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The map label for this gene is mtnE [H]

Identifier: 49186943

GI number: 49186943

Start: 3892188

End: 3893366

Strand: Direct

Name: mtnE [H]

Synonym: BAS3945

Alternate gene names: 49186943

Gene position: 3892188-3893366 (Clockwise)

Preceding gene: 304570532

Following gene: 49186944

Centisome position: 74.44

GC content: 37.15

Gene sequence:

>1179_bases
ATGAAATTATTTCAACCTTCTGAGATAGTAACATCATTGCCAACACAATTTTTTGCTTCACTTGTTGCAAAAGTTAATAA
AGTCGTTGCAGCTGGTCACGATGTTATTAATCTAGGTCAAGGTAATCCAGATCAACCAACGCCGCAGCATATCGTAAAAG
CTTTACAAGATGCTGCAGAAAAGACCATTCATCATAAATATCCGCCATTTCGCGGACATGAAAGTTTAAAAGAAGCCGTG
GCAACATTCTATCAACGTGAATATGATGTAGTAGTAAATCCAAAAACTGAAGTTGCTATTTTGTTTGGTGGAAAGGCTGG
ATTAGTAGAATTACCAGTTTGTTTTACAAACCCTGGTGATACGATTCTCGTTCCCGATCCAGGCTATCCAGATTATTTAT
CAGGAGTTGCTTTAGCAAAAGCACAATTTGAAACAATGCCGCTTATTGCAGAAAATAATTTTTTACCAGATTATACAAAA
ATCGATGACTCTATTGCCGAGCGTGCAAAATTAATGTTTTTAAACTATCCAAATAATCCGACCGGTGCTACTGCATCAAA
AGATTTCTTTGATGAAACCATTCATTTTGCTAATAAACATAATATATTAGTCGTTCATGATTTTGCTTACGGTGCGATTG
GATTCGATGGTCAAAAACCTGTTAGTTTCTTACAAGCAGATGGTGCCAAAGATACAGGAATCGAAATTTACACCTTATCG
AAAACTTTCAATATGGCTGGCTGGCGCATCGCTTTTGCGGTAGGGAATGAAAGTGTGATTGAAACAATTAACTTATTACA
AGATCATATGTATGTTAGTATTTTTGGTGCCATTCAAGATGCTGCCCGCGAAGCACTATTAAGTTCACAGTCTTGCGTCA
TAGACCTTGTAAATAGTTACGAATCTCGAAGAAACGCTCTTATTTCAGCTTGTCACTCAATTGGTTGGAATGTAGACATT
CCAACAGGATCATTCTTTGCATGGCTTCCTGTTCCAGAAGGTTATACATCTGAGCAATTTTCTGATATTTTACTAGAAAA
AGCACACGTTGCGGTTGCTCCTGGTGTTGGATTTGGTGAACATGGCGAAGGGTACGTCCGTGTTGGTCTCTTGCATACAG
AAGATAGATTACGAGAAGCCATTAATCGAATTGATAAATTAAATTTTTTTAAAAAGTAA

Upstream 100 bases:

>100_bases
CATTTTTTCAGCCCCATTCTCATTTTTTCTTTACAAAATACTGGAAAGATTATATTATTTGTCACTAGAATTGTAACAAC
TTTCAAAAGAGGTGGAAAGT

Downstream 100 bases:

>100_bases
TTGACAACATGAAAAATATCTGACAAAATTCAGTTATCTTAAAAATTTAAACATTTCTAAATACTTCTTATCAAGAGCAG
GTGGAGGGACGAGCCCGACG

Product: transaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKLFQPSEIVTSLPTQFFASLVAKVNKVVAAGHDVINLGQGNPDQPTPQHIVKALQDAAEKTIHHKYPPFRGHESLKEAV
ATFYQREYDVVVNPKTEVAILFGGKAGLVELPVCFTNPGDTILVPDPGYPDYLSGVALAKAQFETMPLIAENNFLPDYTK
IDDSIAERAKLMFLNYPNNPTGATASKDFFDETIHFANKHNILVVHDFAYGAIGFDGQKPVSFLQADGAKDTGIEIYTLS
KTFNMAGWRIAFAVGNESVIETINLLQDHMYVSIFGAIQDAAREALLSSQSCVIDLVNSYESRRNALISACHSIGWNVDI
PTGSFFAWLPVPEGYTSEQFSDILLEKAHVAVAPGVGFGEHGEGYVRVGLLHTEDRLREAINRIDKLNFFKK

Sequences:

