| Definition | Bacillus anthracis str. Sterne chromosome, complete genome. |
|---|---|
| Accession | NC_005945 |
| Length | 5,228,663 |
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The map label for this gene is pcrA [H]
Identifier: 49183319
GI number: 49183319
Start: 311188
End: 313443
Strand: Direct
Name: pcrA [H]
Synonym: BAS0291
Alternate gene names: 49183319
Gene position: 311188-313443 (Clockwise)
Preceding gene: 49183318
Following gene: 49183320
Centisome position: 5.95
GC content: 38.61
Gene sequence:
>2256_bases GTGCAGGCGTATATGAGTATGACAGATAGGTTATTAAATGGTTTAAACCCGCAACAACAAAAAGCAGTACAAACAACGAA CGGACCACTTCTATTAATGGCAGGCGCAGGTAGTGGTAAAACACGTGTGTTAACACATCGTATTGCGTATTTACTTGGTG AAAAAGGAGTAGCACCGTGGAATGTACTAGCTATTACCTTTACAAATAAAGCCGCTCGTGAAATGCGCGAGCGTATTGAT ACACTTGTCGGACCAGAAGCCGAAGATATTTGGATTTCTACGTTCCACTCTATGTGTGTACGTATTTTACGACGTGATAT CGATCACATTGGTATTAATCGTAACTTTACAATTTTAGATTCGGGTGATCAGTTAACTGTGGTCAAAAAAATTATGAAAG AGCGCAATATTGATCCGAAGAAATTTGAGCCGCGCTCTATTTTGGCTGGTATTAGTAATGCGAAAAATGAACTGTTATCT GCGGATAAGTATGCAAAGAAAATTACAATTGCTGATCCATATGAAAAATTAACGAGCGATGTATATACAGAATATCAAAA ACGTCTTTTGAAAAATAACTCATTAGACTTTGATGATTTAATTATGACGACGATTCAACTATTTGAACGTGTTCCAGAAG TACTAGAGTTTTATCAGCGCAAATTCCAGTATATTCACGTGGATGAGTATCAAGATACGAACAAAGCGCAGTACCTTCTT GTTAAACATTTGGCAGCACGTTTTAAAAATTTATGCGTTGTAGGTGACTCAGATCAGTCAATTTATCGCTGGCGTGGTGC GGACATTTCCAACATTTTGTCATTCGAAAAAGACTATGAGAATGCGCAAGTTATTCTGTTAGAACAAAATTATCGTTCGT CACAAAATATTTTAAATGCAGCGAATGCTGTTATTGAAAGAAATACGAATCGTAAACCGAAGAAGTTATGGACAGATAAT GAAGTTGGAAGCAAAATCTCGTACTATCGTGCTGCAACGGAAAAGGACGAGGCGTACTTTGTTGCGAAAAAAATTCGCGA CGATATTCAAATGGGAAAACGAAAATATACTGATTTTGCAGTGCTATATCGTACAAATGCGCAGTCTCGTATGGTCGAGG AGATTTTCCTGAAATCTAATATTCCTTACAAAATTGTCGGCGGTACGAAGTTCTACGACCGTAAAGAGATTAAAGACATT TTGGCGTATTTACGTTTAATTGGGAATCCAGATGATGAGATTAGTTTTGCGCGTATTATTAACGTGCCAAAGCGCGGAAT TGGTGCGACTTCTATCGACAAAATTATTAATTATGGTGTACAAAATGGAATTTCTTTAACTGCTGTATTCGATGAGATTG AGCATGTTGGAGTAAGTGCAAAGGTTACAAAGGCAGTAAAAGAATTCGCAGGTTTATTACACAATTGGGTAAATATGCAA GAGTATTTATCTGTTACAGAATTGGTAGAAGAAGTGATTGAAAAAACAGGCTATCGCGATATGTTGAAAAATGAGCGTAC GTTAGAAGCAGAAGGTCGTCTGGAAAACTTAGATGAGTTTTTATCTGTTACGCAAACATTTGAATCTCAAAGCGAGGATA AGAGCCTTGTTGCATTCTTAACAGACTTAGCACTTGTTGCAGATATTGATCGTGTAGATGAAGACCCAACTGCTGGTGAG GAAGTTATTTTAATGACGATGCACTCAGCGAAGGGGTTAGAATTCCCAGTTGTCTTTATTGTTGGTTTAGAGGAAGGAAT ATTCCCACATACTCGTTCTCTAATGGAAGAAGATGAAATGCAAGAAGAGCGTCGTCTTGCTTATGTAGGTATTACTCGTG CGGAAGAAGAGTTGTATTTATCAAATGCACAAATGCGTACTTTATTTGGTAGAACAAGTATGAATGCCGCATCGCGATTT ATTACAGAAATCCCGACAGAACTAGTAGAATCATTAAATGAAACAGCACCGAAGCGTGAAACTTCGTTTGGTGCAAAAGG AAGAGTGGCAAGTAGCAGTAAAACGACAACTACAACACGTTCTCGCTCAGCTTTCGCACGTCCTGCAGCTAAGACGACAG GCGGCGAACAAATTGGCTGGGCAGTAGGTGATAAAGCTTCCCACCAAAAATGGGGAGTCGGTACAGTTATAAGTGTAAAA GGTGAAGGTGATGCAAAAGAATTAGATATTGCGTTCCCAAGCCCAATTGGTGTTAAACGTTTGTTAGCAAAATTTGCACC TGTGACGAAACAATAG
