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The map label for this gene is accC1 [H]

Identifier: 161611179

GI number: 161611179

Start: 4022118

End: 4023470

Strand: Reverse

Name: accC1 [H]

Synonym: BAS4088

Alternate gene names: 161611179

Gene position: 4023470-4022118 (Counterclockwise)

Preceding gene: 49187087

Following gene: 49187085

Centisome position: 76.95

GC content: 39.39

Gene sequence:

>1353_bases
ATGATAAAAAAAGTATTAATAGCCAATCGTGGGGAAATTGCTGTACGAATTATTCGTGCTTGTAAAGAAATGGATATTGA
AACAGTCGCAATTTATTCAGAAGCAGATAAAGAGTCACTTCACGTACAAATTGCTGATGAGGCGTATTGTGTAGGACCAA
CGATCTCGAAAGAAAGCTATTTAAATTTGACGAACATTATTAGTGTTGCGAAGTTAACAGGCTGCGATGCTATTCATCCA
GGATATGGATTTTTAGCTGAGAATGCAGATTTTGCAGAGTTATGCCGTGAATGTAACTTAATTTTTATCGGTCCAAGTCC
AGAAGCTATTTCAAAGATGGGCACAAAAGACGTTGCTCGTGATACAATGAAAGAAGCAGGGGTTCCGATTGTACCAGGTT
CACAAGGAATTATTAAAAATACCGAAGAAGCGATTGAACTTGCTAATCAAATTGGATATCCAGTTATTATTAAAGCGACT
GCAGGTGGCGGCGGAAAAGGTATTCGTGTTGCGCGCCATGAAGAAGAGCTTGTAAAAGGAATTCAAATTACACAGCAAGA
AGCTAGTACCGCTTTTGGGAACCCTGGTGTATACTTAGAAAAGTACGTTGAAGATTTCCGCCATGTTGAGATTCAAATAA
TGGCAGATACACACGGAAATGCCATTCATTTAGGAGAGCGTGATTGTACAATTCAACGCCGCTTGCAAAAACTACTAGAA
GAAAGTCCATCACCAGCACTTGATGAAAATGTGCGTAAACAGATGGGTGAGGCGGCAGTTAAAGCGGCGGTAGCGGTTGA
TTATACAGGTGCTGGTACGGTTGAGTTTATTTATGAATATAAAACGAAAAGCTTTTATTTCATGGAGATGAATACGAGAA
TTCAAGTTGAGCATCCAGTTACTGAAATGGTAACAGGGGTGGACTTAATTAAAGAACAAATTCTTGTTGCTTCTGGAGAA
AAGTTATCGTTACAGCAAGAAGAAGTACAATTTAATGGTTGGGCAATTGAATGCCGAATTAATGCGGAAAACCCTGCCAA
AAAATTTATGCCATCTCCAGGTAAAGTAGAAATGTACTTGCCACCAGGCGGATTTGGTATTCGCGTCGATTCAGCTGTAT
ATCCGGGATATTCAATCCCACCTTTCTATGATTCGATGGTTGCTAAATTAATTGTTCACGGAAAAACACGTGAAGAGGCA
ATTGCAAAAATGAAGCGTGCACTCAGTGAGTTTGTCGTTGAAGGCGTACATACAACAATCCCGTTCCATTTGCAATTGTT
AGATCATCCTGATTTTGTAAAAGGTGAGTTTAATACGAAATTTTTGGAAGAGCATGAACTTGTGACGCAGTGA

Upstream 100 bases:

>100_bases
GTAGATGGCGAAATTGTTGAGATTCTTGTTAATAACGGACAACTTGTAGAGTATGGACAACCGCTATTTCTTGTAAAAGC
GTAATAAGGGAGTCTTTGTG

Downstream 100 bases:

>100_bases
TACATTAAAGGAGGTTTTTTTCATGGCTGAACATATGTTAGATATGGGTCAAGATACAACTCTTGGTAAAGTAGAAATTG
CACCAGAAGTAATTGAAGTA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTISKESYLNLTNIISVAKLTGCDAIHP
GYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVARDTMKEAGVPIVPGSQGIIKNTEEAIELANQIGYPVIIKAT
AGGGGKGIRVARHEEELVKGIQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADTHGNAIHLGERDCTIQRRLQKLLE
ESPSPALDENVRKQMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPVTEMVTGVDLIKEQILVASGE
KLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYLPPGGFGIRVDSAVYPGYSIPPFYDSMVAKLIVHGKTREEA
IAKMKRALSEFVVEGVHTTIPFHLQLLDHPDFVKGEFNTKFLEEHELVTQ

