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The map label for this gene is ipdC [H]

Identifier: 49185320

GI number: 49185320

Start: 2313065

End: 2314750

Strand: Reverse

Name: ipdC [H]

Synonym: BAS2311

Alternate gene names: 49185320

Gene position: 2314750-2313065 (Counterclockwise)

Preceding gene: 49185325

Following gene: 49185312

Centisome position: 44.27

GC content: 34.46

Gene sequence:

>1686_bases
ATGATTCACTTGAAAACTCAATATACTGTAAGTACATATTTATTAGACCGACTAAGCGAATTAGGAATTGAGCATATTTT
TGGTATCCCTGGTGATTATAATTTGGCTTTTTTAGATTATGTACTCGCACATAAAAATTTAGAGTGGATTGGCAATTGTA
ATGAATTAAATGCGGCATATGCTGCAGATGGATATGCTCGTATAAAAGGAATAGCAGCTCTTATTACCACCTTTGGCGTT
GGAGAATTAAGCGCCATAAATGGCATTGCTGGCTCATATGCAGAAAACGTACCAGTTATAAAAATTACAGGTACACCACC
AACAACAGTAATGGAAAATGGAGAGCTAGTTCATCATACGTTAGGTGATGGAAAGTTCAATCATTTTTCCAAAATGTATC
GAGAAATCACTATTGCACAAACTAATTTAACCCCAGAGCATGCAGTCGAGGAAATTGACCGTGTGTTACGTGCATGTTGG
AATGAAAAACGTCCTGTTCATATTAATTTACCTATTGATGTGTATAATAAACCAATTAATAGACCTGCAGAACCAATTTT
ACATAAACCGATTTTAAGTAATAAAGAAACACTGGATAAAATGCTTCTACATGCCATTTCAAAAATAAATAGCGCAAAGA
AACCTATTATTTTAGCTGATTTTGAAGTAGATCGTTTTCATGCAAAAGAATATTTATATCAATTTGTAGAAAAAACGGGG
TTTCCTATTGCAACGTTAAGTATGGGAAAAGGAATATTTCCAGAAAAACACCCTCAATTTATAGGGGTTTATGTTGGTGA
TGTAAGTCCTCCATACTTGCGTAAAAGAATTGATGAATCTGACTGTATTATTAGTATTGGCGTGAAGTTAACTGATACTA
TTACAGGTGGCTTCACACAAGGTTTTACGAAAGAACAAGTTATTGAAATTCATCCCTACACTGTGAAAATTACAGATAAA
AAATACGGGCCAGTTGTAATGAAAGATGTTTTACAACAGTTAAGTGATGTAATTGAGCATCGAAATGAAGAAACGCTTGA
TATTAAGCCATTTATTTCAGAATCTCTATCTATGACAGAAGAGTTCAATCCAAAAGCACACATGGTTACACAAAAACGTT
TTTGGCAACAAATATACCATTTCTTACAAGAAAACGACGTCTTACTTGCAGAGCAAGGAATACCTTTCTTTGGTAGTGCC
GCTATCCCTTTACCAAACAACACTACATATGTAGCGCAACCATTATGGGGATCGATCGGCTATACGTTACCTGCTCTACT
TGGTACACAGCTCGCTAATTTATCGCGGCGCAACATTTTAATTATTGGTGATGGTTCTTTTCAATTAATTGTCCAAGAAT
TATCAACTATACTACGTCAAAATTTAAACCCAATTATATTTTTAATTAACAACAATGGTTATACTGTTGAACGTGCAATT
CATGGTCAAAACGAACCGTATAATGACATACAAATGTGGGAGTACACAAAACTAGCGAAAGTATTCGGAACAGAAGAAAA
AAGCCAAACATTTAAAGTACAAAATGAAACAGAGTTACAAGAAGTCTTAACTAAAATAAGTATTGATAAGAATCAACTTA
CCTTTGTTGAAATTGTAATGAGCCAAGGGGATCAGCCTGAATTGTTAGCTAAGCTTGGGAAGAGATTCGGCCAGCAAAAT
TCTTAA

Upstream 100 bases:

>100_bases
TCCCCCTGTATGTAAATTATACCACATTCTAGTAATGAATATTTTAATCAATGCTCTAGAGCTGCTTTCGTTTATTACAA
GAAAGCAAAACGATTAGGAG

Downstream 100 bases:

>100_bases
TATAAAAAGCATAACCTAATTATATAAAAGGAAAAGGATGGAAGGTGCCACCCTTTTCCTTTTATATATACTATTTTAAG
AACCTTCTTCGACTAACTTC

Product: indolepyruvate decarboxylase

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGV
GELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACW
NEKRPVHINLPIDVYNKPINRPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDK
KYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGIPFFGSA
AIPLPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAI
HGQNEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQGDQPELLAKLGKRFGQQN
S

Sequences:

>Translated_561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGV
GELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACW
NEKRPVHINLPIDVYNKPINRPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDK
KYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGIPFFGSA
AIPLPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAI
HGQNEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQGDQPELLAKLGKRFGQQN
S
>Mature_561_residues
MIHLKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAYAADGYARIKGIAALITTFGV
GELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHTLGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACW
NEKRPVHINLPIDVYNKPINRPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
FPIATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQGFTKEQVIEIHPYTVKITDK
KYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTEEFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGIPFFGSA
AIPLPNNTTYVAQPLWGSIGYTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAI
HGQNEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVMSQGDQPELLAKLGKRFGQQN
S

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=549, Percent_Identity=22.040072859745, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=22.5688073394495, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786717, Length=480, Percent_Identity=23.75, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787096, Length=556, Percent_Identity=21.7625899280576, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=25.6198347107438, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=25.6198347107438, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323163, Length=567, Percent_Identity=38.9770723104056, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323073, Length=571, Percent_Identity=38.5288966725044, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6321524, Length=574, Percent_Identity=37.2822299651568, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320123, Length=560, Percent_Identity=36.25, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320588, Length=597, Percent_Identity=29.9832495812395, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323755, Length=301, Percent_Identity=22.2591362126246, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 63328; Mature: 63328

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAY
CEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCHHH
AADGYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHT
HCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCCCEECCCCEEEEE
LGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPIN
CCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCC
RPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
FPIATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQ
CCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCC
GFTKEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTE
CCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
EFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGIPFFGSAAIPLPNNTTYVAQPLWGSIG
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCCCHHH
YTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAI
HHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEE
HGQNEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCEEEEHHH
SQGDQPELLAKLGKRFGQQNS
CCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIHLKTQYTVSTYLLDRLSELGIEHIFGIPGDYNLAFLDYVLAHKNLEWIGNCNELNAAY
CEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCCCCHHH
AADGYARIKGIAALITTFGVGELSAINGIAGSYAENVPVIKITGTPPTTVMENGELVHHT
HCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCEEEEECCCCCCEECCCCEEEEE
LGDGKFNHFSKMYREITIAQTNLTPEHAVEEIDRVLRACWNEKRPVHINLPIDVYNKPIN
CCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHCCCCCC
RPAEPILHKPILSNKETLDKMLLHAISKINSAKKPIILADFEVDRFHAKEYLYQFVEKTG
CCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
FPIATLSMGKGIFPEKHPQFIGVYVGDVSPPYLRKRIDESDCIISIGVKLTDTITGGFTQ
CCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCEEEECCEEEEEECCCCCC
GFTKEQVIEIHPYTVKITDKKYGPVVMKDVLQQLSDVIEHRNEETLDIKPFISESLSMTE
CCCCCCEEEECCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHH
EFNPKAHMVTQKRFWQQIYHFLQENDVLLAEQGIPFFGSAAIPLPNNTTYVAQPLWGSIG
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCCCHHH
YTLPALLGTQLANLSRRNILIIGDGSFQLIVQELSTILRQNLNPIIFLINNNGYTVERAI
HHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEE
HGQNEPYNDIQMWEYTKLAKVFGTEEKSQTFKVQNETELQEVLTKISIDKNQLTFVEIVM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCEEEEHHH
SQGDQPELLAKLGKRFGQQNS
CCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]