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The map label for this gene is fes [H]

Identifier: 49185517

GI number: 49185517

Start: 2509690

End: 2510907

Strand: Reverse

Name: fes [H]

Synonym: BAS2509

Alternate gene names: 49185517

Gene position: 2510907-2509690 (Counterclockwise)

Preceding gene: 49185518

Following gene: 49185516

Centisome position: 48.02

GC content: 31.2

Gene sequence:

>1218_bases
TTGATCATTTTTCTAATCAATAACTTCTCTAAACACATAACTTACGACTACTTTTATATAGGGATTCTAATGAGAAAACT
ACATATAGAATACTACAAAGGAGGAAGAGAGGTGACTACAATAATCAGTCCTAAATTAGAGAAGCTTAAAAATCACTTAA
AGAACGGAAATGAAAAAGCTCTTTATACTTTTTTGCATGAAATCAAGTCAAATCATACACCACTAGTAGAACAATGTCCT
ATAGATAATCAGTATAAACTTATAACGTATATATGGTTAGGTGATCAAAATACTGAAAATGTTTATGTAGTCGGTAGTTT
TCCTGGTTGGGATCTGTCTGTAAATCAATTACAACGATTATTACAGACAAATATTTGGTATGTTACGTTTAGGACGAATA
AGAGGTTTATTTCAACTTATTATTTTACAGTAAATGATTTTTTCAAAAATGATTGGATAAAGCGTAGTGAACAGTACCGA
CTAGACCCATTCAATGAAAATGTATTTGGAGAAGGTGCCAATAAAGCGTCTGTGTTAAAAATAGATATGGACGTGCAGTA
TAGCAGTCGTTTTCCTTCAAATCATTATCCATCTGGAAAGATTGAAACATATTCTTTTTATAGTTCGATTTTAAATAACA
CACGTAAACTTCATATTTATACGCCTCATGATTATTCTCACACTTCACATCTTCAAGAACTTCTCATTGTATTTGATGGG
AATTCATTCATTAATGACCTTTCAATCACAAAAACACTTAATTATTTAATTTACGAAAAAGAAATCCCATCTTGTATTGC
TGTTGCTATAGATCCTGTTGATCGATTAGAAGAGCTAACTTATAACGATAAAATGAATACATTTTTAATGAAGGAATTAC
TTCCATGGATTCAAACTAAATATCATGTGTATCAAAAAGCAAAACATACAACAATTGCTGGTTTCAGCCTTGGTGGCTTA
GCCGCTTTTTATGTAGCACTTCAAAATCCACATATTTTCGGAAATGTGTTGTCAATGTCTGGATCCGTACATTGGAAAAA
GGATGATTATGAAAATACAATTCCTTGGATTGAAAATCAAATTTCATCAATAGATTCTAATGCGACTCATCTCAATTCTT
ACATAGCAGTAGGTGAACTTGAAAACGAATCTCTTTTAAAGGCTAATAGACGGCTACATAAAGCTTTAGAAGAAAAGAAA
TACCCAAACCACTTATGA

Upstream 100 bases:

>100_bases
CCGTCAATTGAAAAGATTTATGTTAAGTCAAAGCTCGGGAGTCCTCAAAGAACTCTTTTAGAAAGAAGAATAAAATCATT
GGAACTTTCTATTCAAGCAA

Downstream 100 bases:

>100_bases
AGAGTTTCAAGGCGGACATGATAGCGTGTGGTGGCGAGAAAAGCTATTCGATGGATTAAGGGCATTAGAACTTACAAAAA
CGACACTAAAAAATAAAAAG

Product: esterase

Products: Fe [C]

Alternate protein names: Ferric enterobactin esterase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MIIFLINNFSKHITYDYFYIGILMRKLHIEYYKGGREVTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCP
IDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYR
LDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDG
NSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGL
AAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKK
YPNHL

Sequences:

>Translated_405_residues
MIIFLINNFSKHITYDYFYIGILMRKLHIEYYKGGREVTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCP
IDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYR
LDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDG
NSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGL
AAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKK
YPNHL
>Mature_405_residues
MIIFLINNFSKHITYDYFYIGILMRKLHIEYYKGGREVTTIISPKLEKLKNHLKNGNEKALYTFLHEIKSNHTPLVEQCP
IDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQRLLQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYR
LDPFNENVFGEGANKASVLKIDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDG
NSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLMKELLPWIQTKYHVYQKAKHTTIAGFSLGGL
AAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIENQISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKK
YPNHL

Specific function: Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use [H]

COG id: COG2382

COG function: function code P; Enterochelin esterase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fes family [H]

Homologues:

Organism=Escherichia coli, GI1786799, Length=341, Percent_Identity=24.633431085044, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021764
- InterPro:   IPR000801
- InterPro:   IPR014756 [H]

Pfam domain/function: PF11806 DUF3327; PF00756 Esterase [H]

EC number: NA

Molecular weight: Translated: 47456; Mature: 47456

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFLINNFSKHITYDYFYIGILMRKLHIEYYKGGREVTTIISPKLEKLKNHLKNGNEKA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCHH
LYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQRL
HHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHH
LQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLK
HHCCEEEEEEECCCEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
IDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDG
EEEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHEEEEEECC
NSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLMKELLPWIQTK
CCHHCHHHHHHHHHHEEEECCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIENQ
HHHHHHCCCCEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCHHHHH
ISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKKYPNHL
HHHCCCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIIFLINNFSKHITYDYFYIGILMRKLHIEYYKGGREVTTIISPKLEKLKNHLKNGNEKA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCHH
LYTFLHEIKSNHTPLVEQCPIDNQYKLITYIWLGDQNTENVYVVGSFPGWDLSVNQLQRL
HHHHHHHHHCCCCCCHHHCCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHH
LQTNIWYVTFRTNKRFISTYYFTVNDFFKNDWIKRSEQYRLDPFNENVFGEGANKASVLK
HHCCEEEEEEECCCEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
IDMDVQYSSRFPSNHYPSGKIETYSFYSSILNNTRKLHIYTPHDYSHTSHLQELLIVFDG
EEEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHEEEEEECC
NSFINDLSITKTLNYLIYEKEIPSCIAVAIDPVDRLEELTYNDKMNTFLMKELLPWIQTK
CCHHCHHHHHHHHHHEEEECCCCCEEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
YHVYQKAKHTTIAGFSLGGLAAFYVALQNPHIFGNVLSMSGSVHWKKDDYENTIPWIENQ
HHHHHHCCCCEEECCCHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCCCHHHHH
ISSIDSNATHLNSYIAVGELENESLLKANRRLHKALEEKKYPNHL
HHHCCCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ferrienterobactin [C]

Specific reaction: ferrienterobactin = Fe [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2974033; 9278503; 8905232 [H]