| Definition | Bacillus anthracis str. Sterne chromosome, complete genome. |
|---|---|
| Accession | NC_005945 |
| Length | 5,228,663 |
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The map label for this gene is menD [H]
Identifier: 49187741
GI number: 49187741
Start: 4632809
End: 4634563
Strand: Reverse
Name: menD [H]
Synonym: BAS4750
Alternate gene names: 49187741
Gene position: 4634563-4632809 (Counterclockwise)
Preceding gene: 49187742
Following gene: 49187740
Centisome position: 88.64
GC content: 40.63
Gene sequence:
>1755_bases ATGAACAACCATATAGAAGCATTATCATATTATTTAGGCGCGTTCGTGGATGAACTGACGCTTCTAAATGTATGTGATGT TGTCATTAGTCCAGGCTCACGGTCAACGCCGATTGCTCTACTAATGGAACAACATGAAGGAATGAACACATATTTACATG TAGATGAAAGATCTGCAGGATTTTTTGCGCTCGGTATCGCAAAAGCGAAAAAACGTCCGGTTGCATTATTATGTACGTCA GGAACGGCAGCAGCGAACTATTACCCAGCTGTATGTGAAGCTTTTCATTCACGAGTGCCACTTATCGTCTTAACGGCAGA TAGACCGCATGAATTAAGAGATGTCGGTGCACCACAAGCGATGAATCAAATTAATTTATACGGTACGTTTGTGAAGCAAT TTACAGAGATGGCACTTCCAGAAGCGAGTGAAGCGATGTATCATTACGCTCGCTTGACAACGCAGCGCATGATAGCAAGT GCTTGTTTAGCGCCGCAAGGACCTGTTCATCTTAATTTTCCAGTTCGTGAACCGCTTATCCCGGACTTCTCATTAGAAAG TTTATGGGATAAAGGACGCGGAGAATATACAGGAGTAGTTCAGCAAGGGAACGCGGTGATGCCGAGTGAATATGTAGATT CTCTTGTAGGGCGCCTTTCACATATGGAAAAGGGGCTTATTATTTGTGGAGATGATAGTCATTCAGAAATCGCAGCGTTT GCAACGCAACTAGCTGAAAAAACGGGATATCCAATATTAGCGGATCCACTTTCTAACATTCGTAGCGGACACCACGATAA AACGATGGTAATCGACTGTTACGATACATTTTTACGAAATGAGCTGTTAAAGGAAACGTGGAAGCCGGACGTTTTAATTC GCTTCGGTGGTATGCCTGTTTCAAAAGCATTAACGCAGTTCATTAAAAAACAAACGAAAGCTGTTCATATCGTAGTTGAC GAATCAGGACAATGGAGAGATCCAGCTCTCGTTGCAACAGAAGTTGTTCAAGCAAGTGATATTGCATTTTGCAGTGCACT AATAGAAAAAATGCCAGTTATGAAAAAGAATGATTGGTTCCGAATGTGGCAACATATAAACGAAAAAACGAAGGAAACGC TTCGTGAAATGGAAACATATGATACGGCGTTTGAAGGAAGGGTCATTACGGATATTGTCCGCGTATTACCAGAAGGGGCA ACTTTATTTGCGAGTAATAGTATGCCAATTCGTGATACAGATTCATTCTTTTTCACATCGGATAAAAATATTCAAGTGAT GGCTAACCGTGGTGTAAATGGGATTGATGGAATCATTTCGACAGCTTTAGGAGCGAGCATGATTTGCGATCCGCTCGTAT TAGTAATCGGTGATTTATCATTTTATCACGATTTAAATGGATTATTAGCCGCAAAATTACATGAATTAAATATAACAATT GTCGTTGTAAATAATGACGGTGGTGGTATTTTCTCATTCTTACCGCAATATGAGAAAAAGGAACATTTCGAATCGTTATT TGGAACACCGATTGGGCTTGATTATGAGCATGTTGTTACAATGTATGGCGGTTCATTTAGCCGTGTAAATGGTTGGGAGC AATTCCGTGAAGAAGTACAAAAGGGAGTAACGACAGAAGGTTTACACGTTGTGGAAATTTGTACGAACCGTGATGAAAAC TTAACATTGCACCGTACGTTATGGGCAAAAACACAGGACGTAATTACTACATCGTTGCAAGGTGAATCAAAATGA
Upstream 100 bases:
>100_bases CCGGTTGCGGAATTGTAATTGATTCAGTACCACAACTTGAATATGAAGAAACAAGTTTGAAGTTTAGACCGATGCTTGGT GCTTTGGAGGAATTAATGAA
Downstream 100 bases:
>100_bases ACGTAACGCTGCAAGGTGTATCGTATGAATATGAAGTAGTCGGAAGCGGAGAGCCACTTCTACTTCTTCATGGTTTTACG GGAAGCATGGAAACGTGGCG
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 584; Mature: 584
Protein sequence:
>584_residues MNNHIEALSYYLGAFVDELTLLNVCDVVISPGSRSTPIALLMEQHEGMNTYLHVDERSAGFFALGIAKAKKRPVALLCTS GTAAANYYPAVCEAFHSRVPLIVLTADRPHELRDVGAPQAMNQINLYGTFVKQFTEMALPEASEAMYHYARLTTQRMIAS ACLAPQGPVHLNFPVREPLIPDFSLESLWDKGRGEYTGVVQQGNAVMPSEYVDSLVGRLSHMEKGLIICGDDSHSEIAAF ATQLAEKTGYPILADPLSNIRSGHHDKTMVIDCYDTFLRNELLKETWKPDVLIRFGGMPVSKALTQFIKKQTKAVHIVVD ESGQWRDPALVATEVVQASDIAFCSALIEKMPVMKKNDWFRMWQHINEKTKETLREMETYDTAFEGRVITDIVRVLPEGA TLFASNSMPIRDTDSFFFTSDKNIQVMANRGVNGIDGIISTALGASMICDPLVLVIGDLSFYHDLNGLLAAKLHELNITI VVVNNDGGGIFSFLPQYEKKEHFESLFGTPIGLDYEHVVTMYGGSFSRVNGWEQFREEVQKGVTTEGLHVVEICTNRDEN LTLHRTLWAKTQDVITTSLQGESK
Sequences:
>Translated_584_residues MNNHIEALSYYLGAFVDELTLLNVCDVVISPGSRSTPIALLMEQHEGMNTYLHVDERSAGFFALGIAKAKKRPVALLCTS GTAAANYYPAVCEAFHSRVPLIVLTADRPHELRDVGAPQAMNQINLYGTFVKQFTEMALPEASEAMYHYARLTTQRMIAS ACLAPQGPVHLNFPVREPLIPDFSLESLWDKGRGEYTGVVQQGNAVMPSEYVDSLVGRLSHMEKGLIICGDDSHSEIAAF ATQLAEKTGYPILADPLSNIRSGHHDKTMVIDCYDTFLRNELLKETWKPDVLIRFGGMPVSKALTQFIKKQTKAVHIVVD ESGQWRDPALVATEVVQASDIAFCSALIEKMPVMKKNDWFRMWQHINEKTKETLREMETYDTAFEGRVITDIVRVLPEGA TLFASNSMPIRDTDSFFFTSDKNIQVMANRGVNGIDGIISTALGASMICDPLVLVIGDLSFYHDLNGLLAAKLHELNITI VVVNNDGGGIFSFLPQYEKKEHFESLFGTPIGLDYEHVVTMYGGSFSRVNGWEQFREEVQKGVTTEGLHVVEICTNRDEN LTLHRTLWAKTQDVITTSLQGESK >Mature_584_residues MNNHIEALSYYLGAFVDELTLLNVCDVVISPGSRSTPIALLMEQHEGMNTYLHVDERSAGFFALGIAKAKKRPVALLCTS GTAAANYYPAVCEAFHSRVPLIVLTADRPHELRDVGAPQAMNQINLYGTFVKQFTEMALPEASEAMYHYARLTTQRMIAS ACLAPQGPVHLNFPVREPLIPDFSLESLWDKGRGEYTGVVQQGNAVMPSEYVDSLVGRLSHMEKGLIICGDDSHSEIAAF ATQLAEKTGYPILADPLSNIRSGHHDKTMVIDCYDTFLRNELLKETWKPDVLIRFGGMPVSKALTQFIKKQTKAVHIVVD ESGQWRDPALVATEVVQASDIAFCSALIEKMPVMKKNDWFRMWQHINEKTKETLREMETYDTAFEGRVITDIVRVLPEGA TLFASNSMPIRDTDSFFFTSDKNIQVMANRGVNGIDGIISTALGASMICDPLVLVIGDLSFYHDLNGLLAAKLHELNITI VVVNNDGGGIFSFLPQYEKKEHFESLFGTPIGLDYEHVVTMYGGSFSRVNGWEQFREEVQKGVTTEGLHVVEICTNRDEN LTLHRTLWAKTQDVITTSLQGESK
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=553, Percent_Identity=28.5714285714286, Blast_Score=205, Evalue=7e-54,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 64979; Mature: 64979
Theoretical pI: Translated: 5.35; Mature: 5.35
