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The map label for this gene is speA

Identifier: 49186872

GI number: 49186872

Start: 3823507

End: 3824988

Strand: Direct

Name: speA

Synonym: BAS3874

Alternate gene names: 49186872

Gene position: 3823507-3824988 (Clockwise)

Preceding gene: 49186870

Following gene: 49186873

Centisome position: 73.13

GC content: 38.12

Gene sequence:

>1482_bases
GTGTATAGATTGTCCCAATACGAAACACCATTGTTTACCGCTTTAGTTGAGCACAGTAAGCGAAATCCAATTCAATTCCA
TATTCCAGGTCATAAAAAAGGGCAAGGCATGGATCCTGAATTTCGCGAATTTATTGGGCATAATGCATTAGCAATTGATT
TAATTAACATTGCGCCGCTCGATGATTTACATCATCCAAAAGGTATGATTAAAGAAGCACAAGATTTAGCAGCCGCTGCA
TTTGGTGCGGATCATACTTTCTTTTCTATTCAAGGTACAAGTGGCGCAATAATGACAATGGTGATGAGCGTTTGCGGTCC
TGGTGACAAAATACTAGTGCCACGAAACGTGCATAAATCAGTAATGTCAGCTATTATTTTCTCAGGTGCAAAACCTATTT
TCATGCATCCTGAAATCGATCCAAAACTTGGTATTTCACATGGAATCACAATCCAATCTGTCAAAAAAGCACTTGAAGAG
CACTCAGATGCGAAAGGCTTACTTGTTATTAATCCAACATACTTTGGCTTTGCTGCGGACTTAGAACAGATTGTACAATT
AGCACATTCTTACGATATCCCTGTACTCGTTGATGAGGCTCATGGTGTTCATATTCATTTTCACGATGAACTGCCGATGT
CAGCGATGCAAGCCGGTGCAGATATGGCAGCAACGAGTGTTCACAAATTAGGTGGATCTTTAACGCAAAGCTCTATTCTT
AATGTAAAAGAAGGCCTTGTGAACGTAAAACATGTTCAATCTATTATTAGCATGCTTACGACTACATCAACGTCTTACAT
CTTGTTAGCCTCCCTAGATGTTGCTAGAAAACGTCTTGCTACAGAAGGAAAGGCGCTCATAGAACAAACAATACAATTAG
CGGAACAAGTTCGTAATGCTATAAATGATATTGAACATCTTTACTGTCCAGGGAAAGAAATGCTAGGTACGGATGCTACT
TTTAACTATGATCCTACAAAGATAATTGTATCTGTAAAAGATTTAGGTATTACAGGCCATCAGGCTGAAGTATGGCTTAG
AGAGCAATATAACATTGAAGTAGAACTCTCAGATTTATACAACATACTATGTCTTGTCACTTTTGGAGATACAGAAAGTG
AGACGAATACACTTATTGCAGCATTACAAGATTTATCAGCAATATTTAAAAATAAAGCTGATAAAGGTGTTCGAATACAA
GTAGAAATTCCAGAAATACCTGTGTTAGCACTTTCTCCTCGAGATGCTTTTTATTCGGAAACAGAAGTCATCCCATTTGA
AAATGCAGCAGGTCGTATTATAGCTGATTTCGTTATGGTTTATCCGCCAGGGATTCCAATCTTTACTCCGGGGGAAATTA
TTACACAAGACAACTTAGAGTATATTCGTAAAAACTTAGAAGCAGGTTTACCTGTACAAGGTCCTGAAGATATGACATTA
CAAACATTACGCGTGATCAAAGAGTACAAGCCTATCAGTTGA

Upstream 100 bases:

>100_bases
GTGAATGGCAGAAAAACAAGTCTCATTCTAAAAAAGAACTTAACTTTTTTAGAACAAGATTATATAAAACAAACTCTAAT
AAATATTAAAAAAAGAAGGG

Downstream 100 bases:

>100_bases
TAGGCTTTTTTTCACCCTTTTTCCCTTTTCTCATACGATATTATGTAATGTAACGTATAGGTGGGGATACTACTATGATT
GTAATAGGCCGTTCTATTGT

Product: lysine decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MYRLSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPEFREFIGHNALAIDLINIAPLDDLHHPKGMIKEAQDLAAAA
FGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKSVMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEE
HSDAKGLLVINPTYFGFAADLEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSIL
NVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGKALIEQTIQLAEQVRNAINDIEHLYCPGKEMLGTDAT
FNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLYNILCLVTFGDTESETNTLIAALQDLSAIFKNKADKGVRIQ
VEIPEIPVLALSPRDAFYSETEVIPFENAAGRIIADFVMVYPPGIPIFTPGEIITQDNLEYIRKNLEAGLPVQGPEDMTL
QTLRVIKEYKPIS

Sequences:

>Translated_493_residues
MYRLSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPEFREFIGHNALAIDLINIAPLDDLHHPKGMIKEAQDLAAAA
FGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKSVMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEE
HSDAKGLLVINPTYFGFAADLEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSIL
NVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGKALIEQTIQLAEQVRNAINDIEHLYCPGKEMLGTDAT
FNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLYNILCLVTFGDTESETNTLIAALQDLSAIFKNKADKGVRIQ
VEIPEIPVLALSPRDAFYSETEVIPFENAAGRIIADFVMVYPPGIPIFTPGEIITQDNLEYIRKNLEAGLPVQGPEDMTL
QTLRVIKEYKPIS
>Mature_493_residues
MYRLSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPEFREFIGHNALAIDLINIAPLDDLHHPKGMIKEAQDLAAAA
FGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKSVMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEE
HSDAKGLLVINPTYFGFAADLEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSIL
NVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGKALIEQTIQLAEQVRNAINDIEHLYCPGKEMLGTDAT
FNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLYNILCLVTFGDTESETNTLIAALQDLSAIFKNKADKGVRIQ
VEIPEIPVLALSPRDAFYSETEVIPFENAAGRIIADFVMVYPPGIPIFTPGEIITQDNLEYIRKNLEAGLPVQGPEDMTL
QTLRVIKEYKPIS

Specific function: Catalyzes the formation of agmatine from arginine

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family

Homologues:

Organism=Escherichia coli, GI1786384, Length=563, Percent_Identity=24.5115452930728, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790573, Length=570, Percent_Identity=24.9122807017544, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI221142684, Length=380, Percent_Identity=27.3684210526316, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082193, Length=578, Percent_Identity=23.5294117647059, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786909, Length=604, Percent_Identity=23.6754966887417, Blast_Score=95, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEA_BACAN (Q81MS2)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846410.1
- RefSeq:   YP_020819.1
- RefSeq:   YP_030124.1
- ProteinModelPortal:   Q81MS2
- SMR:   Q81MS2
- IntAct:   Q81MS2
- EnsemblBacteria:   EBBACT00000013277
- EnsemblBacteria:   EBBACT00000018668
- EnsemblBacteria:   EBBACT00000021880
- GeneID:   1089028
- GeneID:   2818145
- GeneID:   2851739
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_4172
- KEGG:   bar:GBAA_4172
- KEGG:   bat:BAS3874
- TIGR:   BA_4172
- TIGR:   GBAA_4172
- GeneTree:   EBGT00050000002042
- HOGENOM:   HBG634412
- OMA:   TPHAAWQ
- ProtClustDB:   CLSK873379
- BioCyc:   BANT260799:BAS3874-MONOMER
- BioCyc:   BANT261594:GBAA4172-MONOMER
- BRENDA:   4.1.1.19
- GO:   GO:0005737
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.90.100.10
- Gene3D:   G3DSA:3.40.640.10

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.1.1.19

Molecular weight: Translated: 54216; Mature: 54216

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRLSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPEFREFIGHNALAIDLINIAPL
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCC
DDLHHPKGMIKEAQDLAAAAFGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKS
CCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHHH
VMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEEHSDAKGLLVINPTYFGFAAD
HHHHHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHCHHHH
LEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSIL
HHHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHH
NVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGKALIEQTIQLAEQVRNA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDIEHLYCPGKEMLGTDATFNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLY
HHHHHHHCCCCHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEHHHHC
NILCLVTFGDTESETNTLIAALQDLSAIFKNKADKGVRIQVEIPEIPVLALSPRDAFYSE
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCCCCCCC
TEVIPFENAAGRIIADFVMVYPPGIPIFTPGEIITQDNLEYIRKNLEAGLPVQGPEDMTL
CCEEECCCCCCHHHHHHHHCCCCCCCEECCCCEEECCCHHHHHHHHCCCCCCCCCCCHHH
QTLRVIKEYKPIS
HHHHHHHHCCCCC
>Mature Secondary Structure
MYRLSQYETPLFTALVEHSKRNPIQFHIPGHKKGQGMDPEFREFIGHNALAIDLINIAPL
CCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHCCCEEEEEEEECCCC
DDLHHPKGMIKEAQDLAAAAFGADHTFFSIQGTSGAIMTMVMSVCGPGDKILVPRNVHKS
CCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEECCHHHHH
VMSAIIFSGAKPIFMHPEIDPKLGISHGITIQSVKKALEEHSDAKGLLVINPTYFGFAAD
HHHHHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHCHHHH
LEQIVQLAHSYDIPVLVDEAHGVHIHFHDELPMSAMQAGADMAATSVHKLGGSLTQSSIL
HHHHHHHHHCCCCCEEEECCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHH
NVKEGLVNVKHVQSIISMLTTTSTSYILLASLDVARKRLATEGKALIEQTIQLAEQVRNA
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDIEHLYCPGKEMLGTDATFNYDPTKIIVSVKDLGITGHQAEVWLREQYNIEVELSDLY
HHHHHHHCCCCHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCEEEEHHHHC
NILCLVTFGDTESETNTLIAALQDLSAIFKNKADKGVRIQVEIPEIPVLALSPRDAFYSE
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEECCCCCCCCC
TEVIPFENAAGRIIADFVMVYPPGIPIFTPGEIITQDNLEYIRKNLEAGLPVQGPEDMTL
CCEEECCCCCCHHHHHHHHCCCCCCCEECCCCEEECCCHHHHHHHHCCCCCCCCCCCHHH
QTLRVIKEYKPIS
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629