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The map label for this gene is lon2 [H]

Identifier: 49187363

GI number: 49187363

Start: 4279839

End: 4281512

Strand: Reverse

Name: lon2 [H]

Synonym: BAS4368

Alternate gene names: 49187363

Gene position: 4281512-4279839 (Counterclockwise)

Preceding gene: 49187364

Following gene: 49187362

Centisome position: 81.89

GC content: 39.61

Gene sequence:

>1674_bases
ATGATGAGCTGGACAAATATATTTTTACTTGTTCAACTTGTTTTTGGTGTAATTGTCGGATTGTATTTTTGGCATTTACT
TCGAAATCAGCGAACACAAAAAGTTTCAATTGATCGAGAATCGAAAAAAGAATTAGAGCAGCTTCGTAAAATGCGTGAGA
TTTCTTTAACAGAGCCGCTTGCGGAAAAGGTGCGTCCTACATCCTTTTTAGATATTGTAGGGCAAGAGGACGGGATTAAG
TCGTTAAAAGCGGCTCTTTGTGGCCCGAACCCGCAACATGTAATTATATATGGCCCACCAGGTGTCGGAAAGACAGCGGC
AGCACGTCTTGTATTAGAAGAAGCGAAACGAAATCCAAAATCTCCATTTCGCACAAATGCAACATTTATTGAACTGGATG
CGACGACAGCTCGGTTTGATGAACGTGGTATTGCAGACCCTTTAATCGGTTCGGTGCATGATCCAATTTATCAAGGTGCT
GGTGCGATGGGGCAAGCGGGTATTCCGCAACCAAAAAAAGGTGCGGTAACAGATGCACACGGTGGTATTTTGTTTATTGA
TGAGATTGGTGAGCTACATCCGATTCAAATGAACAAAATGTTAAAGGTGCTAGAAGATCGAAAAGTGTTTTTGGAAAGTG
CATACTACAGTGAAGAGAATACGATGATTCCAACGTATATACATGATATCTTTCAAAAAGGTTTACCAGCCGATTTTCGC
TTAGTTGGGGCAACGACACGTTCGCCAGAGGAGATTCCTCCTGCTATTCGGTCGCGCTGTTTAGAAGTCTTCTTCCGTGA
GTTAGATACAGAAGAAATTCAAAAAGTGGCGAAGAATGCAGCTGACAAAGTAGAAATGCAAATCGGTGAAAATGGTATTG
AAATGATTGGCATGTATGCAAGAAATGGAAGAGAAGCGATTAATCTTGTACAAATTTCTGCTGGAATGGCAATAAATGAA
GAACGTTCTTTCATTAAAGATGAAGATATTGAGTGGGTTGTTCACTCTAGTCAGCTTACACCGAAGTATGAAAAACACAT
TTATCCTATTCCAAGAATCGGTCTTGTAAATGGACTTGCTGTATACGGACCAAATACAGGCGCGTTATTAGAAATTGAAG
TAACAGCAATTAAGGCGAAAGATAAAGGATCGGTAAATGTTACCGGAATTGTTGAAGAGGAAAGTATTGGTAGTCAAACG
AAATCAATTCGCCGTAAAAGTATGGCGAAAGGTTCTGTAGATAATGTATTAACAGTACTTCGATCTCTAGATGTGTTGCC
AGAAGGATACGATATACATATTAATTTTCCAGGTGGTATCCCGATTGATGGGCCTTCAGCAGGAATTGCAATGGCAACAG
GTGTGTATTCAGCAGTGCATCATACGTATGTGAATAATGAAGTGGCGATGACTGGTGAGATAAGTATACATGGAGAAGTG
AAACCTATCGGTGGTGTGTACGCAAAAATAAAAGCTGCGAAAAAGGCGGGAGCTAAGAAAGTTATTATTCCTGCTGAAAA
CATGCAACCGTTTTTGTACACAATAAAAGGAATTGAAATTATCCCTGTTCGTAAGTTAAAAGAAGTATTTGAGCTAACAT
TTATGCAAGAAAATATGCATCGAGAGCTTGATATACATACTACAATAGACGAAACAGATGCACAATCAATGTGA

Upstream 100 bases:

>100_bases
GAAGGAGAAACAGCAATTTTTATAATTGCTGTTTTTCTTTATGTTTAGCTATGTTCCTCCGCGGAAATACTAAGAGATAA
AACATTGCGGGAGGAAATAA

Downstream 100 bases:

>100_bases
GAATGAATGATAATAGTATTTGCCAGACTTCGTTTAAGTTTGTATGCTTAAGCGGAGTCTTTTTTCTTTTCGTAAGAGAG
AAAAAAAGCGGGATTTACAG

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MMSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRKMREISLTEPLAEKVRPTSFLDIVGQEDGIK
SLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKRNPKSPFRTNATFIELDATTARFDERGIADPLIGSVHDPIYQGA
GAMGQAGIPQPKKGAVTDAHGGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTMIPTYIHDIFQKGLPADFR
LVGATTRSPEEIPPAIRSRCLEVFFRELDTEEIQKVAKNAADKVEMQIGENGIEMIGMYARNGREAINLVQISAGMAINE
ERSFIKDEDIEWVVHSSQLTPKYEKHIYPIPRIGLVNGLAVYGPNTGALLEIEVTAIKAKDKGSVNVTGIVEEESIGSQT
KSIRRKSMAKGSVDNVLTVLRSLDVLPEGYDIHINFPGGIPIDGPSAGIAMATGVYSAVHHTYVNNEVAMTGEISIHGEV
KPIGGVYAKIKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELTFMQENMHRELDIHTTIDETDAQSM

