGGPIVGIGVGSIAGIHRYMLGGTT
EEECCCCCCCHHHCCCCCCCCHHHCEEEEECHHHHCCCCEEEECHHHHHHHHHHHHCCHH
ALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVFIVSLEMIMILLIVEDGISIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKS
HHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCC
REVINCQHEGCPLQAAIVIPLTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQL
CCCEECCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALCRTDVEKARKLLLQLSVYFRC
HCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
NLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHCCCHHHHHHHHHH
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTAL
HHHHCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
YNINERLIGLFGKETMLHIESEVNEGTEITFVIPKKVGEEEQIVKSISS
EECCHHHHHHHCCHHHEEEHHHCCCCCEEEEEECCCCCCHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629