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The map label for this gene is ywlC [H]

Identifier: 49188160

GI number: 49188160

Start: 5054284

End: 5055324

Strand: Reverse

Name: ywlC [H]

Synonym: BAS5174

Alternate gene names: 49188160

Gene position: 5055324-5054284 (Counterclockwise)

Preceding gene: 49188161

Following gene: 49188159

Centisome position: 96.68

GC content: 40.83

Gene sequence:

>1041_bases
ATGCATACAAATATGTGGGTTGTGGATAATGTTGTGGAAAGAAAAAAATATTATCCACAGTTACAAGAAGCAGCAAAATT
ATTAAGGGAAAATGAGGCGATTGCCTTCCCGACAGAAACGGTATATGGACTAGGTGCAAACGCGATGAATGATGAAGCGA
TTGCCAAAATTTTTGAAGCAAAAGGAAGACCGAGTGATAATCCACTTATTGTCCACATCGGGACAAAATCGCAGTTAGAT
GGGATTGTGAAGGAAATTCCACCAGTTGCAGAGAAGTTAATGGAGCATTTTTGGCCAGGGCCGTTAACAATTATTTTACC
TAGAAAAGAAGGAATTTCAGAGAAGGTGACGGCAGGACTTCATACAGTTGGAGTGAGGATGCCTGATCATCCAGTAGCGC
TTGCTCTTATTGAAGAGGCAAATGTACCTGTTGCAGCACCGAGTGCGAATCGTTCTGGTCGTCCAAGTCCGACGTTAGCA
TCTCATGTATATGAAGATTTAAATGAGAAGATCGCAGGTATTGTAGATGGTGGTGCAACAGGAGTAGGTGTGGAATCAAC
TGTAATTGATTGTACAAGTGCCGTTCCAACGATTTTACGCCCAGGTGGGATTACGAAAGAACAATTGGAAGCAGTGATTG
GTACGGTTTCGTTAGATCCAGCTTTAAAGGATGAGAAAGAAAAACCGAAATCACCTGGAATGAAATATACACATTATGCA
CCGAAAGCTCCGCTCAGTATCGTTGAAGGATCACGTGAGTTTATTCAGCGCCTTGTGGATGAGAAGAAGGAAGAAGGATT
CAAAGTAGGTGTATTAACGACAGAAGAGTATCACCATATATATAATGCGGATGTTGTATTATCATGTGGTGTTCGAAGTG
ATTTAGCTAGCGTTGCGACTAAATTATATGATGTACTTAGAACGTTTGATGCAAGTGAAGTGGATGTTATTTTTAGTGAA
TCGTTCCCGAATGAAGGAATAGGAAACGCGATTATGAATCGCTTAACAAAAGCGGCAGGACATCATATTATTACTGAATG
A

Upstream 100 bases:

>100_bases
ATCCACATTTTGTGGATAAACCTTGTTTGTCTTTTGGATAAATCTCATAGTAAACTAAAAATAGACAAGTATTTCAGGGT
AGAAAAGGACGTGGGAAAAA

Downstream 100 bases:

>100_bases
TAAGGTACGATTAGCAAACAGAATATTTCTCCTCGGATAAGCATATTGTGAAGTAGCACGTCCGAGGAGGGACATGAATG
ACGTTTGAACAGCTAATACC

Product: sua5/yciO/yrdC/ywlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MHTNMWVVDNVVERKKYYPQLQEAAKLLRENEAIAFPTETVYGLGANAMNDEAIAKIFEAKGRPSDNPLIVHIGTKSQLD
GIVKEIPPVAEKLMEHFWPGPLTIILPRKEGISEKVTAGLHTVGVRMPDHPVALALIEEANVPVAAPSANRSGRPSPTLA
SHVYEDLNEKIAGIVDGGATGVGVESTVIDCTSAVPTILRPGGITKEQLEAVIGTVSLDPALKDEKEKPKSPGMKYTHYA
PKAPLSIVEGSREFIQRLVDEKKEEGFKVGVLTTEEYHHIYNADVVLSCGVRSDLASVATKLYDVLRTFDASEVDVIFSE
SFPNEGIGNAIMNRLTKAAGHHIITE

Sequences:

