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The map label for this gene is pyrG

Identifier: 49188173

GI number: 49188173

Start: 5066963

End: 5068570

Strand: Reverse

Name: pyrG

Synonym: BAS5187

Alternate gene names: 49188173

Gene position: 5068570-5066963 (Counterclockwise)

Preceding gene: 49188174

Following gene: 49188171

Centisome position: 96.94

GC content: 40.17

Gene sequence:

>1608_bases
ATGACTAAGTATATTTTTGTAACAGGCGGTGTAGTATCGTCTTTAGGAAAAGGTATTACAGCAGCATCTCTTGGAAGACT
TTTAAAAAATCGTGGTTTAAACGTAACGATTCAAAAGTTTGATCCATACATTAACGTAGACCCAGGGACTATGAGCCCAT
ACCAACACGGTGAGGTGTTCGTAACAGATGATGGCGCAGAAACTGACTTAGACCTTGGTCACTATGAGCGTTTCATCGAC
ATTAACTTAAACAAATACAGCAACGTAACAACAGGTAAAATTTACTCTTCAGTTCTTCAAAAAGAGCGTCGCGGTGAATA
CCTAGGAGGAACAGTTCAAGTTATTCCTCACATTACTAACGAAATTAAAGAGCGCGTATACCGTTCTGGTCGCGAAACAA
ACGCGGATGTTGTTATTACAGAAATTGGTGGAACTGTTGGTGACATCGAGTCTCTACCATTCTTAGAAGCAATCCGTCAA
ATTAAGAGCGACATCGGTCGTGACAATGTAATGTACATTCACTGTACGTTAATCCCGTACTTAAAAGCAGCGGGTGAAAT
GAAAACAAAACCAACGCAACATAGCGTTAAAGAGCTTCGCAGCTTAGGTATTCAACCAAATATTATCGTTGTTCGTACAG
AAATGCCTGTTTCTCAAGATATGAAAGACAAGCTTGCATTATTCTGTGACATTGATACAAAAGCAGTTATTGAAGCACGC
GATGCAGATACTTTATATGCGGTTCCATTATCTCTTCAAGAGCAAAATATGGACCAAATCGTTTGCGATCACTTAAAATT
AGACAATCCAGCTGCAGATATGACAGAGTGGACTGCGCTAGTTGAAAAAGTGCGTAACCTTTCTAAGAAAACAAAAATCG
CTCTTGTTGGTAAATACGTAGAGCTTCAAGATGCATACATTTCTGTTGTAGAAGCACTTCGTCATGCAGGTTACTCTTTC
GACACAGATGTAGAAGTGAAATGGGTAAACGCTGAGCACGTAACAGCAGAGAACGTACAAGAATTAGTTGGTGACACAGA
CGGTATCCTTGTACCAGGTGGCTTCGGCGATCGTGGTGTAGAAGGTAAAATCGTTGCAATTCAATATGCTCGTGAAAACA
AAGTTCCATTCTTAGGAATTTGCTTAGGTATGCAACTTGCATCAATCGAATTCGCACGTAACGTATTAGGATTAGAAGGA
GCTAACTCTTCTGAAATTAATCCTGACACACCTTATGCAATCATTGACTTATTACCAGAACAAAAAGATGTAGAAGACTT
AGGTGGTACACTTCGTCTTGGTTTATACCCATGTAAGCTTTCTGAAGAAACAAATGCTTACAATGCTTACAATGAGCCGG
TTGTATATGAGCGTCATCGTCATCGTTATGAGTTCAACAATCAATTCCGTCCGGATATGGAAAAAGCAGGATTTGTATTC
TCTGGTACAAGCCCAGACGGCCGTCTAGTTGAAATCATTGAATTAAAAGATCACCCTTGGTTCGTGGCAGCACAGTTCCA
CCCAGAACTAGTTTCTCGTCCAAACCGTCCACAACCATTGTTCCATGACTTTGTAAAAGCTTCTCTTACGAATAAAGAGA
GCAAGTAA

Upstream 100 bases:

>100_bases
AATAAAAAGAGTCTAACAATAAGATGGATACAGTGTTATCTACATACGTTGCGCTTTGCAACGGTGATTATATAACAGCA
AAATAGAAGGGAGCTTTTTC

Downstream 100 bases:

>100_bases
TAAAAAAAGCGCCTGAAATAGGGCGCTTTTTTTAATATTCATTTAACATTTCATCGATTGTAAATTTGATACCGTGATAT
GCAAATAAAGCTATCATTAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQ
IKSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSF
DTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEG
ANSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVKASLTNKESK

Sequences:

>Translated_535_residues
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQ
IKSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSF
DTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEG
ANSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVKASLTNKESK
>Mature_534_residues
TKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDI
NLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQI
KSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEARD
ADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYVELQDAYISVVEALRHAGYSFD
TDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGA
NSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVFS
GTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVKASLTNKESK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=550, Percent_Identity=45.6363636363636, Blast_Score=494, Evalue=1e-139,
Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=45.7350272232305, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=45.7350272232305, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=45.7350272232305, Blast_Score=492, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=56.0521415270019, Blast_Score=601, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI25148299, Length=601, Percent_Identity=40.5990016638935, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=45.2762923351159, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=43.9285714285714, Blast_Score=476, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=47.005444646098, Blast_Score=499, Evalue=1e-141,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=44.9596774193548, Blast_Score=423, Evalue=1e-118,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_BACAA (C3P2A0)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002869553.1
- ProteinModelPortal:   C3P2A0
- SMR:   C3P2A0
- EnsemblBacteria:   EBBACT00000127947
- GeneID:   7851061
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_5608
- GeneTree:   EBGT00050000002533
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59754; Mature: 59622

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 507-507 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
EIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHCTLIPY
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
LKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEC
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYV
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEHH
ELQDAYISVVEALRHAGYSFDTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGANSSEINPDTPYAIIDLLPE
CCEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
QKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
CCCHHHCCCEEEEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCCCCCCCCCCHHHCCEEE
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVKASLTNKESK
ECCCCCCCEEEEEEECCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHHH
EIKERVYRSGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHCTLIPY
HHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHH
LKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDTKAVIEAR
HHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEC
DADTLYAVPLSLQEQNMDQIVCDHLKLDNPAADMTEWTALVEKVRNLSKKTKIALVGKYV
CCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEHH
ELQDAYISVVEALRHAGYSFDTDVEVKWVNAEHVTAENVQELVGDTDGILVPGGFGDRGV
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEECCCCCCCCC
EGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGANSSEINPDTPYAIIDLLPE
CCEEEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCC
QKDVEDLGGTLRLGLYPCKLSEETNAYNAYNEPVVYERHRHRYEFNNQFRPDMEKAGFVF
CCCHHHCCCEEEEEEEEEECCCCCCCCCCCCCCEEEHHHHCCCCCCCCCCCCHHHCCEEE
SGTSPDGRLVEIIELKDHPWFVAAQFHPELVSRPNRPQPLFHDFVKASLTNKESK
ECCCCCCCEEEEEEECCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA