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The map label for this gene is tkt [H]

Identifier: 46447148

GI number: 46447148

Start: 1810308

End: 1812341

Strand: Reverse

Name: tkt [H]

Synonym: pc1514

Alternate gene names: 46447148

Gene position: 1812341-1810308 (Counterclockwise)

Preceding gene: 46447154

Following gene: 46447147

Centisome position: 75.06

GC content: 37.81

Gene sequence:

>2034_bases
TTGGTGAAAAATATGAGCAGCCATCTTCAAGTTTCAGTGCCTCAACCTCTCGATTCTGAGCAAAAGCAAATCATGAAACA
AATAGCAAATACCATTCGAGGTCTTTCGATGGATGCTGTTCAAAAAGCAGATTCAGGTCATCCAGGGCTTCCAATGGGAT
GTGCTGAACTTGGTGCATACTTATATGGTTATTATCTTAAGCAAAATCCCAAAAATTCTAAATGGCTCAATCGTGATCGT
TTTATTTTATCTGCTGGACACGGATCTATGTGGTTATATTCTTGTCTACACTTAGCTGGTTACAAAATCACGTTGGAAGA
CATCAAAAATTTCAGGCAGCTTCATTCCCCAACTCCAGGCCATCCAGAATCATTTATGACGGATGGTGTGGAAACAACGA
CGGGGCCTTTAGGGCAAGGTGTAGGTAATGCTGTCGGTCAAGCACTTGGATTTAAAATTCTTGGAGAAAAATTTAACACA
GAAAAGCATCCCATTTTTAATAATAAAGTTTATGTGTTAATGGGTGATGGTTGTGTAATGGAAGGGATTTCTTCAGAAGT
ATCTTCATTAGCTGGTCATTTAAAATTGAATAATTTGGTTGCTATTTATGATGCGAATCACGTTTCTTTAGATGGACCGT
TAGCAGAAAGTTCTTCAGAAGATACTAAAACTCGTTATAAGGCTTATGGTTGGGATGTATTTGAAATAGATGGAAACGAT
ATTGAAGCTATTGATACTGTATTTTCTCAAATTCGACACTATCAAGAAAAGCCTTGTTTAGTTATAGCTCATACTATTAT
TGGGAAAGGAGCCCCGAATAAAGGGGGGACTTATAAAGCCCATGGATCACCTCTTGGAGTAGAAGAAATTAAAGCAGCTA
AAGATGAACTGGGCATTCCTCAAGAAGATTTCTATGTTCCTCAAGCTGTCATCAACTACTTTCAAAATAAGCTTGTTTCC
GATGCAAAAGAACAAAATGAGTGGAAGCAAATATTTGAAGAATGGGCAAAAGAAAATCCTTCTAAATTCCAAGAATTAGA
AGTCATGCTACATCACAAACTTCCCGACGATTTCGAGCAAAAGCTTCAGCATCTGATGATTAAAGCTCCAATTTCCGGAC
GTAAAGCTTCTCAAGAAGTTCTCAATAGTTTAGCAGATATGATTCCTCAATTATACGGAGGGTCAGCTGATTTATCTTCA
TCCGATATGACAATGTTAAAGAAGTTTTCTTTAATTGCTCCTAACGAATTTCATGGACGCAATATTAAGTTCGGTGTACG
AGAATTTGGGATGGCGACAATAGCGACTGGTCTTTATCAAACTGGAATGATTCTTCCATTTGTAGGAACTTTTTTAACTT
TTTCTGATTATATGCGTAATGCAATTCGCTTGGCGGCTTTACAACATGCACAAGTTTTTTATCAATTTACCCATGATTCT
ATTTTCTTAGGGGAAGATGGGCCTACTCACCAACCTGTTGAACATTATGCAGCTTTAAGAGCTATTCCTCAACTACAAGT
AATCCGCCCAGCAGATAGTTATGAAGTAAAAATGTCTTGGATTGCAGCTTTGCAATATAAAGGCCCTACGGCTTTGATTT
TGTCTCGACAGAATTTACCTGATTTAGCTGGGACAAACATTCCTTATGTTGAAGGAATGGGAAGAGGGGCTTATATCGTA
AAAAAAGAAAAAGGAAAGGCTGACTTTACTTTAGTTGCAACTGGCTCGGAATTGAGTTTAGCGATGAACGTAGCAAATGA
ATTAGAAAAACTTGGTAAAAATGTCCGGGTTATTTCTATGCCTTGCTGGGCTTTATTTGAAAAGCAACCTATAGATTATA
AAGAAAGTCTGTTTGGTGGAGATATTGGTAAAAGGGTCAGTATTGAAGCTGGTGTTGACCTTGGATGGCATAAATACATT
GGCCGTGATGGTATTGCAATTTGTATGGAACATTTTGGAGCCTCAGCTCCTGCGGGTGTATTAGCAAAAGAATTTGGTTT
TACCGTTGAGGCTATACTTGAACGTATTTTATAG