Prosite motif: PS00041 HTH_ARAC_FAMILY_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 4.8 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 4.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNNHIEALSYYLGAFVDELTLLNVCDVVISPGSRSTPIALLMEQHEGMNTYLHVDERSAG CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEECCCCC FFALGIAKAKKRPVALLCTSGTAAANYYPAVCEAFHSRVPLIVLTADRPHELRDVGAPQA EEEEEEHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHCCCCHH MNQINLYGTFVKQFTEMALPEASEAMYHYARLTTQRMIASACLAPQGPVHLNFPVREPLI HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC PDFSLESLWDKGRGEYTGVVQQGNAVMPSEYVDSLVGRLSHMEKGLIICGDDSHSEIAAF CCCCHHHHHHCCCCCEEEEEECCCEECCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHH ATQLAEKTGYPILADPLSNIRSGHHDKTMVIDCYDTFLRNELLKETWKPDVLIRFGGMPV HHHHHHHCCCCEEECCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCH SKALTQFIKKQTKAVHIVVDESGQWRDPALVATEVVQASDIAFCSALIEKMPVMKKNDWF HHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH RMWQHINEKTKETLREMETYDTAFEGRVITDIVRVLPEGATLFASNSMPIRDTDSFFFTS HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEC DKNIQVMANRGVNGIDGIISTALGASMICDPLVLVIGDLSFYHDLNGLLAAKLHELNITI CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE VVVNNDGGGIFSFLPQYEKKEHFESLFGTPIGLDYEHVVTMYGGSFSRVNGWEQFREEVQ EEEECCCCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHEEECCCCHHCCCHHHHHHHHH KGVTTEGLHVVEICTNRDENLTLHRTLWAKTQDVITTSLQGESK HCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHEECCCCCCC >Mature Secondary Structure MNNHIEALSYYLGAFVDELTLLNVCDVVISPGSRSTPIALLMEQHEGMNTYLHVDERSAG CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEECCCCC FFALGIAKAKKRPVALLCTSGTAAANYYPAVCEAFHSRVPLIVLTADRPHELRDVGAPQA EEEEEEHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHCCCCHH MNQINLYGTFVKQFTEMALPEASEAMYHYARLTTQRMIASACLAPQGPVHLNFPVREPLI HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCC PDFSLESLWDKGRGEYTGVVQQGNAVMPSEYVDSLVGRLSHMEKGLIICGDDSHSEIAAF CCCCHHHHHHCCCCCEEEEEECCCEECCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHH ATQLAEKTGYPILADPLSNIRSGHHDKTMVIDCYDTFLRNELLKETWKPDVLIRFGGMPV HHHHHHHCCCCEEECCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCH SKALTQFIKKQTKAVHIVVDESGQWRDPALVATEVVQASDIAFCSALIEKMPVMKKNDWF HHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH RMWQHINEKTKETLREMETYDTAFEGRVITDIVRVLPEGATLFASNSMPIRDTDSFFFTS HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEC DKNIQVMANRGVNGIDGIISTALGASMICDPLVLVIGDLSFYHDLNGLLAAKLHELNITI CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEE VVVNNDGGGIFSFLPQYEKKEHFESLFGTPIGLDYEHVVTMYGGSFSRVNGWEQFREEVQ EEEECCCCCHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHEEECCCCHHCCCHHHHHHHHH KGVTTEGLHVVEICTNRDENLTLHRTLWAKTQDVITTSLQGESK HCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA