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The map label for this gene is gltA [H]

Identifier: 46447405

GI number: 46447405

Start: 2123290

End: 2124450

Strand: Reverse

Name: gltA [H]

Synonym: pc1771

Alternate gene names: 46447405

Gene position: 2124450-2123290 (Counterclockwise)

Preceding gene: 46447406

Following gene: 46447404

Centisome position: 87.99

GC content: 37.47

Gene sequence:

>1161_bases
ATGTCTGAAGTCCTGTTCGAAATAACAAAAGAAAGCTTAGAAACTGGTTTAAGGGGTTATCCAGTCGGGTACTGCACAAC
TTCAAGTGTTGATCCTGTCAAAGGTCTTTTTTATGCAGGGCATCCAGTATCAGAAATTGATCAATGGGAACCCGAGCAAG
TAATTTATTTGCTTTATCATGGATATGTTGGTAAACCTGAAGAGGTTTCTAGATTTAGTCAAGATTTATTAATAAGAGCC
AATTGCTCAACAGCGTTGATTGAATCGATTGAAAAATTGCCTAGAAATATTCATCCTATGAAACTTTTTTCTATTGCTTT
ACTTTTAGCAAGTGGATTTGAAGGAAAAAATGATTATCATGAAGATTATTTAAATTTAATCGCGAAAGTTCCTGAAATTG
CAGCGACTGTTATTAACCATCATGCAGGATGGGGGAAGACCAAACAATCACAGCCTCAACTCGGCTATATGGAAAATTTT
ACGCAAATGCTTAATGTGCCAGATGCTAATCAGCAAGAGTTAGCAAGAGCCTTTAAATTTTTTAACGTTTTGCACTATGA
TCATGGAGGAGGGAATCTTTCAGCTTTTGTTGGTAAAGCTGTTGCTTCAGGCTTAGAAGATTTATATGGATCTATGTCAG
CAGCTATGTGTGCATTAGCAGGGCCACGTCATGGAAAGGCTAATCAAGATTGTTTGACTTTTGTTCATCAACTCGTTGAA
GAGTTAGGCGAACATAGCACAGAAGAAGAATTAGAAAGGCTTATTCGGGCTCATTTAGATAAAGGAGAGTTGATATTTGG
CTTTGGACACGCCGTTTTACGTGTTGAGGATCCACGAGCTACTCTTCTTTACGAAGTAACTAATCAGTATTATGCTTCCC
ATGCTCTTGTAAAAATGGCACAGCTTTTAAGAAAAGTGGGTAGTAAAGTGTTGCAAAATAATCCTAAAATTTCAGATCCT
TATCCCAACGTTGATGCTATTTCAGGAATTTTATTGACAGCCGCTGGCTTTCCTTGTTCTGAATATTACACTGTTTTGTT
TGGACTTGCACGTGTAGTGGGAATTGGAAGACAAATCGTCTATGAAAGAAAAGAAGCGCGAGAAGGAAAAGGCACGCCAA
TTGTGAGACCTAAATACTTTTTTAAGGAAAATAAACAATAG

Upstream 100 bases:

>100_bases
AATTAAAAGAAGAAAGAGAGATGGTTAGTTCAATATTAAAAATTTGAAATATTTTATTTTTTTATTTGATATAAAGATGG
ATTAAACCCAAGGAATCGTT

Downstream 100 bases:

>100_bases
AAGATTTAATGGATTTTAATGCAATTTCTCATATTTTTAATCGGGCTCTAGCTTTAACATTTACAAAGAAAAAACTTTTA
TTGGTTTTTTGTATTCTTGC

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSEVLFEITKESLETGLRGYPVGYCTTSSVDPVKGLFYAGHPVSEIDQWEPEQVIYLLYHGYVGKPEEVSRFSQDLLIRA
NCSTALIESIEKLPRNIHPMKLFSIALLLASGFEGKNDYHEDYLNLIAKVPEIAATVINHHAGWGKTKQSQPQLGYMENF
TQMLNVPDANQQELARAFKFFNVLHYDHGGGNLSAFVGKAVASGLEDLYGSMSAAMCALAGPRHGKANQDCLTFVHQLVE
ELGEHSTEEELERLIRAHLDKGELIFGFGHAVLRVEDPRATLLYEVTNQYYASHALVKMAQLLRKVGSKVLQNNPKISDP
YPNVDAISGILLTAAGFPCSEYYTVLFGLARVVGIGRQIVYERKEAREGKGTPIVRPKYFFKENKQ

Sequences:

>Translated_386_residues
MSEVLFEITKESLETGLRGYPVGYCTTSSVDPVKGLFYAGHPVSEIDQWEPEQVIYLLYHGYVGKPEEVSRFSQDLLIRA
NCSTALIESIEKLPRNIHPMKLFSIALLLASGFEGKNDYHEDYLNLIAKVPEIAATVINHHAGWGKTKQSQPQLGYMENF
TQMLNVPDANQQELARAFKFFNVLHYDHGGGNLSAFVGKAVASGLEDLYGSMSAAMCALAGPRHGKANQDCLTFVHQLVE
ELGEHSTEEELERLIRAHLDKGELIFGFGHAVLRVEDPRATLLYEVTNQYYASHALVKMAQLLRKVGSKVLQNNPKISDP
YPNVDAISGILLTAAGFPCSEYYTVLFGLARVVGIGRQIVYERKEAREGKGTPIVRPKYFFKENKQ
>Mature_385_residues
SEVLFEITKESLETGLRGYPVGYCTTSSVDPVKGLFYAGHPVSEIDQWEPEQVIYLLYHGYVGKPEEVSRFSQDLLIRAN
CSTALIESIEKLPRNIHPMKLFSIALLLASGFEGKNDYHEDYLNLIAKVPEIAATVINHHAGWGKTKQSQPQLGYMENFT
QMLNVPDANQQELARAFKFFNVLHYDHGGGNLSAFVGKAVASGLEDLYGSMSAAMCALAGPRHGKANQDCLTFVHQLVEE
LGEHSTEEELERLIRAHLDKGELIFGFGHAVLRVEDPRATLLYEVTNQYYASHALVKMAQLLRKVGSKVLQNNPKISDPY
PNVDAISGILLTAAGFPCSEYYTVLFGLARVVGIGRQIVYERKEAREGKGTPIVRPKYFFKENKQ

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=408, Percent_Identity=33.3333333333333, Blast_Score=205, Evalue=7e-53,
Organism=Escherichia coli, GI1786939, Length=376, Percent_Identity=27.1276595744681, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786527, Length=377, Percent_Identity=23.8726790450928, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17555174, Length=403, Percent_Identity=33.4987593052109, Blast_Score=207, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6324328, Length=406, Percent_Identity=32.7586206896552, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319850, Length=408, Percent_Identity=32.3529411764706, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6325257, Length=414, Percent_Identity=29.7101449275362, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21356863, Length=404, Percent_Identity=32.6732673267327, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24640124, Length=399, Percent_Identity=32.5814536340852, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24640126, Length=399, Percent_Identity=32.5814536340852, Blast_Score=198, Evalue=6e-51,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 43058; Mature: 42926

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLFEITKESLETGLRGYPVGYCTTSSVDPVKGLFYAGHPVSEIDQWEPEQVIYLLYH
CCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHEECCCCHHHHHCCCHHHHEEHEEC
GYVGKPEEVSRFSQDLLIRANCSTALIESIEKLPRNIHPMKLFSIALLLASGFEGKNDYH
CCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHH
EDYLNLIAKVPEIAATVINHHAGWGKTKQSQPQLGYMENFTQMLNVPDANQQELARAFKF
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
FNVLHYDHGGGNLSAFVGKAVASGLEDLYGSMSAAMCALAGPRHGKANQDCLTFVHQLVE
HHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ELGEHSTEEELERLIRAHLDKGELIFGFGHAVLRVEDPRATLLYEVTNQYYASHALVKMA
HHHCCCCHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QLLRKVGSKVLQNNPKISDPYPNVDAISGILLTAAGFPCSEYYTVLFGLARVVGIGRQIV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YERKEAREGKGTPIVRPKYFFKENKQ
HHHHHHCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
SEVLFEITKESLETGLRGYPVGYCTTSSVDPVKGLFYAGHPVSEIDQWEPEQVIYLLYH
CHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHEECCCCHHHHHCCCHHHHEEHEEC
GYVGKPEEVSRFSQDLLIRANCSTALIESIEKLPRNIHPMKLFSIALLLASGFEGKNDYH
CCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHH
EDYLNLIAKVPEIAATVINHHAGWGKTKQSQPQLGYMENFTQMLNVPDANQQELARAFKF
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
FNVLHYDHGGGNLSAFVGKAVASGLEDLYGSMSAAMCALAGPRHGKANQDCLTFVHQLVE
HHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ELGEHSTEEELERLIRAHLDKGELIFGFGHAVLRVEDPRATLLYEVTNQYYASHALVKMA
HHHCCCCHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
QLLRKVGSKVLQNNPKISDPYPNVDAISGILLTAAGFPCSEYYTVLFGLARVVGIGRQIV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
YERKEAREGKGTPIVRPKYFFKENKQ
HHHHHHCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]