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The map label for this gene is aqpZ [H]

Identifier: 46446430

GI number: 46446430

Start: 976558

End: 977256

Strand: Direct

Name: aqpZ [H]

Synonym: pc0796

Alternate gene names: 46446430

Gene position: 976558-977256 (Clockwise)

Preceding gene: 46446423

Following gene: 46446431

Centisome position: 40.45

GC content: 39.77

Gene sequence:

>699_bases
ATGAATCTTGCATGGTTATTAGCTGAATTTATTGGAACTTTTACGTTGATTTTTATCGGGGTAGGCGCAATTTGTTTAAA
TGAGATGAATCCTGGCAGTGTGGGGCTTGTCGGAATTGCTCTTGCACATGGACTTGCCATTGCTGTGATGGTATCTAACG
TTGGCCATATTTCAGGGGGAAAACTTAATCCAGCTGTTTCTATAGGAGTCTTAATCGGTGGAAGGTCGGACTGGAAAACA
ACAGTGGCAGAAATTTTTGCTCAGTTAGCAGGTGCTGTATTTGCAGCACTATGCCTTAAAATAATCTTTCCAACGGATGT
CACAGAAGTGACAAAATTAGGAACGCCTGTTTTAGCAGATGGAGTTTCTATGGGAATAGGTATTATGGCTGAGGCAATTT
TAACATTTCTCTTAGTATTTACCGTTTACGCCGCTGCAGTTGATCCGAAAGGGGCTTTTAAATCAATTGCTGGTTTTACT
ATTGGTGGTGTAATTATCTTTGATATACTTGTAGGTGGTGGATTAACAGGTGCAGCCATGAATCCTGCTCGCGCATTTGG
ACCTGCTCTTGTAAGCGGAGAATGGATAGATCAAATTGTTTATTGGATTGGTCCAATTCTTGGTGGATTGTTAGCTGGTT
TACTTTATAGCAAATTGATGTTAAAAGATTTAACAACTTTATCTACTCCTTCCGTTTAA

Upstream 100 bases:

>100_bases
TTCTAAGTTAGTAAAATCAAAAAATTAGATGAGCCTGTAAAATTCTGCTTTTAAATTTTACAGTTTTGTTTTTTTGATAT
CACAATTAATACGAGGTTTT

Downstream 100 bases:

>100_bases
TTTATTGGAGACTGAATCTCTAATTATTCAGTCTTTTTTTTAATTATTAAAAAATTCCTAAATATTAAATGAAATTTAAT
AAAAGTCAATTTTGTTTGGA

Product: putative tonoplast intrinsic protein (Aquaporin)

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNLAWLLAEFIGTFTLIFIGVGAICLNEMNPGSVGLVGIALAHGLAIAVMVSNVGHISGGKLNPAVSIGVLIGGRSDWKT
TVAEIFAQLAGAVFAALCLKIIFPTDVTEVTKLGTPVLADGVSMGIGIMAEAILTFLLVFTVYAAAVDPKGAFKSIAGFT
IGGVIIFDILVGGGLTGAAMNPARAFGPALVSGEWIDQIVYWIGPILGGLLAGLLYSKLMLKDLTTLSTPSV

Sequences:

>Translated_232_residues
MNLAWLLAEFIGTFTLIFIGVGAICLNEMNPGSVGLVGIALAHGLAIAVMVSNVGHISGGKLNPAVSIGVLIGGRSDWKT
TVAEIFAQLAGAVFAALCLKIIFPTDVTEVTKLGTPVLADGVSMGIGIMAEAILTFLLVFTVYAAAVDPKGAFKSIAGFT
IGGVIIFDILVGGGLTGAAMNPARAFGPALVSGEWIDQIVYWIGPILGGLLAGLLYSKLMLKDLTTLSTPSV
>Mature_232_residues
MNLAWLLAEFIGTFTLIFIGVGAICLNEMNPGSVGLVGIALAHGLAIAVMVSNVGHISGGKLNPAVSIGVLIGGRSDWKT
TVAEIFAQLAGAVFAALCLKIIFPTDVTEVTKLGTPVLADGVSMGIGIMAEAILTFLLVFTVYAAAVDPKGAFKSIAGFT
IGGVIIFDILVGGGLTGAAMNPARAFGPALVSGEWIDQIVYWIGPILGGLLAGLLYSKLMLKDLTTLSTPSV

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=220, Percent_Identity=35.9090909090909, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4502181, Length=220, Percent_Identity=35.9090909090909, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI6912506, Length=224, Percent_Identity=36.6071428571429, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI4502179, Length=224, Percent_Identity=33.9285714285714, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI86792455, Length=223, Percent_Identity=36.322869955157, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI37694062, Length=217, Percent_Identity=34.1013824884793, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI45446752, Length=198, Percent_Identity=35.3535353535354, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502183, Length=224, Percent_Identity=31.6964285714286, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI4502187, Length=236, Percent_Identity=25, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787101, Length=230, Percent_Identity=36.0869565217391, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790362, Length=250, Percent_Identity=28.8, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558372, Length=237, Percent_Identity=33.7552742616034, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71993722, Length=226, Percent_Identity=30.9734513274336, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24652747, Length=217, Percent_Identity=39.1705069124424, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551084, Length=217, Percent_Identity=39.1705069124424, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19922038, Length=215, Percent_Identity=35.3488372093023, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652751, Length=215, Percent_Identity=35.3488372093023, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24762342, Length=186, Percent_Identity=31.1827956989247, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550503, Length=236, Percent_Identity=28.3898305084746, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24762346, Length=221, Percent_Identity=27.1493212669683, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762348, Length=221, Percent_Identity=27.1493212669683, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20130305, Length=221, Percent_Identity=27.1493212669683, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762344, Length=221, Percent_Identity=27.1493212669683, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136672, Length=185, Percent_Identity=31.8918918918919, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23733; Mature: 23733

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAWLLAEFIGTFTLIFIGVGAICLNEMNPGSVGLVGIALAHGLAIAVMVSNVGHISGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KLNPAVSIGVLIGGRSDWKTTVAEIFAQLAGAVFAALCLKIIFPTDVTEVTKLGTPVLAD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
GVSMGIGIMAEAILTFLLVFTVYAAAVDPKGAFKSIAGFTIGGVIIFDILVGGGLTGAAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NPARAFGPALVSGEWIDQIVYWIGPILGGLLAGLLYSKLMLKDLTTLSTPSV
CHHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLAWLLAEFIGTFTLIFIGVGAICLNEMNPGSVGLVGIALAHGLAIAVMVSNVGHISGG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KLNPAVSIGVLIGGRSDWKTTVAEIFAQLAGAVFAALCLKIIFPTDVTEVTKLGTPVLAD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
GVSMGIGIMAEAILTFLLVFTVYAAAVDPKGAFKSIAGFTIGGVIIFDILVGGGLTGAAM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
NPARAFGPALVSGEWIDQIVYWIGPILGGLLAGLLYSKLMLKDLTTLSTPSV
CHHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]