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The map label for this gene is ykvY [H]

Identifier: 49187503

GI number: 49187503

Start: 4423147

End: 4424244

Strand: Direct

Name: ykvY [H]

Synonym: BAS4508

Alternate gene names: 49187503

Gene position: 4423147-4424244 (Clockwise)

Preceding gene: 49187501

Following gene: 49187506

Centisome position: 84.59

GC content: 39.07

Gene sequence:

>1098_bases
ATGAATGCTAGATTAGAAAATTTAATGCAATGGCTAAAAGAAAAAAACGTAGAAGCTGCGTTCTTAACTTCTACACCAAA
CGTCTTCTACATGACAAACTTCCACTGTGAACCACACGAAAGACTTCTTGGTATGTTTGTATTCCAAGAAAAAGAGCCTA
TTTTAATTTGCCCTAAAATGGAAGAAGGCCAAGCACGTAACGCCGGCTGGGCACATGAAATTATCGGATTTACTGATACT
GACAGACCATGGGATATGATTGCAAAAGCAATTAAAGACCGCGGCATCAATGCAAACGCAGTTGCAATTGAAAAAGAACT
TTTAAACGTAGAGCGCTACGAAGAATTAACAAAACTATTCCCAAATGCAGCTTTCACATCAGCTGAGGAAAAAGTTCGTG
AACTTCGTTTAATTAAAGATGAAAAAGAACTTTCTATTTTACGCGAAGCAGCTAAAATGGCAGACTATGCTGTTGAAGTT
GGTGTAAATGCAATTAAAGAAGATCGTAGCGAACTAGAAGTATTAGCAATTATTGAACATGAATTAAAAACAAAAGGCAT
ACATAAAATGTCATTTGATACGATGGTATTAGCTGGTGCAAACTCTGCTCTTCCACACGGTATTCCAGGTGCAAACAAAA
TGAAACGCGGCGATTTCGTACTATTTGATTTAGGCGTAATCATTGACGGTTATTGCTCTGACATTACACGTACAGTGGCA
TTTGGCGAGATTTCTGAAGAACAAACTCGCATTTACAACACTGTACTTGCTGGACAACTACAAGCAGTTGAAGCATGTAA
ACCAGGTGTTACACTTGGCGCAATCGACAACGCTGCTCGTTCTGTTATCGCAGATGCAGGTTATGGTGACTTCTTCCCGC
ACCGCCTTGGTCACGGACTTGGAATTAGCGTGCACGAATATCCAGATGTAAAAGCTGGTAACGAATCTCCATTAAAAGAA
GGTATGGTCTTCACAATTGAGCCAGGTATTTACGTACCAAACGTAGGTGGCGTTCGTATTGAAGATGATATTTATATCAC
AAAAGACGGGTCAGAAATTTTAACGAAGTTCCCGAAAGAATTACAATTTGTAAAATAA

Upstream 100 bases:

>100_bases
TTTCAATTCCCTGTCTTTTCTAACATCTATTTACTTGTCATAACGCTTTCTTCCGAGTTAAAGTTATATTTGTAATTAAA
TATCTCGGGGGTGCCAATCG

Downstream 100 bases:

>100_bases
TAAAAAAGGCAGCTTAATTGCTGCCTTTTTATTTCTCTGCTATTTCAAATTTCTCTACTATCATTTTCACTGGATAACTC
TCAAACGTTTGAGAAGACCA

Product: proline dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNARLENLMQWLKEKNVEAAFLTSTPNVFYMTNFHCEPHERLLGMFVFQEKEPILICPKMEEGQARNAGWAHEIIGFTDT
DRPWDMIAKAIKDRGINANAVAIEKELLNVERYEELTKLFPNAAFTSAEEKVRELRLIKDEKELSILREAAKMADYAVEV
GVNAIKEDRSELEVLAIIEHELKTKGIHKMSFDTMVLAGANSALPHGIPGANKMKRGDFVLFDLGVIIDGYCSDITRTVA
FGEISEEQTRIYNTVLAGQLQAVEACKPGVTLGAIDNAARSVIADAGYGDFFPHRLGHGLGISVHEYPDVKAGNESPLKE
GMVFTIEPGIYVPNVGGVRIEDDIYITKDGSEILTKFPKELQFVK

Sequences:

>Translated_365_residues
MNARLENLMQWLKEKNVEAAFLTSTPNVFYMTNFHCEPHERLLGMFVFQEKEPILICPKMEEGQARNAGWAHEIIGFTDT
DRPWDMIAKAIKDRGINANAVAIEKELLNVERYEELTKLFPNAAFTSAEEKVRELRLIKDEKELSILREAAKMADYAVEV
GVNAIKEDRSELEVLAIIEHELKTKGIHKMSFDTMVLAGANSALPHGIPGANKMKRGDFVLFDLGVIIDGYCSDITRTVA
FGEISEEQTRIYNTVLAGQLQAVEACKPGVTLGAIDNAARSVIADAGYGDFFPHRLGHGLGISVHEYPDVKAGNESPLKE
GMVFTIEPGIYVPNVGGVRIEDDIYITKDGSEILTKFPKELQFVK
>Mature_365_residues
MNARLENLMQWLKEKNVEAAFLTSTPNVFYMTNFHCEPHERLLGMFVFQEKEPILICPKMEEGQARNAGWAHEIIGFTDT
DRPWDMIAKAIKDRGINANAVAIEKELLNVERYEELTKLFPNAAFTSAEEKVRELRLIKDEKELSILREAAKMADYAVEV
GVNAIKEDRSELEVLAIIEHELKTKGIHKMSFDTMVLAGANSALPHGIPGANKMKRGDFVLFDLGVIIDGYCSDITRTVA
FGEISEEQTRIYNTVLAGQLQAVEACKPGVTLGAIDNAARSVIADAGYGDFFPHRLGHGLGISVHEYPDVKAGNESPLKE
GMVFTIEPGIYVPNVGGVRIEDDIYITKDGSEILTKFPKELQFVK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=262, Percent_Identity=31.6793893129771, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI149589008, Length=332, Percent_Identity=27.1084337349398, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI260593665, Length=332, Percent_Identity=27.1084337349398, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=26.6129032258064, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI260593663, Length=252, Percent_Identity=28.1746031746032, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI93141226, Length=248, Percent_Identity=30.6451612903226, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI264681563, Length=166, Percent_Identity=34.3373493975904, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI164420681, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI264681565, Length=163, Percent_Identity=31.2883435582822, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788728, Length=368, Percent_Identity=35.5978260869565, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1789275, Length=263, Percent_Identity=31.5589353612167, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786364, Length=232, Percent_Identity=28.0172413793103, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=301, Percent_Identity=27.2425249169435, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17509539, Length=364, Percent_Identity=25.2747252747253, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=258, Percent_Identity=29.0697674418605, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321118, Length=281, Percent_Identity=28.8256227758007, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323273, Length=230, Percent_Identity=24.7826086956522, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19920384, Length=282, Percent_Identity=29.7872340425532, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21357079, Length=295, Percent_Identity=29.4915254237288, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21355531, Length=263, Percent_Identity=25.4752851711027, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583427, Length=235, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 40660; Mature: 40660

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARLENLMQWLKEKNVEAAFLTSTPNVFYMTNFHCEPHERLLGMFVFQEKEPILICPKM
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHEEECCCCEEEECCC
EEGQARNAGWAHEIIGFTDTDRPWDMIAKAIKDRGINANAVAIEKELLNVERYEELTKLF
CCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHC
PNAAFTSAEEKVRELRLIKDEKELSILREAAKMADYAVEVGVNAIKEDRSELEVLAIIEH
CCCHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELKTKGIHKMSFDTMVLAGANSALPHGIPGANKMKRGDFVLFDLGVIIDGYCSDITRTVA
HHHHCCCEEECCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
FGEISEEQTRIYNTVLAGQLQAVEACKPGVTLGAIDNAARSVIADAGYGDFFPHRLGHGL
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCCCCCCHHHHCCCC
GISVHEYPDVKAGNESPLKEGMVFTIEPGIYVPNVGGVRIEDDIYITKDGSEILTKFPKE
CCEEECCCCCCCCCCCHHHCCCEEEECCCEEECCCCCEEEECCEEEECCCHHHHHHCHHH
LQFVK
HCCCC
>Mature Secondary Structure
MNARLENLMQWLKEKNVEAAFLTSTPNVFYMTNFHCEPHERLLGMFVFQEKEPILICPKM
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCHHHHHHHHHEEECCCCEEEECCC
EEGQARNAGWAHEIIGFTDTDRPWDMIAKAIKDRGINANAVAIEKELLNVERYEELTKLF
CCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHC
PNAAFTSAEEKVRELRLIKDEKELSILREAAKMADYAVEVGVNAIKEDRSELEVLAIIEH
CCCHHCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELKTKGIHKMSFDTMVLAGANSALPHGIPGANKMKRGDFVLFDLGVIIDGYCSDITRTVA
HHHHCCCEEECCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
FGEISEEQTRIYNTVLAGQLQAVEACKPGVTLGAIDNAARSVIADAGYGDFFPHRLGHGL
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCCCCCCCHHHHCCCC
GISVHEYPDVKAGNESPLKEGMVFTIEPGIYVPNVGGVRIEDDIYITKDGSEILTKFPKE
CCEEECCCCCCCCCCCHHHCCCEEEECCCEEECCCCCEEEECCEEEECCCHHHHHHCHHH
LQFVK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]