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The map label for this gene is mdtG [H]

Identifier: 49184735

GI number: 49184735

Start: 1741451

End: 1742665

Strand: Direct

Name: mdtG [H]

Synonym: BAS1722

Alternate gene names: 49184735

Gene position: 1741451-1742665 (Clockwise)

Preceding gene: 49184734

Following gene: 49184737

Centisome position: 33.31

GC content: 38.02

Gene sequence:

>1215_bases
ATGGCCAGCTGGAAACGAAATTTAATGATTTGTTGGCTAGGTTGTTTTACCACTGCAGCCGGTATGAGTTTAGTAATTCC
TTTTTTATCTTTTTATATTGAGGAATTAGGGGTAACTGGCACTTCTAGTATTGCACAGTGGTCGGGACTTGCATTTGGTG
TAACATTTTTAATGGGTGCGATCGTATCACCAATATGGGGAAAGCTTGGTGATATACATGGACGGAAATTGATGCTAATT
CGTGCGAGCCTTGGTATGGCGATTATTATGACGCTTATGGGGTTTGTAACGGATGTGTATCAACTAGTCGCACTAAGATT
TTTAATGGGAGCAGTATCTGGTTTCCTTTCAACAGCGATGACATTTATTGCAGCAGAAACTCCGAAAGAGCATTCAGGTT
GGGCGATTTCTACAATTTCAACTGGTGGCGTGAGTGGCTCGTTACTTGGCCCATTACTTGGTGGTTATTTATCAGAGTTA
ATTGGAATGCGTCATGTTTTTCTTGTTACAGGAGCTTTTTTATTCCTTTCCTTTCTCATCGTTTTTTTCTTTCTACATGA
AGAAAATCACTCTGCTCAAGCAAAAAAAGTACAAACGAAAAAAGTATGGACGATGGTTCCAGCTAAACATTTGATTATTA
GTTTGTTTGTCACAACATTTATTATTCAACTTGCTAATATGTCTGTTCAGCCAATTGTTACATTGTACGTGAAAAATTTA
GTTGGTCCTCAAACAGCGCATATTGAAACAATTGCGGGTGCCGTTATGTCAGCGACAGGATTAGCGGTTATTTTGGCAGC
ACCAAGATTAGGACGATTATCAGATCATATCGGTCCTCAAAAAACGTTAGTTGTAGCGTTGTTTGCTGCAGGAATTATTT
TTATCCCGCAAGCATTTGTAACCTCAGCTTGGCAACTATTAATTCTTCGATTTTTATTAGGTATCGCACAAGCAGGATTA
TTACCTTCCGTACAAACTCTACTAAAACAACATACACCAACTCATGTAACGGGACGAATATTTGGGTATAATCAATCGTT
TCAGTTTTTAGGAAATATGATTGGACCAATACTTGGTGGACAAATTGCAGCGCATGCTGGTTTTCAATATGTTTTCTTCT
CTACATCATCACTATTGTTTATTGCGTGCATTTGGGTTTATTTTCATAATAAGAACGAAGAGGTATCAGAGAAACGACAT
TTGGAAGTTAGTTAA

Upstream 100 bases:

>100_bases
AAATAGCGGGTTTTGTAGTAAATCTTACAAATAAAGCAAATTACTAAACTTTTTACAAGAAAGGGTGTAGAATGGGTATC
TAAAGAAAGAAGGTGTGAAA

Downstream 100 bases:

>100_bases
CTAAGTGAATGAAAAAAGGATGAAGCAAAGATTGCTTCATCCTTTTCTTTAAAATTGGAGACAAAGATAACTTAATGTAC
CAAGCTCGTAACTGCGATGA

Product: major facilitator family transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLI
RASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSEL
IGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGL
LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPILGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRH
LEVS

Sequences:

>Translated_404_residues
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLI
RASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSEL
IGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGL
LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPILGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRH
LEVS
>Mature_403_residues
ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIR
ASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELI
GMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNLV
GPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLL
PSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPILGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRHL
EVS

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=243, Percent_Identity=26.3374485596708, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787291, Length=396, Percent_Identity=45.7070707070707, Blast_Score=360, Evalue=1e-101,
Organism=Escherichia coli, GI87082404, Length=374, Percent_Identity=24.8663101604278, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319871, Length=152, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43890; Mature: 43759

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGA
CCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAM
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLI
HHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV
CCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPILGG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCC
QIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRHLEVS
HHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGA
CCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAM
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLSELIGMRHVFLVTGAFLFLSFLI
HHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFFFLHEENHSAQAKKVQTKKVWTMVPAKHLIISLFVTTFIIQLANMSVQPIVTLYVKNL
HHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV
CCCCHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPILGG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCC
QIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEKRHLEVS
HHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA