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The map label for this gene is prsA [H]

Identifier: 46447229

GI number: 46447229

Start: 1909193

End: 1910134

Strand: Reverse

Name: prsA [H]

Synonym: pc1595

Alternate gene names: 46447229

Gene position: 1910134-1909193 (Counterclockwise)

Preceding gene: 46447232

Following gene: 46447228

Centisome position: 79.11

GC content: 38.96

Gene sequence:

>942_bases
ATGTCCTTTTGCCACCAACCACTATTATTTGCTGGATCTTCACATCCCATTCTTGCAACTGAAATTGCCCAACAACTCAA
AATTTCTCTTGGTCAAATGCAGTTAAGCAAGTTTCCTGATGGGGAAATAGGGGTGCAGCTTTTGGAGAGTGTGCGTGGTA
AAGATACTTTTGTTTTACAATCGATTGCTCTTGATCCCAATTTTTATTTGATGGAATTACTAATTATTGTTGATGCCCTC
AAAAGAGCATCAGCGCGAAATATTGTAGCAGTGATTCCTTATTATGGATATTGCCGACAAGACCGTAAAGATAAGTTTGA
TGTGTCAATTACAGCGAAACTCGTTGCAAATTTATTGGTAGAAGCCGGCATAACGCGAATTTTGACAATGGATCTTCATG
TAGATCAATTGCAAGGGTTTTTTGATATTCCTGTAGATCATCTTAGTGGACGTCAACTATTGATTGATGAATTACAGAAA
TTAGATTTGACTAATAGTATCGTTGTAGCTCCCGATATAGGAAGCGTCAAAACAGCTCGAACTTTTGCAAGTCAGCTCAG
TGTTGATTTTGCAATCGTTGATAAGCACCGGAAAAGTGCTATAGAAGTTGTAGACTATCACCTAATCGGGGATGTTAACG
GAAAAGATGTACTTCTCGCTGACGATATCTGCTCAACTGGAGCGACATTAATGTCAGCAGCGAAAGCATGCCAAGAGAAG
GGAGCAAATCGTATTTTTGCTGCATTTACCCACGGTTTACTTGTGGATGATTCAGTTAAGCAGATAGAAAATAGTTTGCT
CGAAATAGTATGGATGACGAACACCATTCCTCATACTAAACGGTTAAAAGAAGCTTCTAAGCTTAAAACCGTTTCCATAG
CCTCTCTTTTGACTCATGCCATCCAATGCATTGTATCGGATGAGTCCATTTCTTCTTTATAA

Upstream 100 bases:

>100_bases
CGGTTCATCGATGGGGTGTAGCCAAGCGGTAAGGCAGCGGTTTTTGGTACCGCCATGCGGAGGTTCGAATCCTTCCACCC
CAATGTTATAGGCAATTCAG

Downstream 100 bases:

>100_bases
CATATATAAATGTGTGATAAACTTTTTGAAAAAATGACTGAAAAATTTAGTAACGTAAGTTTTAAATAAGAAAAAAATCT
ATTTCAAACTATCTTTAGTA

Product: phosphoribosyl pyrophosphate synthetase (PRPP)

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSFCHQPLLFAGSSHPILATEIAQQLKISLGQMQLSKFPDGEIGVQLLESVRGKDTFVLQSIALDPNFYLMELLIIVDAL
KRASARNIVAVIPYYGYCRQDRKDKFDVSITAKLVANLLVEAGITRILTMDLHVDQLQGFFDIPVDHLSGRQLLIDELQK
LDLTNSIVVAPDIGSVKTARTFASQLSVDFAIVDKHRKSAIEVVDYHLIGDVNGKDVLLADDICSTGATLMSAAKACQEK
GANRIFAAFTHGLLVDDSVKQIENSLLEIVWMTNTIPHTKRLKEASKLKTVSIASLLTHAIQCIVSDESISSL

Sequences:

>Translated_313_residues
MSFCHQPLLFAGSSHPILATEIAQQLKISLGQMQLSKFPDGEIGVQLLESVRGKDTFVLQSIALDPNFYLMELLIIVDAL
KRASARNIVAVIPYYGYCRQDRKDKFDVSITAKLVANLLVEAGITRILTMDLHVDQLQGFFDIPVDHLSGRQLLIDELQK
LDLTNSIVVAPDIGSVKTARTFASQLSVDFAIVDKHRKSAIEVVDYHLIGDVNGKDVLLADDICSTGATLMSAAKACQEK
GANRIFAAFTHGLLVDDSVKQIENSLLEIVWMTNTIPHTKRLKEASKLKTVSIASLLTHAIQCIVSDESISSL
>Mature_312_residues
SFCHQPLLFAGSSHPILATEIAQQLKISLGQMQLSKFPDGEIGVQLLESVRGKDTFVLQSIALDPNFYLMELLIIVDALK
RASARNIVAVIPYYGYCRQDRKDKFDVSITAKLVANLLVEAGITRILTMDLHVDQLQGFFDIPVDHLSGRQLLIDELQKL
DLTNSIVVAPDIGSVKTARTFASQLSVDFAIVDKHRKSAIEVVDYHLIGDVNGKDVLLADDICSTGATLMSAAKACQEKG
ANRIFAAFTHGLLVDDSVKQIENSLLEIVWMTNTIPHTKRLKEASKLKTVSIASLLTHAIQCIVSDESISSL

