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The map label for this gene is sucD [H]

Identifier: 46446931

GI number: 46446931

Start: 1553340

End: 1554245

Strand: Reverse

Name: sucD [H]

Synonym: pc1297

Alternate gene names: 46446931

Gene position: 1554245-1553340 (Counterclockwise)

Preceding gene: 46446932

Following gene: 46446930

Centisome position: 64.37

GC content: 42.16

Gene sequence:

>906_bases
ATGGCTATTTTGGTTAATAAACAGACACGAGTGATTACGCAAGGAATAACTGGAAAAGCTGGTCGTTTTCACACAGAGCA
AAGCATGCTTTATGCACCAACCTATGTCGGAGGAGTCACACCCGGTAAAGGGGGAGAAGAAATATCCGGTCTCCCGGTAT
TTGATACGGTTTGGGAAGCGAAGCAAAAGACTCAATGCAATGCCTCATTGATTTTTGTTCCTCCACCATTTGCTGCAGAA
GCTATTTTAGAAGCCGAAGAAGCAGGAATTGAATTGATTGTTTGCATCACTGAAGGAATACCCATTCAAGATATGTTAAA
AGTAAGCCAGGTAATGAGAGCAAGTCAAACAAGCCGCTTGATAGGTCCTAATTGCCCTGGTGTTATTACACCAGGAGAGT
GTAAAATGGGGATCATGCCGGGCTACATCCATCAAAAAGGAAATGTTGGCATTGTTTCTCGCTCAGGAACTTTGACTTAC
GAAGCCGTTTGGCAAACCACGCAATTAGGTTTGGGACAATCAACCTGTGTAGGAATAGGAGGGGATCCTCTTAATGGAAC
TAACTTTATCGATGTTTTAAAGCTTTTTGAAAACGATTCTGAGACTGATGCTATTTTACTCATTGGAGAAATTGGAGGAA
AAGCTGAAGAAGAAGCTGCAGAATGGATTAAACAGTTTTGCTCTAAACCGATAGCTGCTTTTATTGCAGGGCAAACTGCC
CCAATTGGTAGACGCATGGGTCATGCGGGAGCTATTGTTTCAGGCGGAAAAGGAACAGCGTCTGATAAAATAAAAACGCT
CAAGCAGGCTGGAGTTTTAATTGCAGAAACCCCTGCGGATATGGGTTTATCTGTCCAGTTATTATTGAATTCTAAATCAC
CTAATTCATCCCCGAGTTTAAAATGA

Upstream 100 bases:

>100_bases
GCAACTTCTTCAACAATCAGGCTTAAAGATTTTAATTACAGAAAATTTGACAGAAGCAGCTCAACAAGCAGTTCAATTAG
CACAATCAGTAAGGTGATCC

Downstream 100 bases:

>100_bases
TCTCCATTTCAAGTTTTATTCCAATTCGTGTTTTTCCTTTTTTTTGGTTTTTGATTGCTATGATTGGTTGGCTAAATAGT
CAATCTTTAATAGGAACAGC

Product: succinate-CoA ligase (ADP-forming) alpha chain

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha; Vegetative protein 239; VEG239 [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MAILVNKQTRVITQGITGKAGRFHTEQSMLYAPTYVGGVTPGKGGEEISGLPVFDTVWEAKQKTQCNASLIFVPPPFAAE
AILEAEEAGIELIVCITEGIPIQDMLKVSQVMRASQTSRLIGPNCPGVITPGECKMGIMPGYIHQKGNVGIVSRSGTLTY
EAVWQTTQLGLGQSTCVGIGGDPLNGTNFIDVLKLFENDSETDAILLIGEIGGKAEEEAAEWIKQFCSKPIAAFIAGQTA
PIGRRMGHAGAIVSGGKGTASDKIKTLKQAGVLIAETPADMGLSVQLLLNSKSPNSSPSLK

Sequences:

>Translated_301_residues
MAILVNKQTRVITQGITGKAGRFHTEQSMLYAPTYVGGVTPGKGGEEISGLPVFDTVWEAKQKTQCNASLIFVPPPFAAE
AILEAEEAGIELIVCITEGIPIQDMLKVSQVMRASQTSRLIGPNCPGVITPGECKMGIMPGYIHQKGNVGIVSRSGTLTY
EAVWQTTQLGLGQSTCVGIGGDPLNGTNFIDVLKLFENDSETDAILLIGEIGGKAEEEAAEWIKQFCSKPIAAFIAGQTA
PIGRRMGHAGAIVSGGKGTASDKIKTLKQAGVLIAETPADMGLSVQLLLNSKSPNSSPSLK
>Mature_300_residues
AILVNKQTRVITQGITGKAGRFHTEQSMLYAPTYVGGVTPGKGGEEISGLPVFDTVWEAKQKTQCNASLIFVPPPFAAEA
ILEAEEAGIELIVCITEGIPIQDMLKVSQVMRASQTSRLIGPNCPGVITPGECKMGIMPGYIHQKGNVGIVSRSGTLTYE
AVWQTTQLGLGQSTCVGIGGDPLNGTNFIDVLKLFENDSETDAILLIGEIGGKAEEEAAEWIKQFCSKPIAAFIAGQTAP
IGRRMGHAGAIVSGGKGTASDKIKTLKQAGVLIAETPADMGLSVQLLLNSKSPNSSPSLK

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=287, Percent_Identity=63.4146341463415, Blast_Score=317, Evalue=6e-87,
Organism=Homo sapiens, GI38569421, Length=251, Percent_Identity=29.8804780876494, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38569423, Length=251, Percent_Identity=29.8804780876494, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786949, Length=290, Percent_Identity=60.6896551724138, Blast_Score=355, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=58.0756013745705, Blast_Score=330, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=59.2982456140351, Blast_Score=327, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17551266, Length=220, Percent_Identity=30.9090909090909, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557344, Length=220, Percent_Identity=30.9090909090909, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=296, Percent_Identity=50.6756756756757, Blast_Score=272, Evalue=5e-74,
Organism=Drosophila melanogaster, GI21356559, Length=282, Percent_Identity=58.8652482269503, Blast_Score=340, Evalue=5e-94,
Organism=Drosophila melanogaster, GI28574296, Length=282, Percent_Identity=59.5744680851064, Blast_Score=315, Evalue=3e-86,
Organism=Drosophila melanogaster, GI281363477, Length=246, Percent_Identity=28.4552845528455, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281363475, Length=246, Percent_Identity=28.4552845528455, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281363473, Length=246, Percent_Identity=28.4552845528455, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 31611; Mature: 31480

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVNKQTRVITQGITGKAGRFHTEQSMLYAPTYVGGVTPGKGGEEISGLPVFDTVWEA
CEEEEECCCEEEECCCCCCCCCEECCCCEEECCCEECCCCCCCCCCCCCCCCHHHHHHHH
KQKTQCNASLIFVPPPFAAEAILEAEEAGIELIVCITEGIPIQDMLKVSQVMRASQTSRL
HHHCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
IGPNCPGVITPGECKMGIMPGYIHQKGNVGIVSRSGTLTYEAVWQTTQLGLGQSTCVGIG
CCCCCCCEECCCCCEECCCCCEEECCCCEEEEECCCCEEEHEEHHHHHCCCCCCEEEECC
GDPLNGTNFIDVLKLFENDSETDAILLIGEIGGKAEEEAAEWIKQFCSKPIAAFIAGQTA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEHHCCCCC
PIGRRMGHAGAIVSGGKGTASDKIKTLKQAGVLIAETPADMGLSVQLLLNSKSPNSSPSL
CHHHHCCCCCEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCEEEEEEECCCCCCCCCC
K
C
>Mature Secondary Structure 
AILVNKQTRVITQGITGKAGRFHTEQSMLYAPTYVGGVTPGKGGEEISGLPVFDTVWEA
EEEEECCCEEEECCCCCCCCCEECCCCEEECCCEECCCCCCCCCCCCCCCCHHHHHHHH
KQKTQCNASLIFVPPPFAAEAILEAEEAGIELIVCITEGIPIQDMLKVSQVMRASQTSRL
HHHCCCCCEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
IGPNCPGVITPGECKMGIMPGYIHQKGNVGIVSRSGTLTYEAVWQTTQLGLGQSTCVGIG
CCCCCCCEECCCCCEECCCCCEEECCCCEEEEECCCCEEEHEEHHHHHCCCCCCEEEECC
GDPLNGTNFIDVLKLFENDSETDAILLIGEIGGKAEEEAAEWIKQFCSKPIAAFIAGQTA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEHHCCCCC
PIGRRMGHAGAIVSGGKGTASDKIKTLKQAGVLIAETPADMGLSVQLLLNSKSPNSSPSL
CHHHHCCCCCEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCEEEEEEECCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]