Click here to switch to the map view.

The map label for this gene is clpC [H]

Identifier: 49183115

GI number: 49183115

Start: 89691

End: 92126

Strand: Direct

Name: clpC [H]

Synonym: BAS0081

Alternate gene names: 49183115

Gene position: 89691-92126 (Clockwise)

Preceding gene: 49183114

Following gene: 49183116

Centisome position: 1.72

GC content: 39.12

Gene sequence:

>2436_bases
ATGATGTTTGGAAGATTTACAGAAAGAGCACAGAAAGTATTAGCTTTATCTCAAGAGGAAGCAATTCGTATTGGGCATAA
CAATATTGGAACAGAACATATTTTACTTGGGCTTGTACGCGAAGGTGAAGGAATTGCAGCAAAAGCGTTGATTGCTCTTG
GATTAAGTCCAGAGAAGGTTCAAAAAGAAGTAGAAGCGTTAATCGGACGTGGAACAGAAGCTTCTCAAACTGTACATTAT
ACACCGCGTGCTAAAAAGGTTATTGAGCTGTCTATGGATGAAGCTCGTAAATTAGGTCATTCTTACGTTGGAACAGAACA
TATTTTACTTGGTTTAATCCGCGAAGGTGAAGGGGTAGCGGCACGCGTTTTAAATAACTTAGGTGTTAGCCTAAATAAGG
CAAGACAACAAGTATTGCAACTTCTTGGAAGTAATGAAGCAAGTTCAGGTCACCAAGGTGGTTCTTCAACAAATGCAAAT
ACACCAACACTTGATAGCTTAGCGCGTGATTTAACAGTTGTTGCACGTGAAAATCGTTTAGACCCTGTTATTGGACGTGG
TAAAGAAATTCAACGTGTAATTGAAGTTTTAAGCCGTAGAACAAAAAACAATCCTGTATTAATCGGGGAGCCTGGTGTAG
GTAAAACGGCAATTGCGGAAGGATTAGCACAACAAATCGTAAATAATGAAGTTCCTGAAACTTTACGAGATAAGCGTGTT
ATGACACTAGATATGGGTACAGTGGTAGCTGGAACGAAATACCGTGGTGAATTTGAAGACCGTTTGAAGAAAGTAATGGA
TGAAATTCGCCAAGCGGGAAATATCATTCTATTTATTGATGAACTTCATACATTAATCGGTGCAGGTGGAGCAGAAGGTG
CTATTGACGCATCGAATATTTTAAAACCATCTTTAGCTCGTGGGGAATTACAATGTATCGGGGCGACAACGTTAGATGAA
TATCGCAAATATATTGAAAAAGACGCAGCTTTAGAGAGACGTTTCCAACCAATTCACGTTGATGAGCCAAGTTTAGATGA
ATCAACTCAAATTTTGAAAGGTTTACGCGATCGTTATGAGGCACATCACCGCGTATCTATTACAGATGATGCAATTGATG
CAGCTGTAAAGCTTTCAGATCGTTATATTACAGATCGTTTCTTACCAGATAAAGCAATTGATTTAATTGATGAAGCTGCT
TCAAAGGTTCGCTTACGCTCTTATACAACACCACCAAATCTAAAAGAGCTTGAAGTGAAGCTTGAGGAAATTAGAAAAGA
AAAAGATGCAGCTGTACAAAGTCAAGAGTTTGAAAAAGCTGCTTCCTTACGTGATATGGAACAACGTTTACGCGAGAAGT
TAGAAGATACGAAGCGTCAATGGAAAGAACAACAAGGAAAAGAAAACTCAGAAGTGACAGTAGAAGATATTGCAAATGTT
GTTTCTACATGGACTCGTATCCCGGTTTCTAAACTTGCACAAACAGAGACTGATAAATTATTAAACTTAGAATCCATCCT
TCACGATCGTGTTATTGGTCAAGATGAAGCGGTAGTAGCTGTAGCGAAAGCTGTTCGCCGTGCTAGAGCAGGATTGAAAG
ATCCGAAACGTCCAATTGGGTCATTTATTTTCTTAGGGCCAACAGGTGTAGGTAAAACGGAGCTAGCAAGAGCGTTAGCA
GAATCTATGTTCGGTGATGAAGATGCAATGATTCGCATCGATATGTCTGAGTACATGGAGAAGCATTCTACTTCTCGTTT
AGTTGGGTCTCCTCCAGGGTATGTTGGATATGAAGAAGGTGGACAATTAACAGAAAAGGTTCGCCGTAAGCCATATTCAG
TTGTCCTATTAGACGAAGTAGAGAAAGCTCATCCTGATGTGTTTAACATTTTACTACAAGTATTAGAAGATGGTCGCTTA
ACAGATTCGAAAGGGCGTACGGTTGATTTCCGCAATACAATTGTTATTATGACATCTAACGTTGGTGCAGAGGCGTTAAA
ACGTAATAAGCATCTTGGATTTAACGTACAAGATGAGAGCCGCGATTATTCGGATATGAAAGGTAAAGTAATGGATGAGC
TGAAAAAAGCCTTCCGTCCAGAATTCTTAAACCGTATTGATGAAATTATCGTGTTCCATATGCTTGAGAAAAAACATATT
CAAGAGATTGTAACACTTATGGTAAATCAGTTAGTAAATCGCTTAAAAGAGCAAGAAATTGAATTGCATTTAACAGAAGG
AGCAATTTCGGCTATTGCTGATAAAGGGTTTGACCGAGAGTACGGTGCTCGCCCGCTTCGTAGAGCGATTCAGAAACATG
TAGAAGATAGACTATCCGAAGAACTGTTAAAAGGTGCTATTGAGAAAGGGCAGAAAGTTATCTTTGATGTTGAAGGAGAA
TCATTTGTCATTCATAGTGCCGAAAAGGTAAAATAA