Upstream 100 bases:
>100_bases GGAAATGGCGCAACATGCTGATACAGTAGTTGTTGGAAATATTATTTATGATGATATAAAAGCAGCGTTAAAAACGGTTA AAGCAGTAAAAGGAGAGTAG
Downstream 100 bases:
>100_bases GAAAGGAATGAGGATATGTCAAAAGAGATAGCAAAAAAACGTATAGAAGAACTACGTGATTTGTTAAATACATTTAACTA TCAATATCACGTATTAGACA
Product: ATP-dependent DNA helicase PcrA
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 751; Mature: 751
Protein sequence:
>751_residues MQAYMSMTDRLLNGLNPQQQKAVQTTNGPLLLMAGAGSGKTRVLTHRIAYLLGEKGVAPWNVLAITFTNKAAREMRERID TLVGPEAEDIWISTFHSMCVRILRRDIDHIGINRNFTILDSGDQLTVVKKIMKERNIDPKKFEPRSILAGISNAKNELLS ADKYAKKITIADPYEKLTSDVYTEYQKRLLKNNSLDFDDLIMTTIQLFERVPEVLEFYQRKFQYIHVDEYQDTNKAQYLL VKHLAARFKNLCVVGDSDQSIYRWRGADISNILSFEKDYENAQVILLEQNYRSSQNILNAANAVIERNTNRKPKKLWTDN EVGSKISYYRAATEKDEAYFVAKKIRDDIQMGKRKYTDFAVLYRTNAQSRMVEEIFLKSNIPYKIVGGTKFYDRKEIKDI LAYLRLIGNPDDEISFARIINVPKRGIGATSIDKIINYGVQNGISLTAVFDEIEHVGVSAKVTKAVKEFAGLLHNWVNMQ EYLSVTELVEEVIEKTGYRDMLKNERTLEAEGRLENLDEFLSVTQTFESQSEDKSLVAFLTDLALVADIDRVDEDPTAGE EVILMTMHSAKGLEFPVVFIVGLEEGIFPHTRSLMEEDEMQEERRLAYVGITRAEEELYLSNAQMRTLFGRTSMNAASRF ITEIPTELVESLNETAPKRETSFGAKGRVASSSKTTTTTRSRSAFARPAAKTTGGEQIGWAVGDKASHQKWGVGTVISVK GEGDAKELDIAFPSPIGVKRLLAKFAPVTKQ
Sequences:
>Translated_751_residues MQAYMSMTDRLLNGLNPQQQKAVQTTNGPLLLMAGAGSGKTRVLTHRIAYLLGEKGVAPWNVLAITFTNKAAREMRERID TLVGPEAEDIWISTFHSMCVRILRRDIDHIGINRNFTILDSGDQLTVVKKIMKERNIDPKKFEPRSILAGISNAKNELLS ADKYAKKITIADPYEKLTSDVYTEYQKRLLKNNSLDFDDLIMTTIQLFERVPEVLEFYQRKFQYIHVDEYQDTNKAQYLL VKHLAARFKNLCVVGDSDQSIYRWRGADISNILSFEKDYENAQVILLEQNYRSSQNILNAANAVIERNTNRKPKKLWTDN EVGSKISYYRAATEKDEAYFVAKKIRDDIQMGKRKYTDFAVLYRTNAQSRMVEEIFLKSNIPYKIVGGTKFYDRKEIKDI LAYLRLIGNPDDEISFARIINVPKRGIGATSIDKIINYGVQNGISLTAVFDEIEHVGVSAKVTKAVKEFAGLLHNWVNMQ EYLSVTELVEEVIEKTGYRDMLKNERTLEAEGRLENLDEFLSVTQTFESQSEDKSLVAFLTDLALVADIDRVDEDPTAGE EVILMTMHSAKGLEFPVVFIVGLEEGIFPHTRSLMEEDEMQEERRLAYVGITRAEEELYLSNAQMRTLFGRTSMNAASRF ITEIPTELVESLNETAPKRETSFGAKGRVASSSKTTTTTRSRSAFARPAAKTTGGEQIGWAVGDKASHQKWGVGTVISVK GEGDAKELDIAFPSPIGVKRLLAKFAPVTKQ >Mature_751_residues MQAYMSMTDRLLNGLNPQQQKAVQTTNGPLLLMAGAGSGKTRVLTHRIAYLLGEKGVAPWNVLAITFTNKAAREMRERID TLVGPEAEDIWISTFHSMCVRILRRDIDHIGINRNFTILDSGDQLTVVKKIMKERNIDPKKFEPRSILAGISNAKNELLS