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The map label for this gene is pepP [H]

Identifier: 49184775

GI number: 49184775

Start: 1784349

End: 1785632

Strand: Direct

Name: pepP [H]

Synonym: BAS1763

Alternate gene names: 49184775

Gene position: 1784349-1785632 (Clockwise)

Preceding gene: 49184772

Following gene: 49184776

Centisome position: 34.13

GC content: 31.93

Gene sequence:

>1284_bases
ATGAAATCAAAATTTTTTGCTCAAAATAGAGAACGACTAGTAAACACATTACCAGATGAATCTATTACTATTTTATTTGC
TGGACAAGCACCTCATATGTCAGCGGATGCACATTATAAATTTGTGCCGAATCGAAATTTTTACTATGTAACAGGAATCG
ATGAACCAAATGTTATTTTCATGTTGAAGAAGTTTGGAAATAGTGTTGAAGAAACACTTTTCATTGAAAAGTCAGATCCA
GTAATGGAAAAATGGGTCGGTAAAACAGTTTCTAACGAAGAAGCAGAGAAAATTTCAGGTATAAAAAAAGTTATATATTT
AGATAGCTTTGAAAAAACAATGTCAAATATATTTTTTACAGAAAATGTGAAACATCTATATTTAGATTTAGAGTGTCGTG
AGTGGAAAGGTACGGAGACAAAAACATTAGCATTTGCTAAACATGTAAGAGAACAATATCCACACGTAACAATTGGTAAT
GTATATCCGAACATTTGTGAATTGCGAGTATTTAAAACAGATGAAGAGATTGAAATTATTAAAGAAGCAATTGCTGTAAC
GAAAGACGGTATTTACAACGTACTTAAGCATGCAAAAGCAGACATGATGGAATATGAATTAGAAGCTCAGTTTGATTTCA
CACTGAAGTCATCTGGCATTAAGCATCATGCGTTCAATACAATTTTGGCAAGTGGGAAAAATGCTACAGTTCTTCATTAT
GAAGATAATGATGCACAAATTCAAAATGGTGATTTAGTATTACTAGATTTAGGCGCTCAAAAAGACTACTATAACGCTGA
TATTAGTTATACATTCCCGGCAAATGGAACATTCTCTAGTCGCCAAAAACAAATTTATAATATTGTATTAAATGCATTAA
AAGAAACAACAGAGATTATTAAGCCAGGTTTGAAGTTCGCTGCATTAAATGAACATGCTAAAAAAGTACTCGCAGAAGGG
TGTAAAGCAGTTGGCTTAATTCAAGAAGATGAGGAACTGTCTAAATATTATTATCATGGAGTCAGCCATTTTCTTGGTTT
AGATACGCATGATGTAGGTACATACAAAGATAGAGTTTTAGAAGAAGGTATGGTTATTACAATTGAACCTGGTCTTTATA
TTGAAGAAGAATCAATTGGCATTCGTATTGAAGATGATATTCTTGTAACGAAAGACGGACATGAAAACTTGTCAAAAGAT
ATCATTAGAGAAGTTGAAGAGATTGAAGAGTTTATGAGAGAAAATAATGTGAATGTAAAACAAGATGAGGTTGTTACGAA
ATAA

Upstream 100 bases:

>100_bases
CTATGAGCACTATTAATTGACGAAAAATTATAACAATAATAAAATGAATTGATTAGATAATTAGTTTTTGAATCATACAT
AGAAAGCTAGGGGGATTATT

Downstream 100 bases:

>100_bases
TAATCAGGAAAGGCGCTCAATTTTGGGCGTCCTTTTATTTTGCCCATTTTAAATCTCCTTATTTTCTTGAAAATCATCTT
CTAGAATGATTTTGAAAAAG

Product: xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKSKFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGNSVEETLFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNIFFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGN
VYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEIIKPGLKFAALNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKD
IIREVEEIEEFMRENNVNVKQDEVVTK

Sequences:

>Translated_427_residues
MKSKFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGNSVEETLFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNIFFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGN
VYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEIIKPGLKFAALNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKD
IIREVEEIEEFMRENNVNVKQDEVVTK
>Mature_427_residues
MKSKFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIFMLKKFGNSVEETLFIEKSDP
VMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNIFFTENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGN
VYPNICELRVFKTDEEIEIIKEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEIIKPGLKFAALNEHAKKVLAEG
CKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVLEEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKD
IIREVEEIEEFMRENNVNVKQDEVVTK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=471, Percent_Identity=28.4501061571125, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI11559925, Length=422, Percent_Identity=28.436018957346, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=32.7868852459016, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI260593663, Length=470, Percent_Identity=25.7446808510638, Blast_Score=146, Evalue=5e-35,
Organism=Escherichia coli, GI1789275, Length=437, Percent_Identity=31.1212814645309, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1788728, Length=237, Percent_Identity=30.379746835443, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790282, Length=287, Percent_Identity=23.6933797909408, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=468, Percent_Identity=30.1282051282051, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=261, Percent_Identity=27.2030651340996, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320922, Length=452, Percent_Identity=27.6548672566372, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6321118, Length=434, Percent_Identity=28.110599078341, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21357079, Length=478, Percent_Identity=30.1255230125523, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI19920384, Length=420, Percent_Identity=27.8571428571429, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48870; Mature: 48870

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIF
CCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCEEE
MLKKFGNSVEETLFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNIFFT
EEHHHCCCHHHEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHEEEECHHHHHHHHEEEE
ENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGNVYPNICELRVFKTDEEIEII
CCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCHHHHHH
KEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEII
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFAALNEHAKKVLAEGCKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCCEEHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKDIIREVEEIEEFMRENNVNVK
HCCEEEEECCCCEEECCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
QDEVVTK
HHHCCCC
>Mature Secondary Structure
MKSKFFAQNRERLVNTLPDESITILFAGQAPHMSADAHYKFVPNRNFYYVTGIDEPNVIF
CCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCEEE
MLKKFGNSVEETLFIEKSDPVMEKWVGKTVSNEEAEKISGIKKVIYLDSFEKTMSNIFFT
EEHHHCCCHHHEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHEEEECHHHHHHHHEEEE
ENVKHLYLDLECREWKGTETKTLAFAKHVREQYPHVTIGNVYPNICELRVFKTDEEIEII
CCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCHHHHHH
KEAIAVTKDGIYNVLKHAKADMMEYELEAQFDFTLKSSGIKHHAFNTILASGKNATVLHY
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
EDNDAQIQNGDLVLLDLGAQKDYYNADISYTFPANGTFSSRQKQIYNIVLNALKETTEII
ECCCCEEECCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KPGLKFAALNEHAKKVLAEGCKAVGLIQEDEELSKYYYHGVSHFLGLDTHDVGTYKDRVL
CCCCCEEHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EEGMVITIEPGLYIEEESIGIRIEDDILVTKDGHENLSKDIIREVEEIEEFMRENNVNVK
HCCEEEEECCCCEEECCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
QDEVVTK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]