Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 49187703

GI number: 49187703

Start: 4596517

End: 4597068

Strand: Direct

Name: hpt [H]

Synonym: BAS4712

Alternate gene names: 49187703

Gene position: 4596517-4597068 (Clockwise)

Preceding gene: 49187696

Following gene: 49187704

Centisome position: 87.91

GC content: 34.24

Gene sequence:

>552_bases
ATGAATATTGAAATAAAAGACACTTTAATTTCTGAAGAACAATTACAAGAAAAAGTAAAAGAACTAGCACTTCAAATCGA
ACGTGATTTTGAAGGAGAAGAAATCGTAGTCATCGCTGTACTAAAAGGATCTTTCGTATTTGCTGCTGATTTAATTCGTC
ACATTAAAAACGATGTAACAATCGACTTTATTTCTGCATCTAGCTACGGAAATCAAACAGAAACAACTGGAAAAGTGAAA
CTATTAAAAGATATCGATGTAAACATTACTGGAAAAAACGTAATTGTCGTAGAAGACATTATCGATTCTGGTTTAACACT
TCACTTCTTAAAAGATCACTTCTTTATGCATAAACCAAAGGCACTCAAATTCTGTACGTTACTTGATAAACCTGAGCGCC
GCAAAGTGGATTTAACAGCTGAATATGTTGGCTTCCAAATTCCAGACGAATTTATCGTTGGCTACGGCATCGACTGCGCA
GAAAAATATCGTAACTTACCATTTATCGCTTCAGTTGTAACGGAAGAATCGTATAACTTAAAAAGTCGATAG

Upstream 100 bases:

>100_bases
TTGTTCGTATTTTGTAAAAAATTACTATCTCCTTTGACTTTTTCCTTTCTATCCTTTACAGTCGAAATGTTCACAAGTTT
TACACTGTAGGAGGACTCCA

Downstream 100 bases:

>100_bases
TACATAAAATTTATATCGGCGATTTTCAAAATATATCGACCGTATCTTAAATTATATCGGCGATTTTTCAAATATATCGA
CCGTAACTCAAATTATATCG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVTIDFISASSYGNQTETTGKVK
LLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPKALKFCTLLDKPERRKVDLTAEYVGFQIPDEFIVGYGIDCA
EKYRNLPFIASVVTEESYNLKSR

Sequences:

>Translated_183_residues
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVTIDFISASSYGNQTETTGKVK
LLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPKALKFCTLLDKPERRKVDLTAEYVGFQIPDEFIVGYGIDCA
EKYRNLPFIASVVTEESYNLKSR
>Mature_183_residues
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVTIDFISASSYGNQTETTGKVK
LLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPKALKFCTLLDKPERRKVDLTAEYVGFQIPDEFIVGYGIDCA
EKYRNLPFIASVVTEESYNLKSR

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=182, Percent_Identity=35.7142857142857, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI9910262, Length=175, Percent_Identity=33.1428571428571, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=47.3372781065089, Blast_Score=176, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=35.3932584269663, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20828; Mature: 20828

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVT
CCEEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCE
IDFISASSYGNQTETTGKVKLLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPK
EEEEECCCCCCCCCCCCEEEEEEECCEEECCCEEEEEEHHHCCCCEEEEEHHHHHHCCCC
ALKFCTLLDKPERRKVDLTAEYVGFQIPDEFIVGYGIDCAEKYRNLPFIASVVTEESYNL
HHEEEHHCCCCCCCEEEEEHHHCCEECCHHHEEECCCCHHHHHCCCCEEEEEHHCCCCCC
KSR
CCC
>Mature Secondary Structure
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVT
CCEEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCE
IDFISASSYGNQTETTGKVKLLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPK
EEEEECCCCCCCCCCCCEEEEEEECCEEECCCEEEEEEHHHCCCCEEEEEHHHHHHCCCC
ALKFCTLLDKPERRKVDLTAEYVGFQIPDEFIVGYGIDCAEKYRNLPFIASVVTEESYNL
HHEEEHHCCCCCCCEEEEEHHHCCEECCHHHEEECCCCHHHHHCCCCEEEEEHHCCCCCC
KSR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]