Upstream 100 bases:

>100_bases
CCAGGGGGGTGGGAAAACGGCAAGTTTAGGTTTTAACCCTTTTTCTTGCGCCTTTTTATGCATTAGAGCTACATTAAGTT
TTTTTAATCTTTAAATTTAT

Downstream 100 bases:

>100_bases
TCAAAAAAACGCACCTAATTCTGTTGTTTCAAATATCATTAGTAGTTCATTTAATGATCGACTACTTCAAGCCCTGCAAT
GTCGCAATAATTCCAGACCT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 677; Mature: 677

Protein sequence:

>677_residues
MVKNMSSHLQVSVPQPLDSEQKQIMKQIANTIRGLSMDAVQKADSGHPGLPMGCAELGAYLYGYYLKQNPKNSKWLNRDR
FILSAGHGSMWLYSCLHLAGYKITLEDIKNFRQLHSPTPGHPESFMTDGVETTTGPLGQGVGNAVGQALGFKILGEKFNT
EKHPIFNNKVYVLMGDGCVMEGISSEVSSLAGHLKLNNLVAIYDANHVSLDGPLAESSSEDTKTRYKAYGWDVFEIDGND
IEAIDTVFSQIRHYQEKPCLVIAHTIIGKGAPNKGGTYKAHGSPLGVEEIKAAKDELGIPQEDFYVPQAVINYFQNKLVS
DAKEQNEWKQIFEEWAKENPSKFQELEVMLHHKLPDDFEQKLQHLMIKAPISGRKASQEVLNSLADMIPQLYGGSADLSS
SDMTMLKKFSLIAPNEFHGRNIKFGVREFGMATIATGLYQTGMILPFVGTFLTFSDYMRNAIRLAALQHAQVFYQFTHDS
IFLGEDGPTHQPVEHYAALRAIPQLQVIRPADSYEVKMSWIAALQYKGPTALILSRQNLPDLAGTNIPYVEGMGRGAYIV
KKEKGKADFTLVATGSELSLAMNVANELEKLGKNVRVISMPCWALFEKQPIDYKESLFGGDIGKRVSIEAGVDLGWHKYI
GRDGIAICMEHFGASAPAGVLAKEFGFTVEAILERIL

Sequences:

>Translated_677_residues
MVKNMSSHLQVSVPQPLDSEQKQIMKQIANTIRGLSMDAVQKADSGHPGLPMGCAELGAYLYGYYLKQNPKNSKWLNRDR
FILSAGHGSMWLYSCLHLAGYKITLEDIKNFRQLHSPTPGHPESFMTDGVETTTGPLGQGVGNAVGQALGFKILGEKFNT
EKHPIFNNKVYVLMGDGCVMEGISSEVSSLAGHLKLNNLVAIYDANHVSLDGPLAESSSEDTKTRYKAYGWDVFEIDGND
IEAIDTVFSQIRHYQEKPCLVIAHTIIGKGAPNKGGTYKAHGSPLGVEEIKAAKDELGIPQEDFYVPQAVINYFQNKLVS
DAKEQNEWKQIFEEWAKENPSKFQELEVMLHHKLPDDFEQKLQHLMIKAPISGRKASQEVLNSLADMIPQLYGGSADLSS
SDMTMLKKFSLIAPNEFHGRNIKFGVREFGMATIATGLYQTGMILPFVGTFLTFSDYMRNAIRLAALQHAQVFYQFTHDS
IFLGEDGPTHQPVEHYAALRAIPQLQVIRPADSYEVKMSWIAALQYKGPTALILSRQNLPDLAGTNIPYVEGMGRGAYIV
KKEKGKADFTLVATGSELSLAMNVANELEKLGKNVRVISMPCWALFEKQPIDYKESLFGGDIGKRVSIEAGVDLGWHKYI
GRDGIAICMEHFGASAPAGVLAKEFGFTVEAILERIL
>Mature_677_residues
MVKNMSSHLQVSVPQPLDSEQKQIMKQIANTIRGLSMDAVQKADSGHPGLPMGCAELGAYLYGYYLKQNPKNSKWLNRDR
FILSAGHGSMWLYSCLHLAGYKITLEDIKNFRQLHSPTPGHPESFMTDGVETTTGPLGQGVGNAVGQALGFKILGEKFNT
EKHPIFNNKVYVLMGDGCVMEGISSEVSSLAGHLKLNNLVAIYDANHVSLDGPLAESSSEDTKTRYKAYGWDVFEIDGND
IEAIDTVFSQIRHYQEKPCLVIAHTIIGKGAPNKGGTYKAHGSPLGVEEIKAAKDELGIPQEDFYVPQAVINYFQNKLVS
DAKEQNEWKQIFEEWAKENPSKFQELEVMLHHKLPDDFEQKLQHLMIKAPISGRKASQEVLNSLADMIPQLYGGSADLSS
SDMTMLKKFSLIAPNEFHGRNIKFGVREFGMATIATGLYQTGMILPFVGTFLTFSDYMRNAIRLAALQHAQVFYQFTHDS
IFLGEDGPTHQPVEHYAALRAIPQLQVIRPADSYEVKMSWIAALQYKGPTALILSRQNLPDLAGTNIPYVEGMGRGAYIV
KKEKGKADFTLVATGSELSLAMNVANELEKLGKNVRVISMPCWALFEKQPIDYKESLFGGDIGKRVSIEAGVDLGWHKYI
GRDGIAICMEHFGASAPAGVLAKEFGFTVEAILERIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=600, Percent_Identity=26.8333333333333, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI4507521, Length=600, Percent_Identity=26.8333333333333, Blast_Score=181, Evalue=3e-45,
Organism=Homo sapiens, GI133778974, Length=598, Percent_Identity=26.5886287625418, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI225637459, Length=591, Percent_Identity=24.1962774957699, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI225637463, Length=484, Percent_Identity=25.6198347107438, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI225637461, Length=484, Percent_Identity=25.6198347107438, Blast_Score=132, Evalue=8e-31,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=45.662100456621, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1788808, Length=657, Percent_Identity=46.1187214611872, Blast_Score=581, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17539652, Length=609, Percent_Identity=26.6009852216749, Blast_Score=175, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=42.0180722891566, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6319593, Length=665, Percent_Identity=39.6992481203008, Blast_Score=469, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45551847, Length=613, Percent_Identity=26.9168026101142, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45550715, Length=613, Percent_Identity=26.9168026101142, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24666278, Length=604, Percent_Identity=25.1655629139073, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24645119, Length=572, Percent_Identity=26.5734265734266, Blast_Score=156, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74888; Mature: 74888

