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The map label for this gene is copA [H]

Identifier: 49184776

GI number: 49184776

Start: 1785750

End: 1787405

Strand: Direct

Name: copA [H]

Synonym: BAS1764

Alternate gene names: 49184776

Gene position: 1785750-1787405 (Clockwise)

Preceding gene: 49184775

Following gene: 49184777

Centisome position: 34.15

GC content: 35.02

Gene sequence:

>1656_bases
ATGATGCGATATATATTAACAGCGGTTACAGTCTCAGTAATATTTTTAATTGCTGCATGTTCTGTGACGACAAATACAAC
AAATGACCATAAAAATAGGAATGATAAAAAAACTAAACAAACTGAAACGGCTACAAAACCATTGGAAATTGTTAAGGGAC
CAGAAGTTACTTTAATAGCGAAAGAAGAAAAGCAAAAATTAAGTAACGGTGTTATTGTTCCGGTCTGGACATTTAATGGC
TCATCTCCTGGTCCGGAAATTCGGGTAAAAAAAGGTGAAAAGGTGAAAGTGACATTAAAAAATGAACTATCTGCACCAGT
ATCTATTCACTGGCATGGGTATCCTGTCCCAAATGATATGGATGGAATTCCAGGTGTGACGCAAGATGCAGTCGAACCAG
GAAAAAGTTTCACTTACGAATTTGAAGCGAACGTACTAGGAACGTACTGGTATCATTCACATCAAGATTCTGTAAATCAA
TTAGATAGAGGATTATATGGTACTTTCGTTGTAGAAGATACAAATGAAAAGTATGATAAAGATTACACATTAATGTTAGA
TGAATGGATAACGGATAAAGAAGAGATGAATAAACAGTTAAAAGAAATGACAAAAGGAAAAACAGAAAAAGCAGACGGTA
ATAAATCTAGTAAGGGTAATGAAAATACGAAAAAGAATGATGATAAGAACAGCATGGATCATTCTGGTATGGACATGGAC
AGTGATAAAAAAGACTCTGGCAATATGGCAGGAATGGACCATGGAAATATGAAGATGGAAGGTCATGATATGAGTATGTA
TGATTTATTCACAATCAACGGAAAAAGTGGTGATTTAGTAGCGCCATTGAAAGTGAATAAGGGAGATAAAGTTCGTCTTC
GACTCGTTAATGCCGGTTATCTATCACATAATATACATGTTCACGGTCATGACATTAAAGTGATTGCAACAGATGGTCAA
CCAATAAACGACCCAAAAGTTATAAAGGATAAAGTAATTTCAATCGCACCGGGTGAACGTTATGATGTTGAGTTTACTGC
TAATAATCCTGGAAAATGGTATGTTGAAGACCATTCAGAAAATAAAGGTGCAAAAGGAATGAAGGCTATTATTGAATATG
ATGGTAGCAAAGAGATGAAAGATATAGCAGATGAAAAAGAAAAATTATCGAAATTAGATATGACGAAATATGGTGCTAAA
AAATTAGGTGGTTTCACGTTAAATCAGCAGTATACTGCCACATATAATATGGACTTAAATACGCAAATGAATGGAAATGA
AATGGTATATACAATTAACGGGAAGGTGTTTCCGGATATTGACCCAGTTCAAGTGAAAAAGGATGATTTAGTAAAAGTGA
AATTGGTAAATCGTTCTAAAATGGATGATCACCCAATGCATTTACATGGTCACTTCTTCCAGGTGTTGAGTAAAGGTGGA
AAACCGGTAGAAGGTTCTCCAATTGTAAAAGATACATTGAACTTAAAACCGGGAGAAGAATATGAAGTAGCCTTTGTAGC
AGACAATCCGGGTGAGTGGATGTTTCATTGTCATGATTTACATCATGCTTCAGCAGGGATGGTAACGGAAGTGAAATATA
AAGATTATAAATCTGACTATGTTCCAAACCCAAATATTCCTAATAAGCCAGAATAA

Upstream 100 bases:

>100_bases
CAATTTTGGGCGTCCTTTTATTTTGCCCATTTTAAATCTCCTTATTTTCTTGAAAATCATCTTCTAGAATGATTTTGAAA
AAGAAAAGGAGGGATTTTCT

Downstream 100 bases:

>100_bases
TATGAAAAACATGTAGTTTATTAATGATGTAAAGCAGTTATCTTTAATAGGTGGCTGCTTTTATATGTCATGTTGTGAAT
TAGGAATATTATTTTTATGA

Product: multicopper oxidase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEEKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGTFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQ
PINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAK
KLGGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKGG
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE

Sequences:

>Translated_551_residues
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEEKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGTFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQ
PINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAK
KLGGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKGG
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE
>Mature_551_residues
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIAKEEKQKLSNGVIVPVWTFNG
SSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDMDGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQ
LDRGLYGTFVVEDTNEKYDKDYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGYLSHNIHVHGHDIKVIATDGQ
PINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSENKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAK
KLGGFTLNQQYTATYNMDLNTQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKGG
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDYVPNPNIPNKPE

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=520, Percent_Identity=25, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320714, Length=527, Percent_Identity=25.2371916508539, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323703, Length=125, Percent_Identity=40, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=162, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330000, Length=305, Percent_Identity=27.8688524590164, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221329998, Length=327, Percent_Identity=27.5229357798165, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24585842, Length=305, Percent_Identity=27.8688524590164, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281360167, Length=327, Percent_Identity=27.5229357798165, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28574104, Length=354, Percent_Identity=24.8587570621469, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650186, Length=154, Percent_Identity=35.0649350649351, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859919, Length=145, Percent_Identity=33.7931034482759, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 61826; Mature: 61826

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEEKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGTFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
CEEEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGY
CCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCE
LSHNIHVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSE
EEEEEEEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEECCCC
NKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKLGGFTLNQQYTATYNMDLN
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHHCHHHHCCEEECCEEEEEEEEEEC
TQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKGG
CEECCCEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHCCC
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDY
CCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCC
VPNPNIPNKPE
CCCCCCCCCCC
>Mature Secondary Structure
MMRYILTAVTVSVIFLIAACSVTTNTTNDHKNRNDKKTKQTETATKPLEIVKGPEVTLIA
CHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
KEEKQKLSNGVIVPVWTFNGSSPGPEIRVKKGEKVKVTLKNELSAPVSIHWHGYPVPNDM
CHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCCCCCEEEEECCCCCCCCC
DGIPGVTQDAVEPGKSFTYEFEANVLGTYWYHSHQDSVNQLDRGLYGTFVVEDTNEKYDK
CCCCCCCHHHHCCCCCEEEEEECCEEEEEEEECCCCHHHHHHCCCEEEEEEECCCCCCCC
DYTLMLDEWITDKEEMNKQLKEMTKGKTEKADGNKSSKGNENTKKNDDKNSMDHSGMDMD
CEEEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDKKDSGNMAGMDHGNMKMEGHDMSMYDLFTINGKSGDLVAPLKVNKGDKVRLRLVNAGY
CCCCCCCCCCCCCCCCEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCEEEEEEEECCE
LSHNIHVHGHDIKVIATDGQPINDPKVIKDKVISIAPGERYDVEFTANNPGKWYVEDHSE
EEEEEEEECCEEEEEECCCCCCCCCHHHHEEEEEECCCCEEEEEEEECCCCEEEEECCCC
NKGAKGMKAIIEYDGSKEMKDIADEKEKLSKLDMTKYGAKKLGGFTLNQQYTATYNMDLN
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHHCHHHHCCEEECCEEEEEEEEEEC
TQMNGNEMVYTINGKVFPDIDPVQVKKDDLVKVKLVNRSKMDDHPMHLHGHFFQVLSKGG
CEECCCEEEEEECCEECCCCCCEEECCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHCCC
KPVEGSPIVKDTLNLKPGEEYEVAFVADNPGEWMFHCHDLHHASAGMVTEVKYKDYKSDY
CCCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCCCC
VPNPNIPNKPE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]