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The map label for this gene is bmrA [H]

Identifier: 49184826

GI number: 49184826

Start: 1840643

End: 1841269

Strand: Direct

Name: bmrA [H]

Synonym: BAS1814

Alternate gene names: 49184826

Gene position: 1840643-1841269 (Clockwise)

Preceding gene: 49184824

Following gene: 49184827

Centisome position: 35.2

GC content: 32.54

Gene sequence:

>627_bases
ATGGAAGTTAGAGATGAAATAAAGAAAAAAGGGAATTGGAGGCAGTTTTTACGCCTTATTCAAGATACAAAGCCTCCGAA
AGGGATTCTTGTTTTTGCGTTATTAATGAGTTTGCTTTCTACGGGAGCAAGTTTATTTATTCCGATGTTAACAAAAGGGT
TAGTAGATAATTTTTCACTTTCCTCAATTAGTACAGGACAAATTGTTGGATTAGTTGCATTCTTTATTATGCAAACTATA
GCTGCAGGATTGTCTATATATTTATTAAATTATATAGGACAGAAGATTGTAGCTGGACTGAGAGAACGTTTGTGGAAAAA
GGTACTTATATTGCCAGTATCTTATTATGATCAAAATAGAACAGGCGATACAATTAGCCGCATGACAAATGATACAGGTG
TTGTGAAGACATTAATTTCTGAGCATTTGTCAAACTTACTAACAGGTGGTATTTCAATCGTCGGATCATTAATTGTATTA
TTTGTTTTAGATTGGAAAATGACACTTTTACTTTTAACGGTTATTCCATTATCAGTACTGATTTTAGTTCCACTAGGAAG
AAAAATGTATAAGATTTCAAAAGCGCTTCAAGATGAAACAGCTTCTTTTACAAGTGTGCTAACATAA

Upstream 100 bases:

>100_bases
TTGTAAAAATACAAAATGTGTGTTTACATTCAGTTTACATTTGTATTGTATTCTATTTTTAGAAAGAACAGTTTTGTTTA
ACACGAGGAGATGAACATGA

Downstream 100 bases:

>100_bases
GTATTATCAGAAATTCGTTTAGTGAAATCTTCGAACACAGAAAAAAGAGAATATGAAACTGGAAATAAAGGTATCGAGAA
GTTATTGCAATTTGGTTTGA

Product: ABC transporter ATP-binding protein, N-terminus

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MEVRDEIKKKGNWRQFLRLIQDTKPPKGILVFALLMSLLSTGASLFIPMLTKGLVDNFSLSSISTGQIVGLVAFFIMQTI
AAGLSIYLLNYIGQKIVAGLRERLWKKVLILPVSYYDQNRTGDTISRMTNDTGVVKTLISEHLSNLLTGGISIVGSLIVL
FVLDWKMTLLLLTVIPLSVLILVPLGRKMYKISKALQDETASFTSVLT

Sequences:

>Translated_208_residues
MEVRDEIKKKGNWRQFLRLIQDTKPPKGILVFALLMSLLSTGASLFIPMLTKGLVDNFSLSSISTGQIVGLVAFFIMQTI
AAGLSIYLLNYIGQKIVAGLRERLWKKVLILPVSYYDQNRTGDTISRMTNDTGVVKTLISEHLSNLLTGGISIVGSLIVL
FVLDWKMTLLLLTVIPLSVLILVPLGRKMYKISKALQDETASFTSVLT
>Mature_208_residues
MEVRDEIKKKGNWRQFLRLIQDTKPPKGILVFALLMSLLSTGASLFIPMLTKGLVDNFSLSSISTGQIVGLVAFFIMQTI
AAGLSIYLLNYIGQKIVAGLRERLWKKVLILPVSYYDQNRTGDTISRMTNDTGVVKTLISEHLSNLLTGGISIVGSLIVL
FVLDWKMTLLLLTVIPLSVLILVPLGRKMYKISKALQDETASFTSVLT

Specific function: An efflux transporter able to transport Hoechst 33342, ethidium bromide, doxorubicin and a number of other drugs in vitro into inside out vesicles. The endogenous substrate is unknown. It has been suggested that NBD dimerization induced by ATP-binding cau

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI171184400, Length=177, Percent_Identity=28.8135593220339, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI9955966, Length=189, Percent_Identity=29.1005291005291, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI45243524, Length=189, Percent_Identity=29.1005291005291, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI9955968, Length=189, Percent_Identity=29.1005291005291, Blast_Score=81, Evalue=8e-16,
Organism=Escherichia coli, GI1787143, Length=201, Percent_Identity=27.363184079602, Blast_Score=80, Evalue=7e-17,
Organism=Escherichia coli, GI1786654, Length=176, Percent_Identity=28.4090909090909, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17543740, Length=116, Percent_Identity=25, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=140, Percent_Identity=30.7142857142857, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641565, Length=136, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 23032; Mature: 23032

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVRDEIKKKGNWRQFLRLIQDTKPPKGILVFALLMSLLSTGASLFIPMLTKGLVDNFSL
CCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
SSISTGQIVGLVAFFIMQTIAAGLSIYLLNYIGQKIVAGLRERLWKKVLILPVSYYDQNR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TGDTISRMTNDTGVVKTLISEHLSNLLTGGISIVGSLIVLFVLDWKMTLLLLTVIPLSVL
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILVPLGRKMYKISKALQDETASFTSVLT
HHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEVRDEIKKKGNWRQFLRLIQDTKPPKGILVFALLMSLLSTGASLFIPMLTKGLVDNFSL
CCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
SSISTGQIVGLVAFFIMQTIAAGLSIYLLNYIGQKIVAGLRERLWKKVLILPVSYYDQNR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TGDTISRMTNDTGVVKTLISEHLSNLLTGGISIVGSLIVLFVLDWKMTLLLLTVIPLSVL
CCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILVPLGRKMYKISKALQDETASFTSVLT
HHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]