Sequences:

>Translated_450_residues
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTISKESYLNLTNIISVAKLTGCDAIHP
GYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVARDTMKEAGVPIVPGSQGIIKNTEEAIELANQIGYPVIIKAT
AGGGGKGIRVARHEEELVKGIQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADTHGNAIHLGERDCTIQRRLQKLLE
ESPSPALDENVRKQMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPVTEMVTGVDLIKEQILVASGE
KLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYLPPGGFGIRVDSAVYPGYSIPPFYDSMVAKLIVHGKTREEA
IAKMKRALSEFVVEGVHTTIPFHLQLLDHPDFVKGEFNTKFLEEHELVTQ
>Mature_450_residues
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTISKESYLNLTNIISVAKLTGCDAIHP
GYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVARDTMKEAGVPIVPGSQGIIKNTEEAIELANQIGYPVIIKAT
AGGGGKGIRVARHEEELVKGIQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADTHGNAIHLGERDCTIQRRLQKLLE
ESPSPALDENVRKQMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPVTEMVTGVDLIKEQILVASGE
KLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYLPPGGFGIRVDSAVYPGYSIPPFYDSMVAKLIVHGKTREEA
IAKMKRALSEFVVEGVHTTIPFHLQLLDHPDFVKGEFNTKFLEEHELVTQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=49.438202247191, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=49.6613995485327, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=49.6613995485327, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=49.6613995485327, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=48.1069042316258, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=48.1069042316258, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=48.1069042316258, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=31.237721021611, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=31.237721021611, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=31.237721021611, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=31.237721021611, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=31.237721021611, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=31.1764705882353, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=53.9325842696629, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI71987519, Length=446, Percent_Identity=47.7578475336323, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=46.9933184855234, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=44.4695259593679, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=30.142566191446, Blast_Score=225, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=30.0395256916996, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=30.0395256916996, Blast_Score=215, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=45.1901565995526, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=43.8752783964365, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=44.543429844098, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=31.9565217391304, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=30.5609284332689, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.0674157303371, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=47.8841870824053, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=45.7002457002457, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=30.7539682539683, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=30.7539682539683, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=30.7539682539683, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=30.7539682539683, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49766; Mature: 49766

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTISKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCCHHH
LNLTNIISVAKLTGCDAIHPGYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
DTMKEAGVPIVPGSQGIIKNTEEAIELANQIGYPVIIKATAGGGGKGIRVARHEEELVKG
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHH
IQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADTHGNAIHLGERDCTIQRRLQKLLE
HHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDENVRKQMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPV
CCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCEEEEEEECCEEEEECCH
TEMVTGVDLIKEQILVASGEKLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCEEEEEEECCCCCHHHHCCCCCCEEEEE
PPGGFGIRVDSAVYPGYSIPPFYDSMVAKLIVHGKTREEAIAKMKRALSEFVVEGVHTTI
CCCCCEEEECCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
PFHLQLLDHPDFVKGEFNTKFLEEHELVTQ
CEEEEEECCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTISKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCCHHH
LNLTNIISVAKLTGCDAIHPGYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
DTMKEAGVPIVPGSQGIIKNTEEAIELANQIGYPVIIKATAGGGGKGIRVARHEEELVKG
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHH
IQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADTHGNAIHLGERDCTIQRRLQKLLE
HHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDENVRKQMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPV
CCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCEEEEEEECCEEEEECCH
TEMVTGVDLIKEQILVASGEKLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCEEEEEEECCCCCHHHHCCCCCCEEEEE
PPGGFGIRVDSAVYPGYSIPPFYDSMVAKLIVHGKTREEAIAKMKRALSEFVVEGVHTTI
CCCCCEEEECCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
PFHLQLLDHPDFVKGEFNTKFLEEHELVTQ
CEEEEEECCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]