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The map label for this gene is cynR [H]

Identifier: 49185280

GI number: 49185280

Start: 2269349

End: 2270251

Strand: Reverse

Name: cynR [H]

Synonym: BAS2271

Alternate gene names: 49185280

Gene position: 2270251-2269349 (Counterclockwise)

Preceding gene: 49185287

Following gene: 49185276

Centisome position: 43.42

GC content: 29.79

Gene sequence:

>903_bases
GTGATCCAAATCGAATTACGACAACTTGAATATTTTTTAGCTGTTTCAAAAGAATTGCATTTCACAAAAGCAGCTGAGAA
ATTAAATATTTCACAGCCTTCACTTAGTCAGCAAATACGTTCATTAGAACATGAAGTTGGAATGCCCCTTTTCGATCGAA
TTGGTAAAAAAATATCTTTAACCGAAGCTGGGAGGATTTTATTATTACATAGTAAAACAATTTTTCATGAAATTGAACAA
GCCCGTTCTGCTATTCAAGATTTAAACGGATTACAACAAGGTTCCTTAACAATTGGATCATTATTAACCGTCGTAAATTA
CTTACTACCACCAGCTATTTTAAATTTTAATAACTTATATCCCAATATAGAACTTTCTGTATTAGGACTTCGCACAGGAG
ATATTCGTGAAAAATTATTACAAAACGAATTAGATATTGGCATTACATTTCTACCGGTGCAAGATAAAGAAATTATTTCT
GCTCCTCTCTACGAAAGTGAACTTATAATAGTCGTACCAACTGGTCATCAATTAGCTAAACATAATCATGTATCTATTGC
TGAATTGCAGAATTACCCTTTAATTCTTTTACCTAAAAATTTCTTTTTAACCGAATTAATTACATCCCATTGTCAAAAAT
TCAACTTTAAACCAAAACCAATTTTAGAAATTAGTACAATGGAATCTTTAATCCAAATGGTTTCAAAAGGAATGGGAATT
ACAGTTTTACCAAAACCGTATATAGACTTTCTACAAAATAAAAACATTCAAGCTATTAAAATAGAAAATCCTACTCCAAC
AATAGAAATAGGGCTTATTTATAGAAAAGATAAATATATGTGTGCTGCAACTCGAGAATTTATTAAACAATTGAAACTAA
CCGTACATTCTTTACAAAATTAA

Upstream 100 bases:

>100_bases
TACTACTATCTCTTTTAGATGATTATAAAACCTAAAAAATCATTGTTCAATCCAATTATTTATATAATAATAATAGGTAA
AACCTATCATTATACTTGAG

Downstream 100 bases:

>100_bases
ACGAACAAAAGAGATTATCCTATGAAGTCATTTCATAACGACCTAGTAGAATAATCTCTTTCCATAATGAAACAAAGTAT
TAACTATAAATTTTAGTGTA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRSLEHEVGMPLFDRIGKKISLTEAGRILLLHSKTIFHEIEQ
ARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLYPNIELSVLGLRTGDIREKLLQNELDIGITFLPVQDKEIIS
APLYESELIIVVPTGHQLAKHNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN

Sequences:

>Translated_300_residues
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRSLEHEVGMPLFDRIGKKISLTEAGRILLLHSKTIFHEIEQ
ARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLYPNIELSVLGLRTGDIREKLLQNELDIGITFLPVQDKEIIS
APLYESELIIVVPTGHQLAKHNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN
>Mature_300_residues
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRSLEHEVGMPLFDRIGKKISLTEAGRILLLHSKTIFHEIEQ
ARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLYPNIELSVLGLRTGDIREKLLQNELDIGITFLPVQDKEIIS
APLYESELIIVVPTGHQLAKHNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=282, Percent_Identity=34.0425531914894, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=29.9651567944251, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788887, Length=291, Percent_Identity=31.2714776632302, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790399, Length=273, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787879, Length=292, Percent_Identity=29.7945205479452, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI2367136, Length=254, Percent_Identity=29.5275590551181, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=30.8474576271186, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1787806, Length=274, Percent_Identity=24.4525547445255, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787530, Length=293, Percent_Identity=23.8907849829352, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1787601, Length=306, Percent_Identity=25.4901960784314, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=24.5674740484429, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=27.2357723577236, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790208, Length=244, Percent_Identity=24.5901639344262, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789204, Length=258, Percent_Identity=25.968992248062, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789173, Length=248, Percent_Identity=27.8225806451613, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082132, Length=242, Percent_Identity=24.3801652892562, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081904, Length=296, Percent_Identity=25.3378378378378, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790262, Length=257, Percent_Identity=26.4591439688716, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788296, Length=232, Percent_Identity=25.8620689655172, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790783, Length=252, Percent_Identity=27.3809523809524, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786401, Length=292, Percent_Identity=22.9452054794521, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787128, Length=300, Percent_Identity=22.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787589, Length=163, Percent_Identity=28.2208588957055, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789639, Length=247, Percent_Identity=24.2914979757085, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788706, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788626, Length=244, Percent_Identity=26.2295081967213, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34056; Mature: 34056

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRSLEHEVGMPLFDRIGKKISL
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEEE
TEAGRILLLHSKTIFHEIEQARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLY
ECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCC
PNIELSVLGLRTGDIREKLLQNELDIGITFLPVQDKEIISAPLYESELIIVVPTGHQLAK
CCEEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCHHHHCCCCCCCCEEEEEECCHHHHH
HNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
CCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCE
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN
EECCCHHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQIELRQLEYFLAVSKELHFTKAAEKLNISQPSLSQQIRSLEHEVGMPLFDRIGKKISL
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHCCCEEEE
TEAGRILLLHSKTIFHEIEQARSAIQDLNGLQQGSLTIGSLLTVVNYLLPPAILNFNNLY
ECCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCC
PNIELSVLGLRTGDIREKLLQNELDIGITFLPVQDKEIISAPLYESELIIVVPTGHQLAK
CCEEEEEEEECCCHHHHHHHHCCCCCCEEEEECCCHHHHCCCCCCCCEEEEEECCHHHHH
HNHVSIAELQNYPLILLPKNFFLTELITSHCQKFNFKPKPILEISTMESLIQMVSKGMGI
CCCCCHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCE
TVLPKPYIDFLQNKNIQAIKIENPTPTIEIGLIYRKDKYMCAATREFIKQLKLTVHSLQN
EECCCHHHHHHCCCCEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]