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The map label for this gene is folK [H]

Identifier: 49183108

GI number: 49183108

Start: 78700

End: 79215

Strand: Direct

Name: folK [H]

Synonym: BAS0073

Alternate gene names: 49183108

Gene position: 78700-79215 (Clockwise)

Preceding gene: 49183107

Following gene: 49183109

Centisome position: 1.51

GC content: 34.11

Gene sequence:

>516_bases
ATGAATAATATAGCTTACATTGCATTAGGTTCAAATATTGGAGAACGTTATACGTATTTAACGGAAGCGATTCAGTTTCT
AAATAAAAATCCTTATATCAAAGTTGAAGATGTTTCATCTGTATATGAAACGGAACCAGTTGGCTATACTGACCAAAGTT
GCTTTTTAAATTTAGTTATAAAAATTTCTACCAATTTATCACCGCAAGAATTATTGAAAGTAACGCAAAAAGTAGAAAAT
GACCTAGGAAGAAAAAGGGAAATTAGGTGGGGCCCTAGGACTATCGACCTTGACATTTTACTATATAATCAAGAAAATAT
TGAAGCAGAGAATCTTATTGTTCCGCATCCGCGGATGTTCGAAAGAGCTTTTGTTATCGTTCCGTTGTTAGAGATTAATC
AAGATATAAAACAAAACATTTCACGTTCACAAGTAGAAGAAATGAAAAGGCGAGAGGGAGTAACGGTATGGAAGCAGAAA
AATGGGGAAGACGCATTCGTGCTTTTCGAAAACTAA

Upstream 100 bases:

>100_bases
ATGAGAGTATTTCAAGATGTACGATAAAGGTAATTAAACCGGATCCGCCGATACCGGGACATTATCGTGCTGTAGCGGTA
GAAATTACGAGAGAACGTCC

Downstream 100 bases:

>100_bases
AAGGTTATACGCAAGAAGGTTTTGCAAAAGAATTAGGGGTATCTGTATCTGTTTTAGGTGAAGTTGAGAGAGGGAATCGA
TCGCCTTCCCAAGATTTTGT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIKVEDVSSVYETEPVGYTDQSCFLNLVIKISTNLSPQELLKVTQKVEN
DLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMFERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFEN

Sequences:

>Translated_171_residues
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIKVEDVSSVYETEPVGYTDQSCFLNLVIKISTNLSPQELLKVTQKVEN
DLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMFERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFEN
>Mature_171_residues
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIKVEDVSSVYETEPVGYTDQSCFLNLVIKISTNLSPQELLKVTQKVEN
DLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMFERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQK
NGEDAFVLFEN

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=135, Percent_Identity=42.962962962963, Blast_Score=113, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=136, Percent_Identity=41.9117647058824, Blast_Score=117, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19908; Mature: 19908

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIKVEDVSSVYETEPVGYTDQSCFLNLVI
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCCCCCCHHHEEEEEE
KISTNLSPQELLKVTQKVENDLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMF
EEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEECCCCHHH
ERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQKNGEDAFVLFEN
HHHEEEEEHHHCCHHHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEC
>Mature Secondary Structure
MNNIAYIALGSNIGERYTYLTEAIQFLNKNPYIKVEDVSSVYETEPVGYTDQSCFLNLVI
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCCCCCCHHHEEEEEE
KISTNLSPQELLKVTQKVENDLGRKREIRWGPRTIDLDILLYNQENIEAENLIVPHPRMF
EEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCCCEECCCCHHH
ERAFVIVPLLEINQDIKQNISRSQVEEMKRREGVTVWKQKNGEDAFVLFEN
HHHEEEEEHHHCCHHHHHCCCHHHHHHHHHHCCCEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 2123867 [H]