>Translated_346_residues
MHTNMWVVDNVVERKKYYPQLQEAAKLLRENEAIAFPTETVYGLGANAMNDEAIAKIFEAKGRPSDNPLIVHIGTKSQLD
GIVKEIPPVAEKLMEHFWPGPLTIILPRKEGISEKVTAGLHTVGVRMPDHPVALALIEEANVPVAAPSANRSGRPSPTLA
SHVYEDLNEKIAGIVDGGATGVGVESTVIDCTSAVPTILRPGGITKEQLEAVIGTVSLDPALKDEKEKPKSPGMKYTHYA
PKAPLSIVEGSREFIQRLVDEKKEEGFKVGVLTTEEYHHIYNADVVLSCGVRSDLASVATKLYDVLRTFDASEVDVIFSE
SFPNEGIGNAIMNRLTKAAGHHIITE
>Mature_346_residues
MHTNMWVVDNVVERKKYYPQLQEAAKLLRENEAIAFPTETVYGLGANAMNDEAIAKIFEAKGRPSDNPLIVHIGTKSQLD
GIVKEIPPVAEKLMEHFWPGPLTIILPRKEGISEKVTAGLHTVGVRMPDHPVALALIEEANVPVAAPSANRSGRPSPTLA
SHVYEDLNEKIAGIVDGGATGVGVESTVIDCTSAVPTILRPGGITKEQLEAVIGTVSLDPALKDEKEKPKSPGMKYTHYA
PKAPLSIVEGSREFIQRLVDEKKEEGFKVGVLTTEEYHHIYNADVVLSCGVRSDLASVATKLYDVLRTFDASEVDVIFSE
SFPNEGIGNAIMNRLTKAAGHHIITE

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=199, Percent_Identity=31.6582914572864, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI2367210, Length=134, Percent_Identity=32.089552238806, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081864, Length=184, Percent_Identity=25.5434782608696, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537239, Length=182, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321269, Length=373, Percent_Identity=39.4101876675603, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI78707274, Length=180, Percent_Identity=32.2222222222222, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 37557; Mature: 37557

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTNMWVVDNVVERKKYYPQLQEAAKLLRENEAIAFPTETVYGLGANAMNDEAIAKIFEA
CCCCEEHHHHHHHHHHHCHHHHHHHHHHHCCCCEECCCHHHHCCCCCCCCHHHHHHHHHH
KGRPSDNPLIVHIGTKSQLDGIVKEIPPVAEKLMEHFWPGPLTIILPRKEGISEKVTAGL
CCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
HTVGVRMPDHPVALALIEEANVPVAAPSANRSGRPSPTLASHVYEDLNEKIAGIVDGGAT
HHEECCCCCCCEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
GVGVESTVIDCTSAVPTILRPGGITKEQLEAVIGTVSLDPALKDEKEKPKSPGMKYTHYA
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCEECCC
PKAPLSIVEGSREFIQRLVDEKKEEGFKVGVLTTEEYHHIYNADVVLSCGVRSDLASVAT
CCCCHHHHCCCHHHHHHHHHHHHHCCEEEEEEECHHHHHHCCCCEEEECCCHHHHHHHHH
KLYDVLRTFDASEVDVIFSESFPNEGIGNAIMNRLTKAAGHHIITE
HHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHTNMWVVDNVVERKKYYPQLQEAAKLLRENEAIAFPTETVYGLGANAMNDEAIAKIFEA
CCCCEEHHHHHHHHHHHCHHHHHHHHHHHCCCCEECCCHHHHCCCCCCCCHHHHHHHHHH
KGRPSDNPLIVHIGTKSQLDGIVKEIPPVAEKLMEHFWPGPLTIILPRKEGISEKVTAGL
CCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
HTVGVRMPDHPVALALIEEANVPVAAPSANRSGRPSPTLASHVYEDLNEKIAGIVDGGAT
HHEECCCCCCCEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
GVGVESTVIDCTSAVPTILRPGGITKEQLEAVIGTVSLDPALKDEKEKPKSPGMKYTHYA
CCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCEECCC
PKAPLSIVEGSREFIQRLVDEKKEEGFKVGVLTTEEYHHIYNADVVLSCGVRSDLASVAT
CCCCHHHHCCCHHHHHHHHHHHHHCCEEEEEEECHHHHHHCCCCEEEECCCHHHHHHHHH
KLYDVLRTFDASEVDVIFSESFPNEGIGNAIMNRLTKAAGHHIITE
HHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]