Click here to switch to the map view.

The map label for this gene is phhA [H]

Identifier: 49187249

GI number: 49187249

Start: 4167276

End: 4169030

Strand: Direct

Name: phhA [H]

Synonym: BAS4253

Alternate gene names: 49187249

Gene position: 4167276-4169030 (Clockwise)

Preceding gene: 49187248

Following gene: 49187250

Centisome position: 79.7

GC content: 37.83

Gene sequence:

>1755_bases
ATGACAAAGAAAACAGAAATTCCATCGCATTTAAAACCATTCGTATCCACACAGCATTATGATCAATACACACCGGTGAA
CCACGCTGTATGGCGTTACATTATGAGACAAAATCATAGTTTCTTAAAAGACGTTGCCCATCCAGCCTATGTGAATGGAC
TACAATCATCTGGTATTAATATAGAGGCAATCCCAAAGGTAGAAGAAATGAATGAATGTTTGGCGTCAAGCGGCTGGGGC
GCTGTAACGATTGACGGACTTATTCCTGGCGTCGCATTTTTCGATTTTCAAGGGCACGGATTGCTACCAATCGCAACAGA
TATTCGCAAAGTAGAAAACATCGAGTATACACCTGCTCCAGATATTGTACACGAAGCAGCAGGACACGCACCTATTTTAC
TTGATCCTACATATGCAAAATATGTAAAACGATTTGGGCAAATTGGTGCAAAAGCTTTTTCTACAAAAGAAGAACATGAT
GCATTCGAGGCTGTTCGTACATTAACGATTGTAAAAGAAAGCCCTACTTCTACTCCTGATGAAGTTACAGCTGCTGAAAA
TAATGTAATTGAAAAACAAAACTTAGTTTCTGGCTTATCAGAAGCGGAACAAATTTCACGTCTTTTCTGGTGGACAGTGG
AATACGGATTGATTGGAGATATAGACAATCCAAAAATATATGGTGCTGGTCTCCTTTCTTCTGTTGGCGAAAGCAAACAT
TGCTTAACAGACGCTGTAGAAAAGGTTCCATTCTCTATAGAGGCATGTACAAGTACAACTTATGACGTAACAAAAATGCA
ACCACAACTATTTGTTTGTAAATCATTTGAAGAATTAACAGAAGCACTTGAGAAATTTGCTGAAACGATGGCCTTTAAAA
CAGGTGGTAAAGAAGGCTTAGAAAAAGCAATTCGCTCTGAAAACCATGCAACTGCTGAATTAAATAGCGGATTACAAATT
ACAGGTACATTCACCGAGACAATTGAAAACGATGCGGGTGAATTGATTTATATGCGAACAAGTTCGCCAACAGCATTAGC
CATTCACAATAAAGAGCTAGCGAATCATTCTACGGCTGTACACAGTGACGGCTTTGGAACACCGATTGGATTACTCACTG
AAAATATTGCATTAGAAAATTGTACAGATGAACAACTACAAGCATTAGGAATTACAATTGGAAATATTGCTGAGTTTACT
TTTGAAAGTGATATTCATGTAAAAGGAACAGTAACAGATATTGTAAAAAACGATAATAAAATCGCTCTTATTTCCTTTAT
CAATTGTACAGTTACTTATAACGACCGCGTTTTATTTGATGCTTCATGGGGCGCATTTGATATGGCTGTTGGTTCAACAA
TCACTTCCGTATTCCCAGGTGCCGCAGATGCTGCAGCATTTTTCCCAATGGATGAAGAAATTCAAGAAATTCCTGCTCCA
CTTGTACTGAATGAACTTGAACGTATGTATCAAACAGTTCGTGATATCCGAAATGAAGGTATTTTACACGACGCACATAT
CGAGCAATTAGTAGCAATTCAAGAGGTATTAAATAAATTCTATACGAAAGAATGGTTGCTTCGCCTTGAAATATTAGAAT
TGCTTTTAGAACATAACAAAGGGCACGAAACATCAGCAGCATTATTACAACAACTTTCTACTTTCACAACTGATGAAGCT
GTAACACGCCTTATTAACAATGGTCTTACGCTACTTCCAGTAAAGGGTGTGAAAAATGATGCTACGATTAACTGA

Upstream 100 bases:

>100_bases
CTTATGATAAAATTTTATAAGCGCTTACAATTTTGAAGGGTGGTGGTACAAGCTATACGAAACCGATATTTAATTTTACA
GAAAAAAGGAGGATGTCTAA

Downstream 100 bases:

>100_bases
AGAAGAAGTTCAAGAGGAATTATTAAAGTTAGATAAATGGGTAGTAAAAGATGAAAAATGGATTGAAAGAAAATATATGT
TTTCCGACTACTTAAAAGGA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MTKKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVNGLQSSGINIEAIPKVEEMNECLASSGWG
AVTIDGLIPGVAFFDFQGHGLLPIATDIRKVENIEYTPAPDIVHEAAGHAPILLDPTYAKYVKRFGQIGAKAFSTKEEHD
AFEAVRTLTIVKESPTSTPDEVTAAENNVIEKQNLVSGLSEAEQISRLFWWTVEYGLIGDIDNPKIYGAGLLSSVGESKH
CLTDAVEKVPFSIEACTSTTYDVTKMQPQLFVCKSFEELTEALEKFAETMAFKTGGKEGLEKAIRSENHATAELNSGLQI
TGTFTETIENDAGELIYMRTSSPTALAIHNKELANHSTAVHSDGFGTPIGLLTENIALENCTDEQLQALGITIGNIAEFT
FESDIHVKGTVTDIVKNDNKIALISFINCTVTYNDRVLFDASWGAFDMAVGSTITSVFPGAADAAAFFPMDEEIQEIPAP
LVLNELERMYQTVRDIRNEGILHDAHIEQLVAIQEVLNKFYTKEWLLRLEILELLLEHNKGHETSAALLQQLSTFTTDEA
VTRLINNGLTLLPVKGVKNDATIN

Sequences:

>Translated_584_residues
MTKKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVNGLQSSGINIEAIPKVEEMNECLASSGWG
AVTIDGLIPGVAFFDFQGHGLLPIATDIRKVENIEYTPAPDIVHEAAGHAPILLDPTYAKYVKRFGQIGAKAFSTKEEHD
AFEAVRTLTIVKESPTSTPDEVTAAENNVIEKQNLVSGLSEAEQISRLFWWTVEYGLIGDIDNPKIYGAGLLSSVGESKH
CLTDAVEKVPFSIEACTSTTYDVTKMQPQLFVCKSFEELTEALEKFAETMAFKTGGKEGLEKAIRSENHATAELNSGLQI
TGTFTETIENDAGELIYMRTSSPTALAIHNKELANHSTAVHSDGFGTPIGLLTENIALENCTDEQLQALGITIGNIAEFT
FESDIHVKGTVTDIVKNDNKIALISFINCTVTYNDRVLFDASWGAFDMAVGSTITSVFPGAADAAAFFPMDEEIQEIPAP
LVLNELERMYQTVRDIRNEGILHDAHIEQLVAIQEVLNKFYTKEWLLRLEILELLLEHNKGHETSAALLQQLSTFTTDEA
VTRLINNGLTLLPVKGVKNDATIN
>Mature_583_residues
TKKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVNGLQSSGINIEAIPKVEEMNECLASSGWGA
VTIDGLIPGVAFFDFQGHGLLPIATDIRKVENIEYTPAPDIVHEAAGHAPILLDPTYAKYVKRFGQIGAKAFSTKEEHDA
FEAVRTLTIVKESPTSTPDEVTAAENNVIEKQNLVSGLSEAEQISRLFWWTVEYGLIGDIDNPKIYGAGLLSSVGESKHC
LTDAVEKVPFSIEACTSTTYDVTKMQPQLFVCKSFEELTEALEKFAETMAFKTGGKEGLEKAIRSENHATAELNSGLQIT
GTFTETIENDAGELIYMRTSSPTALAIHNKELANHSTAVHSDGFGTPIGLLTENIALENCTDEQLQALGITIGNIAEFTF
ESDIHVKGTVTDIVKNDNKIALISFINCTVTYNDRVLFDASWGAFDMAVGSTITSVFPGAADAAAFFPMDEEIQEIPAPL
VLNELERMYQTVRDIRNEGILHDAHIEQLVAIQEVLNKFYTKEWLLRLEILELLLEHNKGHETSAALLQQLSTFTTDEAV
TRLINNGLTLLPVKGVKNDATIN

