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The map label for this gene is aqpZ [H]

Identifier: 49187397

GI number: 49187397

Start: 4313089

End: 4313754

Strand: Direct

Name: aqpZ [H]

Synonym: BAS4402

Alternate gene names: 49187397

Gene position: 4313089-4313754 (Clockwise)

Preceding gene: 49187396

Following gene: 49187401

Centisome position: 82.49

GC content: 36.79

Gene sequence:

>666_bases
ATGTTAAAAAAAGCAATCGCTGAATTTATTGGTACATTTGTACTGGTATTATTCGGAACTGGAGTAGCTGTCATTGGCGG
CGGAATTGAAGGAATTGGGACATTAGGAATCGCTATGGCTTTCGGTCTATCTATTGTGGCTATGGCATATAGCATCGGAA
CAATTTCTGGATGTCACATTAACCCAGCAGTATCAGTAGCTATGTTCATCAATAAAAGAATGAACGCTATGGAACTTTGT
TATTATGTATTAGCTCAAATTTTAGGTGGTTTATTAGGAGCTGCAACATTGGTAACAATTTTACAATCCGCTAAAACACC
TTTAGATAATTTAGGACAAAATGGTTTTGGAACTCTTGGTTTATCTGGAGCATTTCTAGTTGAATTTATTTTAACTTTCG
TATTCATTTTAGTAATCGTCGCTGTAACAGGTAAAAAAGGCAGTTCTTCTCTAGCAGGATTAGTAATTGGTTTCACATTA
GTTTTAGTCCACTTATTAGGTATTCCGTTAACTGGGACTTCTGTTAACCCAGCTCGTAGTATCGCACCAGCTTTATTCGT
TGGCGGAGAAGCACTTTCTCAACTATGGGTATTCATCGTTGCACCAATTCTTGGCGGTATCGTAGCAGCTATCGTAGGCA
AATTTATTTTAAATACTGAAAAATAA

Upstream 100 bases:

>100_bases
TTGTCCCCCTATTTCGCCTTATCAGAATAGTATTTCATTGGCTGTTTATACTAAAACCTATGTTATAATACGTTTCATGC
GCAATAATAGGAGGTAAATT

Downstream 100 bases:

>100_bases
AATTTTCAATATTTCTGAATAAAAAAAGGCGAGCCCTCATTATGAGGATGCTCGCTTTTTTACTCTTTCATTTTAGACTT
TAAATTTGTAACTAATTGAT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHINPAVSVAMFINKRMNAMELC
YYVLAQILGGLLGAATLVTILQSAKTPLDNLGQNGFGTLGLSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTL
VLVHLLGIPLTGTSVNPARSIAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK

Sequences:

>Translated_221_residues
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHINPAVSVAMFINKRMNAMELC
YYVLAQILGGLLGAATLVTILQSAKTPLDNLGQNGFGTLGLSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTL
VLVHLLGIPLTGTSVNPARSIAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK
>Mature_221_residues
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHINPAVSVAMFINKRMNAMELC
YYVLAQILGGLLGAATLVTILQSAKTPLDNLGQNGFGTLGLSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTL
VLVHLLGIPLTGTSVNPARSIAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=38.2882882882883, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=35.7466063348416, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=37.219730941704, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI4755125, Length=217, Percent_Identity=36.405529953917, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI4502181, Length=218, Percent_Identity=36.2385321100917, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI37694062, Length=224, Percent_Identity=32.5892857142857, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI86792455, Length=219, Percent_Identity=34.2465753424658, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI157266307, Length=240, Percent_Identity=32.5, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI4826645, Length=247, Percent_Identity=33.6032388663968, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4502187, Length=244, Percent_Identity=31.1475409836066, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI45446752, Length=189, Percent_Identity=32.8042328042328, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI22538420, Length=235, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=44.4976076555024, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1790362, Length=246, Percent_Identity=27.6422764227642, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71993722, Length=230, Percent_Identity=30.8695652173913, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17531429, Length=239, Percent_Identity=31.3807531380753, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17531431, Length=239, Percent_Identity=31.3807531380753, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=232, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212646268, Length=273, Percent_Identity=24.5421245421245, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=239, Percent_Identity=27.6150627615063, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71992961, Length=225, Percent_Identity=27.1111111111111, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71992966, Length=237, Percent_Identity=25.7383966244726, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321054, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652747, Length=222, Percent_Identity=33.7837837837838, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45551084, Length=222, Percent_Identity=33.7837837837838, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24652751, Length=223, Percent_Identity=33.6322869955157, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922038, Length=223, Percent_Identity=33.6322869955157, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24762344, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24762346, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24762348, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20130305, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136672, Length=186, Percent_Identity=30.1075268817204, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550503, Length=227, Percent_Identity=28.1938325991189, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24762342, Length=195, Percent_Identity=26.1538461538462, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922828, Length=223, Percent_Identity=27.3542600896861, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22583; Mature: 22583

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHI
CCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NPAVSVAMFINKRMNAMELCYYVLAQILGGLLGAATLVTILQSAKTPLDNLGQNGFGTLG
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
LSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTLVLVHLLGIPLTGTSVNPARS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHI
CCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NPAVSVAMFINKRMNAMELCYYVLAQILGGLLGAATLVTILQSAKTPLDNLGQNGFGTLG
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
LSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTLVLVHLLGIPLTGTSVNPARS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]