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=307, Percent_Identity=42.671009771987, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4506127, Length=307, Percent_Identity=42.0195439739414, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=40.9090909090909, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=40.8360128617363, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=35.3801169590643, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI194018537, Length=328, Percent_Identity=34.4512195121951, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI310128524, Length=141, Percent_Identity=32.6241134751773, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI310115209, Length=141, Percent_Identity=32.6241134751773, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI310118259, Length=141, Percent_Identity=32.6241134751773, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI310119946, Length=141, Percent_Identity=32.6241134751773, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1787458, Length=307, Percent_Identity=45.928338762215, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=41.4239482200647, Blast_Score=245, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25149168, Length=307, Percent_Identity=41.3680781758958, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17554702, Length=307, Percent_Identity=41.3680781758958, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71989924, Length=307, Percent_Identity=41.3680781758958, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=30.7462686567164, Blast_Score=171, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321776, Length=307, Percent_Identity=40.0651465798046, Blast_Score=221, Evalue=9e-59,
Organism=Saccharomyces cerevisiae, GI6320946, Length=308, Percent_Identity=40.2597402597403, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319403, Length=309, Percent_Identity=39.8058252427184, Blast_Score=215, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6322667, Length=194, Percent_Identity=39.1752577319588, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324511, Length=106, Percent_Identity=42.4528301886792, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355239, Length=307, Percent_Identity=41.3680781758958, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI45551540, Length=330, Percent_Identity=38.7878787878788, Blast_Score=232, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=33.048433048433, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=33.048433048433, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=33.048433048433, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=33.048433048433, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24651462, Length=193, Percent_Identity=38.860103626943, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24651464, Length=193, Percent_Identity=38.860103626943, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45552010, Length=193, Percent_Identity=38.860103626943, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34358; Mature: 34227

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFCHQPLLFAGSSHPILATEIAQQLKISLGQMQLSKFPDGEIGVQLLESVRGKDTFVLQ
CCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
SIALDPNFYLMELLIIVDALKRASARNIVAVIPYYGYCRQDRKDKFDVSITAKLVANLLV
EEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHH
EAGITRILTMDLHVDQLQGFFDIPVDHLSGRQLLIDELQKLDLTNSIVVAPDIGSVKTAR
HHCHHHEEEEECCHHHHCCEECCCHHHCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHH
TFASQLSVDFAIVDKHRKSAIEVVDYHLIGDVNGKDVLLADDICSTGATLMSAAKACQEK
HHHHHHCCHHEEHHHHHHHHHHHHEEEEEECCCCCEEEEECCHHHCCHHHHHHHHHHHHC
GANRIFAAFTHGLLVDDSVKQIENSLLEIVWMTNTIPHTKRLKEASKLKTVSIASLLTHA
CCCEEEHHHHCCEEECHHHHHHHHHHHEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQCIVSDESISSL
HHHHCCCCHHCCC
>Mature Secondary Structure 
SFCHQPLLFAGSSHPILATEIAQQLKISLGQMQLSKFPDGEIGVQLLESVRGKDTFVLQ
CCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
SIALDPNFYLMELLIIVDALKRASARNIVAVIPYYGYCRQDRKDKFDVSITAKLVANLLV
EEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHH
EAGITRILTMDLHVDQLQGFFDIPVDHLSGRQLLIDELQKLDLTNSIVVAPDIGSVKTAR
HHCHHHEEEEECCHHHHCCEECCCHHHCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHH
TFASQLSVDFAIVDKHRKSAIEVVDYHLIGDVNGKDVLLADDICSTGATLMSAAKACQEK
HHHHHHCCHHEEHHHHHHHHHHHHEEEEEECCCCCEEEEECCHHHCCHHHHHHHHHHHHC
GANRIFAAFTHGLLVDDSVKQIENSLLEIVWMTNTIPHTKRLKEASKLKTVSIASLLTHA
CCCEEEHHHHCCEEECHHHHHHHHHHHEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQCIVSDESISSL
HHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954 [H]