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The map label for this gene is adh3 [H]

Identifier: 46446423

GI number: 46446423

Start: 968952

End: 970079

Strand: Direct

Name: adh3 [H]

Synonym: pc0789

Alternate gene names: 46446423

Gene position: 968952-970079 (Clockwise)

Preceding gene: 46446422

Following gene: 46446430

Centisome position: 40.13

GC content: 37.59

Gene sequence:

>1128_bases
TTGTTATTTCAATATATAAGAGTTTTAATTGGTTTAATCTGTTTAAAAACGTTAAAGGAGCTAACTATGGTTAAAGTTTC
AGGATATGCCGCTCAGCAAGCGACAACACCTTTAACTCCATTCACATTTGATCGACGCGAATTAAGATCAGAGGATGTGC
AAATAGAAATTCTATATTGTGGGGTTTGCCATTCCGATTTACATACAGCGCGCAATGAATGGAAAAGTACAATTTATCCT
TTTGTTCCTGGTCATGAGATTGTGGGAAGAGTTTTAGAAGTTGGTAAAGATGTTAAAGATTTTAAAAAAGATGACGTAGT
TGCTGTTGGATGTATGGTCGATTCTTGTCGAACTTGCTCTAGTTGTAAAGAACATTTAGAGCAATATTGTGAAAATGGAC
CAGTTTTTACCTATAATAGCTATGATAAGTATGATCAATCCATTACACAAGGAGGCTATTCAACCCAAATCGTTGTAGAC
CATCAATTTGTTCTTCATGTTCCAAAAGAATTTAAAGAAAAAGATTATCCAGGTGTAGCTCCTTTACTTTGTGCAGGAAT
TACGACTTACTCACCTTTGAAGCATTGGAATGTTGGAAAGGGAAGTAAAGTAGGCGTCGTTGGTCTCGGAGGTCTTGGGC
ACATGGCCATCAAATTAGCCCATGCAATGGAAGCTCATGTTGTCCTTTTTACTACATCAAAAAATAAAGAACAGGATGCG
AAAAGATTAGGAGCTGATGAGGTTGTTATTTCAAAAAATGAAGAAGATGTTAAAAAACATAACGCTACTTTTGATTTTAT
CCTCGATACAGTGGCCGCTTCCCATAATTTAGATCCTTTGATTGCTTTATTAAAAAGAGAGGGAACTTTATGTTTGGTGG
GTGCTCCTGAATTTCCTCATCCTTCTCCTACTGTCAGCCAACTTATTTTTAAACGTAGGCAAATTGCAGGATCTTTAATT
GGAGGAATTCAAGAAACGCAAGAAATGCTCGACTTCTGCGCGAAGCGTCGAATTACGGCCGATGTGGAAGTCATCCCGAT
CGAGAAAATCAATGACGCTTATGAGCGCATGCTAAAGGGTGATGTTAAATACCGCTTTGTCATAGACAGCGTATCTTTGA
AAAAGTAG

Upstream 100 bases:

>100_bases
AAGAAAGAATTCTGAGGTTACCCATCCTCAATTATTCAGCTTCTTAAAAAAAGATTGACATCTGCAAGATGATTATCTAG
AAATCAAGACATGATGTATT

Downstream 100 bases:

>100_bases
GGATGCAAGCTACCAATGTGTAAGTAAACTCATTGGTAGCAGGTTGAATGATTATTTTTTTTGCGAGGTAGATTGAATAA
TAGTTTCAGGAGTCGCGGTT

Product: putative alcohol dehydrogenase class III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MLFQYIRVLIGLICLKTLKELTMVKVSGYAAQQATTPLTPFTFDRRELRSEDVQIEILYCGVCHSDLHTARNEWKSTIYP
FVPGHEIVGRVLEVGKDVKDFKKDDVVAVGCMVDSCRTCSSCKEHLEQYCENGPVFTYNSYDKYDQSITQGGYSTQIVVD
HQFVLHVPKEFKEKDYPGVAPLLCAGITTYSPLKHWNVGKGSKVGVVGLGGLGHMAIKLAHAMEAHVVLFTTSKNKEQDA
KRLGADEVVISKNEEDVKKHNATFDFILDTVAASHNLDPLIALLKREGTLCLVGAPEFPHPSPTVSQLIFKRRQIAGSLI
GGIQETQEMLDFCAKRRITADVEVIPIEKINDAYERMLKGDVKYRFVIDSVSLKK

Sequences:

>Translated_375_residues
MLFQYIRVLIGLICLKTLKELTMVKVSGYAAQQATTPLTPFTFDRRELRSEDVQIEILYCGVCHSDLHTARNEWKSTIYP
FVPGHEIVGRVLEVGKDVKDFKKDDVVAVGCMVDSCRTCSSCKEHLEQYCENGPVFTYNSYDKYDQSITQGGYSTQIVVD
HQFVLHVPKEFKEKDYPGVAPLLCAGITTYSPLKHWNVGKGSKVGVVGLGGLGHMAIKLAHAMEAHVVLFTTSKNKEQDA
KRLGADEVVISKNEEDVKKHNATFDFILDTVAASHNLDPLIALLKREGTLCLVGAPEFPHPSPTVSQLIFKRRQIAGSLI
GGIQETQEMLDFCAKRRITADVEVIPIEKINDAYERMLKGDVKYRFVIDSVSLKK
>Mature_375_residues
MLFQYIRVLIGLICLKTLKELTMVKVSGYAAQQATTPLTPFTFDRRELRSEDVQIEILYCGVCHSDLHTARNEWKSTIYP
FVPGHEIVGRVLEVGKDVKDFKKDDVVAVGCMVDSCRTCSSCKEHLEQYCENGPVFTYNSYDKYDQSITQGGYSTQIVVD
HQFVLHVPKEFKEKDYPGVAPLLCAGITTYSPLKHWNVGKGSKVGVVGLGGLGHMAIKLAHAMEAHVVLFTTSKNKEQDA
KRLGADEVVISKNEEDVKKHNATFDFILDTVAASHNLDPLIALLKREGTLCLVGAPEFPHPSPTVSQLIFKRRQIAGSLI
GGIQETQEMLDFCAKRRITADVEVIPIEKINDAYERMLKGDVKYRFVIDSVSLKK

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=25.9776536312849, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565152, Length=368, Percent_Identity=22.0108695652174, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786518, Length=350, Percent_Identity=59.4285714285714, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI87082401, Length=350, Percent_Identity=35.4285714285714, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI87081918, Length=328, Percent_Identity=25.9146341463415, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI226510992, Length=314, Percent_Identity=26.1146496815287, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=326, Percent_Identity=26.9938650306748, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988145, Length=322, Percent_Identity=27.0186335403727, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=27.0516717325228, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=364, Percent_Identity=26.9230769230769, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=366, Percent_Identity=26.775956284153, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=27.5147928994083, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319949, Length=333, Percent_Identity=34.2342342342342, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323980, Length=332, Percent_Identity=35.2409638554217, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=30.3951367781155, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324486, Length=329, Percent_Identity=29.1793313069909, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319621, Length=333, Percent_Identity=27.6276276276276, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=29.1666666666667, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319258, Length=320, Percent_Identity=25.3125, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=362, Percent_Identity=25.1381215469613, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 41913; Mature: 41913

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFQYIRVLIGLICLKTLKELTMVKVSGYAAQQATTPLTPFTFDRRELRSEDVQIEILYC
CHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEE
GVCHSDLHTARNEWKSTIYPFVPGHEIVGRVLEVGKDVKDFKKDDVVAVGCMVDSCRTCS
ECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCCEEEEEEHHHHHHHHH
SCKEHLEQYCENGPVFTYNSYDKYDQSITQGGYSTQIVVDHQFVLHVPKEFKEKDYPGVA
HHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEEEEECCEEEECCHHHCCCCCCCHH
PLLCAGITTYSPLKHWNVGKGSKVGVVGLGGLGHMAIKLAHAMEAHVVLFTTSKNKEQDA
HHHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCEEEEEEECCCCCHHHH
KRLGADEVVISKNEEDVKKHNATFDFILDTVAASHNLDPLIALLKREGTLCLVGAPEFPH
HHCCCCCEEEECCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCC
PSPTVSQLIFKRRQIAGSLIGGIQETQEMLDFCAKRRITADVEVIPIEKINDAYERMLKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCC
DVKYRFVIDSVSLKK
CCEEEEEEECCCCCC
>Mature Secondary Structure
MLFQYIRVLIGLICLKTLKELTMVKVSGYAAQQATTPLTPFTFDRRELRSEDVQIEILYC
CHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEE
GVCHSDLHTARNEWKSTIYPFVPGHEIVGRVLEVGKDVKDFKKDDVVAVGCMVDSCRTCS
ECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCCEEEEEEHHHHHHHHH
SCKEHLEQYCENGPVFTYNSYDKYDQSITQGGYSTQIVVDHQFVLHVPKEFKEKDYPGVA
HHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCEEEEEEECCEEEECCHHHCCCCCCCHH
PLLCAGITTYSPLKHWNVGKGSKVGVVGLGGLGHMAIKLAHAMEAHVVLFTTSKNKEQDA
HHHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCEEEEEEECCCCCHHHH
KRLGADEVVISKNEEDVKKHNATFDFILDTVAASHNLDPLIALLKREGTLCLVGAPEFPH
HHCCCCCEEEECCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCC
PSPTVSQLIFKRRQIAGSLIGGIQETQEMLDFCAKRRITADVEVIPIEKINDAYERMLKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCC
DVKYRFVIDSVSLKK
CCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]