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKNMSSHLQVSVPQPLDSEQKQIMKQIANTIRGLSMDAVQKADSGHPGLPMGCAELGAY
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHH
LYGYYLKQNPKNSKWLNRDRFILSAGHGSMWLYSCLHLAGYKITLEDIKNFRQLHSPTPG
HHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCC
HPESFMTDGVETTTGPLGQGVGNAVGQALGFKILGEKFNTEKHPIFNNKVYVLMGDGCVM
CCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHH
EGISSEVSSLAGHLKLNNLVAIYDANHVSLDGPLAESSSEDTKTRYKAYGWDVFEIDGND
HHHHHHHHHHHHHEEECCEEEEEECCEEECCCCCCCCCCCHHHHHHHEECCEEEEECCCC
IEAIDTVFSQIRHYQEKPCLVIAHTIIGKGAPNKGGTYKAHGSPLGVEEIKAAKDELGIP
HHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCC
QEDFYVPQAVINYFQNKLVSDAKEQNEWKQIFEEWAKENPSKFQELEVMLHHKLPDDFEQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
KLQHLMIKAPISGRKASQEVLNSLADMIPQLYGGSADLSSSDMTMLKKFSLIAPNEFHGR
HHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
NIKFGVREFGMATIATGLYQTGMILPFVGTFLTFSDYMRNAIRLAALQHAQVFYQFTHDS
CEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCE
IFLGEDGPTHQPVEHYAALRAIPQLQVIRPADSYEVKMSWIAALQYKGPTALILSRQNLP
EEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEEEECCCCEEEEEECCCCC
DLAGTNIPYVEGMGRGAYIVKKEKGKADFTLVATGSELSLAMNVANELEKLGKNVRVISM
CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEE
PCWALFEKQPIDYKESLFGGDIGKRVSIEAGVDLGWHKYIGRDGIAICMEHFGASAPAGV
CHHHHHCCCCCCHHHHHCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHCCCCCHHH
LAKEFGFTVEAILERIL
HHHHHCCCHHHHHHHHC
>Mature Secondary Structure
MVKNMSSHLQVSVPQPLDSEQKQIMKQIANTIRGLSMDAVQKADSGHPGLPMGCAELGAY
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHH
LYGYYLKQNPKNSKWLNRDRFILSAGHGSMWLYSCLHLAGYKITLEDIKNFRQLHSPTPG
HHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCC
HPESFMTDGVETTTGPLGQGVGNAVGQALGFKILGEKFNTEKHPIFNNKVYVLMGDGCVM
CCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHH
EGISSEVSSLAGHLKLNNLVAIYDANHVSLDGPLAESSSEDTKTRYKAYGWDVFEIDGND
HHHHHHHHHHHHHEEECCEEEEEECCEEECCCCCCCCCCCHHHHHHHEECCEEEEECCCC
IEAIDTVFSQIRHYQEKPCLVIAHTIIGKGAPNKGGTYKAHGSPLGVEEIKAAKDELGIP
HHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCC
QEDFYVPQAVINYFQNKLVSDAKEQNEWKQIFEEWAKENPSKFQELEVMLHHKLPDDFEQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHH
KLQHLMIKAPISGRKASQEVLNSLADMIPQLYGGSADLSSSDMTMLKKFSLIAPNEFHGR
HHHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
NIKFGVREFGMATIATGLYQTGMILPFVGTFLTFSDYMRNAIRLAALQHAQVFYQFTHDS
CEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCE
IFLGEDGPTHQPVEHYAALRAIPQLQVIRPADSYEVKMSWIAALQYKGPTALILSRQNLP
EEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEEEEEEECCCCEEEEEECCCCC
DLAGTNIPYVEGMGRGAYIVKKEKGKADFTLVATGSELSLAMNVANELEKLGKNVRVISM
CCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEE
PCWALFEKQPIDYKESLFGGDIGKRVSIEAGVDLGWHKYIGRDGIAICMEHFGASAPAGV
CHHHHHCCCCCCHHHHHCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHCCCCCHHH
LAKEFGFTVEAILERIL
HHHHHCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]