>Translated_392_residues
MKLFQPSEIVTSLPTQFFASLVAKVNKVVAAGHDVINLGQGNPDQPTPQHIVKALQDAAEKTIHHKYPPFRGHESLKEAV
ATFYQREYDVVVNPKTEVAILFGGKAGLVELPVCFTNPGDTILVPDPGYPDYLSGVALAKAQFETMPLIAENNFLPDYTK
IDDSIAERAKLMFLNYPNNPTGATASKDFFDETIHFANKHNILVVHDFAYGAIGFDGQKPVSFLQADGAKDTGIEIYTLS
KTFNMAGWRIAFAVGNESVIETINLLQDHMYVSIFGAIQDAAREALLSSQSCVIDLVNSYESRRNALISACHSIGWNVDI
PTGSFFAWLPVPEGYTSEQFSDILLEKAHVAVAPGVGFGEHGEGYVRVGLLHTEDRLREAINRIDKLNFFKK
>Mature_392_residues
MKLFQPSEIVTSLPTQFFASLVAKVNKVVAAGHDVINLGQGNPDQPTPQHIVKALQDAAEKTIHHKYPPFRGHESLKEAV
ATFYQREYDVVVNPKTEVAILFGGKAGLVELPVCFTNPGDTILVPDPGYPDYLSGVALAKAQFETMPLIAENNFLPDYTK
IDDSIAERAKLMFLNYPNNPTGATASKDFFDETIHFANKHNILVVHDFAYGAIGFDGQKPVSFLQADGAKDTGIEIYTLS
KTFNMAGWRIAFAVGNESVIETINLLQDHMYVSIFGAIQDAAREALLSSQSCVIDLVNSYESRRNALISACHSIGWNVDI
PTGSFFAWLPVPEGYTSEQFSDILLEKAHVAVAPGVGFGEHGEGYVRVGLLHTEDRLREAINRIDKLNFFKK

Specific function: Catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) (Probable) [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. MtnE subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=316, Percent_Identity=24.6835443037975, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI169881279, Length=316, Percent_Identity=24.6835443037975, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI56713256, Length=314, Percent_Identity=22.6114649681529, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI56713254, Length=314, Percent_Identity=22.6114649681529, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI169881281, Length=305, Percent_Identity=23.2786885245902, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4507369, Length=377, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788722, Length=359, Percent_Identity=37.883008356546, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI1786816, Length=392, Percent_Identity=23.2142857142857, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788627, Length=244, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=363, Percent_Identity=26.4462809917355, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994476, Length=363, Percent_Identity=26.4462809917355, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17567369, Length=267, Percent_Identity=23.5955056179775, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17567663, Length=391, Percent_Identity=22.7621483375959, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=235, Percent_Identity=23.4042553191489, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI28573069, Length=410, Percent_Identity=22.6829268292683, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24646114, Length=410, Percent_Identity=22.6829268292683, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28573067, Length=410, Percent_Identity=22.6829268292683, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28573065, Length=410, Percent_Identity=22.6829268292683, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18859735, Length=359, Percent_Identity=23.6768802228412, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 43150; Mature: 43150

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFQPSEIVTSLPTQFFASLVAKVNKVVAAGHDVINLGQGNPDQPTPQHIVKALQDAAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
KTIHHKYPPFRGHESLKEAVATFYQREYDVVVNPKTEVAILFGGKAGLVELPVCFTNPGD
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCEEEEEEEEECCCC
TILVPDPGYPDYLSGVALAKAQFETMPLIAENNFLPDYTKIDDSIAERAKLMFLNYPNNP
EEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCC
TGATASKDFFDETIHFANKHNILVVHDFAYGAIGFDGQKPVSFLQADGAKDTGIEIYTLS
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHCCCCCCCCEEEEEEE
KTFNMAGWRIAFAVGNESVIETINLLQDHMYVSIFGAIQDAAREALLSSQSCVIDLVNSY
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ESRRNALISACHSIGWNVDIPTGSFFAWLPVPEGYTSEQFSDILLEKAHVAVAPGVGFGE
HHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCC
HGEGYVRVGLLHTEDRLREAINRIDKLNFFKK
CCCCEEEEEEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLFQPSEIVTSLPTQFFASLVAKVNKVVAAGHDVINLGQGNPDQPTPQHIVKALQDAAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
KTIHHKYPPFRGHESLKEAVATFYQREYDVVVNPKTEVAILFGGKAGLVELPVCFTNPGD
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCEEEEEEEEECCCC
TILVPDPGYPDYLSGVALAKAQFETMPLIAENNFLPDYTKIDDSIAERAKLMFLNYPNNP
EEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCC
TGATASKDFFDETIHFANKHNILVVHDFAYGAIGFDGQKPVSFLQADGAKDTGIEIYTLS
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHCCCCCCCCEEEEEEE
KTFNMAGWRIAFAVGNESVIETINLLQDHMYVSIFGAIQDAAREALLSSQSCVIDLVNSY
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ESRRNALISACHSIGWNVDIPTGSFFAWLPVPEGYTSEQFSDILLEKAHVAVAPGVGFGE
HHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCCCCC
HGEGYVRVGLLHTEDRLREAINRIDKLNFFKK
CCCCEEEEEEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 12022921 [H]