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The map label for this gene is ilvC2

Identifier: 49184729

GI number: 49184729

Start: 1734002

End: 1735009

Strand: Direct

Name: ilvC2

Synonym: BAS1716

Alternate gene names: 49184729

Gene position: 1734002-1735009 (Clockwise)

Preceding gene: 49184728

Following gene: 49184730

Centisome position: 33.16

GC content: 41.67

Gene sequence:

>1008_bases
ATGAAAACATATTATGAGCAAGATGCAAATGTAGGGCTATTACAAGGAAAAACTGTTGCGGTAATTGGTTATGGATCTCA
AGGTCATGCGCAGGCACAAAATTTGCGTGATTCTGGTGTGGAAGTGGTAGTTGGTGTTCGTCCTGGTAAGTCTTTTGAAG
TAGCAAAAGCAGATGGGTTTGAAGTAATGTCTGTTTCAGAAGCAGTTCGAACCGCGCAAGTTGTGCAAATGTTATTGCCA
GATGAACAGCAAGCACATGTGTATAAAGCAGAAGTAGAAGAGAATCTCCGCGAAGGACAAATGTTACTTTTCTCACATGG
ATTTAATATTCACTTCGGACAAATTAACCCGCCAAGCTACGTAGATGTAGCAATGGTCGCGCCAAAAAGTCCGGGTCATC
TCGTTCGCCGTGTATTTCAAGAAGGAAACGGTGTTCCGGCATTAGTCGCAGTACATCAAGATGCAACAGGCACAGCATTA
CATGTAGCACTCGCGTACGCAAAAGGTGTAGGGTGTACACGTGCAGGTGTAATTGAAACGACATTCCAAGAAGAAACGGA
GACAGATTTATTCGGAGAGCAAGCTGTACTTTGCGGAGGGGTAACTGCACTTGTGAAAGCTGGTTTTGAAACATTAACAG
AAGGTGGATATCGTCCTGAAATTGCATACTTTGAATGTTTGCATGAATTAAAGTTGATCGTTGATTTAATGTACGAAGGC
GGTTTAACGAATATGCGCCATTCTATATCAGATACGGCAGAGTTCGGGGATTATGTAACAGGATCGAGAATTGTTACAGA
TGAAACGAAGAAAGAGATGAAACGAGTACTTACAGAAATTCAGCAAGGTGAATTCGCGAAGAAATGGATTTTAGAAAATC
AAGCAGGGCGTCCAACGTATAATGCGATGAAAAAAGCAGAACAAAATCATCAGTTGGAAAAAGTAGGAGAAGAGCTTCGT
GAAATGATGAGCTGGATTCATGCACCGAAAGAATTAGTGAAGAAATAG

Upstream 100 bases:

>100_bases
CGGCAGTTTGTACAGAACAAGAAGCAACATTACTCGTTGGTCAGTTGAAAAAGTTAATCAATGTACTACAAGTAAACAAA
TTATAAGGAGTGTATGGAGT

Downstream 100 bases:

>100_bases
AGTAATAGATTGCAAGTGAAAAATACGTAAGAGGGGATTTGACAAGATGAGAAGTGACATGATTAAAAAAGGTTTTGATA
AAGCGCCGCATCGTAGTTTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 2; Alpha-keto-beta-hydroxylacil reductoisomerase 2

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKTYYEQDANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLP
DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTAL
HVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELR
EMMSWIHAPKELVKK

Sequences:

>Translated_335_residues
MKTYYEQDANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLP
DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTAL
HVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELR
EMMSWIHAPKELVKK
>Mature_335_residues
MKTYYEQDANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLP
DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTAL
HVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELR
EMMSWIHAPKELVKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=35.191637630662, Blast_Score=141, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=33.3333333333333, Blast_Score=139, Evalue=9e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC2_BACAN (Q81S27)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_844269.1
- RefSeq:   YP_018492.1
- RefSeq:   YP_027981.1
- ProteinModelPortal:   Q81S27
- SMR:   Q81S27
- IntAct:   Q81S27
- EnsemblBacteria:   EBBACT00000011348
- EnsemblBacteria:   EBBACT00000017963
- EnsemblBacteria:   EBBACT00000019471
- GeneID:   1086430
- GeneID:   2819743
- GeneID:   2848291
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_1852
- KEGG:   bar:GBAA_1852
- KEGG:   bat:BAS1716
- TIGR:   BA_1852
- TIGR:   GBAA_1852
- GeneTree:   EBGT00050000000943
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- ProtClustDB:   PRK13403
- BioCyc:   BANT260799:BAS1716-MONOMER
- BioCyc:   BANT261594:GBAA1852-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36918; Mature: 36918

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: ACT_SITE 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYYEQDANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGF
CCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCEEEECCCCC
EVMSVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCC
VDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIET
EEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEH
TFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTY
CCHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
NAMKKAEQNHQLEKVGEELREMMSWIHAPKELVKK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure
MKTYYEQDANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGF
CCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCEEEECCCCC
EVMSVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCC
VDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIET
EEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEH
TFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTY
CCHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
NAMKKAEQNHQLEKVGEELREMMSWIHAPKELVKK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629