ADKYAKKITIADPYEKLTSDVYTEYQKRLLKNNSLDFDDLIMTTIQLFERVPEVLEFYQRKFQYIHVDEYQDTNKAQYLL VKHLAARFKNLCVVGDSDQSIYRWRGADISNILSFEKDYENAQVILLEQNYRSSQNILNAANAVIERNTNRKPKKLWTDN EVGSKISYYRAATEKDEAYFVAKKIRDDIQMGKRKYTDFAVLYRTNAQSRMVEEIFLKSNIPYKIVGGTKFYDRKEIKDI LAYLRLIGNPDDEISFARIINVPKRGIGATSIDKIINYGVQNGISLTAVFDEIEHVGVSAKVTKAVKEFAGLLHNWVNMQ EYLSVTELVEEVIEKTGYRDMLKNERTLEAEGRLENLDEFLSVTQTFESQSEDKSLVAFLTDLALVADIDRVDEDPTAGE EVILMTMHSAKGLEFPVVFIVGLEEGIFPHTRSLMEEDEMQEERRLAYVGITRAEEELYLSNAQMRTLFGRTSMNAASRF ITEIPTELVESLNETAPKRETSFGAKGRVASSSKTTTTTRSRSAFARPAAKTTGGEQIGWAVGDKASHQKWGVGTVISVK GEGDAKELDIAFPSPIGVKRLLAKFAPVTKQ
Specific function: DNA helicase used for plasmid rolling-circle replication and also involved in UV repair [H]
COG id: COG0210
COG function: function code L; Superfamily I DNA and RNA helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]
Homologues:
Organism=Escherichia coli, GI2367296, Length=745, Percent_Identity=39.1946308724832, Blast_Score=529, Evalue=1e-151, Organism=Escherichia coli, GI48994965, Length=643, Percent_Identity=39.6578538102644, Blast_Score=423, Evalue=1e-119, Organism=Escherichia coli, GI1787196, Length=347, Percent_Identity=27.9538904899135, Blast_Score=101, Evalue=1e-22, Organism=Saccharomyces cerevisiae, GI6322369, Length=774, Percent_Identity=29.0697674418605, Blast_Score=244, Evalue=3e-65, Organism=Saccharomyces cerevisiae, GI6324477, Length=688, Percent_Identity=23.1104651162791, Blast_Score=107, Evalue=6e-24,
Paralogues:
None
Copy number: 3000 [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005751 - InterPro: IPR013986 - InterPro: IPR014017 - InterPro: IPR000212 - InterPro: IPR014016 [H]
Pfam domain/function: PF00580 UvrD-helicase [H]
EC number: =3.6.4.12 [H]
Molecular weight: Translated: 84965; Mature: 84965
Theoretical pI: Translated: 6.88; Mature: 6.88
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQAYMSMTDRLLNGLNPQQQKAVQTTNGPLLLMAGAGSGKTRVLTHRIAYLLGEKGVAPW CCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE NVLAITFTNKAAREMRERIDTLVGPEAEDIWISTFHSMCVRILRRDIDHIGINRNFTILD EEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE SGDQLTVVKKIMKERNIDPKKFEPRSILAGISNAKNELLSADKYAKKITIADPYEKLTSD CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHH VYTEYQKRLLKNNSLDFDDLIMTTIQLFERVPEVLEFYQRKFQYIHVDEYQDTNKAQYLL HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHH VKHLAARFKNLCVVGDSDQSIYRWRGADISNILSFEKDYENAQVILLEQNYRSSQNILNA HHHHHHHHHCEEEECCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH ANAVIERNTNRKPKKLWTDNEVGSKISYYRAATEKDEAYFVAKKIRDDIQMGKRKYTDFA HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEE VLYRTNAQSRMVEEIFLKSNIPYKIVGGTKFYDRKEIKDILAYLRLIGNPDDEISFARII EEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH NVPKRGIGATSIDKIINYGVQNGISLTAVFDEIEHVGVSAKVTKAVKEFAGLLHNWVNMQ CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHH EYLSVTELVEEVIEKTGYRDMLKNERTLEAEGRLENLDEFLSVTQTFESQSEDKSLVAFL HHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH TDLALVADIDRVDEDPTAGEEVILMTMHSAKGLEFPVVFIVGLEEGIFPHTRSLMEEDEM HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH QEERRLAYVGITRAEEELYLSNAQMRTLFGRTSMNAASRFITEIPTELVESLNETAPKRE HHHHCEEEEEEECCHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC TSFGAKGRVASSSKTTTTTRSRSAFARPAAKTTGGEQIGWAVGDKASHQKWGVGTVISVK CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECEECCCCCCCCCCCCCEEEEEE GEGDAKELDIAFPSPIGVKRLLAKFAPVTKQ CCCCCCEEEEECCCCCCHHHHHHHHCCCCCC >Mature Secondary Structure MQAYMSMTDRLLNGLNPQQQKAVQTTNGPLLLMAGAGSGKTRVLTHRIAYLLGEKGVAPW CCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE NVLAITFTNKAAREMRERIDTLVGPEAEDIWISTFHSMCVRILRRDIDHIGINRNFTILD EEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE SGDQLTVVKKIMKERNIDPKKFEPRSILAGISNAKNELLSADKYAKKITIADPYEKLTSD CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEECCHHHHHHHH VYTEYQKRLLKNNSLDFDDLIMTTIQLFERVPEVLEFYQRKFQYIHVDEYQDTNKAQYLL HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHH VKHLAARFKNLCVVGDSDQSIYRWRGADISNILSFEKDYENAQVILLEQNYRSSQNILNA HHHHHHHHHCEEEECCCCCCEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH ANAVIERNTNRKPKKLWTDNEVGSKISYYRAATEKDEAYFVAKKIRDDIQMGKRKYTDFA HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEE VLYRTNAQSRMVEEIFLKSNIPYKIVGGTKFYDRKEIKDILAYLRLIGNPDDEISFARII EEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHH NVPKRGIGATSIDKIINYGVQNGISLTAVFDEIEHVGVSAKVTKAVKEFAGLLHNWVNMQ CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHH EYLSVTELVEEVIEKTGYRDMLKNERTLEAEGRLENLDEFLSVTQTFESQSEDKSLVAFL HHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH TDLALVADIDRVDEDPTAGEEVILMTMHSAKGLEFPVVFIVGLEEGIFPHTRSLMEEDEM HHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH QEERRLAYVGITRAEEELYLSNAQMRTLFGRTSMNAASRFITEIPTELVESLNETAPKRE HHHHCEEEEEEECCHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC TSFGAKGRVASSSKTTTTTRSRSAFARPAAKTTGGEQIGWAVGDKASHQKWGVGTVISVK CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEECEECCCCCCCCCCCCCEEEEEE GEGDAKELDIAFPSPIGVKRLLAKFAPVTKQ CCCCCCEEEEECCCCCCHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9701819; 9384377 [H]