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The map label for this gene is htrA [H]

Identifier: 46446925

GI number: 46446925

Start: 1546640

End: 1548094

Strand: Reverse

Name: htrA [H]

Synonym: pc1291

Alternate gene names: 46446925

Gene position: 1548094-1546640 (Counterclockwise)

Preceding gene: 46446926

Following gene: 46446924

Centisome position: 64.12

GC content: 38.01

Gene sequence:

>1455_bases
ATGAAACAACTATCAATATTTACCAAATTGTGTTTACTTGCCACAGGAGCTGCCTTAATAGGCTCTTCTTTTACGAACCC
AAATTTAATAGAGGCGGCAACTCAGGAACAGAATCGAACTGAAGATATCAAACGTTTGCCCGGAAAGGAGACCGTCGTTG
ATTTTAGAGGCGTCGCAAAGAAAGCGATTCCTGCCGTCGTCTCTATTAAGGTTAAAGGACAAAAAAAAGGACCTTTGTTT
GGGGATGAAAATTCTTTAGAAGATTATTTTGGAGAAAATGGGGATTTTTGGAACTTTTTTGGATTGCCAAAGAGAGATTC
TCGTCAACAATTGTTATCGGGTCAAGCAACGGGTGTGATTGTGAGTCCAGAAGGGTATATTTTAACAAATAGCCATGTCG
TTCATGACATGACAACAATTGCTGTGCAGCTTCATGATGGAAGAGAACTTGCAGCGAAACTGTTAGGAGAAGATCCTAGT
AGTGATTTAGCGCTCATTAAAATTGACGCAAAAGATCTTCCATATTTGACACTTGGTAATTCAGACGATTTAGAAGTTGG
ACAATGGGTTGCCGCAGTTGGAAATCCTTTTGGCTTGCAAGCGACCTTAACTGTTGGTGTCGTGAGTGCAAAAAGTCGCA
ATAATTTAGATATTGCTCGCTATGAAGACTTTATTCAAACGGATGCTTCTATCAATCGAGGAAATTCAGGCGGTCCTTTG
CTCACATTAAATGGAGAAATTGTAGGGATTAATACAGCAATTGCGACTAATGCATCAGCAGGTTACATCGGAATTGGTTT
TGCAATCCCAAGTAATATGGCTAAACATGTGATGGATGAAATTTTATCTCAAGGAAAAGTCTCTAGAGGATTTTTGGGCG
TTTCTTTACAGTCAATTGATTATAATCTGGCTCAATCTTTTGGTTTAGATAAAGTAGAAGGAGCATTAGTCACAAATATT
GTTAAAAATTCTCCTGCTGAAAAAGCTGGAATTCAGGTAGAGGATATTATTTTAAAACTAAATGGTCGTTCGATTGAGAG
CGCGGCTAGTTTACGTAACGCGATTTATCGGATGAAACCTGGTACAAAAGTGAATTTGACAATTTTGAGAAAAGAAAAAC
AGATTGACCTTTCTCTTACTATTGGTGATTTTACTGAAGAAACTGTCGCAGCAGCATCTTCTCACAAAAGTCAGCTCGGA
ATTGAAGTCGCAAATATCCCTTCCGAAATGAAATCAGATGAACAAGGGGTGATGATTACAAAGGTGTATCCAGGCTCAGT
TGCTAACTTTGCTGGGTTAAAAAAAGGAGCCATTATTCTTGGCATTAATCATCAAAAAATCGAAAATGTAGAGCAATTTA
ATAACGCTTTAAAAAATAGTTCTGCAGATAAGCCAATTCTTTTGCAAGTAAAACAAGGAAATGCTTATCTATTCGTTTCG
CTTCGCTCTGAATAG

Upstream 100 bases:

>100_bases
ATTTATATATTCCTTCCTTTTAACTCTTTTCTTCCTCTTGACATTTCCAAAAAAACGTAGTAAAAAAAACATAAAAAATC
ATTAGAGGAGTGCTCTTCAT

Downstream 100 bases:

>100_bases
TTCATCTAAGTGCTGATCATGAAAATCAAAAACTTTTTATGATCAGCGTTTAAGTCCCATTTTTTGCTTTTGCCTTATTA
TTCGCCTAGCTTCTATCGCA

Product: putative serine proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKQLSIFTKLCLLATGAALIGSSFTNPNLIEAATQEQNRTEDIKRLPGKETVVDFRGVAKKAIPAVVSIKVKGQKKGPLF
GDENSLEDYFGENGDFWNFFGLPKRDSRQQLLSGQATGVIVSPEGYILTNSHVVHDMTTIAVQLHDGRELAAKLLGEDPS
SDLALIKIDAKDLPYLTLGNSDDLEVGQWVAAVGNPFGLQATLTVGVVSAKSRNNLDIARYEDFIQTDASINRGNSGGPL
LTLNGEIVGINTAIATNASAGYIGIGFAIPSNMAKHVMDEILSQGKVSRGFLGVSLQSIDYNLAQSFGLDKVEGALVTNI
VKNSPAEKAGIQVEDIILKLNGRSIESAASLRNAIYRMKPGTKVNLTILRKEKQIDLSLTIGDFTEETVAAASSHKSQLG
IEVANIPSEMKSDEQGVMITKVYPGSVANFAGLKKGAIILGINHQKIENVEQFNNALKNSSADKPILLQVKQGNAYLFVS
LRSE

Sequences:

>Translated_484_residues
MKQLSIFTKLCLLATGAALIGSSFTNPNLIEAATQEQNRTEDIKRLPGKETVVDFRGVAKKAIPAVVSIKVKGQKKGPLF
GDENSLEDYFGENGDFWNFFGLPKRDSRQQLLSGQATGVIVSPEGYILTNSHVVHDMTTIAVQLHDGRELAAKLLGEDPS
SDLALIKIDAKDLPYLTLGNSDDLEVGQWVAAVGNPFGLQATLTVGVVSAKSRNNLDIARYEDFIQTDASINRGNSGGPL
LTLNGEIVGINTAIATNASAGYIGIGFAIPSNMAKHVMDEILSQGKVSRGFLGVSLQSIDYNLAQSFGLDKVEGALVTNI
VKNSPAEKAGIQVEDIILKLNGRSIESAASLRNAIYRMKPGTKVNLTILRKEKQIDLSLTIGDFTEETVAAASSHKSQLG
IEVANIPSEMKSDEQGVMITKVYPGSVANFAGLKKGAIILGINHQKIENVEQFNNALKNSSADKPILLQVKQGNAYLFVS
LRSE
>Mature_484_residues
MKQLSIFTKLCLLATGAALIGSSFTNPNLIEAATQEQNRTEDIKRLPGKETVVDFRGVAKKAIPAVVSIKVKGQKKGPLF
GDENSLEDYFGENGDFWNFFGLPKRDSRQQLLSGQATGVIVSPEGYILTNSHVVHDMTTIAVQLHDGRELAAKLLGEDPS
SDLALIKIDAKDLPYLTLGNSDDLEVGQWVAAVGNPFGLQATLTVGVVSAKSRNNLDIARYEDFIQTDASINRGNSGGPL
LTLNGEIVGINTAIATNASAGYIGIGFAIPSNMAKHVMDEILSQGKVSRGFLGVSLQSIDYNLAQSFGLDKVEGALVTNI
VKNSPAEKAGIQVEDIILKLNGRSIESAASLRNAIYRMKPGTKVNLTILRKEKQIDLSLTIGDFTEETVAAASSHKSQLG
IEVANIPSEMKSDEQGVMITKVYPGSVANFAGLKKGAIILGINHQKIENVEQFNNALKNSSADKPILLQVKQGNAYLFVS
LRSE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=401, Percent_Identity=31.6708229426434, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI22129776, Length=262, Percent_Identity=37.4045801526718, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI24308541, Length=254, Percent_Identity=35.4330708661417, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI7019477, Length=284, Percent_Identity=32.7464788732394, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1786356, Length=438, Percent_Identity=39.041095890411, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1789629, Length=428, Percent_Identity=39.7196261682243, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789630, Length=271, Percent_Identity=38.7453874538745, Blast_Score=193, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24646839, Length=348, Percent_Identity=29.3103448275862, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51924; Mature: 51924

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLSIFTKLCLLATGAALIGSSFTNPNLIEAATQEQNRTEDIKRLPGKETVVDFRGVAK
CCHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHH
KAIPAVVSIKVKGQKKGPLFGDENSLEDYFGENGDFWNFFGLPKRDSRQQLLSGQATGVI
HHCCEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCCEEE
VSPEGYILTNSHVVHDMTTIAVQLHDGRELAAKLLGEDPSSDLALIKIDAKDLPYLTLGN
ECCCCEEEECCEEEEEEEEEEEEEECCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECC
SDDLEVGQWVAAVGNPFGLQATLTVGVVSAKSRNNLDIARYEDFIQTDASINRGNSGGPL
CCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCE
LTLNGEIVGINTAIATNASAGYIGIGFAIPSNMAKHVMDEILSQGKVSRGFLGVSLQSID
EEECCEEEEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
YNLAQSFGLDKVEGALVTNIVKNSPAEKAGIQVEDIILKLNGRSIESAASLRNAIYRMKP
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCEEEEEEEEECCCCHHHHHHHHHHHEEECC
GTKVNLTILRKEKQIDLSLTIGDFTEETVAAASSHKSQLGIEVANIPSEMKSDEQGVMIT
CCEEEEEEEEECCEEEEEEEECCCCHHHHHHHHCCHHHCCEEEECCCHHHCCCCCCEEEE
KVYPGSVANFAGLKKGAIILGINHQKIENVEQFNNALKNSSADKPILLQVKQGNAYLFVS
EECCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEE
LRSE
EECC
>Mature Secondary Structure
MKQLSIFTKLCLLATGAALIGSSFTNPNLIEAATQEQNRTEDIKRLPGKETVVDFRGVAK
CCHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCEEEHHHHHHH
KAIPAVVSIKVKGQKKGPLFGDENSLEDYFGENGDFWNFFGLPKRDSRQQLLSGQATGVI
HHCCEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCEEEECCCCCCCCHHHHHCCCCCEEE
VSPEGYILTNSHVVHDMTTIAVQLHDGRELAAKLLGEDPSSDLALIKIDAKDLPYLTLGN
ECCCCEEEECCEEEEEEEEEEEEEECCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEECC
SDDLEVGQWVAAVGNPFGLQATLTVGVVSAKSRNNLDIARYEDFIQTDASINRGNSGGPL
CCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCE
LTLNGEIVGINTAIATNASAGYIGIGFAIPSNMAKHVMDEILSQGKVSRGFLGVSLQSID
EEECCEEEEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
YNLAQSFGLDKVEGALVTNIVKNSPAEKAGIQVEDIILKLNGRSIESAASLRNAIYRMKP
HHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCEEEEEEEEECCCCHHHHHHHHHHHEEECC
GTKVNLTILRKEKQIDLSLTIGDFTEETVAAASSHKSQLGIEVANIPSEMKSDEQGVMIT
CCEEEEEEEEECCEEEEEEEECCCCHHHHHHHHCCHHHCCEEEECCCHHHCCCCCCEEEE
KVYPGSVANFAGLKKGAIILGINHQKIENVEQFNNALKNSSADKPILLQVKQGNAYLFVS
EECCCCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEE
LRSE
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]