Sequences:

>Translated_557_residues
MMSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRKMREISLTEPLAEKVRPTSFLDIVGQEDGIK
SLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKRNPKSPFRTNATFIELDATTARFDERGIADPLIGSVHDPIYQGA
GAMGQAGIPQPKKGAVTDAHGGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTMIPTYIHDIFQKGLPADFR
LVGATTRSPEEIPPAIRSRCLEVFFRELDTEEIQKVAKNAADKVEMQIGENGIEMIGMYARNGREAINLVQISAGMAINE
ERSFIKDEDIEWVVHSSQLTPKYEKHIYPIPRIGLVNGLAVYGPNTGALLEIEVTAIKAKDKGSVNVTGIVEEESIGSQT
KSIRRKSMAKGSVDNVLTVLRSLDVLPEGYDIHINFPGGIPIDGPSAGIAMATGVYSAVHHTYVNNEVAMTGEISIHGEV
KPIGGVYAKIKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELTFMQENMHRELDIHTTIDETDAQSM
>Mature_557_residues
MMSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRKMREISLTEPLAEKVRPTSFLDIVGQEDGIK
SLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKRNPKSPFRTNATFIELDATTARFDERGIADPLIGSVHDPIYQGA
GAMGQAGIPQPKKGAVTDAHGGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTMIPTYIHDIFQKGLPADFR
LVGATTRSPEEIPPAIRSRCLEVFFRELDTEEIQKVAKNAADKVEMQIGENGIEMIGMYARNGREAINLVQISAGMAINE
ERSFIKDEDIEWVVHSSQLTPKYEKHIYPIPRIGLVNGLAVYGPNTGALLEIEVTAIKAKDKGSVNVTGIVEEESIGSQT
KSIRRKSMAKGSVDNVLTVLRSLDVLPEGYDIHINFPGGIPIDGPSAGIAMATGVYSAVHHTYVNNEVAMTGEISIHGEV
KPIGGVYAKIKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELTFMQENMHRELDIHTTIDETDAQSM

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=209, Percent_Identity=30.622009569378, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI31377667, Length=171, Percent_Identity=35.0877192982456, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1786643, Length=198, Percent_Identity=37.3737373737374, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17505831, Length=471, Percent_Identity=25.2653927813163, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17556486, Length=86, Percent_Identity=40.6976744186046, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319449, Length=85, Percent_Identity=43.5294117647059, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221513036, Length=540, Percent_Identity=24.0740740740741, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24666867, Length=540, Percent_Identity=24.0740740740741, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 61604; Mature: 61604

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRKMREISLTEPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHH
AEKVRPTSFLDIVGQEDGIKSLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKRNPK
HHHCCCCHHHEECCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
SPFRTNATFIELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKKGAVTDAH
CCCCCCCEEEEECCHHHHHCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEECC
GGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTMIPTYIHDIFQKGLPADFR
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEE
LVGATTRSPEEIPPAIRSRCLEVFFRELDTEEIQKVAKNAADKVEMQIGENGIEMIGMYA
EEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCHHEEEEHH
RNGREAINLVQISAGMAINEERSFIKDEDIEWVVHSSQLTPKYEKHIYPIPRIGLVNGLA
CCCCCCEEEEEEECCCEECCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCCCHHHCCEE
VYGPNTGALLEIEVTAIKAKDKGSVNVTGIVEEESIGSQTKSIRRKSMAKGSVDNVLTVL
EECCCCCCEEEEEEEEEEECCCCCEEEEEEEECHHCCHHHHHHHHHHHHCCCHHHHHHHH
RSLDVLPEGYDIHINFPGGIPIDGPSAGIAMATGVYSAVHHTYVNNEVAMTGEISIHGEV
HHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCC
KPIGGVYAKIKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELTFMQENMH
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHC
RELDIHTTIDETDAQSM
CEEEEEECCCCCCCCCC
>Mature Secondary Structure
MMSWTNIFLLVQLVFGVIVGLYFWHLLRNQRTQKVSIDRESKKELEQLRKMREISLTEPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCHHH
AEKVRPTSFLDIVGQEDGIKSLKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKRNPK
HHHCCCCHHHEECCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCC
SPFRTNATFIELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKKGAVTDAH
CCCCCCCEEEEECCHHHHHCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCEECC
GGILFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTMIPTYIHDIFQKGLPADFR
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEE
LVGATTRSPEEIPPAIRSRCLEVFFRELDTEEIQKVAKNAADKVEMQIGENGIEMIGMYA
EEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCHHEEEEHH
RNGREAINLVQISAGMAINEERSFIKDEDIEWVVHSSQLTPKYEKHIYPIPRIGLVNGLA
CCCCCCEEEEEEECCCEECCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCCCHHHCCEE
VYGPNTGALLEIEVTAIKAKDKGSVNVTGIVEEESIGSQTKSIRRKSMAKGSVDNVLTVL
EECCCCCCEEEEEEEEEEECCCCCEEEEEEEECHHCCHHHHHHHHHHHHCCCHHHHHHHH
RSLDVLPEGYDIHINFPGGIPIDGPSAGIAMATGVYSAVHHTYVNNEVAMTGEISIHGEV
HHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCC
KPIGGVYAKIKAAKKAGAKKVIIPAENMQPFLYTIKGIEIIPVRKLKEVFELTFMQENMH
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHC
RELDIHTTIDETDAQSM
CEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]