Upstream 100 bases:

>100_bases
GGACCTTTAGGCCCAGAAGAAAGAGATTATCGAAGAGCAACCTTAATCCGTGAGCGATTACGTATTGAAAAAAACTAAGC
GCAAGTAGGAGGCGATTTCT

Downstream 100 bases:

>100_bases
GTATAGACAAACTAAGAGGGCTACGAGATAGCCCTCTTTCTTGTACGAGAAGGATAAACTGTCTATAGATGAAAGTGAAG
TGAAATATAAAACGATATGG

Product: negative regulator of genetic competence ClpC/MecB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 811; Mature: 811

Protein sequence:

>811_residues
MMFGRFTERAQKVLALSQEEAIRIGHNNIGTEHILLGLVREGEGIAAKALIALGLSPEKVQKEVEALIGRGTEASQTVHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNEASSGHQGGSSTNAN
TPTLDSLARDLTVVARENRLDPVIGRGKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPSLDESTQILKGLRDRYEAHHRVSITDDAIDAAVKLSDRYITDRFLPDKAIDLIDEAA
SKVRLRSYTTPPNLKELEVKLEEIRKEKDAAVQSQEFEKAASLRDMEQRLREKLEDTKRQWKEQQGKENSEVTVEDIANV
VSTWTRIPVSKLAQTETDKLLNLESILHDRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
ESMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEVEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIVIMTSNVGAEALKRNKHLGFNVQDESRDYSDMKGKVMDELKKAFRPEFLNRIDEIIVFHMLEKKHI
QEIVTLMVNQLVNRLKEQEIELHLTEGAISAIADKGFDREYGARPLRRAIQKHVEDRLSEELLKGAIEKGQKVIFDVEGE
SFVIHSAEKVK

Sequences:

>Translated_811_residues
MMFGRFTERAQKVLALSQEEAIRIGHNNIGTEHILLGLVREGEGIAAKALIALGLSPEKVQKEVEALIGRGTEASQTVHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNEASSGHQGGSSTNAN
TPTLDSLARDLTVVARENRLDPVIGRGKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPSLDESTQILKGLRDRYEAHHRVSITDDAIDAAVKLSDRYITDRFLPDKAIDLIDEAA
SKVRLRSYTTPPNLKELEVKLEEIRKEKDAAVQSQEFEKAASLRDMEQRLREKLEDTKRQWKEQQGKENSEVTVEDIANV
VSTWTRIPVSKLAQTETDKLLNLESILHDRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
ESMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEVEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIVIMTSNVGAEALKRNKHLGFNVQDESRDYSDMKGKVMDELKKAFRPEFLNRIDEIIVFHMLEKKHI
QEIVTLMVNQLVNRLKEQEIELHLTEGAISAIADKGFDREYGARPLRRAIQKHVEDRLSEELLKGAIEKGQKVIFDVEGE
SFVIHSAEKVK
>Mature_811_residues
MMFGRFTERAQKVLALSQEEAIRIGHNNIGTEHILLGLVREGEGIAAKALIALGLSPEKVQKEVEALIGRGTEASQTVHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNEASSGHQGGSSTNAN
TPTLDSLARDLTVVARENRLDPVIGRGKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPSLDESTQILKGLRDRYEAHHRVSITDDAIDAAVKLSDRYITDRFLPDKAIDLIDEAA
SKVRLRSYTTPPNLKELEVKLEEIRKEKDAAVQSQEFEKAASLRDMEQRLREKLEDTKRQWKEQQGKENSEVTVEDIANV
VSTWTRIPVSKLAQTETDKLLNLESILHDRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
ESMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEVEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIVIMTSNVGAEALKRNKHLGFNVQDESRDYSDMKGKVMDELKKAFRPEFLNRIDEIIVFHMLEKKHI
QEIVTLMVNQLVNRLKEQEIELHLTEGAISAIADKGFDREYGARPLRRAIQKHVEDRLSEELLKGAIEKGQKVIFDVEGE
SFVIHSAEKVK