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=236, Percent_Identity=27.5423728813559, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI88900503, Length=235, Percent_Identity=26.8085106382979, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI88900501, Length=235, Percent_Identity=26.8085106382979, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI88900505, Length=235, Percent_Identity=26.8085106382979, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531391, Length=239, Percent_Identity=26.7782426778243, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI62472054, Length=243, Percent_Identity=27.9835390946502, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24660393, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136774, Length=278, Percent_Identity=25.1798561151079, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136776, Length=288, Percent_Identity=25, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 64362; Mature: 64231

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVNGLQSSGIN
CCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCHHHHCCHHHCCCC
IEAIPKVEEMNECLASSGWGAVTIDGLIPGVAFFDFQGHGLLPIATDIRKVENIEYTPAP
EEECCCHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCC
DIVHEAAGHAPILLDPTYAKYVKRFGQIGAKAFSTKEEHDAFEAVRTLTIVKESPTSTPD
HHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCC
EVTAAENNVIEKQNLVSGLSEAEQISRLFWWTVEYGLIGDIDNPKIYGAGLLSSVGESKH
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCEEECCCCCEEECCHHHHHCCCCHH
CLTDAVEKVPFSIEACTSTTYDVTKMQPQLFVCKSFEELTEALEKFAETMAFKTGGKEGL
HHHHHHHHCCCEEEECCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
EKAIRSENHATAELNSGLQITGTFTETIENDAGELIYMRTSSPTALAIHNKELANHSTAV
HHHHHCCCCCEEECCCCEEEEEEHHHHHHCCCCCEEEEECCCCCEEEEECHHHHCCCCEE
HSDGFGTPIGLLTENIALENCTDEQLQALGITIGNIAEFTFESDIHVKGTVTDIVKNDNK
CCCCCCCCHHHHHHCHHHCCCCHHHHHHHCCCHHHHHHEEECCCCEEEEEHHHHHCCCCC
IALISFINCTVTYNDRVLFDASWGAFDMAVGSTITSVFPGAADAAAFFPMDEEIQEIPAP
EEEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHEECCCCHHHHHCCCH
LVLNELERMYQTVRDIRNEGILHDAHIEQLVAIQEVLNKFYTKEWLLRLEILELLLEHNK
HHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GHETSAALLQQLSTFTTDEAVTRLINNGLTLLPVKGVKNDATIN
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TKKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVNGLQSSGIN
CCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCHHHHCCHHHCCCC
IEAIPKVEEMNECLASSGWGAVTIDGLIPGVAFFDFQGHGLLPIATDIRKVENIEYTPAP
EEECCCHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCC
DIVHEAAGHAPILLDPTYAKYVKRFGQIGAKAFSTKEEHDAFEAVRTLTIVKESPTSTPD
HHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCC
EVTAAENNVIEKQNLVSGLSEAEQISRLFWWTVEYGLIGDIDNPKIYGAGLLSSVGESKH
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCEEECCCCCEEECCHHHHHCCCCHH
CLTDAVEKVPFSIEACTSTTYDVTKMQPQLFVCKSFEELTEALEKFAETMAFKTGGKEGL
HHHHHHHHCCCEEEECCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
EKAIRSENHATAELNSGLQITGTFTETIENDAGELIYMRTSSPTALAIHNKELANHSTAV
HHHHHCCCCCEEECCCCEEEEEEHHHHHHCCCCCEEEEECCCCCEEEEECHHHHCCCCEE
HSDGFGTPIGLLTENIALENCTDEQLQALGITIGNIAEFTFESDIHVKGTVTDIVKNDNK
CCCCCCCCHHHHHHCHHHCCCCHHHHHHHCCCHHHHHHEEECCCCEEEEEHHHHHCCCCC
IALISFINCTVTYNDRVLFDASWGAFDMAVGSTITSVFPGAADAAAFFPMDEEIQEIPAP
EEEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHEECCCCHHHHHCCCH
LVLNELERMYQTVRDIRNEGILHDAHIEQLVAIQEVLNKFYTKEWLLRLEILELLLEHNK
HHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GHETSAALLQQLSTFTTDEAVTRLINNGLTLLPVKGVKNDATIN
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]