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The map label for this gene is ppx [H]

Identifier: 49186902

GI number: 49186902

Start: 3851735

End: 3853273

Strand: Reverse

Name: ppx [H]

Synonym: BAS3904

Alternate gene names: 49186902

Gene position: 3853273-3851735 (Counterclockwise)

Preceding gene: 49186904

Following gene: 49186901

Centisome position: 73.7

GC content: 33.14

Gene sequence:

>1539_bases
TTGAAAGAAATATTAAAACAGCAATATGCCATTATAGATATTGGATCTAATACAATGCGTTTAGTTATTTATGAAAAACA
AAACGGGGGTTTTTATAAAGAGATTGAAAATACGAAAGTGGTTGCAAGGTTAAGGAATTACTTAGTCGATGGCGTGTTGA
TTGAAGAAGGAATAGAGGTATTGTTACAAACATTATTTCAATTTCAAGAAAGTACACGATTCCATCAGTTGCACCATGTA
CTTTGTGTTGCAACAGCAACAATTAGACAGGCTAAGAATCAAGAGGAAATTAAAAAACTTGTTGAAGGACAAACAGACTT
TACTCTTAGAGTATTATCAGAATATGAAGAAGCACGTTACGGCTATTTAGCAGTTATGAATTCAACTTCGTTCTCTGAAG
GGATTACAGTAGATATTGGTGGGGGGAGTACGGAGGTTACATACTTTCGAAATAGAGAGATTCTAGAGTATCATAGCTTT
CCTTTTGGAGCACTTTCTTTAAAGCAACAATTTATTAAAGACGATATACCTACAGAAGAAGAGTTGGAAAAGCTTCAAAC
GTATCTAGAATATCAATTTCGAACATTACCATGGTTAATTGATAAGAAATTGCCTCTTATTGCAATTGGTGGTAGTGCGA
GGAACTTAGTGAAAATTCATCAAAATTTAATTTGTTATCCTATAGCAGGAGTACATTTATACAAGATGAAAGAAGAAGAT
ATTAAAAATGTGAAAGAAGAATTGGAAGCATTGTCGTTCATAGAACTTCAAAAATTAGAAGGATTGGCAAAAGATCGAGC
AGATACAATTGTTCCAGCAGTCGAAGTATTTCATACGCTTGTTAATGTTATAGAGGCGCCAGCATTTGTATTAAGTAGAA
AAGGATTACGAGAAGGTGTTTTCTATGAAGAGTTGACAAAAGATTTGGGGATTTCATATTATCCGAACGTAGTCGAAGAA
AGTTTGTATTTATTATCACATGAATATGAAATGGATATGGAATTTGTAATGCAGCTTATTAAACATGGGAGATTGATTTG
TCAACAGCTTGAAGAAACCGGGCTGATTTCTATGTCAGTAGAAGACTGGGAAGTATTCCATCAAGCAGCGAAAGTATTTA
ATATAGGCAAATATATAGACGAAGAAGCGAGCCGCTTACATACATTTTATTTATTAGCGAATAAAACAATTGATGGTATG
ATGCATAAAGAGCGAGTTAGATTAGCGCTTATTGCGTCTTATAAATCAAAAATGTTATTCAAACAACATTTGTCTCCATT
TGAAGGCTGGTTTGATAAAAACGAACAAAAAAAAATCCGCCTATTAGGGGCTGTTTTACAATTTTCAGCAGCTCTAAATA
TAAGACAAAGATCGCTTGTTGAATCCATATCTATAACAGAAAGTAAAGAAGGATTAACATTTGAAATTGTATGTGAACAA
TCGGCGTTAGCGGAAAAAGTGCAAGCTGAAAAGCAGAAGAAACAGCTAGAAAGAGTATTGAAAACAAATATTATCTTGTT
ATTTAAATTAAAGAATTGA

Upstream 100 bases:

>100_bases
ATATTTTCAATATTAAAGCAATATTGTTACAAAAAACAACTATTTTGTATAATAGTAATAGAATGTGTTTTAGAAATTTG
ATAATGAAAGAGTGAGAAGT

Downstream 100 bases:

>100_bases
GTTGTACGGATGTCTTTGCGAAAAATTTATACTTTATAATATTGTAATTTGCTAAAATGAAAGTAACTAAATTATAGTAA
AAAAGTTTCAAGGGGAAGTG

Product: Ppx/GppA phosphatase family protein

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQLHHV
LCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEARYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSF
PFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMKEED
IKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNVVEE
SLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGM
MHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIVCEQ
SALAEKVQAEKQKKQLERVLKTNIILLFKLKN

Sequences:

>Translated_512_residues
MKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQLHHV
LCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEARYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSF
PFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMKEED
IKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNVVEE
SLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGM
MHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIVCEQ
SALAEKVQAEKQKKQLERVLKTNIILLFKLKN
>Mature_512_residues
MKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQLHHV
LCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEARYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSF
PFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMKEED
IKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNVVEE
SLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGM
MHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIVCEQ
SALAEKVQAEKQKKQLERVLKTNIILLFKLKN

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=437, Percent_Identity=25.1716247139588, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI48994966, Length=405, Percent_Identity=20.9876543209877, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 59177; Mature: 59177

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEV
CHHHHHCCEEEEEECCCEEEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LLQTLFQFQESTRFHQLHHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
GYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSFPFGALSLKQQFIKDDIPTEE
CEEEEEECCCCCCCEEEEECCCCEEEEEECCCCEEHHCCCCCHHHHHHHHHHHCCCCCHH
ELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMKEED
HHHHHHHHHHHHHHHCCHHHCCCCCEEEECCCHHHHHHHHHCEEEEEECCEEEEECCHHH
IKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHCCC
FYEELTKDLGISYYPNVVEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSV
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEH
EDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGMMHKERVRLALIASYKSKMLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
KQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIVCEQ
HHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECH
SALAEKVQAEKQKKQLERVLKTNIILLFKLKN
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECC
>Mature Secondary Structure
MKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEV
CHHHHHCCEEEEEECCCEEEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LLQTLFQFQESTRFHQLHHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHCCC
GYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSFPFGALSLKQQFIKDDIPTEE
CEEEEEECCCCCCCEEEEECCCCEEEEEECCCCEEHHCCCCCHHHHHHHHHHHCCCCCHH
ELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMKEED
HHHHHHHHHHHHHHHCCHHHCCCCCEEEECCCHHHHHHHHHCEEEEEECCEEEEECCHHH
IKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHCCC
FYEELTKDLGISYYPNVVEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSV
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEH
EDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGMMHKERVRLALIASYKSKMLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
KQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIVCEQ
HHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECH
SALAEKVQAEKQKKQLERVLKTNIILLFKLKN
HHHHHHHHHHHHHHHHHHHHHCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]