Specific function: Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=310, Percent_Identity=38.7096774193548, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1788943, Length=871, Percent_Identity=47.8760045924225, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=806, Percent_Identity=38.833746898263, Blast_Score=515, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=47.7337110481586, Blast_Score=641, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=868, Percent_Identity=37.5576036866359, Blast_Score=535, Evalue=1e-153,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 90532; Mature: 90532

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGRFTERAQKVLALSQEEAIRIGHNNIGTEHILLGLVREGEGIAAKALIALGLSPEKV
CCCCHHHHHHHHHHHHCHHHHHEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
QKEVEALIGRGTEASQTVHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
ARVLNNLGVSLNKARQQVLQLLGSNEASSGHQGGSSTNANTPTLDSLARDLTVVARENRL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DPVIGRGKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
CCHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCEE
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNI
EEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIHVDEPSLDESTQILKGLRDRYE
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
AHHRVSITDDAIDAAVKLSDRYITDRFLPDKAIDLIDEAASKVRLRSYTTPPNLKELEVK
HCCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEEIRKEKDAAVQSQEFEKAASLRDMEQRLREKLEDTKRQWKEQQGKENSEVTVEDIANV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHH
VSTWTRIPVSKLAQTETDKLLNLESILHDRVIGQDEAVVAVAKAVRRARAGLKDPKRPIG
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
SFIFLGPTGVGKTELARALAESMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGYEEG
CEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCC
GQLTEKVRRKPYSVVLLDEVEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTIVIMTSN
CHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECC
VGAEALKRNKHLGFNVQDESRDYSDMKGKVMDELKKAFRPEFLNRIDEIIVFHMLEKKHI
CCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
QEIVTLMVNQLVNRLKEQEIELHLTEGAISAIADKGFDREYGARPLRRAIQKHVEDRLSE
HHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ELLKGAIEKGQKVIFDVEGESFVIHSAEKVK
HHHHHHHHCCCEEEEEECCCEEEEECHHHCC
>Mature Secondary Structure
MMFGRFTERAQKVLALSQEEAIRIGHNNIGTEHILLGLVREGEGIAAKALIALGLSPEKV
CCCCHHHHHHHHHHHHCHHHHHEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
QKEVEALIGRGTEASQTVHYTPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVA
HHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHH
ARVLNNLGVSLNKARQQVLQLLGSNEASSGHQGGSSTNANTPTLDSLARDLTVVARENRL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DPVIGRGKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
CCHHCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCEE
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNI
EEEECCCEEECCCCCCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCHHHH
LKPSLARGELQCIGATTLDEYRKYIEKDAALERRFQPIHVDEPSLDESTQILKGLRDRYE
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
AHHRVSITDDAIDAAVKLSDRYITDRFLPDKAIDLIDEAASKVRLRSYTTPPNLKELEVK
HCCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LEEIRKEKDAAVQSQEFEKAASLRDMEQRLREKLEDTKRQWKEQQGKENSEVTVEDIANV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHH
VSTWTRIPVSKLAQTETDKLLNLESILHDRVIGQDEAVVAVAKAVRRARAGLKDPKRPIG
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
SFIFLGPTGVGKTELARALAESMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGYEEG
CEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCC
GQLTEKVRRKPYSVVLLDEVEKAHPDVFNILLQVLEDGRLTDSKGRTVDFRNTIVIMTSN
CHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECC
VGAEALKRNKHLGFNVQDESRDYSDMKGKVMDELKKAFRPEFLNRIDEIIVFHMLEKKHI
CCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
QEIVTLMVNQLVNRLKEQEIELHLTEGAISAIADKGFDREYGARPLRRAIQKHVEDRLSE
HHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ELLKGAIEKGQKVIFDVEGESFVIHSAEKVK
HHHHHHHHCCCEEEEEECCCEEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8016066; 7584024; 9384377; 8195092 [H]