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The map label for this gene is yciC [H]

Identifier: 49184647

GI number: 49184647

Start: 1649435

End: 1651018

Strand: Reverse

Name: yciC [H]

Synonym: BAS1633

Alternate gene names: 49184647

Gene position: 1651018-1649435 (Counterclockwise)

Preceding gene: 49184652

Following gene: 49184645

Centisome position: 31.58

GC content: 32.32

Gene sequence:

>1584_bases
ATGAGTGAAGAAACGATTATCCCTAGTAAAATAAAAGGTATTGCTTCAAAAATAATACTTAAAAAGAGTGTGTTCACATT
CAACCATACTTGCGGCATACTTTTGTGCAAATTTGCTAGGCTTGTAAAATCTACCAAAAATAATAAAAAGAGAAAAATAA
CAATAAGCACTATGCCTGCTAATTCTTTTGAAACTCTATTAAAAACCAACCTTCTCGCCTCCATTTTATTTATATGTAAA
CATGTGCTTGTCCAAATGCATCTACTACTACAACACAAATGTTATAGTCTATTCCTATTCTTAAATCGTAATCATTATGA
TTTATTATTGATTTTTCCCTTTCAATCATTTAACATAAAACGTAATCATTACGATTTAAAGGAGAGAAATAATTTCATGA
AAAAAATACCTATCACTGTATTAAGTGGGTTTTTAGGATCCGGAAAAACTACATTACTACATCATATTTTAACTAATAAG
AACAACTTAAAAGTAGCTGTTATCGTTAATGATATGAGCGAAGTAAACTTTGATGCCTCCCTTATAAAAAAAGGTGGTTT
TTCACGTACGGAGGAAAAACTAGTAGAAATTCAAAATGGCTGTATTTGTTGTACACTACGAGAAGATTTAATAATAGAAG
TGAATCGCCTTGTTGAAAACGGTGATATTGACTATATAGTGATTGAATCTTCCGGTATAAGTGAGCCGATTCCAGTTGCC
CAAACATTTACTTATACTGACGACGTTCTTAACATTGATTTAACGAAAAATTGTCGCCTCGATACGATGGTTACAGTTGT
AGATGCAAATAGATTTTGGGATGATTTTGCAGATGGAGAAAGTTTATTAGATCGCAAACAAGCAATCAATGAAAATGATA
CTCGGGAAGTTATTGATTTATTAATAGATCAAATTGAGTTTGCAAATGTAATTATTCTTAATAAGATAGATTTACTAGAA
AAAGAAGATGTGATAGAACTTCATCAACTGCTACAGAAATTAAATCCTAATGCAAAAATTATTGAATCTTCCTTTAGCAA
CGTACCACTGCAAGAAATTTTAAATACAAATGTATTCAATTATGAGGAAGCCAGTCAATCGGCGGGTTGGATACAAGAAT
TAAATAGTGAACATCATACACCCGAAACGGAAGAATACGGTATCAATTCCTTTGTATACCGTCGTAAATACCCTTTCCAT
CCTGAACGCCTTATGAATTGGCTAGAAAAATGGCCTGTAGATGTCGTAAGAGCAAAAGGCTTTTTCTGGCTCGCATCTCG
TAATAATATGATAGGTCTTCTATCTCAAGCAGGTTCCTCTATTACAATTCAAGGAGCCGGTGAATGGATAGCAGCATTAC
CTGAAACTGAAAGAAATCAAATGATCATAGAAGAGCCAGAAGTATTGAAAAACTGGGATAAACAATATGGAGATCGAATA
ACTGAACTCGTATTTATTGGAATTGATATGAACCGTTCTTTAATTGAACAATCATTAGATGATTGTCTATTAACAGAAAA
AGAAATGACACAAAACTGGAATACATTCATTGATCCTATTCCAGCTTTTACTTACACTTCATAA

Upstream 100 bases:

>100_bases
CATTGGAAAAAGAATTCCTACAAATACTGCTGGAATCATTGCAACAATTGGAGATCTCAGCATTACTTTTTGAATCATAT
CTTCTGTCACAAACACTTGA

Downstream 100 bases:

>100_bases
TTCAAAATAGAGAGGCTTCCGTTTACGGAAGCCTTTCTATTTTATCGTTCTCTTATTTAACAAACTTCTTTCATTTGAAT
AATAACTTTACATTAAGTAA

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSEETIIPSKIKGIASKIILKKSVFTFNHTCGILLCKFARLVKSTKNNKKRKITISTMPANSFETLLKTNLLASILFICK
HVLVQMHLLLQHKCYSLFLFLNRNHYDLLLIFPFQSFNIKRNHYDLKERNNFMKKIPITVLSGFLGSGKTTLLHHILTNK
NNLKVAVIVNDMSEVNFDASLIKKGGFSRTEEKLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVA
QTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFADGESLLDRKQAINENDTREVIDLLIDQIEFANVIILNKIDLLE
KEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQELNSEHHTPETEEYGINSFVYRRKYPFH
PERLMNWLEKWPVDVVRAKGFFWLASRNNMIGLLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRI
TELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS

Sequences:

>Translated_527_residues
MSEETIIPSKIKGIASKIILKKSVFTFNHTCGILLCKFARLVKSTKNNKKRKITISTMPANSFETLLKTNLLASILFICK
HVLVQMHLLLQHKCYSLFLFLNRNHYDLLLIFPFQSFNIKRNHYDLKERNNFMKKIPITVLSGFLGSGKTTLLHHILTNK
NNLKVAVIVNDMSEVNFDASLIKKGGFSRTEEKLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVA
QTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFADGESLLDRKQAINENDTREVIDLLIDQIEFANVIILNKIDLLE
KEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQELNSEHHTPETEEYGINSFVYRRKYPFH
PERLMNWLEKWPVDVVRAKGFFWLASRNNMIGLLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRI
TELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS
>Mature_526_residues
SEETIIPSKIKGIASKIILKKSVFTFNHTCGILLCKFARLVKSTKNNKKRKITISTMPANSFETLLKTNLLASILFICKH
VLVQMHLLLQHKCYSLFLFLNRNHYDLLLIFPFQSFNIKRNHYDLKERNNFMKKIPITVLSGFLGSGKTTLLHHILTNKN
NLKVAVIVNDMSEVNFDASLIKKGGFSRTEEKLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVAQ
TFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFADGESLLDRKQAINENDTREVIDLLIDQIEFANVIILNKIDLLEK
EDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQELNSEHHTPETEEYGINSFVYRRKYPFHP
ERLMNWLEKWPVDVVRAKGFFWLASRNNMIGLLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRIT
ELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=268, Percent_Identity=30.9701492537313, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI126722884, Length=276, Percent_Identity=30.0724637681159, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI146231952, Length=276, Percent_Identity=30.0724637681159, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI148727351, Length=276, Percent_Identity=29.7101449275362, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI223941779, Length=232, Percent_Identity=31.0344827586207, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI223941776, Length=249, Percent_Identity=29.3172690763052, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI119120938, Length=153, Percent_Identity=34.640522875817, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI87082430, Length=369, Percent_Identity=27.6422764227642, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788499, Length=211, Percent_Identity=31.2796208530806, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=237, Percent_Identity=32.0675105485232, Blast_Score=110, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 60606; Mature: 60474

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEETIIPSKIKGIASKIILKKSVFTFNHTCGILLCKFARLVKSTKNNKKRKITISTMPA
CCCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
NSFETLLKTNLLASILFICKHVLVQMHLLLQHKCYSLFLFLNRNHYDLLLIFPFQSFNIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEEECCCCCCC
RNHYDLKERNNFMKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMSEVNFDAS
CCCCCHHHHCCHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCHHCCCCHH
LIKKGGFSRTEEKLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVA
HHHCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
QTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFADGESLLDRKQAINENDTREVIDL
EEEEECCCEEEEEECCCCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHH
LIDQIEFANVIILNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFN
HHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCC
YEEASQSAGWIQELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLEKWPVDVVRAKG
CHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEECCCCCCHHHHHHHHHHCCHHHEEECC
FFWLASRNNMIGLLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRI
EEEEECCCCEEEEHCCCCCEEEEEECCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHHE
TELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS
EEEEEEEECCCHHHHHHHHHHHHCCHHHHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure 
SEETIIPSKIKGIASKIILKKSVFTFNHTCGILLCKFARLVKSTKNNKKRKITISTMPA
CCCCCCHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
NSFETLLKTNLLASILFICKHVLVQMHLLLQHKCYSLFLFLNRNHYDLLLIFPFQSFNIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCEEEEEEEECCCCCCC
RNHYDLKERNNFMKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMSEVNFDAS
CCCCCHHHHCCHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCHHCCCCHH
LIKKGGFSRTEEKLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVA
HHHCCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
QTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFADGESLLDRKQAINENDTREVIDL
EEEEECCCEEEEEECCCCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHH
LIDQIEFANVIILNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFN
HHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCC
YEEASQSAGWIQELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLEKWPVDVVRAKG
CHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEECCCCCCHHHHHHHHHHCCHHHEEECC
FFWLASRNNMIGLLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRI
EEEEECCCCEEEEHCCCCCEEEEEECCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHHE
TELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS
EEEEEEEECCCHHHHHHHHHHHHCCHHHHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]