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The map label for this gene is nhaC [H]

Identifier: 49187028

GI number: 49187028

Start: 3965693

End: 3967066

Strand: Direct

Name: nhaC [H]

Synonym: BAS4030

Alternate gene names: 49187028

Gene position: 3965693-3967066 (Clockwise)

Preceding gene: 49187019

Following gene: 49187030

Centisome position: 75.85

GC content: 36.46

Gene sequence:

>1374_bases
ATGGTTTCAAAAATTGAATCTGTTCTTTTAACAATTTTTATCTTTTTCTGTATTGGCTTTAGTGTTATCAAATTAGAAGT
TTCACCACACATCCCGATTTTATTTGGTATCGTTCTTTTATTAGCATTTGGATTTATGAAAAAAATTGATTGGTCTACTA
TGGAAAAAGGAATGATAAGTAGTATTTCAGCTGGTATTCCGTCTATTTTTATTTTCTTACTTGTAGGCGTATTAATTAGT
GTTTGGATCGCCGCTGGAACAATTCCAACTTTAATGGTATACGGCTTCCAGCTTGTATCTCCTAAAATTTTCATTCCAAC
TGTTTTTGTTGTTTGTGCAATTGTTGGAACAAGTATCGGTAGTGCCTTTACAACTGCTGCTACTGTAGGACTTGCCTTTA
TGGGTATGGGTAGTGCTCTCGGATACGATCCAGCTCTAATCGCTGGTGCAATTATTTCTGGTGCATTCTTTGGAGATAAA
ATGTCTCCTTTATCTGATACAACAAACTTAGCGCCAGCTGTAACAGGTGTAGATTTATTTGAGCACATTCGCAACATGCT
TTGGACAACAGTTCCAGCTTTCATTATTGCTTTTATCGCATTTTTCATTTTAGGAAGCGGTACTAGTGGAGATGTTGACT
TCACAAACTTCATTAGCACATTAGAGAAAAATGCAACGATTTCTATCTTTACACTTATTCCAATTTTATTACTGTTCCTA
TTCGCATTTAAGAAGGTACCCGCAGTTCCAACATTACTTGCTGGAATTATAGTAGGGATCATTATCCTCTTTATATTTAA
ACCTAGTACTTCTTTAACTGATTTAATGAAAATTATGCAAGACGGTTACGTTTCTAAAACTGGTATAAAAGATATTGATA
GCTTATTATCTCGCGGTGGCCTGCAAAGTATGATGATGTCAATCGCTCTTATTTTCCTAGCTCTTTGTATGGGAGGATTA
TTACAAGGAATGGGTATTATCACGCAGCTAATGAATATCATCTCTAGCTTCGTAAAAACTAGCACACGCTTAATCATCTC
TACTGCCTCAACTGCAATCGGTGTAAACTTCTTACTTGGTGAGCAGTACTTATCTATCGTCTTAACAGGACAAGCATTTG
CTAATAAATACGATGAAGTCGGTTTAGAACGTCGTAATTTATCACGTGTATTAGAAGACGCAGGTACAGTTATTAACCCC
CTCGTACCGTGGGGAGTAAGTGGTGTATTCTTATCGAACGTCCTTGGTGTTCCGACATTTGATTACGTTCCATTCGCAAT
CTTCTGCTTAGCTTGTCCAATCGTAACAATTATTGTTGGTTTCACTGGATTTGGCCTTTCATGGAAGAAAGAAAAGGCAG
TAACAATTTCATAA

Upstream 100 bases:

>100_bases
GTAATTTGTCACAAAATTCTAAAATTTAGAAGGAAATAAACAATATTGGCGAATTTTATATAAAAAAGAGCTATTTTAGA
TTACTTAGGAGGGGAAAACA

Downstream 100 bases:

>100_bases
TATACGAAAAAGGATTACCGATTAAGGTAATCCTTTTTATATTTCTCGATTATCTATTTGCTTTCTTTCTTCTAAATAAC
AGAAGGAATCCAGCTCCGAT

Product: Na+/H+ antiporter NhaC

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MVSKIESVLLTIFIFFCIGFSVIKLEVSPHIPILFGIVLLLAFGFMKKIDWSTMEKGMISSISAGIPSIFIFLLVGVLIS
VWIAAGTIPTLMVYGFQLVSPKIFIPTVFVVCAIVGTSIGSAFTTAATVGLAFMGMGSALGYDPALIAGAIISGAFFGDK
MSPLSDTTNLAPAVTGVDLFEHIRNMLWTTVPAFIIAFIAFFILGSGTSGDVDFTNFISTLEKNATISIFTLIPILLLFL
FAFKKVPAVPTLLAGIIVGIIILFIFKPSTSLTDLMKIMQDGYVSKTGIKDIDSLLSRGGLQSMMMSIALIFLALCMGGL
LQGMGIITQLMNIISSFVKTSTRLIISTASTAIGVNFLLGEQYLSIVLTGQAFANKYDEVGLERRNLSRVLEDAGTVINP
LVPWGVSGVFLSNVLGVPTFDYVPFAIFCLACPIVTIIVGFTGFGLSWKKEKAVTIS

Sequences:

>Translated_457_residues
MVSKIESVLLTIFIFFCIGFSVIKLEVSPHIPILFGIVLLLAFGFMKKIDWSTMEKGMISSISAGIPSIFIFLLVGVLIS
VWIAAGTIPTLMVYGFQLVSPKIFIPTVFVVCAIVGTSIGSAFTTAATVGLAFMGMGSALGYDPALIAGAIISGAFFGDK
MSPLSDTTNLAPAVTGVDLFEHIRNMLWTTVPAFIIAFIAFFILGSGTSGDVDFTNFISTLEKNATISIFTLIPILLLFL
FAFKKVPAVPTLLAGIIVGIIILFIFKPSTSLTDLMKIMQDGYVSKTGIKDIDSLLSRGGLQSMMMSIALIFLALCMGGL
LQGMGIITQLMNIISSFVKTSTRLIISTASTAIGVNFLLGEQYLSIVLTGQAFANKYDEVGLERRNLSRVLEDAGTVINP
LVPWGVSGVFLSNVLGVPTFDYVPFAIFCLACPIVTIIVGFTGFGLSWKKEKAVTIS
>Mature_457_residues
MVSKIESVLLTIFIFFCIGFSVIKLEVSPHIPILFGIVLLLAFGFMKKIDWSTMEKGMISSISAGIPSIFIFLLVGVLIS
VWIAAGTIPTLMVYGFQLVSPKIFIPTVFVVCAIVGTSIGSAFTTAATVGLAFMGMGSALGYDPALIAGAIISGAFFGDK
MSPLSDTTNLAPAVTGVDLFEHIRNMLWTTVPAFIIAFIAFFILGSGTSGDVDFTNFISTLEKNATISIFTLIPILLLFL
FAFKKVPAVPTLLAGIIVGIIILFIFKPSTSLTDLMKIMQDGYVSKTGIKDIDSLLSRGGLQSMMMSIALIFLALCMGGL
LQGMGIITQLMNIISSFVKTSTRLIISTASTAIGVNFLLGEQYLSIVLTGQAFANKYDEVGLERRNLSRVLEDAGTVINP
LVPWGVSGVFLSNVLGVPTFDYVPFAIFCLACPIVTIIVGFTGFGLSWKKEKAVTIS

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 48863; Mature: 48863

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]